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Icteric flare of chronic hepatitis B in a 95-year old patient

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World Journal of Gastroenterology 2003年第12期9卷 2876-2877页

作者： ws wong Wai Keung Leung Henry L Y Chan Department of Medicine and Therapeutics the Prince of Wales HospitalHong Kong SARThe Chinese University of Hong Kong

A 95-year old gentleman developed fatal icteric flare of chronic hepatitis B despite lamivudine treatment. This article highlights the atypical presentations of chronic hepatitis B in elderly patient and the need to c... 详细信息

关键词：慢性乙型肝炎高龄患者黄疸拉米夫定急性暴发性肝炎

β_2-adrenoceptor in obstructive airway diseases:Agonism, antagonism or both?

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World Journal of Respirology 2015年第3期5卷 199-206页

作者： Daniel ws Tan Jyi Lin wong Siew Teck Tie John A Abisheganaden Albert YH Lim ws Fred wong Department of Pharmacology Yong Loo Lin School of MedicineNational University Health System Respiratory Unit Department of MedicineSarawak General Hospital Department of Respiratory and Critical Care Medicine Tan Tock Seng Hospital Immunology Program Life Science InstituteNational University of Singapore

Obstructive airway disease is a complex disease entity including several maladies characterized by bronchoconstriction and abnormal airway inflammation. Reversing bronchoconstriction leads to symptomatic relief and improvement in quality of life, both in reversible(bronchial asthma) and partially reversible(chronic obstructive airway disease) obstructive airway diseases. β2-adrenoceptor expressed in human airway is the main β-receptor subtype, and its activation in airway smooth muscle cells leads to bronchodilatation. Drugs targeting β-adrenoceptors have been around for many years, for which agonists of the receptors are used in bronchodilation while antagonists are used in cardiovascular diseases. This review article summarizes the effect and usage of β2-agonist in obstructive airway disease, addressing the benefits and potential risks of β2-agonist. The article also looks at the safety of β-blocker usage for cardiovascular disease in patients with obstructive airway disease. There is also emerging evidence that non-selective β-blockers with inverse agonism ironically can have longterm beneficial effects in obstructive airway disease that is beyond cardiovascular protection. Further trials are urgently needed in this area as it might lead to a dramatic turnaround in clinical practice for obstructive airway diseases as has already been seen in the usage of β-blockers for heart failure.

关键词： β-adrenoceptors β2-agonist β-blocker Inverse agonist Heart failure β-arrestin

Development of Chinese medicinal anti-malarial drug artesunate for allergy,asthma and COPD

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Development of Chinese medicinal anti-malarial drug artesuna...

中国药理学会第十一次全国学术会议

作者： ws Fred wong Eugene WX HO Tze Khee CHAN David SW NG Pharmacology Yong Loo Lin School of MedicineNational University of SingaporeSingapore

Artesunate is a semi-synthetic derivative of artemisinin,a sesquiterpene trioxane lactone isolated from the herb Artemisia annua *** medicinal plant has been used as a remedy for fevers and chills for centuries in *** is a clinically effective drug for both uncomplicated and severe *** have recently found that artesunate may be effective for allergy,asthma and *** reported for the first time that artesunate effectively reduced ovalbumin-induced inflammatory cell recruitment into bron-choalveolar fluid,IL-4,IL-5,IL-13 and eotaxin production,pulmonary eosinophilia,mucus hypersecretion and airway hyperrespons-iveness in a mouse asthma model probably via inhibition of the phosphoinositide 3-kinase(PI3K)/Akt signaling pathway[Cheng et al. (2011) PLoS ONE 6:e20932].Artesunate significantly suppressed ovalbumin-induced increases in oxidative damage markers 8-isoprostane, 8-hydroxy-2-deoxy-guanosine and 3-nitrotyrosine levels,and pro-oxidants iNOS and NADPH oxidase(NOX 1,2,3 and 4) ***,artesunate markedly suppressed passive cutaneous anaphylaxis,passive systemic anaphylaxis,ovalbumin-induced mast cell degranulation in the airways and serum histamine level,and IgE-mediated mast cell degranulation,probably mediated through reduction of inositol trisphosphate(IP) and intracellular Ca ***,artesunate was able to ameliorate pulmonary cell infiltration in a cigarette smoke induced COPD mouse *** together,our results clearly demonstrate broad-spectrum anti-inflammatory effects of artesunate in mouse models of asthma,allergy and COPD by inhibiting PI3K/Akt and IP/Ca signaling pathways. Our present findings support a novel therapeutic use of artesunate in the treatment of allergy,asthma and COPD.

