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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue wu Zhi Geng Wenjie Hu Panpan Hu Xingqi wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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pcDNA3.1-Egr.1p-p16基因联合放射治疗对裸鼠肿瘤的作用

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中南大学学报（医学版） 2005年第1期30卷 7-10,15页

作者：马红兵王西京胡海涛狄政莉夏辉王铮李琤韩志楷马洁吴丛梅西安交通大学第二医院肿瘤科西安710004 西安交通大学医学院解剖教研室西安710068 中国医学科学院肿瘤研究所分子肿瘤学国家重点实验室北京100021 汕头大学医学院生物教研室汕头515031

目的:探讨pcDNA3.1 Egr.1p p16基因联合放射治疗移植人胰腺癌细胞JF 305裸鼠的抗肿瘤作用的适宜照射剂量和质粒注入量。方法:不同剂量X射线照射(2,10,20Gy)及瘤内不同量脂质体包裹的pcDNA3.1 Egr.1p p16质粒(10,20,30μg)注入接种... 详细信息

目的:探讨pcDNA3.1 Egr.1p p16基因联合放射治疗移植人胰腺癌细胞JF 305裸鼠的抗肿瘤作用的适宜照射剂量和质粒注入量。方法:不同剂量X射线照射(2,10,20Gy)及瘤内不同量脂质体包裹的pcDNA3.1 Egr.1p p16质粒(10,20,30μg)注入接种JF305胰腺癌细胞的裸鼠体内,测定各组裸鼠体积以观察各种处理抑瘤效应的差异,并用RT PCR检测放射治疗后48h各组肿瘤局部p16mRNA水平。结果:质粒注入后接受20GyX射线照射组照射后4～28d,肿瘤生长速率明显低于2Gy和10Gy照射组(P<0.05)。质粒注入量为20μg或30μg的联合治疗组照射后4～28d,肿瘤生长速率明显低于注入量为10μg的联合治疗组(P<0.05)。单纯接种 pcDNA3.1 Egr.1p p16质粒组和接种pcDNA3.1 Egr.1p p16质粒照射组小鼠的肿瘤组织内有p16mRNA表达,且 pcDNA3.1 Egr.1p p16质粒照射组的p16mRNA水平明显高于单纯pcDNA3.1 Egr.1p p16质粒组(P<0.05)。结论:pcDNA3.1 Egr.1p p16基因联合放射治疗小鼠体内抗肿瘤作用的适宜射线照射剂量为20Gy,质粒注入量为20 μg;pcDNA3.1 Egr.1p p16基因联合放射治疗的抗肿瘤作用明显优于单纯放射治疗或单纯基因治疗,这可能与辐射激活Egr.1p基因后增强抑瘤基因p16的表达有关。

关键词： pcDNA3.1-Egr.1p-p16重组质粒基因联合放射治疗 X射线抗肿瘤作用剂量质粒注入量

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Estimation of Chloride Diffusivity in Hydrated Tricalcium Silicate Using a Hydration-Diffusion Integrated Method

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Journal of wuhan University of Technology(Materials Science) 2025年第1期40卷 49-64页

作者： WANG Xin SHEN Dejian TAO Sijie LIU Ruixin wu Shengxing College of Civil and Transportation Engineering Hohai UniversityNanjing 210098China

This study aims to develop a chloride diffusion simulation method that considers the hydration microstructure and pore solution properties during the hydration of tricalcium silicate(C3S).The method combines the hydration simulation,thermodynamic calculation,and finite element analysis to examine the effects of pore solution,including effect of electrochemical potential,effect of chemical activity,and effect of mechanical interactions between ions,on the chloride effective diffusion coefficient of hydrated C3S *** results indicate that the effect of electrochemical potential on chloride diffusion becomes stronger with increasing hydration age due to the increase in the content of hydrated calcium silicate;as the hydration age increases,the effect of chemical activity on chloride diffusion weakens when the number of diffusible elements decreases;the effect of mechanical interactions between ions on chloride diffusion decreases with the increase of hydration age.

关键词： tricalcium silicate simulation method chloride diffusion coefficient pore solution

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Mechanism Study on the Effect of Retarder on Polyurethane Setting Time Based on Molecular Simulation

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Journal of wuhan University of Technology(Materials Science) 2025年第1期40卷 224-231页

作者： wu Yuxuan XU Wenyuan YU Tianlai JI Yongcheng School of Civil Engineering Northeast Forestry UniversityHarbin 150040China

This study identified castor oil and phosphate ester as effective retarders through setting time,tensile,and flexural tests,and determined their optimal *** mechanism by which phosphate ester affects the setting time of polyurethane was further investigated using molecular dynamics *** transform infrared spectroscopy was also employed to systematically study the physical and chemical interactions between phosphate esters and polyurethane *** results demonstrate that a 1%concentration of phosphate ester provides the most effective retarding effect with minimal impact on the strength of *** phosphate ester is added to the B component of the two-component polyurethane system,its interaction energy with component A decreases,as do the diffusion coefficient and aggregation degree of component B on the surface of component *** reduction in interaction slows the setting ***,the addition of phosphate ester to polyurethane leads to the disappearance or weakening of functional groups,indicating competitive interactions within the phosphate ester components that inhibit the reaction rate.

