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MOF-derived 1D/3D N-doped porous carbon for spatially confined electrochemical CO2 reduction to adjustable syngas

CARBON ENERGY 2024年第8期6卷 1-13页

作者： Zhang, Wei Li, Hui Feng, Daming wu, chenglin Sun, Chenghua Jia, Baohua Liu, Xue Ma, Tianyi Liaoning Univ Inst Clean Energy Chem Coll Chem Key Lab Green Synth & Preparat Chem Adv Mat Shenyang 110036 Liaoning Peoples R China RMIT Univ Sch Sci Melbourne Vic 3000 Australia Taizhou Univ Sch Pharmaceut & Chem Engn Taizhou Zhejiang Peoples R China Swinburne Univ Technol Dept Chem & Biotechnol Hawthorn Vic Australia

Electrochemical reduction of CO2 to syngas (CO and H-2) offers an efficient way to mitigate carbon emissions and store intermittent renewable energy in chemicals. Herein, the hierarchical one-dimensional/three-dimensional nitrogen-doped porous carbon (1D/3D NPC) is prepared by carbonizing the composite of Zn-MOF-74 crystals in situ grown on a commercial melamine sponge (MS), for electrochemical CO2 reduction reaction (CO2RR). The 1D/3D NPC exhibits a high CO/H-2 ratio (5.06) and CO yield (31 mmol g(-1) h(-1)) at -0.55 V, which are 13.7 times and 21.4 times those of 1D porous carbon (derived from Zn-MOF-74) and N-doped carbon (carbonized by MS), respectively. This is attributed to the unique spatial environment of 1D/3D NPC, which increases the adsorption capacity of CO2 and promotes electron transfer from the 3D N-doped carbon framework to 1D carbon, improving the reaction kinetics of CO2RR. Experimental results and charge density difference plots indicate that the active site of CO2RR is the positively charged carbon atom adjacent to graphitic N on 1D carbon and the active site of HER is the pyridinic N on 1D carbon. The presence of pyridinic N and pyrrolic N reduces the number of electron transfer, decreasing the reaction kinetics and the activity of CO2RR. The CO/H-2 ratio is related to the distribution of N species and the specific surface area, which are determined by the degree of spatial confinement effect. The CO/H2 ratios can be regulated by adjusting the carbonization temperature to adjust the degree of spatial confinement effect. Given the low cost of feedstock and easy strategy, 1D/3D NPC catalysts have great potential for industrial application.

关键词： electrochemical CO2 reduction reaction melamine sponge metal-organic frameworks porous carbon syngas NITROGEN CATALYST DEFECT ELECTROREDUCTION GRAPHENE

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Outcomes in pediatric recipients of single kidney transplantation from pediatric donors with acute kidney injury:A single-center pilot study

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Chinese Medical Journal 2024年第12期137卷 1489-1491页

作者： Qiang Zhang Yanxu Chen Haiyue Yu Jun Li chenglin wu Sizhe Long Pengan Li Qian Fu Huanxi Zhang Xiaojun Su Bowen Xu Longshan Liu Changxi Wang Organ Transplant Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080China Stomatological Hospital Southern Medical UniversityGuangzhouGuangdong 510280China Center for Information Technology and Statistics The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080China Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology GuangzhouGuangdong 510080China Guangdong Provincial Key Laboratory Guangdong Provincial International Cooperation Base of Science and Technology(Organ Transplantation) GuangzhouGuangdong 510080China

To the Editor:The shortage of deceased donor(DD)kidneys for transplantation remains a persistent *** the potential reversibility of acute kidney injury(AKI)lesions,kidneys from pediatric donors with AKI are often underutilized,especially in the context of pediatric *** implementing single kidney transplantation(SKT)from pediatric donors to pediatric recipients(PTP),we can optimize the utilization of available kidneys and increase the number of pediatric recipients.

