检索结果-南通市图书馆

Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury

Virologica Sinica 2024年第2期39卷 309-318页

作者： Jian-Bo Cao Shu-Tong Zhu Xiao-shan Huang Xing-Yuan Wang Meng-Li wu Xin Li feng-liang Liu Ling Chen Yong-Tang Zheng Jian-Hua Wang guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China School of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230026China Key Laboratory of Bioactive Peptides of Yunnan Province Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of SciencesKIZCUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China University of Chinese Academy of Sciences Beijing 101408China

SARS-CoV-2 infection-induced hyper-inflammation is a key pathogenic factor of *** research,along with others',has demonstrated that mast cells(MCs)play a vital role in the initiation of hyper-inflammation caused by *** previous study,we observed that SARS-CoV-2 infection induced the accumulation of MCs in the peri-bronchus and bronchioalveolar-duct junction in humanized ***,we found that MC degranulation triggered by the spike protein resulted in inflammation in alveolar epithelial cells and capillary endothelial cells,leading to subsequent lung *** trachea and bronchus are the routes for SARS-CoV-2 transmission after virus inhalation,and inflammation in these regions could promote viral *** are widely distributed throughout the respiratory ***,in this study,we investigated the role of MCs and their degranulation in the development of inflammation in tracheal-bronchial *** analyses showed the accumulation and degranulation of MCs in the peri-trachea of humanized mice infected with *** degranulation caused lesions in trachea,and the formation of papillary hyperplasia was *** transcriptome analysis in bronchial epithelial cells,we found that MC degranulation significantly altered multiple cellular signaling,particularly,leading to upregulated immune responses and *** administration of ebastine or loratadine effectively suppressed the induction of inflammatory factors in bronchial epithelial cells and alleviated tracheal injury in *** together,our findings confirm the essential role of MC degranulation in SARS-CoV-2-induced hyper-inflammation and the subsequent tissue ***,our results support the use of ebastine or loratadine to inhibit SARS-CoV-2-triggered degranulation,thereby preventing tissue damage caused by hyper-inflammation.

关键词： SARS-CoV-2 Mast cell(MC) Bronchial epithelial cell Inflammation Tracheal injury

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Passivation remediation of weakly alkaline Cd-contaminated soils using combined treatments of biochar and sepiolite

引用

Ecological Processes 2024年第1期13卷 40-52页

作者： Yuxin zhang shan Gao Hongtao Jia Tao Sun Shunan Zheng Shihang wu Yuebing Sun Key Laboratory of Original AgroEnvironmental Pollution Prevention and Control Ministry of Agriculture and Rural Affairs (MARA)/Tianjin Key Laboratory of Agro-Environment and Agro-Product Safety Agro–Environmental Protection InstituteMARA College of Resources and Environment Sciences Xinjiang Agricultural University Rural Energy and Environment Agency Ministry of Agriculture and Rural Affairs

Background Cadmium(Cd) pollution in agricultural soils has become a priority environmental concern globally. A reasonable application of passivators is critical to address the problem. In this study, we examined the remediation effects of rice husk biochar(r BC) and sepiolite(Sep) as single and combined(r BC + Sep) treatments on Cd pollution in a weakly alkaline soil using three maize cultivars(Liyu 16, Zhengdan 958, and Sanbei 218) as test crops. We also explained the mechanisms involved in the remediation *** The pseudo-second-order kinetic equation and Langmuir model could well describe the adsorption process of r BC + Sep for Cd2+. Compared with the control treatment(CK), soil available Cd concentration decreased by 29.51–36.34% under r BC + Sep treatment(p 0.05).Conclusions The application of 0.2% r BC + 0.5% Sep composite passivation material to weakly alkaline Cd-contaminated soil can effectively reduce the Cd concentration of soil and maize.

