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Chinese Journal of Chemical Engineering 2024年第8期72卷 44-52页

作者： hongmei wu Xinyu Liu Yu Guo School of Chemical and Environmental Engineering Liaoning University of TechnologyJinzhou 121001China

With the development of hydrogen energy,palladium-based membranes have been widely used in hydrogen separation and ***,the poor chemical stability of palladium composite membranes limits their commercial *** this study,a zeolite-palladium composite membrane with a sandwich-like structure was obtained by using a TS-1 zeolite film grown on the surface of palladium *** membrane microstructure was characterized by SEM and *** effects of the TS-1 film on the hydrogen permeability and stability of palladium composite membrane were investigated in *** from the protection of the TS-1 zeolite film,the stability of palladium composite membrane was *** results indicate that the TS-1-Pd composite membrane was stable after eight cycles of the temperature exchange cycles between 773 K and 623 ***,the loss of hydrogen permeance for TS-1-Pd composite membrane was much smaller than that of the pure palladium membrane when the membrane was tested in the presence of *** indicated that the TS-1-Pd composite membrane had better chemical stability in comparison with pure palladium membrane,owing to its sandwich-like *** work provides an efficient way for the deposition of zeolite film on palladium membrane to enhance the membrane stability.

关键词： Palladium membrane Zeolite film Hydrogen separation Stability

Association of polymorphisms of Nramp1 gene with immune function and production performance of large white pig

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Journal of Genetics and Genomics 2008年第2期35卷 91-95页

作者： hongmei wu Duxue Cheng Lixian Wang Institute of Animal Science Chinese Academy of Agricultural Science Beijing 100094 China

The present research was designed to study the association of polymorphism of natural resistance-associated macrophage proteinl （Nrampl） with some immune function and the production performance in Large White pig. The PCR-RFLP technique was applied to analyze the correlation between the polymorphisms of Nrampl gene and immune function [value of Polymorphonuclear Leukocytes （PMN） obtained by Nitroblue Tetrazolium （NBT） Reduction and effect of Cytotoxin in Monocyte] and production performance in 165 Large White pigs. The results showed that there was one Nde I restriction locus in Large White pig, and both values of PMN by NBT Reduction and effect of Cytotoxin in Monocyte in genotype BB were higher than those in genotype AB （P〈0.05）. Simultaneously, the weight of 180-day-old pigs with genotype BB was higher than that with genotype AB （P〈0.05）. The results indicated that there was a significant correlation between different genotypes of Nrampl gene and Immune function and production performance, and it can be regarded as a candidate gene of disease resistance. All these results provide valuable reference to further studies of pig disease resistance.

关键词： Large White pig Nrampl gene immune function production performance

Simulation of groundwater and nuclide transport in the near-field of the high-level radioactive waste repository with TOUGHREACT

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Chinese Journal Of Geochemistry 2008年第3期27卷 299-305页

作者： LI Xun YANG Zeping ZHENG Zhihong wu hongmei College of Engineering andArchitecture Zhejiang University Hangzhou 310027 China East China Institute of Technology （ECIT） Fuzhou 344000 China

In order to know the mechanism of groundwater transport and the variation of ion concentrations in the near-field of the high-level radioactive waste repository,the whole process was simulated by EOS3 module of ***,the pH and cation concentrations vary obviously in the near-field saturated zone due to interaction between groundwater and ***,the simulated results showed that calcite precipitation could not cause obvious variations in the porosity of media in the near-filed if the chemical components and their concentrations of groundwater and bentonite pore water are similar to those used in this study.

关键词：液体饱和度地下水传输地质放射性废弃物

COMPACT INTERLOCKED-COUPLED FILTER USING FOLDED STEPPED-IMPEDANCE RESONATORS

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Journal of Electronics(China) 2012年第1期29卷 137-141页

作者： Chen Chunhong wu Wen wu hongmei Ministerial Key Laboratory of JGMT Nanjing University of Science and TechnologyNanjing 210094China

A microstrip interlocked-coupled bandpass filter is proposed with a markedly compact structure. The low-impedance open-end line of the quarter-wavelength Stepped-Impedance Resonator (SIR) is replaced by two open-end high-impedance lines, which not only facilitate the coupling mechanism but also provide the strong electric coupling between resonators. With the proper utilization of folded SIRs, the occupied area of coupled-resonator pair can be reduced. By applying the proposed coupled-resonator pair, the passband filter with the compact size can be realized. Good agreement between measured and simulated results is observed. The proposed filter is desirable for compact and high-performance microwave circuit applications.