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来源： cnki会议评论

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腹腔镜下止血设备新进展

中国微创外科杂志 2011年第5期11卷 385-390页

作者： Eric Lee ws Felix wong 黄倩应小燕 Consultant Caritas Hospital Conjoint Professor Division of Women's and Children HealthThe University of New South Wales Division of Minimally Invasive Gynecology St.Paul's Hospital 南京医科大学第二附属医院南京210011

目的为提高血管闭合性能、手术效果和临床结局,市场上研发了许多新式的血管闭合系统。在微创手术中,爆破压、横向热扩散、闭合率和故障率是选择器备并获得最理想手术效果的重要考虑参数。本文详细介绍多种新式止血设备的物理学原理和基... 详细信息

目的为提高血管闭合性能、手术效果和临床结局,市场上研发了许多新式的血管闭合系统。在微创手术中,爆破压、横向热扩散、闭合率和故障率是选择器备并获得最理想手术效果的重要考虑参数。本文详细介绍多种新式止血设备的物理学原理和基本运行机制,并回顾相关文献评价各个设备的优缺点。

关键词：血管闭合止血设备腹腔镜手术

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DOUBLE VALVE DENVER PERITONEAL VENOUS SHUNT USED IN OVARIAN MALIGNANT ASCITES: A CASE REPORT

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中华医学杂志(英文版) 1989年第4期102卷 302-302页

作者： KW Michael Li ws Felix wong Department of Surgery and Department of Obstetrics and Gynecology Prince of Wales Hospital Chinese University of Hong Kong Shatin Hong Kong

Malignant ascites in patients with advanced or recurrent ovarian cancer poses a common problem to gynecologic oncologists. The traditional treatment with diuretics, salt, and fluid restriction is rarely effective. The patients usually undergo repeated paracentesis, resulting in the imbalance of protein and electrolytes. We treated a patient with ovarian malignant ascites by using a double valve Denver peritoneal venous shunt with satisfactory results.

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Effect of music on procedure time and sedation during colonoscopy:A meta-analysis

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World Journal of Gastroenterology 2008年第34期14卷 5336-5343页

作者： Wilson ws Tam Eliza LY wong Sheila F Twinn Nethersole School ofNursing 8/F Esther Lee BuildingThe Chinese University of Hong Kong School of Public Health 4/F PostgraduateEducation CentrePrince of Wales Hospital

AIM:To integrate results from different studies in examining the effectiveness of music in reducing the procedure time and the amount of sedation used during colonoscopic procedure. METHODS: An electronic search in various databases was performed to identify related articles. Study quality was evaluated by the Jadad’s scale. The random effect model was used to pool the effect from individual trials and the Cohen Q-statistic was used to determine heterogeneity. Egger’s regression was used to detect publication bias. RESULTS: Eight studies with 722 subjects were included in this meta-analysis. The combined mean difference for the time taken for the colonoscopy procedure between the music and control groups was -2.84 with 95% CI (-5.61 to -0.08), implying a short time for the music group. The combined mean difference for the use of sedation was -0.46 with 95%CI (-0.91 to -0.01), showing a significant reduction in the use of sedation in the music group. Heterogeneity was observed in both analyses but no publication bias was detected. CONCLUSION: Listening to music is effective in reducing procedure time and amount of sedation during colonoscopy and should be promoted.

