检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

车轮对整车气动性能影响的试验与仿真研究

汽车工程 2021年第12期43卷 1848-1857页

作者：任超吴海波陈蒨上汽大众汽车有限公司上海201805

基于某款轿车通过风洞试验研究了5种轮胎和3种轮辋对整车气动性能的影响及其相互作用,并利用PIV(粒子成像测速)对车轮区域的流场进行了测量对比。结果表明,不同花纹轮胎产生的阻力和升力系数差别分别达到了0.003和0.026,且该差别因轮辋... 详细信息

基于某款轿车通过风洞试验研究了5种轮胎和3种轮辋对整车气动性能的影响及其相互作用,并利用PIV(粒子成像测速)对车轮区域的流场进行了测量对比。结果表明,不同花纹轮胎产生的阻力和升力系数差别分别达到了0.003和0.026,且该差别因轮辋造型而异。其次利用图像识别测量了不同轮胎受力旋转时的变形,还原了真实的轮胎几何以进行仿真计算。通过对比仿真计算和试验结果,分析了不同花纹轮胎造成气动性能差异的原因,为车轮的空气动力学开发提供了参考。

关键词：空气动力学轮胎变形阻力风洞试验 PIV

Pyroptotic inflammatory macrophages ignite the SARS-CoV2-associated cytokine storm

在线全文

学校读者我要写书评

暂无评论

Pyroptotic inflammatory macrophages ignite the SARS-CoV2-ass...

第十四届全国免疫学学术大会

作者： Jinghe Zhang haibo wu Zhigang Tian Xiuwu Bian Haiming Wei Division of Life Sciences and Medicine University of Science and Technology of China Institute of Pathology Southwest Hospital Third Military Medical University (Army Medical University)

The cytokine storm(also called cytokine secretion symptom) increases the risk of death and deterioration of COVID-19 patients. Here, we demonstrate that the cytokine storm originates in the lungs based on the analysis of 13 autopsy samples from severe COVID-19 patients. Further, we found that the macrophages infiltrating into the lungs of severe COVID-19 patients were inflammatory macrophages. These pulmonary inflammatory macrophages are the main source of inflammatory cytokines, including interleukin(IL)-1b, IL-6, and IL-18. Finally, we found that inflammatory macrophages ignited the SARS-CoV2-associated cytokine storm via gasdermin D(GSDMD)-mediated pyroptosis. We propose targeting the pyroptosis-associated pathway will reduce the intensity of the cytokine storm and will provide more time to improve treatment efficacy.

关键词： COVID-19 SARS-CoV2 Cytokine storm Pyroptosis IL-1β IL-6 IL-18

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

ForCES体系结构下路由器内部路由机制

清华大学学报（自然科学版） 2008年第1期48卷 124-127页

作者：吴海博徐明伟清华大学软件学院北京100084 清华大学计算机科学与技术系北京100084

控制和转发单元分离结构(forwarding and control element separation,ForCES)路由器必须能够支持上百个转发单元(forwarding element,FE),为解决分组在路由器内部的路由问题,在ForCES路由器拓扑发现的基础上,提出基于标签的内部路由机... 详细信息

控制和转发单元分离结构(forwarding and control element separation,ForCES)路由器必须能够支持上百个转发单元(forwarding element,FE),为解决分组在路由器内部的路由问题,在ForCES路由器拓扑发现的基础上,提出基于标签的内部路由机制。引入备份路径减少了路由恢复时间。若n代表FE结点数,m代表含外部接口的FE数,e代表平均边数,则该机制与OSPF(open shortest path first)相比,计算量由O(n3)减小为O(mn2),通信开销由ne的数量级减至n的数量级。实验结果表明:转发表更新算法的计算开销优于OSPF。该机制收敛速度快,通信开销小,路径发生故障时能够快速恢复。

关键词：计算机网络控制和转发单元分离(ForCES) 路由器内部路由标签备份路径

Analysis of the Badong Ms5. 1 earthquake source characteristics

在线全文

学校读者我要写书评

暂无评论

Geodesy and Geodynamics 2014年第4期5卷 16-24页

作者： wu haibo Chen Junhua Shen Xuelin Zhang Lifen Zhao Lingyun Zhang Ke Key Laboratory of Earthquake Geodesy Institute of SeismologyChina Earthquake Administration Earthquake Administration of Hubei Province Earthquake Administration of Shiyan City

The mainshock location of the Badong MsS. 1 earthquake is determined using four location methods ： the simplex method, HYP2000, hyposat, and locSAT; the 350 aftershocks over 3 months are relocated using the double difference location method. The results indicate that aftershocks are distributed as bands along the NEE direction and that the aftershocks 1 month after the mainshock, which are mainly distributed in the west of the mainshock and near the Gaoqiao fault, arc shallow earthquakes within 5 km; the depth of each after- shock after one month is deeper, and two distinct fault planes, for which the geological occurrence is similar to the Gaoqiao and Zhoujiashan-Niukou fault, are shaped. The frequency-spectrum analysis of the recorded wave- form in 12 seismic events indicates that the corner frequency of the mainshock is significantly lower than that of its aftershock and is also lower than a tectonic earthquake of the same magnitude. We considered that this result is related to the constraint of the parameter calibration relationship in the focal spectrum and the lithology change due to water erosion. Combined with the focal mechanism and geological tectonic setting, we conclude that the occurrence of the earthquake is related to the activity of the Daping and Gaoqiao fault and is a reser- voir-induced tectonic seismicity.

