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Jug-PLGA-NPs, a New Form of Juglone with Enhanced Efficiency and Reduced Toxicity on Melanoma

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Chinese Journal of Integrative Medicine 2022年第10期28卷 909-917页

作者： YUE wu-heng QIN Lan-qun cai Juan mei Rui QIAN Han-qing ZOU Zheng-yun The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing(210008)China Department of Oncology Taicang TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhouJiangsu Province(215499)China The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjing(210008)China The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital Medical School of Nanjing University&Clinical Cancer Institute of Nanjing UniversityNanjing(210008)China

Objective: To verrify the anti-tumor efficacy and toxicity between juglone(Jug) and Jug-loaded poly lactic-co-glycolic acid(PLGA) nanoparticles(Jug-PLGA-NPs). Methods: Jug-PLGA-NPs were prepared by ultrasonic emulsification. The anti-tumor activity of Jug(2, 3, 4 μg/mL) and Jug-PLGA-NPs(Jug: 2, 3, 4 μg/mL) in vitro was measured by MTT assay and cell apoptosis analysis. The distribution, anti-tumor effect and biological safety in vivo was evaluated on A375 nude mice. Results: With the advantage of good penetration and targeting properties, Jug-PLGA-NPs significantly inhibited proliferation and migration of melanoma cells both in vitro and in vivo(P<0.05 or P<0.01) with acceptable biocompatibility. Conclusions: Jug can inhibit the growth of melanoma but is highly toxic. With the advantage of sustained release, tumor targeting, anti-tumor activity and acceptable biological safety, Jug-PLGA-NPs provide a new pharmaceutical form for future application of Jug.

关键词： juglone PLGA nanoparticles malignant melanoma Jug-PLGA-NPs

光谱辐射照度国际关键比对装置、方法与结果分析

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光谱学与光谱分析 2025年第1期45卷 1-7页

作者：代彩红王彦飞李玲吴志峰谢一航中国计量科学研究院光学与激光计量科学研究所北京100029

基于高温黑体辐射源和双光栅光谱辐射比较测量系统,中国计量科学研究院自主研制了新一代光谱辐射照度国家基准装置,波长范围覆盖230~2550 nm,以一组稳定的卤钨灯作为副基准灯组,保存和传递光谱辐射照度量值。黑体的温度溯源至铂-碳Pt-C... 详细信息

基于高温黑体辐射源和双光栅光谱辐射比较测量系统,中国计量科学研究院自主研制了新一代光谱辐射照度国家基准装置,波长范围覆盖230~2550 nm,以一组稳定的卤钨灯作为副基准灯组,保存和传递光谱辐射照度量值。黑体的温度溯源至铂-碳Pt-C和铼-碳Re-C共晶点黑体,在3021 K采用钨碳-碳WC-C共晶点黑体进行验证。采用新基准装置,2017年-2019年NIM参加国际计量局组织的光谱辐射照度国际关键比对CCPR-K1.a,比对由全俄光学物理学测量研究院(VNIIOFI)主导,共有12个实验室参加。比对结果表明:除少数实验室外,在250~290、300~1300、1500~2500 nm波长范围,各参比实验室之间的一致性分别为±2.0%、±1.0%和±2.0%。在紫外、可见和近红外波段,NIM与国际比对参考值的平均相对偏差分别为0.13%、0.28%和0.15%。在250~2500 nm全波段,NIM与国际比对参考值的平均相对偏差为0.17%,与2004年平均相对偏差0.9%相比,测量能力提升显著。

关键词：光谱辐射照度国际比对高温黑体测量不确定度国家基准

Survey of Performance Evaluation Standardization and Research Methods on GNSS-Based Localization for Railways

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Chinese Journal of Electronics 2020年第1期29卷 22-33页

作者： cai Baigen wu Boqian LU Debiao Beijing Engineering Research Center of EMC and GNSS Technology for Rail Transportation School of Electronic and Information Engineering Beijing Jiaotong University

Global navigation satellite systems(GNSS) has been regarded as a key technology for train localization in the future, as GNSS-based localization can reduce the deployment of wayside equipment, and offer a high-accuracy determination in a cost effective ***, the standardization of GNSS-based localization performance characteristics has not been done in *** can restrict the development of GNSS for safety related applications, which need critical requirement for the. The main objective of this paper is to provide a survey of research dealing with performance evaluation standardization. Train localization technique and performance requirement in Chinese train control system(CTCS), GNSS performance characteristics suggested in standards and guidelines, characteristics of accuracy/integrity/reliability/availability/safety for GNSS-based train localization and related evaluation approaches are presented. Some issues in GNSS-based train localization are highlighted based on the survey.

