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Correlations of β-catenin,Ki67 and Her-2/neu with gastric cancer

Asian Pacific Journal of Tropical Medicine 2014年第4期7卷 257-261页

作者： hong-Wen wu Cheng-Yong Qin Ji-Lai Huang Xian-Yi Kong Wen-Ji Wang Wen-Kun Bai School of Medicine Shandong University Digestive Internal Medicine The First Hospital of Zibo City Digestive Internal Medicine Shandong Provincial Hospital Digestive Internal Medicine Shandong Qianfoshan Hospital

Objective:To study the clinical pathologic characteristics ofβ-catenin,Ki67 and Her-2/neu in gastric cancer and the correlation ofβ-catenin and Ki67 to the protein expression and gene conditions of Her-2/***:The protein expression ofβ-catenin,Ki67 and Her-2/Neu was detected by immunohistochemistry in 101 cases of gastric cancer and the gene conditions of Her-2/Neu by fluorescence in situ hybridization(FISH).Results:The protein expression ofβ-catenin,Ki67 and Her-2/Neu had close relationship with the clinical pathologic characteristics of gastric ***β-catenin and Ki67 had obvious correlation to the differentiation,infiltration and lymphatic metastasis of the gastric cancer(P<0.05).The Ki67 had close relationship with the tumor-node-metastasis staging staging of gastric cancer(P<0.05).Her-2/Neu had close relationship with the differentiation and tumor-node-metastasis staging of gastric cancer(P<0.05)but had no relationship with the infiltration and lymphatic metastasis of the gastric cancer(P<0.05).The protein expression of Ki67 had significantly positive correlation to the protein expression and gene amplification conditions of Her-2/Neu(r=0.567,P<0.05 for protein;r=0.304,P<0.05 for gene).Conclusions:Combined detection ofβ-catenin,Ki67 and Her-2/Neu can be used as a reliable method to help the observation of biological behavior,diagnosis and prognosis of gastric cancer,and Ki67 can be used to serve the preliminary screening of Her-2/Neu gene state.

关键词： Gastric cancer β-catenin Ki67 Her-2/neu Immunohistochemistry Fluorescence in situ hybridization Tumor marker

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Recent progress of pediatric cardiac surgery in China

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Chinese Medical Journal 2006年第23期119卷 2005-2012页

作者： wu Kai-hong LU Xiao-dong LIU Ying-long Pediatric Cardiac Center Department of Surgery CardiovascularInstitute and Fuwai Hospital Chinese Academy of MedicalSciences and Peking Union Medical College Beijing 100037China

Pediatric cardiac surgery in China has madegreat progress since the first successful open heart operation for correction of ventricular septal defect （VSD） with an artificial heart-lung machine in 1958.1 In recent years, the state has paid much attention to both the basic research and the primary, secondary and tertiary prevention of congenital heart disease. The surgical treatment for congenital heart diseases in infancy was listed as one of the Family Planning Technology Specific Projects among the Key Tasks in the Tenth Five-Year Plan. Due to economic and social conditions in China primary or secondary prevention and treatment of congenital heart disease are still in the early phase of development. Therefore, tertiary prevention -- surgical treatment--is still of crucial importance. Here we review the current status of pediatric cardiac surgery in China and highlight the latest advances in this exciting field.

关键词： cardiac surgery cardiopulmonary bypass congenital heart defect pediatrics

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屈原《离骚》在英语世界的译介特征与传播影响

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三峡大学学报（人文社会科学版） 2025年第1期47卷 24-28页

作者：伍钢北京外国语大学英语学院北京100089 三峡大学外国语学院湖北宜昌443002

屈原《离骚》是我国古代乃至世界诗歌史上最伟大的诗篇之一。自《离骚》1879年首次被汉学家帕克尔(庄延龄)翻译成英语以来,先后有近20位中外学者参与和从事了《离骚》的英译,因此《离骚》也形成了不少风格各异的英语译本。本文采用历时... 详细信息

屈原《离骚》是我国古代乃至世界诗歌史上最伟大的诗篇之一。自《离骚》1879年首次被汉学家帕克尔(庄延龄)翻译成英语以来,先后有近20位中外学者参与和从事了《离骚》的英译,因此《离骚》也形成了不少风格各异的英语译本。本文采用历时分析法对屈原《离骚》在英语世界的译介特征和传播影响展开梳理和总结,发现《离骚》目前在英语世界的译介特征具备以下特点:译者身份呈现多重性、译者风格呈现多元化、译介模式呈现复合性。其传播影响具备以下特点:传播媒介呈现多样性、译本影响呈现深远性。