关键词： Colonoscopy Colon cancer Meta-analysis Music therapy Screening

The electroweak monopole–antimonopole pair in the standard model

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Communications in Theoretical Physics 2024年第3期76卷 113-119页

作者： Dan Zhu Khai-Ming wong Guo-Quan wong School of Physics Universiti Sains Malaysia11800 USMPenangMalaysia

We present the first numerical solution that corresponds to a pair of Cho–Maison monopoles and antimonopoles(MAPs) in the SU(2) × U(1) Weinberg–Salam(ws) *** monopoles are finitely separated,while each pole carries a magnetic charge ±4π/*** positive pole is situated in the upper hemisphere,whereas the negative pole is in the lower *** Cho–Maison MAP is investigated for a range of Weinberg angles,0.4675≤ tan θ_(W)≤10,and Higgs self-coupling,0 ≤ β ≤ *** magnetic dipole moment(μm) and pole separation(d_(z)) of the numerical solutions are calculated and *** total energy of the system,however,is infinite due to point singularities at the locations of monopoles.

关键词： magnetic monopole Cho-Maison monopole Weinberg-Salam model

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Autonomous scanning probe microscopy investigations over ws_(2)and Au{111}

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npj Computational Materials 2022年第1期8卷 916-922页

作者： John C.Thomas Antonio Rossi Darian Smalley Luca Francaviglia Zhuohang Yu Tianyi Zhang Shalini Kumari Joshua A.Robinson Mauricio Terrones Masahiro Ishigami Eli Rotenberg Edward S.Barnard Archana Raja Ed wong D.Frank Ogletree Marcus M.Noack Alexander Weber-Bargioni Molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCA94720United States Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA94720United States Department of Physics and NanoScience Technology Center University of Central FloridaOrlandoFL32816United States Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA16082United States Center for Two-Dimensional and Layered Materials The Pennsylvania State UniversityUniversity ParkPA16802United States Department of Physics and Department of Chemistry The Pennsylvania State UniversityUniversity ParkPA16802United States Center for Advanced Mathematics for Energy Research Applications Lawrence Berkeley National LaboratoryBerkeleyCA94720United States

Individual atomic defects in 2D materials impact their macroscopic *** the interplay is challenging,however,intelligent hyperspectral scanning tunneling spectroscopy(STS)mapping provides a feasible solution to this technically difficult and time consuming ***,dense spectroscopic volume is collected autonomously via Gaussian process regression,where convolutional neural networks are used in tandem for spectral *** data enable defect segmentation,and a workflow is provided for machine-driven decision making during experimentation with capability for user *** provide a means towards autonomous experimentation for the benefit of both enhanced reproducibility and *** investigations on ws_(2)sulfur vacancy sites are explored,which is combined with local density of states confirmation on the Au{111}herringbone *** vacancies,pristine ws_(2),Au face-centered cubic,and Au hexagonal close-packed regions are examined and detected by machine learning methods to demonstrate the potential of artificial intelligence for hyperspectral STS mapping.

关键词： autonomous consuming packed

ANALYSIS OF PARAMETERS OF ELECTRIC STIMULATION OF ELECTROACUPUNCTURE THERAPY TO PATIENTS WITH BI-SYNDROME, TAN-SYNDROME AND WEI-SYNDROME

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World Journal of Acupuncture-Moxibustion 1994年第1期4卷 34-39页

作者： Xing Jianghuai, wong Runsheng, Yuan Cunxin, Gu XinjianAcupuncture and Moxibustion Hospital of Anhui College of Traditional Chinese Medicine, Anhui 230061, China

In this paper the therapeutic results of PCE - 88A programme-controlled elec-troacupuncture machine in 191 patients of Bi-Syndrome (BS), Tan-Syndrome (TS) and Wei-Syn-drome(ws)are reported. The total effective rate was 98. 4 %. The study on the frequency and inten-sity of stimulation showed that the stimulation of an electric current with 5- 20 Hz was comfortable tothe patients. The intensity of stimulation should be varied according to the nature of the disease andthe location of stimulation to the body. The stimulation for ws should be much higher than that forother two diseases; higher for head than for limbs; and higher for the diseased side than for the nor-mal side. The intensity of stimulation to the diseased side should be gradually reduced following theamelioration of the disease.

关键词： Electroacupuncture Stimulation frequency Stimulation intensity

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