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Publication trends of Leber congenital amaurosis researches:a bibliometric study during 2002-2022

International Journal of Ophthalmology(English edition) 2024年第8期17卷 1501-1509页

作者： xiao-Xu Huang Yi-min Wang min-Yue Xie Yi-Qing Sun xiao-Huan Zhao Yu-Hong Chen Jie-Qiong Chen Si-Yang Han min-Wen Zhou xiao-Dong Sun Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China National Clinical Research Center for Eye Disease Shanghai 200080China Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai 200080China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080China Department of Ophthalmology Zhongshan HospitalFudan UniversityShanghai 200030China Beijing Tongren Hospital Capital Medical UniversityBeijing 100054China Eberly College of Science Penn State UniversityUniversity Park 16802-1503United States

AIM:To analyze the changes in scientific output relating to Leber congenital amaurosis(LCA)and forecast the study trends in this ***:All of the publications in the field of LCA from 2002 to 2022 were collected from Web of Science(WOS)*** analyzed the quantity(number of publications),quality(citation and H-index)and development trends(relative research interest,RRI)of published LCA research over the last two ***,VOSviewer software was applied to define the co-occurrence network of keywords in this ***:A total of 2158 publications were ultimately *** found that the focus on LCA kept rising and peaked in 2015 and 2018,which is consistent with the development trend of gene *** USA has contributed most to this field with 1162 publications,56674 citations and the highest H-index value(116).The keywords analysis was divided into five clusters to show the hotspots in the field of LCA,namely mechanism-related,genotype-related,local phenotype-related,system phenotype-related,and *** also identified gene therapy and antiretinal degeneration therapy as a major focus in recent ***:Our study illustrates historical research process and future development trends in LCA *** may help to guide the orientation for further clinical diagnosis,treatment and scientific research.

关键词： VOSviewer bibliometrics Leber congenital amaurosis gene therapy hotpots

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Sliding behaviors of the trapezoidal roof rock block under a lateral dynamic disturbance

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 741-760页

作者： Feng Dai Wancheng Zhu min Ren Shunchuan wu Leilei Niu Faculty of Land Resources Engineering Kunming University of Science and TechnologyKunming650093China Center for Rock Instability and Seismicity Research Department of Mining EngineeringSchool of Resource and Civil EngineeringNortheastern UniversityShenyang110819China

The surrounding rock of underground space is always affected by external dynamic disturbance from the side position,such as blasting vibration from a stope at the same level or seismic waves from adjacent strata.A series of laboratory tests,numerical simulations and theoretical analyses were carried out in this study to disclose the sliding mechanism of roof rock blocks under lateral ***,the experiments on trapezoidal key block under various clamping loads and disturbance were conducted,followed by numerical simulations using the fast Lagrangian analysis of continua(FLAC3D).Then,based on the conventional wave propagation model and the classical shear-slip constitutive model,a theoretical model was proposed to capture the relative displacement between blocks and the sliding displacement of the key *** results indicate that the sliding displacement of the key block increased linearly with the disturbance energy and decreased exponentially with the clamping load when the key block was disturbed to slide(without instability).Meanwhile,when the key block was disturbed to fall,two types of instability process may appear as immediate type or delayed *** addition,the propagation of stress waves in the block system exhibited obvious low-velocity and lowfrequency characteristics,resulting in the friction reduction effect appearing at the contact interface,which is the essential reason for the sliding of rock *** results can be applied to practical underground engineering and provide valuable guidance for the early detection and prevention of rockfalling disasters.