关键词： Cd Rice husk biochar Sepiolite Passivation restoration Weakly alkaline soil Maize

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Recent advances in bioinspired vision systems with curved imaging structures

引用

Rare Metals 2024年第4期43卷 1407-1434页

作者： Ze-Ping He Xun Han Wen-Qiang wu zhang-Sheng Xu Cao-feng Pan CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing100049China ZJU-Hangzhou Global Scientific and Technological Innovation Center School of Micro-Nano ElectronicsZhejiang UniversityHangzhou311200China Institute of Microscale Optoelectronics Shenzhen UniversityShenzhen518060China

Limited by the planar imaging structure,the commercial camera needs to introduce additional optical elements to compensate for the curved focal plane to match the planar image *** results in a complex and bulky *** contrast,biological eyes possess a simple and compact structure due to their curved imaging structure that can directly match with the curved focal *** by the structures and functions of biological eyes,curved vision systems not only improve the image quality,but also offer a variety of advanced ***,we review the recent advances in bioinspired vision systems with curved imaging ***,we focus on their applications in implementing different functions of biological eyes,as well as the emerging curved neuromorphic imaging systems that incorporate bioinspired optical and neuromorphic processing *** addition,the challenges and opportunities of bioinspired curved imaging systems are also discussed.

关键词： Bioinspired Curved vision system Compound eye Chambered eye Neuromorphic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Two-color emissive AIEgens with anti-Kasha property for dual-organelle imaging and phototherapy

引用

Science China Chemistry 2024年第5期67卷 1740-1752页

作者： Pu Chen Guogang shan Qingli Nie Yuting Yan Pengfei zhang Zujin Zhao Hai-Tao feng Ben Zhong Tang AIE Research Center Shaanxi Key Laboratory of PhytochemistryCollege of Chemistry and Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013China Institute of Functional Material Chemistry and National&Local United Engineering Lab for Power Battery Faculty of ChemistryNortheast Normal UniversityChangchun 130024China College of Chemistry&Materials Science Northwest UniversityXi’an 710127China guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong ProvinceSouth China University of TechnologyGuangzhou 510640China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Despite the rapid development of probes for targeting single organelle, the construction of robust dual-organelle targeting probes with multicolor emission was rarely reported. Herein, two dual-emissive aggregation-induced emission luminogens(AIEgens)with donor-π-acceptor structures were designed and synthesized, namely QT-1 and QF-2. Both two AIEgens exhibited excitation wavelength-dependence defying the Kasha's rule, and could stain lipid droplets(LDs) and mitochondria in blue and red fluorescence, respectively. Moreover, thanks to the near-infrared emission and abundant reactive oxygen species(ROS) generation efficiency of QT-1, it was chosen as a photodynamic therapy agent to selectively kill cancer cells from normal cells. Upon light irradiation, an obvious decrease of mitochondrial membrane potential(MMP) and serious change of mitochondrial shape in cells were observed, which corresponded to the efficient inhibition of tumor growth in vivo. This work afforded a promising strategy for the construction of multicolor emission by tuning anti-Kasha behaviors and expanding their application in dualorganelle targeting-based phototheranostics.

关键词： aggregation-induced emission anti-Kasha luminescence fluorescent probe bioimaging photodynamic therapy

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The nature of electron density enhancement over a wide altitude range during ionosphere heating experiments at EISCAT

引用

Earth and Planetary Physics 2024年第2期8卷 408-414页

作者： Jun wu Jian wu Jie feng Qingliang Li ShuJi Hao ZhengWen Xu HaiSheng Zhao YaBin zhang National Key Laboratory of Electromagnetic Environment China Research Institute of Radio Wave PropagationBeijing 102206China School of Physics Xidian UniversityXi’an 710071China

During the course of ionospheric heating experiments, researchers at the European Incoherent Scatter Scientific Association (EISCAT) observed an apparent electron density enhancement. The enhancement extended over a wide range of altitudes, above the reflection altitude of the high-frequency pump wave. However, whether this enhancement actually corresponds to a true enhancement in electron density remains an open question. When the dispersion relation of ion acoustic waves is followed, the frequency ratio of the enhanced ion line to the background ion line suggests that the profile of the effective ion mass may have remained unchanged. Furthermore, the solar radio flux and ion drift velocity indicate no significant changes in the ion species and their densities. In conclusion, the electron density enhancement observed at EISCAT should not, in fact, be considered a true enhancement.

