检索结果-南通市图书馆

Structural changes of cellobiohydrolase I (1,4-β-D-glucan-cellobiohydrolase I, CBHI) and PNPC (p-nitro-phenyl-β-D-cellobioside) during the binding process

引用

Science china(Life Sciences) 2008年第5期51卷 459-469页

作者： wu bin1,2, wang lushan1 & gao peiji1 1 state key laboratory of microbial technology, shandong university, jinan 250100, china 2 Institute of Poultry Science, shandong Academy of Agricultural Sciences, jinan 250023, china state key laboratory of microbial technology Shandong University Jinan 250100 China Institute of Poultry Science Shandong Academy of Agricultural Sciences Jinan 250023 China

Conformational changes to 1,4-β-D-glucan cellobiohydrolase I (CBHI) in response to its binding with p-nitrophenyl β-D-cellobioside (PNPC) were analyzed by second-derivative fluorescence spectrometry at the saturation binding point. Irreversible changes to the configuration of PNPC during the course of the binding process were characterized by UV spectral analysis. Isothermal titration calorimetry (ITC) was used to determine the stoichiometry of binding (i.e. the number of molar binding sites) of PNPC to CBHI. Two points on the surface of the CBHI molecule interact with PNPC, and irreversible changes to the configuration of PNPC occur during its conversion to p-nitrophenyl (PNP). The ITC studies demonstrated that the binding of PNPC to CBHI is an irreversible process, in which heat is released, but where there is no reversible equilibrium between PNPC-CBHI and CBHI and PNPC. On the other hand, PNP and cellobiose need to be released from the PNPC-CBHI complex to facilitate the repeated binding of new PNPC molecules to the renewable CBHI molecules. Therefore, we speculate that the energy, which powers the configurational change of PNPC as it is converted to PNP, is generated from cyclic changes in the conformation of CBHI during the binding/de-sorption process. These new insights may provide a basis for a better understanding of the binding mechanism in enzyme-substrate interactions.

关键词： saturated binding point cellobiohydrolase I p-nitrophenyl β-D-cellobioside conformation/configuration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Estimation of Cellobiohydrolase I Activity by Numerical Differentiation of Dynamic Ultraviolet Spectroscopy

引用

Acta Biochimica et Biophysica Sinica 2006年第6期38卷 372-378页

作者： bin wu Yue ZHAO Pei-Ji gao The state key laboratory of microbial technology,shandong university,jinan 250100,china The state key laboratory of microbial technology Shandong UniversityJinan 250100 China

1,4-β-D-glucan cellobiohydrolase I （CBH I）,p-nitrophenyl β-D-cellobioside,p-nitrophenol andcellobiose show distinct ultraviolet spectra,allowing the design of an assay to track the dynamic process ofp-nitrophenyl β-D-cellobioside hydrolysis by CBH *** on the linear relationship between p-nitrophenolformation in the hydrolysate and its first derivative absorption Curve of AUC340400nm（area under the curve）,a new sensitive assay for the determination of CBH I activity was *** dynamic parameters ofcatalysis reaction,such as Vm and kcat,can all be derived from this *** influence of β-glucosidase andendoglucanase in crude enzyme sample on the assay was discussed in *** approach is useful foraccurate determination of the activity of CBHs.

关键词： cellobiohydrolase dynamic spectrum area under the curve(AUC)

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Crystal Structure of the N-terminal Domain of Linker LR and the Assembly of Cyanobacterial Phycobilisome Rods

Crystal Structure of the N-terminal Domain of Linker LR and ...

引用

中国藻类学会第八次会员大会暨第十六次学术讨论会

作者： Xiang gao~(a,b,1),Nan Zhang~(a,1),Tian-Di Wei~(a,1),Hai-Nan Su~a,bin-bin Xie~a,Chuang-Chuang Dong~a, Xi-Ying Zhang~a,Xiu-Lan Chen~a,Bai-Cheng Zhou~a,Zhi-Xinwang~b,Jia-Wei wu~b,Yu-Zhong Zhang~(a,*) a state key laboratory of microbial technology,Marine Biotechnology Research Center, shandong university,jinan,250100,china b The Ministry of Education key laboratory of Bioinformatics,Department of Biological Sciences and Biotechnology,Tsinghua university,Beijing,100084,china.