关键词：屈原离骚英语世界译介特征传播影响

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燃料电池编织复合材料侧板的力学分析

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中国机械工程 2005年第22期16卷 2056-2060页

作者：周平吴承伟于平大连理工大学大连116024

为了减小整体结构体积和重量,现代燃料电池结构大量使用纤维增强复合材料。针对燃料电池复合材料侧板中经常出现的螺栓沉孔局部破坏现象进行了研究。利用Anasys有限元分析程序对复合材料侧板上的螺栓沉孔和螺帽垫片进行了接触力学分析,... 详细信息

为了减小整体结构体积和重量,现代燃料电池结构大量使用纤维增强复合材料。针对燃料电池复合材料侧板中经常出现的螺栓沉孔局部破坏现象进行了研究。利用Anasys有限元分析程序对复合材料侧板上的螺栓沉孔和螺帽垫片进行了接触力学分析,主要研究了螺栓直径和螺栓沉孔内圆角对结构破坏的影响,发现在螺栓沉孔内圆角处主要是复合材料层间拉伸破坏,而螺栓沉孔边缘处主要是局部压缩破坏。当螺栓沉孔内圆角大于某个临界值时,拉伸破坏基本被抑制;沉孔边缘的压缩破坏主要引起材料的局部损伤,但不引起整体破坏。另外,还对二维编织复合材料的层间力学性能和压缩破坏机理做了初步研究,发现这类复合材料层间基体压缩破坏不是材料的最后破坏形式,并得到了试验验证。

关键词：燃料电池复合材料螺栓沉孔有限元方法

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超短激光脉冲调制上转换放大

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物理学报 2005年第8期54卷 3749-3756页

作者：吴昆吴健徐晗曾和平华东师范大学物理系光谱学与波谱学教育部重点实验室上海200062

在超短激光脉冲倍频过程中,由于调制不稳定性而产生多色圆锥辐射.在多色圆锥辐射的任意方向上同步注入一束宽带种子光,可以得到相应频率的调制上转换放大.放大的光脉冲的中心波长在500nm时单脉冲能量最大可至150μJ并且具有60nm的频谱宽... 详细信息

在超短激光脉冲倍频过程中,由于调制不稳定性而产生多色圆锥辐射.在多色圆锥辐射的任意方向上同步注入一束宽带种子光,可以得到相应频率的调制上转换放大.放大的光脉冲的中心波长在500nm时单脉冲能量最大可至150μJ并且具有60nm的频谱宽度.通过改变种子光的入射角度而实现上转换放大中心波长的连续调谐,范围约为290nm.

关键词：上转换光脉冲调制调制不稳定性中心波长脉冲倍频超短激光任意方向连续调谐入射角度频谱宽度脉冲能量种子光辐射圆锥多色宽带

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Balancing electron transfer and intermediate adsorption ability of metallic Ni-Fe-RE-P bifunctional catalysts via 4f-2p-3d electron interaction for enhanced water splitting

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Journal of Energy Chemistry 2024年第7期94卷 458-465页

作者： hong-Rui Zhao Cheng-Zong Yuan Chenliang Zhou Wenkai Zhao Lunliang Zhang Cong-Hui Li Lei Xin Fuling wu Shufeng Ye Xiaomeng Zhang Yunfa Chen School of Rare Earths University of Science and Technology of ChinaHefei 230026AnhuiChina Jiangxi Province Research Institute of Rare Earths Ganjiang Innovation AcademyChinese Academy of SciencesGanzhou 341119JiangxiChina State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Balancing electron transfer and intermediate adsorption ability of bifunctional catalysts via tailoring electronic structures is crucial for green hydrogen production,while it still remains challenging due to lacking efficient ***,one efficient and universal strategy is developed to greatly regulate electronic structures of the metallic Ni-Fe-P catalysts via in-situ introducing the rare earth(RE)atoms(Ni-Fe-RE-P,RE=La,Ce,Pr,and Nd).Accordingly,the as-prepared optimal Ni-Fe-Ce-P/CC self-supported bifunctional electrodes exhibited superior electrocatalytic activity and excellent stability with the low overpotentials of 247 and 331 mV at 100 mA cm^(-2) for HER and OER,*** the assembled electrolyzer,the Ni-Fe-Ce-P/CC as bifunctional electrodes displayed low operation potential of 1.49 V to achieve a current density of 10 mA cm^(-2),and the catalytic performance can be maintained for 100 *** results combined with density functional theory(DFT)calculation reveal that Ce doping leads to electron decentralization and crystal structure distortion,which can tailor the band structures and d-band center of Ni-Fe-P,further increasing conductivity and optimizing intermediate adsorption *** work not only proposes a valuable strategy to regulate the electron transfer and intermediate adsorption of electrocatalysts via RE atoms doping,but also provides a deep under-standing of regulation mechanism of metallic electrocatalysts for enhanced water splitting.