关键词： precise location of the mainshock double difference location deep profile corner frequency

在线全文

学校读者我要写书评

暂无评论

火参果化学成分及其抗氧化性与杀线活性研究

贵州农业科学 2024年第5期52卷 76-84页

作者：张浩王建国张学军陈积豪梁其干符小发王敏周勃高强吴海波黄远新疆农业科学院海南三亚农作物育种试验中心海南三亚572000 三亚明珠甜瓜西瓜展示评价研究中心海南三亚572000 华中农业大学湖北武汉430070 海南农业科学院蔬菜研究所海南海口570100

【目的】探明火参果化学成分及其抗氧化性和杀线活性,为制备植物源杀线虫剂奠定理论基础。【方法】利用硅胶、反相中低压、凝胶Sephadex LH-20柱色谱及制备型高效液相色谱等手段进行分离纯化,并通过理化性质和各种波谱及文献报道数据对... 详细信息

【目的】探明火参果化学成分及其抗氧化性和杀线活性,为制备植物源杀线虫剂奠定理论基础。【方法】利用硅胶、反相中低压、凝胶Sephadex LH-20柱色谱及制备型高效液相色谱等手段进行分离纯化,并通过理化性质和各种波谱及文献报道数据对化合物进行鉴定,对分离得到的化合物进行杀线活性和抗氧化活性分析。【结果】从火参果中分离得到异牡荆素-2''-O-葡萄糖苷(化合物1)、2E,4E-十三碳二烯二酸(化合物2)、9E,11E-(13-氧代)十三碳二烯酸(化合物3)、9E,11E-(13-羟基)十三碳二烯酸(化合物4)共4个化合物。化合物1具有一定抗氧化性,当质量浓度为1 mg/mL时,对DPPH清除率达49.40%。化合物1、化合物3和化合物4显示出一定杀线活性,化合物1在2.0 mg/mL时具有较强的杀线虫能力,致死率为90.5%;化合物3和化合物4在0.25 mg/mL时对线虫的致死率均为100%。【结论】异牡荆素-2''-O-葡萄糖苷、2E,4E-十三碳二烯二酸、9E,11E-(13-氧代)十三碳二烯酸、9E,11E-(13-羟基)十三碳二烯酸4个化合物均首次从火参果分离得到,其中,2E,4E-十三碳二烯二酸、9E,11E-(13-氧代)十三碳二烯酸为新天然产物。异牡荆素-2''-O-葡萄糖苷、9E,11E-(13-氧代)十三碳二烯酸、9E,11E-(13-羟基)十三碳二烯酸3个化合物具有杀线活性,异牡荆素-2''-O-葡萄糖苷具有抗氧化活性。

关键词：火参果植物源农药化学成分根结线虫抗氧化活性杀线活性

主动脉左冠窦瘤破入左心室流出道误诊为主动脉-左心室隧道1例

在线全文

学校读者我要写书评

暂无评论

中国医学影像技术 2023年第5期39卷 797-798页

作者：王超吴海波武俊大连医科大学附属第二医院心血管超声科辽宁大连116027

患者男,33岁,无明显诱因胸闷、干咳1个月,2周前阵发性发热,最高体温38℃,未经处理而于数小时内降至正常,之后胸闷及干咳症状加重;既往体健。查体:体温36.8℃,心率110次/分,血压126/62 mmHg。实验室检查未见明显异常。心电图提示心电轴左... 详细信息

患者男,33岁,无明显诱因胸闷、干咳1个月,2周前阵发性发热,最高体温38℃,未经处理而于数小时内降至正常,之后胸闷及干咳症状加重;既往体健。查体:体温36.8℃,心率110次/分,血压126/62 mmHg。实验室检查未见明显异常。心电图提示心电轴左偏,窦性心动过速,完全性左束支传导阻滞。经胸及经食管超声心动图:左心室长轴切面示左心室增大,主动脉根部前方见43.1 mm×16.0 mm囊性无回声通道,突入左心室流出道。