关键词： Lateral dynamic disturbance Trapezoidal rock block system Low-velocity and low-frequency wave Friction reduction effect Instability mode

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Facile semisynthesis of histone H3 enables nucleosome probes for investigation of histone H_(3)K79 modifications

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Chinese Chemical Letters 2024年第10期35卷 321-324页

作者： Kun Zou Yihang xiao jinyu Yang mingxuan wu Department of Chemistry Zhejiang UniversityHangzhou 310027China Department of Chemistry School of ScienceWestlake UniversityHangzhou 310030China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China

Histone H3K79 modifications are essential to regulate chromatin structure and gene transcription,but understanding of the molecular mechanisms is *** H3K79 is at globular domain,short histone peptide cannot mimic H3K79 in ***,reconstituted nucleosome-based chemical tools are ideally used to investigate H3K79 *** consequence,H3K79-modified histone H3 with additional chemical handles are required,but such synthesis is challenging and *** we report a facile semisynthesis method that enables multifunctional histone H3 readily available.H3K79-containing fragment is short for straight peptide synthesis that was later ligated to recombinant expressed H3 fragments for full-length product in large *** a result,nucleosomes with H3K79 modifications as well as photo-reactive group and affinity tag were obtained to investigate potential binding *** believe this method that enhances synthetic accessibility of nucleosome probes will accelerate understanding of the underexplored H3K79 modifications.

关键词： Histone H3K79 modifications Methylation Succinylation Semisynthesis Nucleosome probes

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mRNA vaccine technology for infectious diseases and beyond

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Science China(Life Sciences) 2024年第10期67卷 2267-2270页

作者： Pei Hao xiao Li Xuan Li wu Zhong Key Laboratory of Molecular Virology and Immunology Shanghai Institute of Immunity and InfectionChinese Academy of SciencesShanghai 200031China Changchun Veterinary Research Institute Chinese Academy of Agricultural SciencesChangchun 130122China Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China National Engineering Research Center for the Emergency Drug Beijing Institute of Pharmacology and ToxicologyBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

The rise of mRNA vaccine technology Vaccines stand as one of the most significant medical advancements,playing a crucial role in the prevention of infectious diseases and the improvement of global *** triumph of smallpox vaccination stands as a towering achievement in the annals of healthcare,leading to the complete elimination of a oncedevastating disease and showcasing the efficacy of vaccination methods.

关键词： methods vaccination prevention

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Thermal and hydrological processes in permafrost slope wetlands affect thermosyphon embankment stability

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Advances in Climate Change Research 2024年第4期15卷 680-694页

作者： Bo-Wen TAI Qing-Bai wu xiao-ming XU State Key Laboratory of Frozen Soil Engineering Key Laboratory of Cryospheric Science and Frozen Soil EngineeringNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

To ensure the long-term service performance of infrastructure such as railways,highways,airports and oil pipelines built on permafrost slope wetland sites,it is imperative to systematically uncover the long-term heat-water changes of soil in slope wetlands environment under climate *** specifically,considering valuable field data from 2001 to 2019,the long-term heat and water changes in active layers of the slope wetland site along the Qinghai-Xizang Railway(QXR)are illustrated,the effect of thermosyphon measures in protecting the permafrost environment is evaluated,and the influences of climate warming and hydrological effects on the stability of slope wetland embankments are systematically *** permafrost at the slope wetland site is rapidly degrading,demonstrating a reduction in active layer thickness of>3.7 cm per year and a permafrost temperature warming of>0.006℃ per *** thermosiphon embankment developed by QXR has a specific cooling period;thus,to mitigate the long-term impacts of climate warming on the thermal stability of permafrost foundation,it is essential to implement strengthening measures for the thermosiphon embankment,such as adding a crushed-rock layer or sunshade board on the slope of thermosiphon embankment to creating a composite cooling ***-term seasonal groundwater seepage intensifies frost damage to the slope wetland embankment,while long-term seasonal supra-permafrost water and groundwater seepage exacerbates uneven transverse deformation of slope wetland ***-term climate warming and slope effects have altered the surface water and groundwater hydrological processes of slope wetlands,potentially leading to an increased occurrence of slope embankment *** results are crucial for improving our understanding of heat and water variation processes in the active layer of slope wetland sites located in permafrost regions and ensuring long-term service safety for the QXR.