关键词： Railway GNSS Performance evaluation Train localization Safety

Research progress on the cleaning and regeneration of PM_(2.5) filter media

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Particuology 2021年第4期19卷 28-44页

作者： Shunjie wu Rongrong cai Lizhi Zhang Key Laboratory of Enhanced Heat Transfer and Energy Conservation of Education Ministry School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China State Key Laboratory of Subtropical Building Science South China University of TechnologyGuangzhou 510640China

Reusable PM_(2.5) filter media and their regeneration techniques have attracted widespread attention and shown significant prospect for application in air *** this study,we reviewed the recent research progress on the cleaning and regeneration of indoor PM_(2.5) filters considering two methods,namely,dry and wet *** principles,application status,and limitations of air back-blow and air pulse-jet dry-cleaning techniques were *** wet-cleaning characteristics and regeneration performance of novel washable PM_(2.5) filters,including superhydrophobic,electrostatically enhanced,metal-organic framework composite,and microchannel monolith filters,were evaluated and *** the structural stability and chemical resistance of the filter media during the cleaning process was determined to be key to filter ***,cleaning and regeneration characteristics should be integrated into the design of high-efficiency and low-resistance filter materials to develop more practical reusable PM_(2.5) filter media.

关键词： Aerosol filtration Reusable filter media Cleaning technique Regeneration

Multifaceted functions of Siva-1: more than an Indian God of Destruction

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Protein & Cell 2012年第2期3卷 117-122页

作者： Yide mei Mian wu Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences University of Science and Technology of ChinaHefei 230027China

Siva-1,as a p53-inducible gene,has been shown to induce extensive apoptosis in a number of different cell *** evidence suggests that Siva-1 functions as a part of the auto-regulatory feedback loop that restrains p53 through facilitating Mdm2-mediated p53 ***,Siva-1 plays an important role in suppressing tumor *** we review the current understanding of Siva-1-mediated apoptotic signaling *** also add comments on the p53-Siva-1 feedback loop,the novel function of Siva-1 in suppressing tumor metastasis,and their potential implications.

关键词： Siva-1 p53 apoptosis tumor metastasis stathmin

Supported Pt-Ni bimetallic nanoparticles catalyzed hydrodeoxygenation of dibenzofuran with high selectivity to bicyclohexane

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Chinese Chemical Letters 2022年第1期33卷 234-238页

作者： Pengyu wu Chun cai Chemical Engineering College Nanjing University of Science and TechnologyNanjing 210094China

Catalytic hydrodeoxygenation(HDO)is one of the most effective methods to upgrade the oxygen-containing compounds derived from coal tar to valuable ***,an efficient bimetallic catalyst Pt_(1)Ni_(4)/MgO was prepared and applied in the HDO of dibenzofuran(DBF).High yield(95%)of the desired product bicyclohexane(BCH)was achieved at 240℃and 1.2 MPa of H_(2).Superior catalytic performance could be ascribed to the"relay catalysis"of Pt sites and Ni sites,and the reaction pathway is proposed as ***-up experiment and recyclability test were also performed,which demonstrated the recyclability and promising potential application of Pt_(1)Ni_(4)/MgO.

关键词： Hydrodeoxygenation Dibenzofuran Bicyclohexane Bimetallic catalyst Relay catalysis

Key Variables Explaining Soil Organic Carbon Content Variations in Croplands and Non-Croplands in Chinese Provinces

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Chinese Geographical Science 2012年第3期22卷 255-263页

作者： wu Lezhi cai Zucong Department of Geographical Science Hubei Normal University Huangshi 435002 China College of Geographical Science Nanjing Normal University Nanjing 210046 China

Soil organic carbon (SOC) plays an important role in global carbon *** spatial variations in SOC contents result in uncertain estimates of the SOC pool and its *** the present study,the key variables explaining the SOC contents of croplands (CPs) and non-croplands (NCPs) in Chinese provinces were *** on SOC and other soil properties (obtained from the Second National Soil Survey conducted in the late 1970s to the early 1990s),climate parameters,as well as the proportion of the CP to the total land area (Pcp) were *** content variations within a province were larger than those among *** clay and total phosphorus content,ratio of annual precipitation to mean temperature,as well as Pcp were able to explain 75% of the SOC content variations in whole soil *** pH,mean temperature during the growing season from May to October,and mean annual wind velocity were able to explain 63% of the SOC content variations in NCP *** with NCP soils,CP soils had lower SOC contents,with smaller variations within and among provinces and lower C/N *** regression showed that the soil clay content was a unique factor significantly correlated with the SOC content of CP ***,this factor only explained 24% of the *** result suggested that variables related to human activities had greater effects on SOC content variations in CP soils than soil properties and climate *** on SOC contents directly averaged from soil samples and estimated by regression equations,the total SOC pool in the topsoil (0-20 cm) of China was estimated at 60.02 Pg and 57.6 *** of years of intensive cultivation in China resulted in CP topsoil SOC loss of 4.34-4.98 Pg.