关键词： pediatric kidney acute

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12Cr2Mo1V钢凸台附加填充丝埋弧堆焊工艺研究

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压力容器 2024年第4期41卷 16-21,79页

作者：王雪骄何鹏晏君文吴成林二重(德阳)重型装备有限公司四川德阳618000

针对12Cr2Mo1V钢加氢反应器壳体凸台采用单丝埋弧焊进行堆焊、制造效率低的问题,研究了采用附加填充丝埋弧焊的焊接方法堆焊12Cr2Mo1V材质凸台本体的工艺可行性。研究结果表明,在12Cr2Mo1V钢上采用附加填充丝埋弧焊进行本体堆焊,焊接工... 详细信息

针对12Cr2Mo1V钢加氢反应器壳体凸台采用单丝埋弧焊进行堆焊、制造效率低的问题,研究了采用附加填充丝埋弧焊的焊接方法堆焊12Cr2Mo1V材质凸台本体的工艺可行性。研究结果表明,在12Cr2Mo1V钢上采用附加填充丝埋弧焊进行本体堆焊,焊接工艺性良好;其工艺评定试验的各项力学性能完全满足母材的要求,特别是-30℃夏比KV_(2)型缺口冲击试验冲击值均≥54 J,抗回火脆化倾向评定试验结果均满足v Tr54+3Δv Tr54≤0℃的要求。与单丝埋弧堆焊相比,两枪六丝附加填充丝埋弧堆焊凸台可提高生产效率200%~250%。该项工艺研究在满足加钒钢凸台性能的前提条件下,能极大缩短凸台制造周期、节能减排,为加氢反应器先进绿色制造的发展提供了新的制造手段。

关键词：附加填充丝埋弧焊 12Cr2Mo1V钢凸台堆焊

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White spot syndrome virus envelope protein VP124 involved in the virus infection

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Acta Oceanologica Sinica 2008年第4期27卷 130-136页

作者： ZHU Yanbing wu chenglin YANG Feng School of Biotechnology Engineering Jimei University Xiamen 361021 China Key Laboratory of Marine Biogenetic Resources Third Institute of Oceanography State Oceanic Administration Xiamen361005 China

White spot syndrome virus （WSSV） is one of the major shrimp pathogens causing large economic losses to shrimp farming. In an attempt to identify the envelope proteins involved in the virus infection, purified WSSV virions were mixed with three antisera against WSSV envelope proteins （VP39, VP124 and VP187 ）, individually. And then they were injected intramuscularly into crayfish （Procambarus clarkii） to conduct in vivo neutralization assays. The results showed that for groups injected with virions only and groups injected with the mixture of virions and antiserum against VP124, the crayfish mortalities were 100% and 60% on the 8th day postinfection, individually. The virus infection could be delayed or neutralized by antibody against the envelope protein VP124. Quantitative PCR was used to further investigate the influence of three antisera described above on the virus infection. The results showed that the antiserum against VP124 could restrain the propagation of WSSV in crayfish. All of the results suggested that the viral envelope protein VP124 played a role in WSSV infection.

关键词： white spot syndrome virus envelope protein VP124 antibody infection neutralization assay

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Micellization of copolymers via noncovalent interaction with TPPS and aggregation of TPPS

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Science China Chemistry 2011年第2期54卷 343-350页

作者： ZHAO LiZhi XIANG Rui ZHANG LiYan wu chenglin MA RuJiang AN YingLi SHI LinQi Key Laboratory of Functional Polymer Materials Ministry of EducationInstitute of Polymer ChemistryNankai UniversityTianjin 300071China

Aggregation of 5,10,15,20-tetrakis-(4-sulfonatophenyl)-porphyrin (TPPS) was investigated in complex micelles composed of poly(ethylene glycol)-block-poly(4-vinylpyridine) (PEG-b-P4VP) and poly(2-(dimethylamino)ethyl methylacrylate)-b-poly(Nisopropylacrylamide) (PDMAEMA-b-PNIPAM) in aqueous *** resultant complex micelles had a complex P4VP/ PDMAEMA/TPPS core and a mixed PEG/PNIPAM *** noncovalent interaction modes between the porphyrin and each copolymer accomplished a co-effect on the aggregation of *** formation of aggregates was *** pH 3.2–6.5,TPPS existed as a mixture of H-aggregates and monomers because of the aromatic-aromatic interaction with P4VP and electrostatic interaction with *** monomers translated into J-aggregates,stabilized by electrostatic interaction with the both polyelectrolyte blocks,upon decreasing the pH to *** free-base monomer was the one and only form for the dye at pH 11.0 due to aromatic stacking with the pyridyl rings.

