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Chinese Journal of Mechanical Engineering 2024年第1期37卷 203-214页

作者： Xiaokang Huang Xiaoyong Tian Qi Zhong Shunwen He Cunbao Huo yi Cao Zhiqiang Tong Dichen Li State Key Laboratory of Manufacturing Systems Engineering Xi’an Jiaotong UniversityXian 710049China

Improvement of fabrication efficiency and part performance was the main challenge for the large-scale powder bed fusion(PBF)*** this study,a dynamic monitoring and feedback system of powder bed temperature field using an infrared thermal imager has been established and integrated into a four-laser PBF equipment with a working area of 2000 mm×2000 *** heat-affected zone(HAZ)temperature field has been controlled by adjusting the scanning speed ***,the relationship among spot size,HAZ temperature,and part performance has been *** fluctuation of the HAZ temperature in four-laser scanning areas was decreased from 30.85℃to 17.41℃.Thus,the consistency of the sintering performance of the produced large component has been *** on the controllable temperature field,a dynamically adjusting strategy for laser spot size was proposed,by which the fabrication efficiency was improved up to 65.38%.The current research results were of great significance to the further industrial applications of large-scale PBF equipment.

关键词： Powder bed fusion Efficiency Large-scale Spot size Heat-affected zone(HAZ)

Computational Approaches for Traditional Chinese Painting: From the “Six Principles of Painting” Perspective

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Journal of Computer Science & Technology 2024年第2期39卷 269-285页

作者：张玮张建伟黄锦畦王懿芳封颖超杰王璐玮陈为 State Key Laboratory of CAD&CG Zhejiang UniversityHangzhou 310058China Department of Computer Science and Engineering The Hong Kong University of Science and Technology Hong Kong 999077China Kellogg School of Management Northwestern UniversityEvanston 60208U.S.A Laboratory of Art and Archaeology Image Zhejiang UniversityHangzhou 310058China

Traditional Chinese painting(TCP)is an invaluable cultural heritage resource and a unique visual art *** recent years,there has been a growing emphasis on the digitalization of TCP for cultural preservation and *** resulting digital copies have enabled the advancement of computational methods for a structured and systematic understanding of *** explore this topic,we conduct an in-depth analysis of 94 pieces of *** examine the current use of computer technologies on TCP from three perspectives,based on numerous conversations with ***,in light of the“Six Principles of Painting”theory,we categorize the articles according to their research focus on artistic ***,we create a four-stage framework to illustrate the purposes of TCP ***,we summarize the popular computational techniques applied to *** work also provides insights into potential applications and prospects,with professional opinion.

关键词： traditional Chinese painting(TCP) digital humanities cultural heritage computer vision deep learning

All-sky Guide Star Catalog for CSST

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Research in Astronomy and Astrophysics 2024年第4期24卷 35-59页

作者： Hui-Mei Feng Zi-Huang Cao Man I Lam Ran Li Hao Tian Da-yi yin Yuan-Yu Yang Xin Zhang Dong-Wei Fan yi-Qiao Dong Xin-Feng Li Wei Wang Long Li Hugh RAJones yi-Han Tao Jia-Lu Nie Pei-Pei Wang Mao-Yuan Liu He-jun Yang Chao Liu Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of ChineseAcademy of Sciences Beijing 100049China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai200083China Technology and Engineering Center for Space Utilization.Chinese Academy of Sciences Beijing 100094China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Centre for Astrophysics University of HertfordshireHatfieldUK Beijing University of Technology Beijing 100124China

The China Space Station Telescope(CSST)is a two-meter space telescope with multiple back-end *** Fine Guidance Sensor(FGS)is an essential subsystem of the CSST Precision Image Stability System to ensure the required absolute pointing accuracy and line-of-sight *** this study,we construct the Main Guide Star Catalog for *** accomplish this,we utilize the information about the FGS and object information from the Gaia Data Release *** provide an FGS instrument magnitude and exclude variables,binaries,and high proper motion stars from the catalog to ensure uniform FGS guidance ***,we generate a HEALPix index,which provides a hierarchical tessellation of the celestial sphere,and employ the Voronoi algorithm to achieve a homogeneous distribution of stars across the *** distribution ensures adequate coverage and sampling of the *** performance of the CSST guide star catalog was assessed by simulating the field of view of the FGS according to the CSST mock survey strategy *** analysis of the results indicates that this catalog provides adequate coverage and *** catalog's performance meets the FGS requirements,ensuring the functioning of the FGS and its guidance capabilities.