关键词： RE atoms Electron transfer Adsorption energy Oxygen evolution Hydrogen evolution

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Coexpression of TLR9 and VEGF-C is associated with lymphatic metastasis in prostate cancer

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Asian Journal of Andrology 2022年第4期24卷 380-385页

作者： Xian-Zi Zeng Zhan-Sen Huang hong-Peng Fang Jie-Ying wu Qun-Xiong Huang Chu-Bin Zhuang Jing Zhou Jin-Ming Di Department of Urology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Infertility and Sexual Medicine The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Pathology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Prostate cancer(PCa)is one of the most frequent cancers in men,and its biomolecular targets have been extensively *** study aimed to analyze the expression of toll-like receptor 9(TLR9)and vascular endothelial growth factor C(VEGF-C)and the clinical value of the coexpression of TLR9 and VEGF-C in *** retrospectively evaluated 55 patients with clinically localized,intermediate-risk,or high-risk PCa who underwent laparoscopic radical prostatectomy(LRP)and extended pelvic lymph node dissection(ePLND)without neoadjuvant hormonal therapy at a single institution from June 2013 to December *** all 55 patients,the median number of lymph nodes(LNs)resected was 23(range:18-31),and a total of 1269 LNs were removed,of which 78 LNs were *** patients had positive LNs,with a positive rate of 30.9%.In addition,the immunohistochemical results in the above patients revealed that high TLR9 expression was correlated with higher Gleason score(GS)(P=0.049),increased LN metastasis(P=0.004),and more perineural invasion(PNI)(P=0.033).Moreover,VEGF-C expression was associated with GS(P=0.040),pathological stage(pT stage)(P=0.022),LN metastasis(P=0.003),and PNI(P=0.001).Furthermore,a significant positive correlation between TLR9 and VEGF-C was found(P<0.001),and the TLR9/VEGF-C phenotype was associated with LN metastasis(P=0.047).Collectively,we propose that TLR9 stimulation may promote LN metastasis in PCa cells through the upregulation of VEGF-C expression,thereby affecting the prognosis of PCa ***,these markers may serve as valuable targets for the treatment of PCa.

关键词： biochemical progression-free survival coexpression lymphatic metastasis prostate cancer toll-like receptor 9 vascular endothelial growth factor C

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Selective separation of pyrene from mixed polycyclic aromatic hydrocarbons by a hexahedral metal-organic cage

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Chinese Chemical Letters 2024年第1期35卷 523-527页

作者： Ya-Liang Lai Juan Su Le-Xiong wu Dong Luo Xue-Zhi Wang Xian-Chao Zhou Chuang-Wei Zhou Xiao-ping Zhou Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou 510632China

Polycyclic aromatic hydrocarbons(PAHs)play an important role in the industry,and the development of new materials for the selective separation of PAHs is of great *** this work,we report a hexahedral metal-organic cage with low symmetry by subcomponent *** this cage,the eight ZnII centers adopt an interestin∧∧/△△△△△△or∧∧∧∧∧∧/△△*** cage with a cavity volume of 520˚A3 can bind anthracene,phenanthrene,and pyrene to form 1:1 host-guest complexes,while the bigger triphenylene,chrysene,perylene,and coronene cannot be *** binding constant Ka of pyrene is about 1.110×10^(3)(mol/L)^(−1),which is more than an order of magnitude larger than that of anthracene and phenanthrene(111(mol/L)^(−1),277(mol/L)^(−1),respectively).X-ray structure studies reveal that the pyrene is located in the cavity and stabilized by multiple C–H…π*** separation from a mixture of PAHs,pyrene with>96.1%purity can be *** work provides a useful method for the first time for the selective separation of pyrene from PAHs mixture by utilizing a metal-organic cage as the material,making it a useful tool for purifying and separating specific compounds from complex mixtures.

