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Mutation Analysis of AVPR2 and AQP2 Gene in Chinese Patients with Congenital Nephrogenic Diabetes Insipidus

Chemical Research in Chinese Universities 2008年第3期24卷 312-315页

作者： WANG Ying LI hong-jun YU Zhen-xiang BAO Yong-li wu Yin YU Chun-lei MENG Xiang-ying LI Yu-xin Institute of Genetics and Cytology Northeast Normal University Changchun 130024 P. R. China Out-patient Department China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China Department of Respiratory Medicine First Hospital of Jilin University Changchun 130021 P. R. China Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education Northeast Normal University Changchun 130024 P. R. China

To detect mutations of the aquaporin 2 gene（AQP2） and the arginine vasopressin V2 receptor gene（AVPR2） of Chinese congenital nephrogenic diabetes insipidus, and to establish the foundation for further studying the emergence mechanism of the disease and clinical diagnosis, all the exons and part of introns of AQP2 and AVPR2 genes were amplified with intronic primers, using genomic DNA extracted from three patients with congenital nephrogenic diabetes insipidus and two mothers as template, PCR product was ligated into a T-vector and then sequenced. The result was compared with the database sequence to identify the mutable sites via a BLAST search, the incidence of every mutation was analyzed, and the putative transcription factor binding sites that maybe disturbed were analyzed by MAPPER. Mutation g.1394A〉G in exon 3 of AVPR2 was detected in all the subjects, g.861C〉T（S167L） in exon 2 of AVPR2 and IVS1＋3G〉A in intron of AQP2 were detected, respectively, in two patients, and c.836A〉C in 3′ untranslated region of AQP2 was detected in two patients and one mother. Four mutations were identified. g.1394A〉G of AVPR2 and c.836A〉C of AQP2 have high incidence in patients with nephrogenic diabetes insipidus. Detection on the two sites may become auxiliary diagnosis index of congenital nephrogenic diabetes insipidus.

关键词： Nephrogenic diabetes insipidus Gene mutation AQP2 A VPR2

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Comparative calculation on Li^+ solvation in common organic electrolyte solvents for lithium ion batteries

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Chinese Physics B 2020年第4期29卷 49-57页

作者： Qi Liu Feng wu Daobin Mu Borong wu Beijing Key Laboratory of Environment Science and Engineering School of Material Science and EngineeringCollaborative Innovation Center of Electric Vehicles in BeijingBeijing Institute of TechnologyBeijing 100081China

It is important for the electrolytes to maintain and enhance the lithium ion battery electrochemical performance,and solvation of Li^+is a key parameter for the property of the *** comparative study on Li^+ solvation structures,energy,enthalpy,Gibbs free energy,infrared and Raman spectra in common organic electrolyte solvents is completed by density functional theory(DFT)*** solvation reaction energy results suggest that the Li^+solvation priority order is propylene carbonate(PC)>ethylene carbonate(EC)>ethyl methyl carbonate(EMC)>diethyl carbonate(DEC)>tetrahydrofuran(THF)>dimethyl carbonate(DMC)>1,3-dioxolane(DOL)>dimethoxyethane(DME)to form 5sol Li^+.It is also indicated that the most innermost solvation shell compounds formations by stepwise spontaneous solvation reaction are four cyclic solvent molecules and three linear solvent molecules combining one Li^+ forming 4sol-Li^+ and 3sol-Li^+,respectively,at room ***,the vibration peaks for C=O and C-O bonds in carbonate ester solvents-Li^+ compounds shift to lower frequency and higher frequency,respectively,when the Li^+ concentration increases in the solvation *** Li-O stretching vibration peaks shift to higher frequency until forming 2solvent-Li^+ complexes,and C-H stretching also shifts to higher frequency except for nDME-Li^+ solvation *** Raman spectrum is more agile to characterize C-H vibrations and IR is agile to C=O,C-O,and Li-O vibrations for Li^+solvation compounds.

