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Accurate prediction of essential proteins using ensemble machine learning

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Chinese Physics B 2025年第1期34卷 108-115页

作者： Dezhi Lu hao wu Yutong Hou Yuncheng wu Yuanyuan Liu Jinwu Wang School of Medicine Shanghai UniversityShanghai 200444China Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China University of Shanghai for Science and Technology Shanghai 200093China

Essential proteins are crucial for biological processes and can be identified through both experimental and computational *** experimental approaches are highly accurate,they often demand extensive time and *** address these challenges,we present a computational ensemble learning framework designed to identify essential proteins more *** method begins by using node2vec to transform proteins in the protein–protein interaction(PPI)network into continuous,low-dimensional *** also extract a range of features from protein sequences,including graph-theory-based,information-based,compositional,and physiochemical ***,we leverage deep learning techniques to analyze high-dimensional position-specific scoring matrices(PSSMs)and capture evolutionary *** then combine these features for classification using various machine learning *** enhance performance,we integrate the outputs of these algorithms through ensemble methods such as voting,weighted averaging,and *** approach effectively addresses data imbalances and improves both robustness and *** ensemble learning framework achieves an AUC of 0.960 and an accuracy of 0.9252,outperforming other computational *** results demonstrate the effectiveness of our approach in accurately identifying essential proteins and highlight its superior feature extraction capabilities.

关键词： protein-protein interaction(PPI) essential proteins deep learning ensemble learning

Impact of aerosol-radiation interaction and heterogeneous chemistry on the winter decreasing PM_(2.5)and increasing O_(3)in Eastern China 2014–2020

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Journal of Environmental Sciences 2025年第5期151卷 469-483页

作者： Yasong Li Tijian Wang Qin’geng Wang Mengmeng Li Yawei Qu hao wu Min Xie School of the Environment Nanjing UniversityNanjing 210023China School of Atmospheric Sciences Nanjing UniversityNanjing 210023China College of Intelligent Science and Control Engineering Jinling Institute of TechnologyNanjing 211169China Key Laboratory of Transportation Meteorology of China Meteorological Administration Nanjing Joint Institute for Atmospheric SciencesNanjing 210041China School of Environment Nanjing Normal UniversityNanjing 210023China

In the context of the prevalent winter air quality issues in China marked by declining PM_(2.5)and rising O_(3),this study employed amodified WRF-Chem model to examine the aerosol radiation interaction(ARI),heterogeneous chemistry(AHC),and their combined impact(ALL)on the variations in O_(3)and PM_(2.5)during the 2014–2020 in eastern *** analysis confirmed that ARI curtailed O_(3)while elevating PM_(2.5).AHC reduced O_(3)through heterogeneous absorption of NOx and hydroxideswhile notably fostering fine-grained sulfate,resulting in a PM_(2.5)*** reductions mitigated the inhibitory impact of ARI on meteorological fields and photolysis *** reduction individually without aerosol feedback led to a 5.43 ppb O_(3)increase and a 22.89μg/m^(3)PM_(2.5)*** and AHC amplified the emission-reduction-induced(ERI)O_(3)rise by 1.83 and 0.31 ppb,*** response of ARI to emission diminution brought about a modest PM_(2.5)increase of 0.31μg/m^(3).Conversely,AHC,acting as the primary contributor,caused a noteworthy PM_(2.5)decrease of 4.60μg/m^(3).As efforts concentrate on reducing PM_(2.5),the promotion of ARI on PM_(2.5)counterbalanced the efficacy of emission reduction and the AHC-induced strengthening of PM_(2.5)*** ALL magnified the ERI O_(3)increase by 38.9%and PM_(2.5)decrease by 18.7%.Sensitivity experiments with different degrees of emission reduction demonstrated a consistent linear relationship between the ALL-induced enhancement of O_(3)increase and PM_(2.5)decrease to the ERI PM_(2.5)*** investigation revealed the complex connection between emissions and aerosol feedback in influencing air quality.