关键词： Microstrip filter Bandpass filter Stepped-Impedance Resonator (SIR) Quarter-wavelength

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro and in vivo

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Frontiers of Medicine 2016年第1期10卷 41-51页

作者： Lan Wang Juehengwu Jie Yuan Xun Zhu hongmei wu Mengfeng Li Department of Microbiology and Immunology School of Basic Courses Guangdong Pharmaceutical University Guangzhou 510006 China Department of Microbiology Zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080 China Key Laboratory of Tropical Disease Control (Sun Yat-sen University) Ministry of Education Guangzhou 510080 China

Midline2 （MID2） is an ubiquitin-conjugating E2 enzyme linked to tumor progression and a novel interacting partner of breast cancer 1, early-onset 0BRCA1）. However, the role of MID2 in breast cancer remains unknown. This study investigated the expression, prognostic value, and role of MID2 in breast cancer. The expression of MID2 mRNA and protein was significantly upregulated in breast cancer tissue and established cell lines compared with that in normal breast epithelial cells and paired adjacent non-tumor tissue （P 〈 0.001）. Immunohistochemical analysis demonstrated that MID2 was overexpressed in 272 of 284 （95.8%） paraffin- embedded, archived breast cancer tissue. Moreover, MID2 expression increased with advanced clinical stage （P 〈 0.001）. High MID2 expression was significantly associated with advanced clinical stages and T, N, and M staging （all P 〈 0.05）. Univariate and multivariate analyses indicated that high MID2 expression was an independent prognostic factor for poor overall survival in the entire cohort （93.73 vs. 172.1 months; P 〈 0.001, log- rank test） and in subgroups with stages Tis ＋ Ⅰ ＋ Ⅱ and Ⅲ ＋ Ⅳ. Furthermore, 3-（4,5-dimethyl-2-thiazolyl）-2,5- diphenyl-2H-tetrazolium bromide colony formation, and anchorage-independent growth ability assays were conducted. Results showed that siRNA silencing of MID2 expression significantly reduced MCF-7 and MDA-MB- 231 cell proliferation in vitro and blocked the growth of MDA-MB-231 cell xenograft tumors in vivo （P 〈 0.05）. This study indicated that MID2 may be a novel prognostic marker and interventional target in breast cancer.

关键词： breast cancer MID2 proliferation overall survival xenograft

Research progress of protein phosphatase 2A in cellular autophagy

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BIOCELL 2023年第3期47卷 485-491页

作者： hongmei wu DI LI YUANYUAN HUANG RUYUAN LIU XIAONIAN ZHU Department of Health Toxicology School of Public HealthGuilin Medical UniversityGuilin541199China

Autophagy is an important metabolic *** facilitates the recycling of intracellular substances by removing,degrading,and recycling damaged organelles,proteins,and lipids in lysosomal vacuoles and plays an important role in maintaining cellular *** phosphatase 2A(PP2A)is a key serine/threonine phosphatase and one of the main cell cycle regulatory *** PP2A activity is essential for the cell,dysfunction or dysregulation of PP2A can affect various physiological processes,including ***,we review the autophagy-related factors that target PP2A in different diseases,such as breast cancer,colorectal cancer,liver cancer,and Alzheimer’s disease,to maintain cell homeostasis by modulating the level of autophagy through mTORC1/ULK1 pathway,MAPK pathway,or AMPK pathway.

关键词： PP2A Autophagy mTOR MAPK AMPK

Mercury accumulation,distribution,and isotopic composition in tissues of the Collared Scops Owl(Otus lettia)

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Acta Geochimica 2023年第4期42卷 637-647页

作者： Dongya Jia Kang Luo Zhidong Xu Xiaohang Xu Chan Li hongmei wu Dawei Wang Hui Ye Gaoen wu Zhuo Chen Guangle Qiu School of Chemistry and Materials Science Guizhou Normal UniversityGuiyang 550001China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China School of Ecology and Environmental Science Yunnan UniversityYunnan 650091China University of Chinese Academy of Sciences Beijing 100049China School of Public Health Guizhou Medical UniversityGuiyang 550025China College of Ecology and Environment Hainan UniversityHainan 570228China

Mercury is a ubiquitous contaminant known to accumulate in wildlife,particularly bird species at higher trophic *** of tissue-specific Hg distributions aids our understanding of Hg bioaccumulation in *** this study,one adult and three juvenile Collared Scops Owls(Otus lettia)were studied to elucidate the bioaccumulation of Hg in body *** tissues and organs(feathers,nails,heart,liver,gizzard,and muscle),as well as gastric contents,were examined for total Hg(THg)and methylmercury(MeHg)contents,Hg isotopic compositions including mass-dependent fractionation(MDF;δ202Hg)and mass-independent fractionation(MIF;Δ199Hg andΔ201Hg),and C(δ13C)and N(δ15N)isotopic ***-specific THg and MeHg concentrations in the adult were in the ranges of 150–1360 ng/g and17–1060 ng/g,and lower in the juveniles at 91–419 ng/g and 67–350 ng/g,***δ^(202)Hg values in the adult were strongly negative at-1.75‰±0.17‰compared with the juveniles at-0.99‰±0.25‰.The adult exhibited lower MIF values than the juveniles,at0.23‰±0.07‰forΔ^(199)Hg and 0.2‰±0.11‰forΔ^(201)Hg,comparedwith0.81‰±0.09‰and0.66‰±0.07‰,*** lower adult MDF and MIF values suggest that the adult tended to accumulate negative Hg isotopes but the juvenile's positive Hg *** between adult and juvenile tissue Hg concentrations indicate that metabolic processes play an important role in Hg accumulation.