关键词： Li^+solvation frequency shift infrared spectra Raman spectra

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Transcatheter arterial chemoembolization combined with CT-guided percutaneous thermal ablation versus hepatectomy in the treatment of hepatocellular carcinoma

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Chinese Journal of Cancer 2015年第6期34卷 29-38页

作者： Sheng Li Liang Zhang Zhi-Mei Huang Pei-hong wu Department of Medical Imaging & Interventional Radiology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Col aborative Innovation Center for Cancer Medicine

Introduction:Transcatheter arterial chemoembolization(TACE)plus thermal ablation has been widely used recently in the treatment of hepatocellular carcinoma(HCC).In this study,we aimed to compare results of the combination of TACE and percutaneous thermal ablation with those of hepatectomy in patients with ***:The clinical data of 137 HCC patients who sequentially received TACE and computed tomography(CT)-guided percutaneous thermal ablation as an initial curative treatment(combination group)and 148 matched HCC patients who received hepatectomy(surgery group)between 2004 and 2011 were collected and *** TACE,multiphase contrast-enhanced CT was performed to identify the total number of tumors as well as lipiodol deposition in the *** was calculated by using the Kaplan-Meier method and compared by using the log-rank *** prognostic factors were assessed with multivariate Cox proportional hazards regression ***:Of all 285 patients,225(79.0%)had cancerous lesions≤5 cm in *** preoperative contrast-enhanced CT or magnetic resonance imaging,the number of tumors was 1–4 for each *** 1-,3-,and 5-year overall survival rates were 95,74%,and 67%in the combination group and 88,66,and 47%in the surgery group,respectively(P=0.004);the corresponding recurrence-free survival rates for the two groups were 92,69,and 61%and 75,58,and44%,respectively(P=0.001).In the multivariate analysis,treatment allocation was an independent prognostic factor for *** 60 patients in the combination group had sufficient imaging data,and 135 new lesions with lipiodol deposition were diagnosed as malignancies in 22 of 60 patients,whereas 20 new lesions were found in 11 of 148patients in the surgery ***:The combination of TACE and CT-guided percutaneous thermal ablation for HCC improves survival of HCC patients compared with hepatectomy.

关键词：原发性肝癌切除术肝动脉治疗 CT 引导计算机断层扫描肝细胞癌

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Conventional radiological strategy of common gastrointestinal neoplasms

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World Journal of Radiology 2015年第1期7卷 7-16页

作者： Yi-Zhuo Li Pei-hong wu Imaging Diagnosis and Interventional Center State Key Laboratory of Oncology in Southern China Cancer Center Sun Yat-sen University Collaborative Innovation Center for Cancer Medicine

This article summarizes the clinical characteristics and imaging features of common gastrointestinal(GI) neoplasms in terms of conventional radiological imaging methods. Barium studies are readily available for displaying primary malignancies and are minimallyor not at all invasive. A neoplasm may be manifested as various imaging findings, including mucosal disruption, soft mass, ulcer, submucosal invasion and lumen stenosis on barium studies. Benign tumors typically appear as smoothly marginated intramural masses. Malignant neoplasms most often appear as irregular infiltrative lesions on barium examination. Tumor extension to adjacent GI segments may be indistinct on barium images. Cross-sectional images such as computed tomography and magnetic resonance imaging may provide more accurate details of the adjacent organ invasion, omental or peritoneal spread.