关键词： block copolymer TPPS H-aggregates J-aggregates

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烟草胚珠单倍体植株加倍与快繁一体化技术研究

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烟草科技 2024年第4期57卷 32-41页

作者：曹景林王欣程君奇李亚培吴成林张俊杰蔡长春湖北省烟草科学研究院武汉430030

为探讨胚珠单倍体植株的染色体加倍及其双单倍体快繁技术,以烟草雄性不育杂交种KRK26的胚珠单倍体植株为材料,选取6种发育阶段的叶片,以其主脉切段作为外植体,采用细胞培养加倍法对胚珠单倍体植株进行染色体加倍。结果表明,采用体细胞... 详细信息

为探讨胚珠单倍体植株的染色体加倍及其双单倍体快繁技术,以烟草雄性不育杂交种KRK26的胚珠单倍体植株为材料,选取6种发育阶段的叶片,以其主脉切段作为外植体,采用细胞培养加倍法对胚珠单倍体植株进行染色体加倍。结果表明,采用体细胞培养加倍法对胚珠单倍体植株进行染色体加倍优于秋水仙碱浸苗法;在不同发育阶段的叶片中,以完全展开达21~28 d的叶片的主脉切段所诱导再生植株的染色体加倍频率最高,达50.15%~54.06%;同一发育阶段的叶片,其主脉切段所诱导再生植株的染色体加倍频率高于叶肉组织小块所诱导再生植株的染色体加倍频率;同一发育阶段的叶片,其主脉基部至近主脉基部1/4处的主脉切段所诱导再生植株的染色体加倍频率最高,达81.79%;通过流式细胞仪鉴定筛选出的双单倍体幼苗经水培炼苗14 d左右,烟苗移栽成活率可达100%。建立了胚珠单倍体植株染色体加倍与快繁一体化育苗技术体系。

关键词：烟草胚珠单倍体染色体加倍双单倍体快繁技术

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三维打印导板辅助关节镜下微创踝关节融合术治疗晚期踝关节炎的临床效果

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中华外科杂志 2024年第6期62卷 572-580页

作者：李广翼王诚王嘉正吴承霖张解元邹剑薛剑锋苏琰梅国华施忠民马昕上海交通大学医学院附属第六人民医院骨科上海200233

目的比较三维打印导板辅助关节镜下微创踝关节融合术和传统开放式踝关节融合术治疗晚期踝关节炎的临床效果。方法本研究为回顾性队列研究。回顾性分析2018年5月至2023年2月上海交通大学医学院附属第六人民医院骨科收治的256例行踝关节... 详细信息

目的比较三维打印导板辅助关节镜下微创踝关节融合术和传统开放式踝关节融合术治疗晚期踝关节炎的临床效果。方法本研究为回顾性队列研究。回顾性分析2018年5月至2023年2月上海交通大学医学院附属第六人民医院骨科收治的256例行踝关节融合术的晚期创伤性踝关节炎患者资料。男性119例,女性137例,年龄(59.6±9.5)岁(范围:37~83岁)。其中行接骨板螺钉内固定(外侧+内侧双入路58例,单纯外侧入路117例)175例;行传统开放式前路螺钉内固定48例(传统开放组);行三维打印导板辅助关节镜下微创踝关节融合术33例(三维打印导板组)。采用倾向性评分匹配对三维打印导板组和传统开放组患者的基本资料进行1∶1匹配,卡钳值为0.02。采用独立样本t检验、Mann-Whitney U检验、Wilcoxon符号秩检验、χ^(2)检验或矫正χ^(2)检验对患者围手术期数据及随访资料进行比较。结果三维打印导板组和传统开放组各20例匹配成功,术前基本资料的差异均无统计学意义(P值均>0.05)。与传统开放组相比,三维打印导板组的手术时间更长[(88.9±5.6)min比(77.9±11.7)min;t=-2.392,P=0.022],但术中透视次数更少[(1.7±0.8)次比(5.2±1.2)次;t=10.604,P<0.01],住院时间更短[(5.5±0.9)d比(6.4±1.5)d;t=2.480,P=0.018],差异均有统计学意义。三维打印导板组的融合率为95.0%(19/20),传统开放组为85.0%(17/20),组间差异无统计学意义(χ^(2)=0.278,P=0.598);传统开放组的融合时间为(12.1±2.0)周,三维打印导板组为(11.1±1.7)周,组间差异无统计学意义(t=1.607,P=0.116)。末次随访时,三维打印导板组的美国足踝外科学会踝与后足评分为(72.6±5.5)分,传统开放组为(70.5±5.8)分,差异无统计学意义(t=-1.003,P=0.322);三维打印导板组的疼痛视觉模拟评分为[M(IQR)]1.50(1.00)分,低于传统开放组的3.00(1.00)分,差异有统计学意义(Z=-3.937,P<0.01)。传统开放组与三维打印导板组并发症发生率的差异无统计学意义[25.0%(5/20)比5.0%(1/20),χ^(2)=1.765,P=0.184]。结论三维打印导板辅助关节镜进行踝关节融合术与传统开放手术相比,手术时间略长,但在减少术中透视次数、减轻术后疼痛和缩短住院天数方面有一定优势。