＜正＞Phycobilisomes are light-harvesting supramolecular complexes in cyanobacteria and red *** play a pivotal role in the assembly and energy transfer modulation of ***,how linkers function remains unclear due to the... 详细信息

关键词： phycobilisome linkers protein docking crystal structure

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

应用美兰吸附法测定纤维素表面积的讨论

引用

纤维素科学与技术 2004年第4期12卷 23-30页

作者：武彬王禄山张为灿赵越高培基山东大学微生物技术国家重点实验室山东济南250100

以Prism4.0软件包将不同纤维材料吸附美兰的数据拟合Scatchard方程、Klotz-Hunston方程、Langmuir方程的一般形式和单点双曲线吸附方程,据此研究了由美兰等染料分子在纤维基质表面上的吸附从而推算基质的表面积的方法机理和局限性。分... 详细信息

以Prism4.0软件包将不同纤维材料吸附美兰的数据拟合Scatchard方程、Klotz-Hunston方程、Langmuir方程的一般形式和单点双曲线吸附方程,据此研究了由美兰等染料分子在纤维基质表面上的吸附从而推算基质的表面积的方法机理和局限性。分析表明Langmuir模型和单点双曲线模型的拟合得到的饱和吸附量为外推值,会导致测量结果失真;而用Sigmoidal dose-response(Variable slope)模型拟合时,则能给出真实吸附量。研究结果还显示,由纤维素分子链自由羟基所介导的美兰吸附不会发挥主导作用,而红外ATR结果和美兰的脱吸附试验表明美兰在纤维素表面上的吸附应为物理吸附,所以根据美兰分子平卧于纤维表面面积162 ?,计算纤维表面积,得到了四种纤维材料的比表面积。但由于真实界面浓度的确定方法仍存在矛盾,也缺少一个直观的检测标准,因此文章中给出的数值仍为一相对的比较值。

关键词：美兰附方平卧研究结果介导纤维素 ATR 界面浓度表面积分子链

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanism of cellobiose inhibition in cellulose hydrolysis by cellobiohydrolase

引用

Science china(Life Sciences) 2004年第1期47卷 18-24页

作者： ZHAO Yue wu bin YAN Baixu gao peiji state key laboratory of microbial technology Shandong University Jinan 250100 China State Key Laboratory of Microbial Technology Shandong University Jinan 250100 China State Key Laboratory of Microbial Technology Shandong University Jinan 250100 China State Key Laboratory of Microbial Technology Shandong University Jinan 250100 China

An experimental study of cellobiose inhibition in cellulose hydrolysis by synergism of cellobiohydrolyse I and endoglucanase I is presented. Cellobiose is the structural unit of cellulose molecules and also the main product in enzymatic hydrolysis of cellulose. It has been identified that cellobiose can strongly inhibit hydrolysis reaction of cellulase, whereas it has no effect on the adsorption of cellulase on cellulose surface. The experimental data of FT-IR spectra, fluorescence spectrum and circular dichroism suggested that cellobiose can be combined with tryptophan residue located near the active site of cellobiohydrolase and then form steric hindrance, which prevents cellulose molecule chains from diffusing into active site of cellulase. In addition, the molecular conformation of cellobiohydrolase changes after cellobiose binding, which also causes most of the non-productive adsorption. Under these conditions, microfibrils cannot be separated from cellulose chains, thus further hydrolysis of cellulose can hardly proceed.

关键词： cellobiohydrolase, cellobiose, inhibition.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

瑞氏木霉EGⅠ3′-UTR对基因在酿酒酵母中表达的影响

引用

微生物学报 2001年第5期41卷 587-591页

作者：肖志壮吴志红王婷曲音波高培基汪天虹山东大学微生物技术国家重点实验室济南250100

将纤维素降解菌丝状真菌瑞氏木霉内切葡聚糖酶Ⅰ (EGⅠ )全长cDNA克隆于酿酒酵母H1 58中得到表达。重组酿酒酵母产生的EGⅠ的最适pH值为 5 0 ,最适作用温度为 50℃～ 60℃。EGⅠcDNA中的 3′ 非翻译区 (3′ UTR)序列的删除导致EGI基因... 详细信息

将纤维素降解菌丝状真菌瑞氏木霉内切葡聚糖酶Ⅰ (EGⅠ )全长cDNA克隆于酿酒酵母H1 58中得到表达。重组酿酒酵母产生的EGⅠ的最适pH值为 5 0 ,最适作用温度为 50℃～ 60℃。EGⅠcDNA中的 3′ 非翻译区 (3′ UTR)序列的删除导致EGI基因在酵母菌中没有活性产物表达。通过RT PCR技术检测EGⅠmRNA转录水平的结果表明 ,带有 3′ UTR的EGⅠcDNA在酿酒酵母中具有明显的转录产物生成 ,但删除 3′ UTR之后的EGⅠcDNA却检测不到转录产物。这说明EGⅠ的 3′ UTR对基因在酵母菌中的表达具有重要作用。