关键词： Mercury Methylmercury Mass-dependent fractionation Mass-independent fractionation Tissue Terrestrial bird

N-methyl-D-aspartate receptor subunit 1 protein expression in the hippocampus and temporal cortex of kainic acid-induced epilepsy rats

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Neural Regeneration Research 2010年第14期5卷 1045-1049页

作者： Zan Wang Hongyu Jiang Suisheng wu hongmei Meng Li Ji Li Cui Weihong Lin Department of Neurology First Hospital of Jilin University Changchun 130021 Jilin Province China

BACKGROUND： The N-methyl-D-aspartate receptor subunit 1 （NMDAR1） contributes to the incidence of epilepsy. However, the relationship between epilepsy-induced brain injury and NMDAR1 remains poorly understood. OBJECTIVE： To investigate changes in NMDAR1 protein expression in the hippocampus and temporal cortex of kainic acid-induced epilepsy rats. DESIGN, TIME AND SETFING： A randomized, controlled, animal experiment was performed at the Department of Physiology and Department of Pathology, Basic Medical College of Jilin University from March 2002 to March 2003. MATERIALS： Rabbit anti-NMDAR1 antibody was purchased from wuhan Boster Biological Technology, China. METHODS： A total of 80 healthy, male, Wistar rats, aged 22 weeks, were randomly assigned to sham-surgery （n = 10） and model （n = 70） groups. Epilepsy models were established by injecting kainic acid （1μL） into the right amygdala, and rats were sacrificed at 2, 6, 24, 72 hours, and 7, 15, 30 days after surgery, with 10 animals at each time point. The rats in the sham-surgery group were injected with 1μL phosphate buffered saline into the right amygdala. MAIN OUTCOME MEASURES： NMDAR1 protein expression in the hippocampus and temporal cortex at 2, 6, 24, 72 hours and 7, 15, 30 days after epilepsy was detected using immunohistochemistry and flow cytometry analysis. RESULTS： In the sham-surgery group, a few NMDARl-positive cells were distributed in the hippocampus and temporal cortex. In the model group, NMDARl-positive cells were increased in the hippocampus and temporal cortex at 2 hours following kainic acid-induced epilepsy. They were significantly increased at 6 hours, and slightly decreased at 7 days （CA3 region and temporal cortex）, but remained greater than the sham-surgery group. This continued until day 30 （P 〈 0.01 ）. In addition, there were more NMDAR1 positive cells in the hippocampal CA3 and dentate gyrus than the temporal cortex （P 〈 0.01）. CONCLUSION： In epilepsy model rats, NMDAR1 protein ex

关键词： kainic acid epilepsy N-methyI-D-aspartate receptor rat subunit neural regeneration

PRECISE RATES IN THE LAW OF THE ITERATED LOGARITHM FOR R/S STATISTICS

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Applied Mathematics(A Journal of Chinese Universities) 2006年第4期21卷 461-466页

作者： wu hongmei Wen Jiwei City College of Zhejiang University Hangzhou 310015 China. Department of Mathematics Zhejiang University Hangzhou 310027 China.

Let{Xn;n≥1}be a sequence of i.i.d, random variables with finite variance,Q（n）be the related R/S statistics. It is proved that lim ε↓0 ε^2 ∑n=1 ^8 n log n/1 P{Q（n）≥ε√2n log log n}=2/1 EY^2,where Y=sup0≤t... 详细信息

关键词： law of the iterated logarithm R/S statistics tail probability.

Research progress of TRIMs protein family in tumors

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BIOCELL 2023年第3期47卷 445-454页

作者： YUANYUAN HUANG hongmei wu RUYUAN LIU SONG JIN WEILAI XIANG CHANG YANG LI XU XIAONIAN ZHU Department of Health Toxicology School of Public HealthGuilin Medical UniversityGuilin541199China

The tripartite motif(TRIMs)protein family has E3 ubiquitin ligase activity among most of its *** participate in multiple cellular processes and signaling pathways in living organisms,including cell cycle,growth,and metabolism,and mediate chromatin modification,transcriptional regulation,post-translational modification,and cellular *** studies have confirmed that the TRIMs protein family is involved in the development of various cancers and correlated with the prognosis of tumor *** we summarize the biological roles of the TRIMs protein family in cancers.

关键词： TRIMs protein family Liver cancer Lung cancer Colorectal cancer Breast cancer Gastric cancer