关键词：骨关节炎踝关节踝关节炎踝关节融合术关节镜导板三维打印

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Design,synthesis,and biological evaluation of novel tetrahydroprotoberberine derivatives(THPBs) as proprotein convertase subtilisin/kexin type 9(PCSK9)modulators for the treatment of hyperlipidemia

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Acta Pharmaceutica Sinica B 2019年第6期9卷 1216-1230页

作者： chenglin wu Cong Xi Junhua Tong Jing Zhao Hualiang Jiang Jiang Wang Yiping Wang Hong Liu State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy China Pharmaceutical UniversityNanjing 210009China University of Chinese Academy of Sciences Beijing 100049China

Proprotein convertase subtilisin/kexin type 9(PCSK9)modulators may attenuate PCSK9-induced low-density lipoprotein receptor(LDLR)degradation in lysosome and promote the clearance of circulating low-density lipoprotein cholesterol(LDL-C).A novel series of tetrahydroprotoberberine derivatives(THPBs)were designed,synthesized,and evaluated as PCSK9 modulators for the treatment of *** them,eight compounds exhibited excellent activities in downregulatinghepatic PCSK9 expression better than berberine in HepG2 *** addition,five compounds 15,18,22,(R)-22,and(S)-22 showed better performance in the low-density lipoprotein,labeled with 1,1’-dioctadecyl-3,3,3’,3’-tetramethyl-indocarbocyanine perchlorate(Dil-LDL)uptake assay,compared with berberine at the same *** 22,selected for in vivo evaluation,demonstrated significant reductions of total cholesterol(TC)and LDL-C in hyperlipidemic hamsters with a good pharmacokinetic *** exploring of the lipid-lowering mechanism showed that compound 22 promoted hepatic LDLR expression in a dose-dependent manner in HepG2 *** results of human ether-ago-go related gene(hERG)inhibition assay indicated the potential druggability for compound 22,which is a promising lead compound for the development of PCSK9 modulator for the treatment of hyperlipidemia.

关键词： PCSK9 Tetrahydroprotoberberine derivatives Low-density lipoprotein cholesterol Lipid-lowering PCSK9 expression Low-density lipoprotein receptor Total cholesterol Hyperlipidemia hamster

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Risk factors for chronic ankle instability after first episode of lateral ankle sprain:A retrospective analysis of 362 cases

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Journal of Sport and Health Science 2023年第5期12卷 606-612页

作者： Jieyuan Zhang Kai Yang Cheng Wang Wenqi Gu Xueqian Li Shaoling Fu Guoxun Song Jiazheng Wang chenglin wu Hongyi Zhu Zhongmin Shi National Center for Orthopaedics Shanghai Sixth People’s HospitalShanghai 200233China Department of Orthopedic Surgery Shanghai Sixth People’s HospitalShanghai 200233China Department of Radiology Shanghai Sixth People’s HospitalShanghai 200233China Institute of Clinical Research National Center for OrthopaedicsShanghai Sixth People’s HospitalShanghai 200233China