关键词： incoherent scatter radar(ISR) ionospheric heating electron density ion acoustic wave

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rapid Phase Ambiguity Elimination Methods for DOA Estimator via Hybrid Massive MIMO Receive Array

引用

Chinese Journal of Electronics 2024年第1期33卷 175-184页

作者： Xichao ZHAN Zhongwen SUN feng SHU Yiwen CHEN Xin CHENG Yuanyuan wu Qi zhang Yifan LI Peng zhang School of Information and Communication Engineering Hainan University School of Electronic and Optical Engineering Nanjing University of Science and Technology

For a sub-connected hybrid multiple-input multiple-output(MIMO) receiver with K subarrays and N antennas, there exists a challenging problem of how to rapidly remove phase ambiguity in only single time-slot. A direction of arrival(DOA) estimator of maximizing received power(Max-RP) is proposed to find the maximum value of K-subarray output powers, where each subarray is in charge of one sector, and the center angle of the sector corresponding to the maximum output is the estimated true DOA. To make an enhancement on precision, Max-RP plus quadratic interpolation(Max-RP-QI) method is designed. In the proposed Max-RP-QI, a quadratic interpolation scheme is adopted to interpolate the three DOA values corresponding to the largest three receive powers of *** achieve the Cramer Rao lower bound, a Root-MUSIC plus Max-RP-QI scheme is developed. Simulation results show that the proposed three methods eliminate the phase ambiguity during one time-slot and also show low computational complexities. The proposed Root-MUSIC plus Max-RP-QI scheme can reach the Cramer Rao lower bound,and the proposed Max-RP and Max-RP-QI are still some performance losses 2–4 d B compared to the Cramer Rao lower bound.

关键词： Phased arrays Interpolation Wireless sensor networks Direction-of-arrival estimation Simulation Receiving antennas Massive MIMO

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Adverse effects of exposure to fine particles and ultrafine particles in the environment on different organs of organisms

引用

Journal of Environmental Sciences 2024年第1期135卷 449-473页

作者： Jianwei zhang Zhao Chen Dan shan Yang wu Yue Zhao Chen Li Yue Shu Xiaoyu Linghu Baiqi Wang Department of Occupational and Environmental Health School of Public HealthTianjin Medical UniversityTianjin 300070China Department of Medical Tianjin Stomatological HospitalSchool of MedicineNankai UniversityTianjin 300041China Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjin 300070China National Demonstration Center for Experimental Preventive Medicine Education(Tianjin Medical University) Tianjin 300070China

Particulate pollution is a global risk factor that seriously threatens human *** particles(FPs)and ultrafine particles(UFPs)have small particle diameters and large specific surface areas,which can easily adsorb metals,microorganisms and other *** and UFPs can enter the human body in multiple ways and can be easily and quickly absorbed by the cells,tissues and *** the body,the particles can induce oxidative stress,inflammatory response and apoptosis,furthermore causing great adverse *** studies mainly take the population as the research object to study the distribution of diseases and health conditions in a specific population and to focus on the identification of influencing ***,the mechanism by which a substance harms the health of organisms is mainly demonstrated through toxicological *** epidemiological studies with toxicological studies will provide a more systematic and comprehensive understanding of the impact of PM on the health of *** this review,the sources,compositions,and morphologies of FPs and UFPs are briefly introduced in the first *** effects and action mechanisms of exposure to FPs and UFPs on the heart,lungs,brain,liver,spleen,kidneys,pancreas,gastrointestinal tract,joints and reproductive system are systematically *** addition,challenges are further pointed out at the end of the *** work provides useful theoretical guidance and a strong experimental foundation for investigating and preventing the adverse effects of FPs and UFPs on human health.

关键词： Fine particles Ultrafine particles Organs Adverse effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficient nitrate electroreduction over Mn-doped Cu catalyst via regulating N-containing intermediates adsorption configuration

引用

Science China Chemistry 2024年第6期67卷 1969-1975页

作者： Limin wu Shunhan Jia Libing zhang Ruhan Wang Jiaqi feng Xiaofu Sun Buxing Han Beijing National Laboratory for Molecular Sciences CAS Laboratory of Colloid and Interface and ThermodynamicsCAS Research/Education Center for Excellence in Molecular SciencesCenter for Carbon Neutral ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing100049China College of Chemical Engineering and Environment China University of PetroleumBeijing102249China shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai200062China