关键词：瑞氏木霉内切葡聚糖酶Ⅰ 3'-非翻译区基因表达酿酒酵母 EGⅠ基因纤维素酶

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese guideline for the application of rectal cancer staging recognition systems based on artificial intelligence platforms (2021 edition)

引用

Chinese Medical Journal 2021年第11期134卷 1261-1263页

作者： Yuan gao Yun Lu Shuai Li Yong Dai Bo Feng Fang-Hai Han Jia-Gang Han Jing-Jing He Xin-Xiang Li Guo-Le Lin Qian Liu Gui-Ying wang Quan wang Zhen-Ning wang Zheng wang Ai-Wen wu bin wu Ying-Chi Yang Hong-Wei Yao Wei Zhang Jian-Ping Zhou Ai-Min Hao Zhong-Tao Zhang Colorectal Surgery Group of the Surgery Branch in the Chinese Medical Association Beihang university state key laboratory of Virtual Reality technology and Systems Department of General Surgery The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266555China Beihang university state key laboratory of Virtual Reality technology and Systems Beijing 100191China Department of General Surgery Qilu Hospital of Shandong UniversityJinanShandong 250012China Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Minimally Invasive Surgery Center Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Gastrointestinal Surgery Sun Yat-sen UniversityGuangzhouGuangdong 510120China Department of General Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Institute of International Law Chinese Academy of Social SciencesBeijing 100732China Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 201321China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 201321China Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100021China Third Hospital of Hebei Medical university ShijiazhuangHebei 050051China Department of Colon and Rectum Surgery The First Hospital of Jilin UniversityChangchunJilin 130021China Department of Surgical Oncology and General Surgery Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal TumorsMinistry of EducationThe First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Unit III&Ostomy Service Key laboratory of Carcinogenesis and Translational Research(Ministry of Education)Gastrointest

Development and Application of Artificial Intelligence Recognition Systems in Rectal Cancer Staging Whether for surgical treatment or for neoadjuvant chemoradiotherapy,imaging evaluation has become an important basis to perform the treatment plans.[1]The reading of imaging results requires a large number of experienced radiologists to complete,but shortages and uneven distributions of personnel cause delays and biases in imaging ***,independent research and development of automatic recognition systems of rectal cancer staging based on artificial intelligence(AI)platforms aim to partially replace practitioners’work and achieve rapid and accurate identification of rectal cancer staging.

关键词： staging artificial replace

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CEPC Technical Design Report

引用

Radiation Detection technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and technology Beijing china Institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel PGAM5 inhibitor LFHP-1c protects bloodebrain barrier integrity in ischemic stroke

引用

Acta Pharmaceutica Sinica B 2021年第7期11卷 1867-1884页

作者： Chenglong gao Yazhou Xu Zhuangzhuang Liang Yunjie wang Qinghong Shang Shengbin Zhang Cunfang wang Mingmin Ni Dalei wu Zhangjian Huang Tao Pang state key laboratory of Natural Medicines Jiangsu Key Laboratory of Drug ScreeningJiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesChina Pharmaceutical UniversityNanjing 210009China Helmholtz International Lab State Key Laboratory of Microbial TechnologyShandong UniversityQingdao 266237China Guangdong Long Fu Pharmaceutical Co. Ltd.Zhongshan 528451China key laboratory of Drug Quality Control and Pharmacovigilance(china Pharmaceutical university) Ministry of EducationNanjing 210009China

Bloodebrain barrier(BBB)damage after ischemia significantly influences stroke *** LFHP-1 c was previously discovered with neuroprotective role in stroke model,but its mechanism of action on protection of BBB disruption after stroke remains ***,we show that LFHP-1 c,as a direct PGAM5 inhibitor,prevented BBB disruption after transient middle cerebral artery occlusion(tMCAO)in ***,LFHP-1 c binding with endothelial PGAM5 not only inhibited the PGAM5 phosphatase activity,but also reduced the interaction of PGAM5 with NRF2,which facilitated nuclear translocation of NRF2 to prevent BBB disruption from ***,LFHP-1 c administration by targeting PGAM5 shows a trend toward reduced infarct volume,brain edema and neurological deficits in nonhuman primate Macaca fascicularis model with t ***,our study identifies compound LFHP-1 c as a firstly direct PGAM5 inhibitor showing amelioration of ischemia-induced BBB disruption in vitro and in vivo,and provides a potentially therapeutics for brain ischemic stroke.