关键词： Gastrointestinal Barium enema Computed tomography Magnetic resonance imaging Neoplasm

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Multidisciplinary management of ulcerative colitis complicated by immune checkpoint inhibitor-associated colitis with life-threatening gastrointestinal hemorrhage:A case report

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2329-2336页

作者： Na hong Bo Wang Hang-Cheng Zhou Zheng-Xiang wu Hua-Ying Fang Geng-Qing Song Yue Yu Department of Gastroenterology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036Anhui ProvinceChina Intelligent Pathology Institute Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036Anhui ProvinceChina Department of Gastroenterology and Hepatology Metro Health Medical CenterCase Western Reserve UniversityClevelandOH 44109United States

BACKGROUND Programmed cell death 1(PD-1)inhibitors are immune checkpoint inhibitors(ICI)that have demonstrated significant efficacy in treating various advanced malignant *** most patients tolerate treatment well,several adverse drug reactions,such as fatigue,myelosuppression,and ICI-associated colitis,have been *** SUMMARY This case involved a 57-year-old male patient with ulcerative colitis complicated by hepatocarcinoma who underwent treatment with tirelizumab(a PD-1 inhibitor)for six *** treatment led to repeated life-threatening lower gastrointestinal *** patient received infliximab,vedolizumab,and other salvage procedures but ultimately required subtotal colectomy due to uncontrollable massive lower gastrointestinal ***,postoperative gastrointestinal bleeding has stopped,the patient’s stool has turned yellow,and his full blood cell count has returned to *** This case highlights the necessity of early identification,timely and adequate treatment of ICI-related colitis,and rapid escalation to achieve the goal of improving prognosis.

关键词： Ulcerative colitis Hepatocarcinoma Immune checkpoint inhibitor-associated colitis Colectomy Case report

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Simulations of the Transient Flow Generated from a Started Flat Plate

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Chinese Journal of Mechanical Engineering 2012年第6期25卷 1190-1197页

作者： WANG Leqin MA Xudan LI Zhifeng wu Peng wu Dazhuan Institute of Process Equipment Zhejiang UniversityHangzhou 310027China Engineering Research Center of High Pressure Process Equipment and Safety Ministry of EducationHangzhou 310027China

Transient operations are commonly founded in fluid machineries such as the starting, stopping, and variations of rotor speeds, etc. Flow generated from a started fiat plate is of fundamental importance. Experiments have been done to observe the flow evolution in current researches. And in order to explore the flow in more detailed scale, some vortex methods with high resolution and other numerical methods were developed to solve various related problems by some researchers. But the promotion of vortex method to engineering application is rare due to its complexity and difficulty in specifying the boundary conditions. In order to build up a method of numerical study for such problems, a simplified model is built up with a flat plate. The development of two-dimensional viscous incompressible flow generated from an impulsively started and uniformly accelerated infinitesimally thin flat plate is simulated numerically. A dynamic mesh（DM） method based on the spring analogue and local remeshing is applied to realize the mesh motion caused by the started plate. Researches show that the mesh quality will decline under large grid shear force during the updating process. To conquer this problem, a region near the plate is separated to guarantee the mesh quality at location of interest which is the innovation of the present paper. All computations at least cover a period during which the plate translates 6 times its length. The simulated instantaneous velocity profiles, flow structures and drag coefficients under several Reynolds numbers （20 ≤ Re ≤ 126） and accelerations （20 m/s2≤ a ≤ 152 m/s2） are presented and compared with existing results in literatures. Comparisons are found to be satisfactory, confirming the validity of the current proposed method（region separated DM）. The proposed DM method is firstly used to study the transient flow generated from a started flat plate and can be used in further study of transient characteristics during transient operations of turbo mach

关键词： numerical simulation flat plate start transient flow region separated dynamic mesh

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Pure three-dimensional laparoscopic full left hepatectomy of a living donor for an adolescent in China

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Chinese Medical Journal 2019年第2期132卷 242-244页

作者： Jiu-Lin Song hong wu Jia-Yin Yang Liver Transplantation Center Department of Liver SurgeryWest China Hospital of Sichuan UniversityChengduSichuan 610041China

To the Editor:Living donor liver transplantation (LDLT) has expanded the donor pool in countries with low cadaveric organ donation ***, a left-side liver allograft is sufficient and safe for child and adolescent recipients.[1] For the sake of the donor's cosmetic demands and for early functional rehabilitation, laparoscopic technology has been used in live hepatectomy since 2002.[2] Three-dimensional visualization provides better depth perception and tactile feedback than does conventional two-dimensional laparoscopy.[3] In this report, we presented a case of pure three-dimensional laparoscopic full left live hepatectomy.