关键词： Polycyclic aromatic hydrocarbons Metal-organic cage Host-guest chemistry Selective separation

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Aligned 3D porous polyurethane scaffolds for biological anisotropic tissue regeneration

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Regenerative Biomaterials 2020年第1期7卷 19-27页

作者： Weiwei Lin Wanling Lan Yingke wu Daiguo Zhao Yanchao Wang Xueling He Jiehua Li Zhen Li Feng Luo hong Tan Qiang Fu College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Sichuan Institute for Food and Drug Control Chengdu 611731China Department of Neurosurgery West China Hospital Sichuan UniversityChengdu 610065China Laboratory Animal Center of Sichuan University Chengdu 610041China

A green fabrication process(organic solvent-free)of artificial scaffolds is required in tissue engineering *** this work,a series of aligned three-dimensional(3D)scaffolds are made from biodegradable waterborne polyurethane(PU)emulsion via directional freeze–drying method to ensure no organic *** optimizing the concentration of polymer in the emulsion and investigating different freezing temperatures,an aligned PUs scaffold(PU14)generated from 14wt%polymer content and processed at196C was selected based on the desired oriented porous structure(pore size of 32.569.3 lm,porosity of 92%)and balanced mechanical properties both in the horizontal direction(strength of 41.3 kPa,modulus of 72.3 kPa)and in the vertical direction(strength of 45.5 kPa,modulus of 139.3 kPa).The response of L929 cells and the regeneration of muscle tissue demonstrated that such pure material-based aligned 3D scaffold can facilitate the development of orientated cells and anisotropic tissue regeneration both in vitro and in ***,these pure material-based scaffolds with ordered architecture have great potentials in tissue engineering for biological anisotropic tissue regeneration,such as muscle,nerve,spinal cord and so on.

关键词： polyurethane aligned scaffolds tissue engineering anisotropic regeneration

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The Dynamic Pollen Tube Cytoskeleton： Live Cell Studies Using Actin-Binding and Microtubule- Binding Reporter Proteins

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Molecular Plant 2008年第4期1卷 686-702页

作者： Alice Y. Cheung Qiao-hong Duan Silvia Santos Costa Barend H.J. de Graaf Veronica S. DiStilio Jose Feijo Hen-Ming wu Department of Biochemistry and Molecular Biology Molecular Cell Biology Program Plant Biology Graduate Program University of Massachusetts Lederle Graduate Research Tower Amherst MA 01003 USA Instituto Gulbenkian de Ciencia Centro de Biologia de Desenvolvimento PT-2780-156 Oeiras Portugal Universidale de Lisboa Faculdade de Ciencias Dept. Biologia Vegetal Campo Grande Ed.C2. PT-1749-016 Lisboa Portugal Present address: School of Biosciences University of Birmingham Edgbaston B15 2TT UK Present address: Department of Biology University of Washington Box 351800 Seattle WA 98195 USA

Pollen tubes elongate within the pistil to transport sperm cells to the embryo sac for fertilization. Growth occurs exclusively at the tube apex, rendering pollen tube elongation a most dramatic polar cell growth process. A hall- mark pollen tube feature is its cytoskeleton, which comprises elaborately organized and dynamic actin microfilaments and microtubules. Pollen tube growth is dependent on the actin cytoskeleton; its organization and regulation have been examined extensively by various approaches, including fluorescent protein labeled actin-binding proteins in live cell studies. Using the previously described GFP-NtADF1 and GFP-LIADF1, and a new actin reporter protein NtPLIM2b-GFP, we re-affirm that the predominant actin structures in elongating tobacco and lily pollen tubes are long, streaming actin cables along the pollen tube shank, and a subapical structure comprising shorter actin cables. The subapical collection of actin microfilaments undergoes dynamic changes, giving rise to the appearance of structures that range from basket- or funnel-shaped, mesh-like to a subtle ring. NtPLIM2b-GFP is used in combination with a guanine nucleotide exchange factor for the Rho GTPases, AtROP-GEF1, to illustrate the use of these actin reporter proteins to explore the linkage between the polar cell growth process and its actin cytoskeleton. Contrary to the actin cytoskeleton, microtubules appear not to play a direct role in supporting the polar cell growth process in angiosperm pollen tubes. Using a microtubule reporter protein based on the microtubule end-binding protein from Arabidopsis AtEB1, GFP-AtEB1, we show that the extensive microtubule network in elongating pollen tubes displays varying degrees of dynamics. These reporter proteins provide versatile tools to explore the functional connection between major structural and signaling components of the polar pollen tube growth process.

关键词： Dynamic Pollen Tube Cytoskeleton Live Cell Studies Using Actin-Binding Microtubule-Binding Reporter Proteins

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