关键词： Ischemic stroke Bloodebrain barrier Brain microvascular endothelial cells Target identification Surface plasmon resonance PGAM5 NRF2 LFHP-1c

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nationwide survey analysis of esophagogastric varices in portal hypertension based on endoscopic management in china

引用

Portal Hypertension & Cirrhosis 2024年第3期3卷 129-138页

作者： Xing wang bing Hu Yiling Li Weichun Lin Zhijie Feng Yanjing gao Zhining Fan Feng Ji bingrong Liu Jinhai wang Wenhui Zhang Tong Dang Hong Xu Derun Kong Lili Yuan Liangbi Xu Shengjuan Hu Liangzhi Wen Ping Yao Yunxiao Liang Xiaodong Zhou Huiling Xiang Xiaowei Liu Xiaoquan Huang Yinglei Miao Xiaoliang Zhu De‐An Tian Feihu Bai Jitao Song Ligang Chen Yangzhen Bian Ba Yingcai Ma Yifei Huang bin wu Xiaolong Qi CHESS‐Endoscopyconsortium Department of Gastroenterology The Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouGuangdongChina Guangdong Province Engineering and technology Research Center of Digestive Endoscopy GuangzhouGuangdongChina Department of Gastroenterology and Hepatology West China Hospital of Sichuan UniversityChengduSichuanChina Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyangLiaoningChina Department of Gastroenterology The Second Hospital of Hebei Medical UniversityShijiazhuangHebeiChina Department of Gastroenterology Qilu Hospital of Shandong UniversityJinanShandongChina Department of Digestive Endoscopy The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Gastroenterology The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiangChina Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Gastroenterology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxiChina Department of Gastroenterology Beijing Daxing District People's HospitalBeijingChina Department of Gastroenterology The Second Affiliated Hospital of Baotou Medical CollegeBaotouInner MongoliaChina Department of Gastroenterology The First Hospital of Jilin UniversityChangchunJilinChina Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhuiChina Department of Digestive Endoscopy The Second Hospital of Shanxi Medical UniversityTaiyuanShanxiChina Digestive Endoscopy Center The Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhouChina Department of Gastroenterology People's Hospital of Ningxia Hui Autonomous RegionNingxia Medical UniversityYinchuanNingxiaChina Department of Gastroenterology Daping HospitalArmy Medical UniversityChongqingChina Department of Gastroenterology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina Department of Gastroente

Aims:The endoscopic treatment of esophagogastric varices is challenging,and the nationwide application of endoscopic therapies for various types of esophagogastric varices and different clinical scenarios remains *** study investigated the use of endoscopic therapy for portal hypertension in ***:This study used a questionnaire survey initiated by the Liver Health Consortium in china to investigate the use of endoscopic therapies for portal *** were released online from January 30,2023 to February 28,2023 and filled out by chief physicians or senior instructors responsible for endoscopic therapies in participating hospitals across 31 provinces(autonomous regions and municipalities)in *** of guideline adherence between primary and referral medical centers were performed using the chi‐square test or Fisher's exact ***:In total,836 hospitals participated in the *** primary and secondary prophylaxis of esophagogastric variceal bleeding(EGVB),adherence to the national guidelines was 72.5%(606/836)and 39.2%(328/836),*** differences were observed in the rate of adherence between the primary and referral centers for primary(79.9%[111/139]vs.71.0%[495/697],p=0.033)and secondary prophylaxis(27.3%[38/139]vs.41.6%[290/697],p=0.002).Of the hospitals,78.2%(654/836)preferred endoscopic therapies for acute EGVB,and the timing of endoscopy was usually within 12 h(48.5%,317/654)and 12-24 h(36.9%,241/654)after *** therapy was more likely to be the first choice of treatment for acute EGVB in referral centers than in primary centers(82.6%[576/697]vs.56.1%[78/139],p2 and isolated gastric varices type 1,the most prevalent procedures were cyanoacrylate injection combined with sclerotherapy(48.2%[403/836]and 29.9%[250/836],respectively);however,substantial hospitals preferred clip-assisted therapies(12.4%[104/836]and 2

关键词： endoscopy esophagogastric varices guideline adherence portal hypertension questionnaire survey

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：