关键词： Heat and water process Active layer Slope wetland Permafrost environment Thermosyphon embankment

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Study on impedance spectroscopy based on dynamic equivalent circuit of solar cell

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Optoelectronics Letters 2024年第8期20卷 449-453页

作者： xiao Wenbo LI Ao wu Huaming LI Yongbo xiao Bangzhi Key Laboratory of Nondestructive Testing Ministry of EducationNanchang Hangkong UniversityNanchang 330063China Jiangxi Engineering Laboratory for Optoelectronics Testing Technology Nanchang 330063China College of Science and Technology Nanchang Hangkong UniversityGongqingcheng 332020China School of Engineering and Construction Nanchang UniversityNanchang 330031China

This paper investigates the impedance spectroscopy of monocrystalline silicon solar cells(MSSC)and dye-sensitized solar cells(DSSC)using solar cell dynamic equivalent resistor-capacitance(RC)and capacitor sum capacitor(CSC)***,these circuits effectively represent the dynamic behavior of MSSC and ***,the measurement method significantly impacts the accuracy of impedance measurements in the high-frequency ***,the series resistance affects the distance between the left end of the impedance spectroscopy and the origin,while the parallel resistance influences the size of the impedance *** the CSC circuit,the relative magnitudes of dielectric relaxation capacitance and chemical capacitance affect the number and position of arc in the impedance *** value of the dielectric relaxation capacitor determines the number of impedance spectroscopy *** conclusions provide guidelines for improving the accuracy of solar cell impedance measurements.

关键词： spectroscopy impedance capacitance

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超疏水表面上多液滴合并触发液滴弹跳现象的理论分析

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工程热物理学报 2017年第2期38卷 352-357页

作者：褚福强吴晓敏朱毅清华大学热能工程系热科学与动力工程教育部重点实验室北京市CO2资源利用与减排技术重点实验室北京100084

超疏水表面上由冷凝液滴的合并触发的液滴弹跳现象在自清洁、强化传热、防结霜等工程领域均有广阔的应用前景。本文建立了一个能量模型以分析多液滴合并触发的液滴弹跳现象。依据本文模型,在液滴弹跳过程中,涉及到表面能、黏性耗散、重... 详细信息

超疏水表面上由冷凝液滴的合并触发的液滴弹跳现象在自清洁、强化传热、防结霜等工程领域均有广阔的应用前景。本文建立了一个能量模型以分析多液滴合并触发的液滴弹跳现象。依据本文模型,在液滴弹跳过程中,涉及到表面能、黏性耗散、重力势能、阻滞功、振动动能和平动动能等能量形式的变化及转换,当有更多的表面能转化为平动动能时,液滴弹跳速度会更快。结果表明,多液滴合并能够释放更多的表面能,分布更集中的液滴之间的合并有利于获得更多的平动动能,使液滴弹跳速度更大。此外,存在最小的临界液滴半径和半径比,小于该半径或半径比时,不会发生液滴弹跳。随合并液滴数量的增加,该最小的临界液滴半径和半径比均减小。

关键词：超疏水液滴弹跳多液滴合并能量模型

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Sodium butyrate alleviates fructose-induced non-alcoholic fatty liver disease by remodeling gut microbiota to promoteγ-amino butyric acid production

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Food Science and Human Wellness 2024年第2期13卷 961-971页

作者： Qu Chen Lei wu Aijia Zhang Chen wu Liuping Cai Yingping xiao Yingdong Ni Key Laboratory of Animal Physiology and Biochemistry Ministry of Agriculture and Rural AffairsNanjing Agricultural UniversityNanjing 210095China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of Agro-product Safety and NutritionZhejiang Academy of Agricultural SciencesHangzhou 310022China

Sodium butyrate(NaB)can regulate lipid metabolism and inhibit hepatic *** study aimed to investigate whether NaB can alleviate fructose-induced hepat ic steatosis via remodeling the gut microbiota and evaluate the anti-fatty liver *** results showed that NaB and NaB-remodeled gut microbiota significantly alleviated fructose-induced hepatic steatosis and increased plasma uric acid and fructose ***,both NaB and NaB-remodeled gut microbiota increased the abundance of Lactobacillus and altered the levels of plasma amino acids(upregulating gamma-amino butyric acid(GABA)and downregulating L-glutamic acid and L-arginine)in fructose-exposed *** correlation analysis showed that GABA levels positively correlated with Lactobacillus abundance,and increased GABA levels might promote the reduction of the hepatic triglyceride *** studies confirmed that GABA significantly reduced lipid deposition in mouse hepatocytes induced via fructose pretreatment in *** findings suggested that NaB could ameliorate fructose-induced hepatic steatosis by regulating gut microbiota.