关键词： catalogs astrometry instrumentation:detectors

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui yi Ho Feijun Hu Yujeong Kim Hill Lam Lau ying Lo Law Chi Seng Leung Chun yin Tong Kai Kap wong Wing Lam yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

Synergistic fluorescent hydrogel actuators with selective spatial shape/color-changing behaviors via interfacial supramolecular assembly

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SmartMat 2024年第2期5卷 93-102页

作者： Wei Lu Ruijia Wang Muqing Si yi Zhang Shuangshuang Wu Ning Zhu Wenqin Wang Tao Chen Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina School of Chemical Sciences University of Chinese Academy of SciencesBeijingChina Faculty of Materials Science and Chemical Engineering Ningbo UniversityNingboChina College of Biotechnology and Pharmaceutical Engineering Nanjing Tech UniversityNanjingJiangsuChina

Biomimetic intelligent polymeric hydrogel actuators with cooperative fluorescence-color switchable behaviors are expected to find great potential applications in soft robotics,visual detection/display,and camouflage ***,it remains challenging to realize the spatial manipulation of synergistic shape/color-changing ***,we report an interfacial supramolecular assembly(ISA)approach that enables the construction of robust fluorescent polymeric hydrogel actuators with spatially anisotropic *** the basis of this ISA approach,diverse 2D/3D soft fluorescent hydrogel actuators,including chameleon-and octopi-shaped ones with spatially anisotropic structures,were facilely assembled from two different fluorescent hydrogel building blocks sharing the same physically cross-linked agar *** control over synergistic shape/color-changing behaviors was then realized in one single anisotropic hydrogel *** proposed ISA approach is universal and expected to open promising avenues for developing powerful bioinspired intelligent soft actuators/robotics with selective spatial shape/color-changing behaviors.

关键词： actuator anisotropic structure interfacial supramolecular assembly multicolor fluorescent hydrogels self-gluing

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Glory Days

China Weekly 2024年第3期 48-51页

作者： yi Ziyi Gu Xin 不详

Directed by Hong Kong filmmaker wong Kar-wai,acclaimed TV shew Blossoms Shanghai portrays Gatsby-estue vignettes from the 9os that have stirred a nationwidenostalgia for China's economic *** and blues seep from the softly lit *** latest pop hits from Hong Kong swell through the bustling restaurants as neon lights contend for customers on the streets.A few blocks away,quiet alleys are drenched in pale streetlight,where men in bespoke suits chat about newly listed stocks.

关键词： nationwide listed restaurant

Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant

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World Journal of Pediatrics 2024年第3期20卷 272-286页

作者： Rong-Meng Jiang Zheng-De Xie yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Yun-Xiao Shang Bao-Ping Xu Zhi-Sheng Liu Gen Lu Ji-Kui Deng Guang-Hua Liu Xiao-Chuan Wang Jian-She Wang Lu-Zhao Feng Wei Liu yi Zheng Sai-Nan Shu Min Lu Wan-Jun Luo Miao Liu Yu-Xia Cui Le-Ping Ye A-Dong Shen Gang Liu Li-Wei Gao Li-Juan Xiong Yan Bai Li-Kai Lin Zhuang Wei Feng-Xia Xue Tian-You Wang Dong-Chi Zhao Jian-Bo Shao Daniel Kwok-keung Ng Gary Wing-kin wong Zheng-Yan Zhao Xing-Wang Li Yong-Hong Yang Kun-Ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Pediatrics Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Respiratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Respiratory Shenzhen Children's HospitalShenzhen 518038China Department of Pediatric Respiratory Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004China Department of Respiratory Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China Department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Respiratory Guangzhou Women and Children's Medical CenterGuangzhou 510623China Department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518038China Department of Pediatrics Fujian Branch of Shanghai Children's Medical CenterFujian Children's HospitalFuzhou350005China Department of Clinical Immunology and Allergy Children's Hospital of Fudan UniversityNational Center for Children's HealthShanghai 201102China Department of Infectious Diseases Children's Hospital of Fudan UniversityNational Center for Children's Health.Shanghai

It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged *** coronavirus disease 2019(COVID-19)has greatly influenced human *** to data from the World Health Organization(WHO),there were ove... 详细信息

关键词： prevention infection statement

考虑砂浆随机分布的多孔沥青混合料黏附/黏聚失效行为

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交通运输工程学报 2024年第3期24卷 139-153页

作者：王晓威张一鸣王兴威任家兴杨旭黄育兆汪海年西安建筑科技大学土木工程学院陕西西安710055 新加坡南洋理工大学土木与环境工程学院新加坡639798 长安大学未来交通学院陕西西安710064 长安大学公路学院陕西西安710064

为获得更加真实的多孔沥青混合料(PAC)黏附/黏聚失效行为,提出了一种考虑砂浆随机分布的细观有限元建模方法;基于X射线CT扫描和图像处理技术量化了PAC的真实细观结构和砂浆分布,研究了砂浆的随机分布特性;通过可精确控制砂浆厚度的拉拔... 详细信息