The electrochemical reduction of NO_(3)^(-)to NH_(3)holds promise for economic and environmental benefits,presenting an energyefficient alternative to the traditional Haber-Bosch ***,challenges exist due to its sluggish kinetics,multiple intermediates,and various reaction *** this study,Mn-doped-Cu catalyst was synthesized and employed for electrochemical NO_(3)^(-)-to-NH_(3)*** doping of Mn into Cu resulted in exceptional performance,achieving a FE of 95.8%and an NH_(3)yield rate of 0.91 mol g^(-1)h^(-1)at-0.6 V in a neutral electrolyte at low NO_(3)^(-)*** experimental studies and theoretical calculations revealed that the Mn dopant enhanced the kinetic rate of NO_(2)~--to-NH_(3)and induced a distinct configuration of**** alteration decreased the energy barrier of*NO-to-*NOH,consequently promoting the conversion of NO_(3)^(-)-to-NH_(3).

关键词： nitrate reduction electrocatalysis ammonia synthesis N-intermediate green chemistry

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Covalent organic framework monolayer:Accurate syntheses and advanced application

引用

Nano Research 2024年第7期17卷 6603-6618页

作者： guangyuan feng Xiaojuan Li Miao zhang Jiabi Xu Zhiping Liu Lingli wu Shengbin Lei Key Laboratory of Organic Integrated Circuit Ministry of Education and Tianjin Key Laboratory of Molecular Optoelectronic SciencesDepartment of ChemistrySchool of Science and Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin UniversityTianjin 300072China Medical College Northwest Minzu UniversityLanzhou 730000China School of Chemistry and Chemical Engineering Lanzhou Jiaotong UniversityLanzhou 730070China

Covalent organic framework(COF)monolayers,with atomically thin,ordered networks,and rich functionality,are widely studied due to their unusual structure/property ***,synthesizing COF monolayer has remained an unmet challenge due to the difficulty of controlling reactions at the monolayer limit with large-scale *** identification and development of new reactions and polymerization conditions are critical for the further advancement of COF monolayer ***,as one-molecule-thick a freestanding films,COF monolayer offers an ideal material *** advanced applications of COF monolayer have been explored in recent *** review provides an overview of the current state of precise synthetic strategies for COF monolayer,highlighting the advantages and limitations of different synthetic approaches and key challenges related to enhancing quality,and emphasizing the unique benefits of COF monolayer as both an ideal model system and for advanced applications.

关键词： covalent organic frameworks monolayer accurate syntheses advanced application

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The hydrophobic cluster on the surface of protein is the key structural basis for the SDS-resistance of chondroitinase VhChlABC

引用

Marine Life Science & Technology 2024年第1期6卷 93-101页

作者： Juanjuan Su Hao wu Chengying Yin fengchao zhang feng Han Wengong Yu School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology CenterQingdao 266237China Key Laboratory of Marine Drugs Ministry of EducationQingdao 266003China shandong Provincial Key Laboratory of Glycoscience and Glycoengineering Qingdao 266003China

The application of chondroitinase requires consideration of the complex microenvironment of the *** previous research reported a marine-derived sodium dodecyl sulfate(SDS)-resistant chondroitinase *** study further investigated the mechanism of VhChlABC resistance to *** on the hydrophobic cluster on its strong hydrophilic surface,it was found that the reduction of hydrophobicity of surface residues Ala181,Met182,Met183,Ala184,Val185,and Ile305 significantly reduced the SDS resistance and *** dynamics(MD)simulation and molecular docking analysis showed that I305G had more conformational flexibility around residue 305 than wild type(WT),which was more conducive to SDS insertion and *** affinity of A181G,M182A,M183A,V185A and I305G to SDS was significantly higher than that of *** conclusion,the surface hydrophobic microenvironment composed of six residues was the structural basis for SDS *** feature could prevent the binding of SDS and the destruction of hydrophobic packaging by increasing the rigid conformation of protein and reducing the binding force of *** study provides a new idea for the rational design of SDS-resistant proteins and may further promote chondroitinase research in the targeted therapy of lung diseases under the pressure of pulmonary surfactant.

关键词： Hydrophobic cluster Protein surface SDS-resistance Chondroitinase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：