关键词： Aerosol-radiation interaction Heterogeneous chemistry O_(3)increase PM_(2.5)decrease Emission reduction

Characterization of ultraviolet communication in a mixed aerosol environment

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Optoelectronics Letters 2025年第2期21卷 77-84页

作者： Zhao Taifei SUN Yuxin WANG wuxin ZHANG Haijun PAN Feixiang wu hao Artificial Intelligence Key Laboratory of Sichuan Province Sichuan University of Science&EngineeringZigong 643000China Faculty of Automation and Information Engineering Xi’an University of TechnologyXi’an 710048China

Wireless ultraviolet (UV) has strong scattering characteristics and can communicate through non-direct *** UV signals are transmitted in the atmosphere,they are affected by the absorption and scattering effects of atmospheric particles and atmospheric turbulence,resulting in attenuation of UV signal energy and reduced reliability of the communication *** paper focuses on the channel model of UV non-direct-view single scattering communication,and simulates and analyzes the communication characteristics of UV light in atmospheric turbulence and mixed aerosol environment under horizontal,vertical and oblique range communication *** results show that at equal relative humidity,the wireless UV non-directive scattering communication performance for vertical communication scenarios is more affected by the mixed aerosol environment and the communication performance is worse.

关键词： communication scattering ultraviolet

Influence of material characteristics on the failure mode and process of landslide dam

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Journal of Mountain Science 2025年第1期22卷 89-109页

作者： HU Liang ZHONG Qiming CHEN Liang YANG Meng ZHANG Lucheng wu hao College of Civil and Transportation Engineering Hohai UniversityNanjing 210098China Department of Geotechnical Engineering Nanjing Hydraulic Research Institute National Key Laboratory of Water Disaster Prevention Nanjing 210098China Key Laboratory of Reservoir and Dam Safety of the Ministry of Water Resources Nanjing 210029China

Landslide dams,as frequent natural hazards,pose significant risks to human lives,property,and ecological *** grading characteristics and density of dam materials play a crucial role in determining the stability of landslide dams and the potential for dam *** explore the failure mechanisms and evolutionary processes of landslide dams with varying soil properties,this study conducted a series of flume experiments,considering different grain compositions and material *** results demonstrated that grading characteristics significantly influence landslide dam stability,affecting failure patterns,breach processes,and final breach ***-graded materials exhibited a sequence of surface erosion,head-cut erosion,and subsequent surface erosion during the breach process,while well-graded materials typically experienced head-cut erosion followed by surface *** coarse-graded dams,the high permeability of coarse particles allowed the dam to remain stable,as inflows matched *** dam breach model experiments also showed that increasing material density effectively delayed the breach and reduced peak breach flow ***,higher fine particle content led to a reduction in the residual dam height and the base slope of the final breach profile,although the relationship between peak breach discharge and the content of fine and coarse particles was *** better understand breach morphology evolution under different soil characteristics and hydraulic conditions,three key points were identified—erosion point,control point,and scouring *** study,by examining the evolution of failure patterns,breach processes,and breach flow discharges under various grading and density conditions,offers valuable insights into the mechanisms behind landslide dam failures.

关键词： Landslide dams Overtopping Grain size distribution Breaching process Outflow discharge

The assembly and activation of the PANoptosome promote porcine granulosa cell programmed cell death during follicular atresia

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Journal of Animal Science and Biotechnology 2025年第1期16卷 121-135页

作者： hao wu Yingxue Han Jikang Liu Rong Zhao Shizhen Dai Yajun Guo Nan Li Feng Yang Shenming Zeng National Engineering Laboratory for Animal Breeding Key Laboratory of Animal Genetics and Breeding of the Ministry of AgricultureCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Department of Clinical Sciences College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China College of Animal Science and Technology Henan Agricultural UniversityZhengzhou 450046China

Background Follicular atresia significantly impairs female fertility and hastens reproductive *** of granulosa cells is the primary cause of follicular *** and necroptosis,as additional forms of pro-grammed cell death,have been reported in mammalian ***,the understanding of pyroptosis and necrop-tosis pathways in granulosa cells during follicular atresia remains *** study explored the effects of pro-grammed cell death in granulosa cells on follicular atresia and the underlying *** The results revealed that granulosa cells undergo programmed cell death including apoptosis,pyroptosis,and necroptosis during follicular *** the first time,we identified the formation of a PANoptosome com-plex in porcine granulosa *** complex was initially identified as being composed of ZBP1,RIPK3,and RIPK1,and is recruited through the RHIM ***,we demonstrated that caspase-6 is activated and cleaved,interacting with RIPK3 as a component of the *** stress may exacerbate the activation of the PANop-tosome,leading to programmed cell death in granulosa *** Our data identified the formation of a PANoptosome complex that promoted programmed cell death in granulosa cells during the process of follicular *** findings provide new insights into the molecular mechanisms underlying follicular atresia.