为获得更加真实的多孔沥青混合料(PAC)黏附/黏聚失效行为,提出了一种考虑砂浆随机分布的细观有限元建模方法;基于X射线CT扫描和图像处理技术量化了PAC的真实细观结构和砂浆分布,研究了砂浆的随机分布特性;通过可精确控制砂浆厚度的拉拔试验评价了不同厚度砂浆的黏附/黏聚性能,确定了不同厚度砂浆对应的内聚力模型参数;在砂浆-集料边界和砂浆内部嵌入零厚度内聚力单元,并基于PAC内不同区域的砂浆厚度赋予该区域内聚力单元相应的模型参数,最终构建了考虑砂浆随机分布的细观有限元模型(模型A),研究了PAC黏附/黏聚失效行为的细观演化过程。研究结果表明:推荐将试件分割为36份用于表征砂浆的随机分布特性,砂浆厚度对其黏附/黏聚性能、失效模式以及内聚力模型参数具有显著影响,当砂浆厚度小于0.9 mm或在1.2~1.8 mm时为黏附失效,大于1.9 mm时为黏附-黏聚混合失效,其他厚度下为黏聚失效,且同一失效模式下,黏附/黏聚强度随着砂浆厚度的增大而增大;与不考虑砂浆随机分布的细观有限元模型(模型B)相比,模型A和B的起裂点均为黏附失效,但失效位置不同,模型B以单一的黏附失效为主,模型A表现出多种黏附/黏聚失效行为,与现场复杂的黏附/黏聚失效行为更加一致;砂浆的随机分布对PAC黏附/黏聚失效过程、应力分布、裂缝发展具有显著的影响,故考虑砂浆的随机分布能够更加准确地识别PAC黏附/黏聚失效的最不利位置,增大砂浆厚度能够延缓黏附/黏聚失效的扩展过程。

关键词：路面工程多孔沥青混合料黏附/黏聚失效随机分布细观有限元模型耐久性

Place-and Age-Responsive Disaster Risk Reduction for Hong Kong:Collaborative Place Audit and Social Vulnerability Index for Elders

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International Journal of Disaster Risk Science 2017年第2期8卷 121-133页

作者： yi Sun Pui Hing Chau Moses wong Jean Woo CUHK Jockey Club Institute of Ageing The Chinese University of Hong Kong Department of Building and Real Estate The Hong Kong Polytechnic University School of Nursing The University of Hong Kong Department of Medicine and Therapeutics The Chinese University of Hong Kong

This study reformulates the concept and contents of disaster risk reduction(DRR) in Hong Kong through an explorative study on collaborative place audit(CPA) and social vulnerability index(SVI) for *** believe that DRR should be place-and ***,DRR needs to go beyond technical concerns and address vulnerability and risk encountered in the built environment where an individual is located.A place-centered DRR begins with an assessment of person–environment relations from an interdependent *** becomes a significant scale at which to address vulnerability and risks across a range of environmental,socioeconomic,and institutional factors.A CPA is a ground-level assessment tool that identifies vulnerability and risk in the built and social *** audit encourages collaboration in problem solving that uses social capital to effect decisionmaking change in hierarchies and policy *** DRR facilitates distinguishing living-alone elders from the general *** perspective addresses varying degrees of vulnerability due to social and communicational isolation,poverty,disability,being sent to hospital and/or receiving institutional care,as well as lack of access to primary ***,SVI,based oncompound indicators,is developed to assess the differentiation of vulnerability across the territory with particular reference to the *** two approaches,namely,CPA and SVI,build community capacity to develop a resilient city,as well as to provide evidence-based recommendations that improve government-led disaster preparedness and contingency plans.

关键词： Disaster risk reduction Hong Kong Place audit Social capital Social vulnerability

Anti-cancer activities of S-allylmercaptocysteine from aged garlic

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Chinese Journal of Natural Medicines 2019年第1期17卷 43-49页

作者： LV yi SO Kwok-Fai wong Nai-Kei XIAO Jia Laboratory of Neuroendocrinology School of Biological SciencesFujian Normal University National Key Disciplines for Infectious Diseases Shenzhen Third People's HospitalThe Second Hospital Affiliated to Southern University of Science and Technology School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong Kong

While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract(AGE) exhibits stronger anti-cancer activities than that of fresh garlic, by virtue of enrichment of several AGE-specific organosulfur compounds, including S-allylmercaptocysteine(SAMC). In this review, we summarize the up-to-date mechanistic pathways associated with the anti-proliferative, anti-metastatic and pro-apoptotic effects of SAMC in various cancer models. Based upon the proven safety and improved understanding on its anti-neoplastic properties, SAMC has gained recognition as a promising daily food supplement for cancer prevention or management.

关键词： Aged garlic S-allylmercaptocysteine Cancer Molecular pathway Reactive oxygen species