关键词： soil organic carbon land use carbon loss soil property climatic variable

Atractylenolide Ⅰ protects against lipopolysaccharide-induced disseminated intravascular coagulation by anti-inflammatory and anticoagulation effect

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Asian Pacific Journal of Tropical Medicine 2017年第6期10卷 651-657页

作者： Xiao-mei Tang Zhi-Kai Liao You-Wei Huang Xi Lin Liang-cai wu Department of Obstetrics and Gynecology The First Affiliated Hospital of Jinan University Department of Pharmacology Medical College Jinan University Department of Dermatology The 6th Affiliated Hospital Sun Yat-sen University

Objective:To investigate whether atractylenolide Ⅰ(ATL-Ⅰ) has protective effect on lipopolysaccharide(LPS)-induced disseminated intravascular coagulation(DIC) in vivo and in vitro,and explore whether NF-κB signaling pathway is involved in ATL-Ⅰ ***:New Zealand white rabbits were injected with LPS through marginal ear vein over a period of 6h at a rate of 600 μg/kg(10 mL/h).Similarly,in the treatment groups,1.0,2.0,or 5.0 mg/kg ATL-Ⅰ were *** survival rate and organ function were tested,including the level of alanine aminotransferase(ALT),blood urine nitrogen(BUN),and TNF-α were examined by *** haemostatic and fibrinolytic parameters in serum were *** 264.7 macrophage cells were administered with control,LPS,LPS + ATL-Ⅰ and ATL-Ⅰ alone,and TNF-α,phosphorylation(P)-IκBα,phosphorylation(P)-NF-κB(P65) and NF-κB(P65) were determined by Western ***:The administration of LPS resulted in 73.3%mortality rate,and the increase of serum TNF-α,BUN and ALT *** ATL-Ⅰ treatment significantly increased the survival rate of LPS-induced DIC model,also improved the function of blood *** protein analysis indicated that ATL-Ⅰ remarkably protected liver and renal as decreasing TNF-α *** vitro,ATL-Ⅰ obviously decreased LPS-induced TNF-αproduction and the expression of P-NF-κB(P65),with the decrease of P-IκBα.Conclusions:ATL-Ⅰ has protective effect on LPS-induced DIC,which can elevate the survival rate,reduce organ damage,improve the function of blood coagulation and suppress TNF-α expression by inhibiting the activation of NF-κB signaling pathway.

关键词： Atractylenolide Ⅰ Disseminated intravascular coagulation Anti-inflammatory Anticoagulation Macrophag

Interface engineering by redox reaction on ferrites to prepare efficient electromagnetic wave absorbers

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Journal of Materials Science & Technology 2024年第21期188卷 1-10页

作者： Ming Qin Qianxu Ye Xiaoming cai Jinming cai Hongjing wu Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China Faculty of Mechanical and Electrical Engineering Kunming University of Science and TechnologyKunming 650500China MOE Key Laboratory of Material Physics and Chemistry Under Extraordinary School of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710072China Southwest United Graduate School Kunming 650092China

Preparation of electromagnetic(EM)wave-absorbing composites by interface engineering has been the main strategy to obtain high-performance ***,the conventional strategy is tedious and time-consuming,which hinders the scalable synthesis of stable EM wave-absorbing ***,interface engineering by a redox reaction between transition metal elements in Co-based spinel ferrites was employed to create EM wave-absorbing composites to solve the above *** serial M Co_(2)O_(4)(M=Ni,Cu,and Zn)spinel ferrites,redox reactions during synthesis only occurred between Cu and Co elements,thus leading to the presence of multiple crystal phases on final *** the aid of increased polyethylene glycol(PEG)molecular weight(MW),more heterogenous interfaces between CuO and CuCo_(2)O_(4)phases as well as induced crystal defects were *** synergetic interface engineering by means of PEG-assisted redox reaction,interfacial polarization,and defect-induced polarization loss were markedly enhanced on a CuCo_(2)O_(4)-based sample that was prepared with PEG MW of 100 *** effective absorption bandwidth of the corresponding sample could reach 6.48 GHz(11.52–18 GHz)with a thickness of 2.28 *** short,this work provides a novel strategy for designing EM wave absorbing composites by interface engineering through redox reaction instead of the conventional composition coupling process.

关键词： Electromagnetic wave absorption Redox reaction Interfacial engineering Spinel ferrite