关键词： Follicular atresia Granulosa cells PANoptosome Programmed cell death

Control of Differential Tectonic Evolution on Tectonic Fractures in Different Tectonic Segments of Tight Gas Sandstone Reservoirs: Upper Triassic Xujiahe Formation， Western Sichuan Foreland Basin

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Journal of Earth Science 2025年

作者： Yunzhao Zhang Lianbo Zeng Rongjun Zhang Le Qu hao wu Quanqi Dai School of Earth Sciences and Engineering， Xi'an Shiyou University Shaanxi Key Laboratory of Petroleum Accumulation Geology， School of Earth Sciences and Engineering， Xi'an Shiyou University State Key Laboratory of Petroleum Resources and Prospecting， China University of Petroleum (Beijing) College of Geosciences， China University of Petroleum (Beijing) College of Petroleum Engineering， Xi'an Shiyou University Xi'an Key Laboratory of Tight oil (Shale oil) Development， Xi'an Shiyou University China Key Laboratory of Mineral Resources in Western China， School of Earth Sciences， Lanzhou University State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development， SINOPEC Key Laboratory of Carbon Capture， Utilization and Storage， Petroleum Exploration and Production Research Institute of SINOPEC

In the context of complex tectonic evolution， due to the control of tectonic compression stress and faults on tectonic fractures， the formation and development of tectonic fractures in the T3x2tight reservoirs present significant variations across different tectonic segments in the Western Sichuan Foreland Basin. We clarified the control of differential tectonic evolution on the formation and development of tectonic fractures in different tectonic segments through field-based observations， core samples， image logging， as well as fluid inclusion petrography and temperature determinations of fracture-filling materials， combined with 2D balanced cross-section restoration. The study area primarily manifests two types of tectonic fractures in the tight reservoirs: orogen-related fractures （regional fractures） and fault-related fractures. The orientations of these fractures are predominantly E-W， nearly N-S， NE， and NW. Specifically， the northern segment area only shows the development of regional fractures， while the southern and middle segments exhibit the development of both regional and tectonic fractures. There are three phases of tectonic fractures in different tectonic segments， and their formation times are relatively consistent. The Mesozoic tectonic events had a significant impact on the northern and central segments， with the amount of tectonic shortening and the rate of stratigraphic shortening gradually decreasing from the northeast to the southwest. The compressional stress resulting from tectonic compression also decreases from the northeast to the southwest. As a result， the development of first-phase and second-phase tectonic shear fractures is more pronounced in the northern and middle segments compared to the southern segment. Under the significant control of faults， the development of N-S- and NE-oriented fault-related fractures is more pronounced in the southern segment， while the development of NE-oriented fault-related fractures is relatively higher

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Krill oil attenuates obesity-induced skeletal muscle atrophy in mice

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Food Science and Human Wellness 2025年第1期14卷 250-261页

作者： Mengqing Zhou Yuhong Yang Yan Zheng Zijian wu Chen Chen Qijian Liang Yu Yang hao wu Xin Guo Lei Du Department of Nutrition and Food Hygiene School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Research Center of Translational Medicine Jinan Central HospitalShandong UniversityJinan 250013China School of Food Science and Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China