关键词： Living donor liver transplantation expanded liver

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Laparoscopic donor right hepatectomy with reconstruction of segment V and VIII tributaries of the middle hepatic vein using a cadaveric iliac artery allograft

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Chinese Medical Journal 2019年第9期132卷 1122-1124页

作者： Jiu-Lin Song hong wu Jia-Yin Yang Liver Transplantation Center Department of Liver SurgeryWest China Hospital of Sichuan UniversityChengduSichuan 610041China

To the Editor:Living donor liver transplantation (LDLT) has effectively expanded the donor ***,up to 40% of living donors suffer from postoperative complications,which are mostly associated with a right subcostal lapa... 详细信息

关键词： Editor LDLT wound

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A GNSS Anti-Spoofing Technique Based on the Spatial Distribution Characteristic of the Residual Vectors

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Tsinghua Science and Technology 2024年第2期29卷 457-468页

作者： Qi'an wu Xiaowei Cui Mingquan Lu Pengxiang Yang Peng wu Department of Electronic Enginnering Tsinghua UniversityBeijing 100084China Xi’an Modern Control Technology Research Institute Xi’an 710065China

Anti-spoofing is becoming a crucial technique for applications with high navigation accuracy and reliability ***-spoofing technique based on Receiver Autonomous Integrity Monitoring(RAIM)is a good choice for most Global Navigation Satellite System(GNSS)receivers because it does not require any change to the hardware of the ***,the conventional RAIM method can only detect and mitigate a single spoofing *** improved RAIM methods can deal with more spoofing signals,but the computational complexity increases dramatically when the number of satellites in view increase or need additional *** paper proposes a new RAIM method,called the SRV-RAIM method,which has a very low computation complexity regardless of the number of satellites in view and can deal with any number of spoofing *** key to the new method is the spatial distribution characteristic of the Satellites'Residual Vectors(SRV).In replay or generative spoofing scenarios,the pseudorange measurements of spoofing signals are consistent,the residual vectors of real satellites and those of spoofing satellites have good separation characteristics in spatial *** on this characteristic,the SRV-RAIM method is proposed,and the simulation results show that the method can separate the real signals and the spoofing signals with an average probability of 86.55%in the case of 12 visible satellites,regardless of the number of spoofing *** to the conventional traversal-RAIM method,the performance is only reduced by 3.59%,but the computational cost is reduced by 98.3%,so most of the GNSS receivers can run the SRV-RAIM algorithm in time.

关键词： Global Navigation Satellite System(GNSS) anti-spoofing Receiver Autonomous Integrity Monitoring(RAIM) Satellites'Residual Vectors(SRV)

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关于“一三五不论”的内涵

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西南民族学院学报（哲学社会科学版） 2002年第9期23卷 53-55页

作者：吴东平 wu Dong-ping 孝感学院学报编辑部湖北孝感432100

七言近体诗的“一三五不论”和五言近体诗的“一三不论”在各自的基本句式中其情况有所不同。七言句的四种基本句型中真正具有“一三五不论”全部内容的只有“平平仄仄平平仄”这一句型。五言句的四种基本句型中真正具有“一三不论”全... 详细信息

七言近体诗的“一三五不论”和五言近体诗的“一三不论”在各自的基本句式中其情况有所不同。七言句的四种基本句型中真正具有“一三五不论”全部内容的只有“平平仄仄平平仄”这一句型。五言句的四种基本句型中真正具有“一三不论”全部内容的只有“仄仄平平仄”这一句型。

关键词：一三五不论" 平仄培近体诗五言近体诗句型律诗诗歌 "一三不论

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