关键词： polyurethane retarder setting time molecular dynamics diffusion coefficient

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The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying wu Shan Ye Xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

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Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： You wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui Yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

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A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu wu Zhongjie Zhu Hongwei Zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

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The mechanical and water absorption properties of carbon fiber buoyancy materials under hydrostatic pressure

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Science China Technological Sciences 2025年第1期 251-265页

作者： Fanglin cong Zihan LI Guocai YU Yang JIN Zixu ZHU Linzhi wu College of Aerospace and Civil Engineering Harbin Engineering University Key Laboratory of Advanced Ship Materials and Mechanics Harbin Engineering University Department of Basic Courses Naval University of Engineering

Buoyancy material technology is of paramount importance for the development of marine engineering. In this study,a novel carbon fiber buoyancy material(CFBM) is designed and prepared by utilizing composite circular tubes with light weight and high strength. To reveal the failure mechanism under hydrostatic pressure, a finite element model(FEM) based on the three-dimensional Hashin and Yeh failure criterion is developed and validated experimentally. Both the simulated and experimental results indicate that the hydrostatic strength of the CFBM is mainly determined by the buckling of carbon fiber tubes located at the edges of the CFBM. Parametric analysis is conducted to investigate the effect of the number of unit-cells,length, and wall thickness of carbon fiber tubes on the mechanical properties of the CFBM. In addition, a 60-day water absorption test of the CFBM at 12.5 MPa is conducted to characterize its durability. Experimental results indicate that the maximum water absorption rate of the CFBM is 0.59% and the hydrostatic strength is reduced by only 7.97% during the 60-day test period. Finally, the designed CFBM is used at the water depth of 1000 m as buoyancy material. Compared with traditional buoyancy materials, the proposed CFBM has significant advantages in both hydrostatic strength and density. This work has broad engineering application prospects and is of high significance for promoting the implementation of carbon fiber composites in the ocean engineering field.

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Bioinspired Passive Tactile Sensors Enabled by Reversible Polarization of Conjugated Polymers

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Nano-Micro Letters 2025年第1期17卷 361-377页

作者： Feng He Sitong Chen Ruili Zhou Hanyu Diao Yangyang Han Xiaodong wu School of Mechanical Engineering Sichuan UniversityChengdu 610065People’s Republic of China School of Software Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065People’s Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China

Tactile perception plays a vital role for the human body and is also highly desired for smart prosthesis and advanced *** to active sensing devices,passive piezoelectric and triboelectric tactile sensors consume less power,but lack the capability to resolve static ***,we address this issue by utilizing the unique polarization chemistry of conjugated polymers for the first time and propose a new type of bioinspired,passive,and bio-friendly tactile sensors for resolving both static and dynamic ***,to emulate the polarization process of natural sensory cells,conjugated polymers(including poly(3,4-ethylenedioxythiophen e):poly(styrenesulfonate),polyaniline,or polypyrrole)are controllably polarized into two opposite states to create artificial potential *** controllable and reversible polarization process of the conjugated polymers is fully in situ ***,a micro-structured ionic electrolyte is employed to imitate the natural ion channels and to encode external touch stimulations into the variation in potential difference *** with the currently existing tactile sensing devices,the developed tactile sensors feature distinct characteristics including fully organic composition,high sensitivity(up to 773 mV N^(−1)),ultralow power consumption(nW),as well as superior *** demonstrations,both single point tactile perception(surface texture perception and material property perception)and two-dimensional tactile recognitions(shape or profile perception)with high accuracy are successfully realized using self-defined machine learning *** tactile sensing concept innovation based on the polarization chemistry of conjugated polymers opens up a new path to create robotic tactile sensors and prosthetic electronic skins.

关键词： Passive tactile sensors Reversible polarization of conjugated polymers Tactile perception Machine learning algorithm Object recognition

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pEgr-MDA7重组质粒辐射诱导特性的检测

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癌变．畸变．突变 2006年第5期18卷 381-383页

作者：吴丛梅黄天华吴德生谢庆东徐小虎汕头大学医学院生殖医学研究中心广东汕头515041 汕头大学法医学教研室广东汕头515041

背景与目的克隆人MDA7cDNA基因,构建pEgr-MDA7重组质粒并检测其在人食管癌细胞系EC9706中经辐射诱导后mRNA水平。材料与方法从人外周血mRNA中克隆人MDA7cDNA基因,连接到Egr-1启动子的下游构建成pEgr-MDA7重组质粒,利用脂质体介导转染人E... 详细信息

背景与目的克隆人MDA7cDNA基因,构建pEgr-MDA7重组质粒并检测其在人食管癌细胞系EC9706中经辐射诱导后mRNA水平。材料与方法从人外周血mRNA中克隆人MDA7cDNA基因,连接到Egr-1启动子的下游构建成pEgr-MDA7重组质粒,利用脂质体介导转染人EC9706细胞,用定量PCR方法检测不同剂量X射线照射后被转染细胞中MDA7的mRNA水平。结果测序结果证实MDA7cDNA基因序列正确,酶切鉴定证实pEgr-MDA7重组质粒构建正确。被pEgr-MDA7重组质粒转染的人食管癌EC9706细胞经不同剂量X射线照射后,MDA7基因mRNA水平均高于未照射组。结论X射线可诱导pEgr-MDA7重组质粒在人EC9706细胞中表达增强。

关键词： MDA-7基因 pEgr-MDA7重组质粒辐射

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