Background:Chronic ankle instability(CAI) is a common sequela following an acute lateral ankle sprain(LAS).To treat an acture LAS more effectively and efficiently,it is important to identify patients at substantial risk for developing *** study identifies magnetic resonance imaging(MRI) manifestations for predicting CAI development after a first episode of LAS and explores appropriate clinical indications for ordering MRI scans for these ***:All patients with a first-episode LAS who received plain radiograph and MRI scanning within the first 2 weeks after LAS from December 1,2017 to December 1,2019 were *** were collected using the Cumberland Ankle Instability Tool at final *** and other related clinical variables,including age,sex,body mass index,and treatment were also *** and multivariable analyses were performed successively to identify risk factors for CAI after first-episode ***:A total 131 out of 362 patients with a mean follow-up of 3.0± 0.6 years(mean ± SD;2.0—4.1 years) developed CAI after first-episode *** to multivariable regression,development of CAI after first-episode LAS was associated with 5 prognostic factors:age(odds ratio(OR)=0.96,95% confidence interval(95%CI):0.93-1.00,p=0.032);body mass index(OR=1.09,95%CI:1.02-1.17,p=0.009);posterior talofibular ligament injury(OR=2.17,95%CI:1.05-4.48,p=0.035);large bone marrow lesion of the talus(OR=2.69,95%CI:1.30-5.58,p=0.008),and Grade 2 effusion of the tibiotalar joint(OR=2.61,95%CI:1.39-4.89,p=0.003).When patients had at least 1 positive clinical finding in the 10-m walk test,anterior drawer test,or inversion tilt test,they had a 90.2% sensitivity and 77.4% specificity in terms of detecting at least 1 prognostic factor by ***:MRI scanning is valuable in predicting CAI after first-episode LAS for those patients with at least 1 positive clinical finding in the10-m walk test,anterior drawer test,and inversion tilt

关键词： Chronic ankle instability Lateral ankle sprain MRI Risk factorsTagedAPTARAEnd

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股骨远端截骨术联合强筋健膝方治疗膝关节外侧单间室骨性关节炎的临床观察

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江西中医药 2024年第5期55卷 48-50页

作者：杨海峰吴成林张国福邱崇慧曾志奎涂峰巫英俊赣州市中医院江西赣州341099 江西中医药大学南昌330004 江西中医药大学附属医院南昌330006

目的:观察股骨远端截骨术联合自拟方强筋健膝方治疗膝关节外侧单间室骨性关节炎的临床疗效,并探讨其作用机制。方法:选取2020年10月—2022年12月赣州市中医院24例符合纳入标准的膝关节单间室骨性关节炎患者随机分为对照组和观察组,各12... 详细信息

目的:观察股骨远端截骨术联合自拟方强筋健膝方治疗膝关节外侧单间室骨性关节炎的临床疗效,并探讨其作用机制。方法:选取2020年10月—2022年12月赣州市中医院24例符合纳入标准的膝关节单间室骨性关节炎患者随机分为对照组和观察组,各12例。对照组选用股骨远端截骨术治疗,观察组在对照组基础上加用强筋健膝方。比较2组治疗前后患者疼痛VAS评分与膝关节HSS评分,并通过酶联免疫吸附试验检测2组患者血清中肿瘤细胞坏死因子(TNF-α)、白细胞介素6(IL-6)表达水平。结果:术后2组患者疼痛VAS评分较术前均显著降低(P<0.05),膝关节HSS评分较术前均显著升高(P<0.05),血清中IL-6、TNF-α均明显降低,观察组上述指标改善均优于对照组(P<0.05)。结论:股骨远端截骨术联合强筋健膝方可明显改善膝关节外侧单间室骨性关节炎的症状与外翻畸形,提高疗效,其作用机制可能与抑制TNF-α、IL-6表达相关。

关键词：膝关节外侧单间室骨性关节炎股骨远端截骨术强筋健膝方肿瘤细胞坏死因子白细胞介素6

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