关键词： Butyrate Fructose Gut microbiota Hepatic steatosis

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Treg Immunomodulation Contributes to the Anti-atherosclerotic Effects of Huxin Formula in ApoE^(-/-)Mice

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Chinese Journal of Integrative Medicine 2024年第10期30卷 896-905页

作者： OU xiao-min CAI Jing HU xiao-yue ZENG Qiao-huang LAN Tao-hua JIANG Wei The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510405China Department of Cardiology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510020China Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou510020China

Objective:To explore the effects of Huxin formula(HXF)in curtailing atherosclerosis and its underlying ***:According to random number table method,24 specific pathogen free male ApoE^(-/-)mice were randomly divided into model group,HXF low-dose(HXF-L)group(8.4 g/kg daily),HXF high-dose(HXF-H)group(16.8 g/kg daily),and pravastatin(8 mg/kg daily)group in ExperimentⅠ(n=6 per group).C57BL/6J mice served as the control group(n=6).ApoE^(-/-)mice in HXF-L,HXF-H,pravastatin groups were fed a Western diet and administered continuously by gavage for 12 weeks,while C57BL/6J mice in the control group were fed conventional lab mouse chow for 12 ***,Tregs were depleted by weekly intraperitoneal injection of purified anti-mouse CD25 antibody(PC61,250μg per mouse)for 4 weeks in ExperimentⅡ(n=6 per group).Oil Red O and Masson staining were used to evaluate the plaque area and aortic root *** CD4^(+)CD25^(+)Foxp3^(+)Treg counts in the lymph nodes and spleen cells were detected using flow cytometric *** transforming growth factor-β1(TGF-β1),interleukin(IL)-10,and IL-6 serum levels were examined by MILLIPLEX?MAP *** real-time reverse transcription PCR(qRT-PCR)and Western blot were utilized to assess the expression of TGF-βmRNA and protein in the *** expression of CD4^(+)T lymphocytes,macrophages and smooth muscle cells in the aortic root were detected by immunofluorescence ***:HXF reduced plaque area in ApoE^(-/-)mice(P0.05).Also,HXF upregulated the expression of TGF-βmRNA and protein in the aorta(P<0.05).Additionally,HXF attenuated CD4^(+)T lymphocytes,macrophages and smooth muscle cells in aortic root plaque(P<0.01).Furthermore,the depletion of Tregs with CD25

关键词： atherosclerosis Huxin Formula Tregs immune responses inflammation

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pH-responsive metal nanoparticles as high contrast theranostic agents for selective imaging and synergistic cancer therapy

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Science China Chemistry 2024年第9期67卷 3063-3070页

作者： Sichao Tian xiaofeng He xiao wu Dongxue Hu Qing-Hua Xu Department of Chemistry National University of SingaporeSingapore 117543Singapore National University of Singapore(Suzhou)Research Institute Suzhou 215123China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117558Singapore

The low signal-to-noise ratio(S/N)and single functionality of fluorescence imaging agents have limited their practical *** two-photon excitation(2PE)imaging probes are highly desirable in vivo with larger imaging depth,minor autofluorescence background,and less ***,we developed responsive aggregated gold nanoparticles(Au NPs)as high contrast 2PE imaging agents,capable of emitting red fluorescence upon excitation of near-infrared(NIR)laser and possessing a high signal-to-noise ratio(S/N of 2,475).By forming aggregates in situ inside tumor tissue,doxorubicin hydrochloride(DOX)-loaded mix-charged gold nanoparticles(DOX-MC-Au NPs)were utilized to act as selective fluorescence imaging probes and precise therapy *** high-contrast theranostic agents offer a promising potential for precise cancer imaging and therapy,which might open a new venue to multifunctional and noninvasive theranostics.

关键词： metal nanoparticles two-photon excitation high contrast imaging agents fluorescence imaging cancer therapy

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