Obesity is associated with skeletal muscle mass loss and physical *** oil(KO)has been shown to be beneficial in human ***,the effect of KO on obesity-induced skeletal muscle atrophy is still *** this study,the male C57BL/6J mice were fed a high-fat diet(HFD)for 12 weeks to induce obesity,and then were intragastric administration with 400 mg/kg bw KO for an additional 6 *** results showed that KO treatment reduced body weight,fat accumulation and serum pro-inflammatory cytokines in HFD-induced obese ***,KO treatment attenuated skeletal muscle atrophy in HFD-fed mice,as evidenced by preserving skeletal muscle mass,average myofiber cross-sectional area and grip *** administration also mitigated obesity-induced ectopic lipid deposition and inflammatory response in skeletal ***,KO treatment inhibited the transcriptional activities of nuclear factor-κB(NF-κB)p65 and forkhead box O 3a(FoxO3a),and then down-regulated muscle atrophy F-box(MAFbx)and muscle-specific RING finger protein 1(MuRF1)protein levels in skeletal muscle from HFD-fed *** administration also improved obesity-induced impaired muscle protein synthesis via activating PI3K/Akt ***,KO treatment enhanced muscle mitochondrial biogenesis in HFD-induced obese mice via activating PGC-1α***,KO might be developed as a potential nutritional supplement for the prevention and treatment of obesity-induced skeletal muscle atrophy.

关键词： Obesity Skeletal muscle atrophy Inflammation Protein turnover Mitochondrial biogenesis

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新时代“革命史诗”小说话语新建构——以孙甘露《千里江山图》为例

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文学评论 2025年第1期29卷 194-204页

作者：吴昊中国传媒大学戏剧影视学院

孙甘露的《千里江山图》是史诗性文学的变体,在“历史事实表现”和“历史话语建构”方面作了诸多创新性探索。小说继承史诗性写作的宏大叙事视野与总体性诉求,又积极地运用互现、回叙等方法,一方面丰富了历史事实,展现了历史复杂性;另... 详细信息

孙甘露的《千里江山图》是史诗性文学的变体,在“历史事实表现”和“历史话语建构”方面作了诸多创新性探索。小说继承史诗性写作的宏大叙事视野与总体性诉求,又积极地运用互现、回叙等方法,一方面丰富了历史事实,展现了历史复杂性;另一方面又表现出历史话语建构的勇气,借鉴悬疑、谍战等类型小说经验,塑造了新时代背景下“可信、可敬、可爱”的革命英雄人物形象。小说对“十七年”革命叙事传统以及20世纪80年代以来的新历史叙事传统与先锋性创作经验进行转化、融通与创新,形成了新的讲述方式,为新时代革命历史小说的话语新建构提供了经验。

关键词：孙甘露《千里江山图》革命史诗历史话语

Role of triggering receptor expressed on myeloid cells 1/2 in secondary injury after cerebral hemorrhage

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World Journal of Clinical Cases 2025年第9期13卷 1-12页

作者： Fan Yi hao wu Hai-Kang Zhao Xi’an Medical University Xi’an 710021Shaanxi ProvinceChina Department of Neurosurgery The Second Affiliated Hospital of Xi’an Medical UniversityXi’an 710038Shaanxi ProvinceChina

Intracerebral hemorrhage(ICH)is a common severe emergency in neurosurgery,causing tremendous economic pressure on families and society and devastating effects on patients both physically and psychologically,especially among patients with poor functional *** is often accompanied by decreased consciousness and limb *** seriously affects patients’ability to live *** rapid advances in neurosurgery have greatly improved patient survival,there remains insufficient evidence that surgical treatment significantly improves long-term *** in-depth pathophysiological studies after ICH,increasing evidence has shown that secondary injury after ICH is related to long-term prognosis and that the key to secondary injury is various immune-mediated neuroinflammatory reactions after *** basic and clinical studies of various systemic inflammatory diseases,triggering receptor expressed on myeloid cells 1/2(TREM-1/2),and the TREM receptor family is closely related to the inflammatory *** inflammatory diseases can be upregulated and downregulated through receptor *** the TREM receptor functions after ICH,the types of results from intervention,and whether the outcomes can improve secondary brain injury and the long-term prognosis of patients are *** analysis of relevant research results from basic and clinical trials revealed that the inhibition of TREM-1 and the activation of TREM-2 can alleviate the neuroinflammatory immune response,significantly improve the long-term prognosis of neurological function in patients with cerebral hemorrhage,and thus improve the ability of patients to live independently.

关键词： Cerebral hemorrhage Secondary injury Triggering receptor expressed on myeloid cells 1/2 Neurosurgery Inflammatory response