关键词：主动脉窦瘤心室,左超声心动描记术

Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第5期18卷 1305-1307页

作者： Jinghe Zhang haibo wu XiaoHong Yao Dingyu Zhang Yonggang Zhou Binqing Fu Wei Wang Heng Li Zhe Wang Ziming Hu Yong Ren Rui Sun Zhigang Tian Xiuwu Bian Haiming Wei Department of Pathology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiChina Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Science and Medical CenterUniversity of Science and Technology of ChinaHefeiAnhuiChina Intelligent Pathology Institute Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiChina Institute of Pathology Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina wuhan Jinyintan Hospital(wuhan Hospital for Infectious Diseases) WuhanHubeiChina General Hospital of Central Theater Command PLAWuhanChina

Coronavirus disease 2019(COVID-19)is an unprecedented pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).As of 22 February 2021,the worldwide pandemic has resulted in more than 110 million cases and 2.4 million deaths.1 Clinical investigation of COVID-19 patients has shown that a systemic cytokine storm can occur,especially in severe cases.2 Treatment of the SARS-CoV-2-associated cytokine storm with tocilizumab3 or anakinra4 has been shown to immediately improve the clinical outcome in most severe and critical COVID-19 *** data highlight the systemic cytokine storm as an important exacerbating event in severe COVID-19;however,our understanding of the molecular mechanisms involved in the initiation of the SARS-CoV-2-associated cytokine storm is *** the present study,we uncovered a reasonable explanation for cytokine storm initiation through the analysis of 13 autopsy samples from severe COVID-19 patients.

关键词： cytokine storm acute

基于γ修正的转捩模型汽车后视镜啸叫理论研究与试验验证

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

汽车工程 2021年第6期43卷 885-890,933页

作者：吴海波邢鹏周江彬上汽大众汽车有限公司产品研发部上海201805

针对汽车后视镜啸叫声,本文中以κ-ωSST转捩输运函数为基础,引入湍流间歇度γ和动量厚度雷诺数Reθ,详细解释了汽车后视镜表面层流边界层流体变化。将经γ修正的转捩模型应用于某一具体车型,并与风洞试验、声学照相机测试相结合进行验... 详细信息

针对汽车后视镜啸叫声,本文中以κ-ωSST转捩输运函数为基础,引入湍流间歇度γ和动量厚度雷诺数Reθ,详细解释了汽车后视镜表面层流边界层流体变化。将经γ修正的转捩模型应用于某一具体车型,并与风洞试验、声学照相机测试相结合进行验证。结果表明,基于γ修正的转捩模型通过剪切力(或者表面摩擦因数Cf)和动量厚度θ云图可准确预测层流边界层的转捩、分离、再附着的流动现象,结合湍动能κ可明确湍流加剧的原因,从而可准确预测后视镜产生啸叫的倾向。该方法为汽车前期开发阶段后视镜啸叫倾向的评估提供了一定的指导依据,有效缩短了开发周期和降低后期实车啸叫声的测试成本。

关键词：啸叫 SST转捩模型动量厚度雷诺数湍动能剪切力

Edible prodelphinidins that improve postprandial hyperglycemia were first discovered in Chinese bayberry(Myrica rubra Sieb. et Zucc.) fruits

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Yi Wang Laiming Zhang Jiaxiong wu Chengxiao Yu Xingqian Ye haibo Pan Shiguo Chen Ningbo Research Institute， Zhejiang University College of Biosystems Engineering and Food Science，Zhejiang Key Laboratory for Agro-Food Processing， Integrated Research Base of Southern Fruit and Vegetable Preservation Technology， Zhejiang International Scientific and Technological Cooperation Base of Health Food Manufacturing and Quality Control， Zhejiang University Zhejiang University Zhongyuan Institute Innovation Center of Yangtze River Delta， Zhejiang University

Plant polyphenols are potential substitutes for clinical α-glucosidase inhibitors. Our previous studies indicated that prodelphinidins from Chinese bayberry leaves (BLPs) have stronger α-glucosidase inhibitory activity than other common polyphenols， but they have no safe history of consumption. There is a reasonable prospect that prodelphinidins from Chinese bayberry fruits (BFPs) can improve postprandial hyperglycemia， though known active components are only myricetin and cyanidin-3-O-glucoside. Hence， the aim of this study was to analyze structure and hypoglycemic effect of BFPs of “Biqi” (BQPs) and “Dongkui” (DKPs) cultivars， and compare their difference with BLPs. The contents of BQPs and DKPs were (221.73±0.60) and (136.82±4.33) mg EC equivalents/g dry weight， respectively. The most subunits were EGCG along with a small amount of EGC， ECG and EC connected by B-type linkages and a small portion of A-type linkages with mean polymerization degree of 4.25 and 4.08， respectively. Importantly， BQPs and DKPs were α-glucosidase inhibitors with IC50of 11.91 and 9.47 μg/mL respectively， which were significantly stronger than BLPs. DKPs could also improve postprandial hyperglycemia of normal mice and high fat diet-induced type Ⅱ diabetic mice. Therefore， edible prodelphinidins， which have stronger hypoglycemic effect than BLPs， were first found in Chinese bayberry fruits.

关键词：