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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1311-1318页

作者： wong yeong yi F L Supian A Radzwan M Musa N F N Abd Karim Department of Physics Sultan Idris Education UniversityTanjong Malim 35900Malaysia Department of Chemistry Sultan Idris Education UniversityTanjong Malim 35900Malaysia

Calix[n]arenes was utilized to detect PABA,the primary sunscreen *** study investigates the interaction of calix[4]arene(C4),calix[6]arene(C6),and PABA using the Langmuir method and first-principle density functional theory(DFT).Using the Langmuir-Schaefer(LS)technique,an ultrathin film composed of calix[n]arenes and their complexes with PABA was deposited on various *** on the Langmuir study,the PABA molecule was bonded to the lower rims of both C4 and C6 with the host-guest ratio of 1:*** of the LS films formed were then characterized by ultravioletvisible spectroscopy(UV-Vis),Fourier-transform infrared spectroscopy(FTIR)and carbon,hydrogen,nitrogen,sulfur elemental analyzer(CHNS).The band gap reduction obtained in the DFT study denotes the charge transfer interaction with promising reactivity between the calix[n]arenes and *** sensing of PABA by C4 and C6 is successful based on the formation of bonding between them due to the hosts’effective trapping *** outcomes of this study could be applied to drug delivery systems for future pharmaceutical and medical applications.

关键词： calix[n]arenes band gap density functional theory Langmuir-Schaefer PABA sensor

Place-and Age-Responsive Disaster Risk Reduction for Hong Kong:Collaborative Place Audit and Social Vulnerability Index for Elders

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International Journal of Disaster Risk Science 2017年第2期8卷 121-133页

作者： yi Sun Pui Hing Chau Moses wong Jean Woo CUHK Jockey Club Institute of Ageing The Chinese University of Hong Kong Department of Building and Real Estate The Hong Kong Polytechnic University School of Nursing The University of Hong Kong Department of Medicine and Therapeutics The Chinese University of Hong Kong

This study reformulates the concept and contents of disaster risk reduction(DRR) in Hong Kong through an explorative study on collaborative place audit(CPA) and social vulnerability index(SVI) for *** believe that DRR should be place-and ***,DRR needs to go beyond technical concerns and address vulnerability and risk encountered in the built environment where an individual is located.A place-centered DRR begins with an assessment of person–environment relations from an interdependent *** becomes a significant scale at which to address vulnerability and risks across a range of environmental,socioeconomic,and institutional factors.A CPA is a ground-level assessment tool that identifies vulnerability and risk in the built and social *** audit encourages collaboration in problem solving that uses social capital to effect decisionmaking change in hierarchies and policy *** DRR facilitates distinguishing living-alone elders from the general *** perspective addresses varying degrees of vulnerability due to social and communicational isolation,poverty,disability,being sent to hospital and/or receiving institutional care,as well as lack of access to primary ***,SVI,based oncompound indicators,is developed to assess the differentiation of vulnerability across the territory with particular reference to the *** two approaches,namely,CPA and SVI,build community capacity to develop a resilient city,as well as to provide evidence-based recommendations that improve government-led disaster preparedness and contingency plans.

关键词： Disaster risk reduction Hong Kong Place audit Social capital Social vulnerability

Anti-cancer activities of S-allylmercaptocysteine from aged garlic

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Chinese Journal of Natural Medicines 2019年第1期17卷 43-49页

作者： LV yi SO Kwok-Fai wong Nai-Kei XIAO Jia Laboratory of Neuroendocrinology School of Biological SciencesFujian Normal University National Key Disciplines for Infectious Diseases Shenzhen Third People's HospitalThe Second Hospital Affiliated to Southern University of Science and Technology School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong Kong

While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract(AGE) exhibits stronger anti-cancer activities than that of fresh garlic, by virtue of enrichment of several AGE-specific organosulfur compounds, including S-allylmercaptocysteine(SAMC). In this review, we summarize the up-to-date mechanistic pathways associated with the anti-proliferative, anti-metastatic and pro-apoptotic effects of SAMC in various cancer models. Based upon the proven safety and improved understanding on its anti-neoplastic properties, SAMC has gained recognition as a promising daily food supplement for cancer prevention or management.

关键词： Aged garlic S-allylmercaptocysteine Cancer Molecular pathway Reactive oxygen species

Application of 3D bioprinting in the prevention and the therapy for human diseases

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1681-1697页

作者： Hee-Gyeong yi Hyeonji Kim Junyoung Kwon yeong-Jin Choi Jinah Jang Dong-Woo Cho Department of Rural and Biosystems Engineering College of Agriculture and Life SciencesChonnam National University77 Yongbong-RoGwangju 61186Korea Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)77 Cheongam-RoPohangKyungbuk 37673Korea Department of Advanced Biomaterials Research Korea Institute of Materials Science(KIMS)797 ChangwondaeroChangwonKyungnam 51508Korea Department of Convergence IT Engineering POSTECH77 Cheongam-RoPohangKyungbuk 37673Korea Institute of Convergence Science Yonsei University50 Yonsei-RoSeoul 03722Korea

Rapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious *** speed up the drug discovery process,the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery *** this regard,layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease *** addition,the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines,therapeutics,and relevant delivery ***,we discuss the potential of 3D bioprinting technologies for the control of infectious *** also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.

关键词： printing prevention introducing

Highly catalytic metal–organic framework coating enabled by liquid superwetting and confinement

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Nano Research 2023年第5期16卷 7716-7723页

作者： Bo yi Yan-Lung wong Kedi Li Changshun Hou Tengrui Ma Zhengtao Xu Xi Yao Department of Biomedical Sciences City University of Hong KongHong Kong 999077China Department of Chemistry City University of Hong KongHong Kong 999077China Institute of Materials Research and Engineering Agency for ScienceTechnology and Research(A*STAR)Singapore 138634Singapore City University of Hong Kong Shenzhen Research Institute Shenzhen 518057China

In this work,we report that high catalytic performance of metal–organic frameworks(MOFs)can be obtained through a synergistic effect of postsynthetic modification of MOF nanoparticles and liquid superwetting and confinement in the MOF ***,2-ureido-4[1H]pyrimidinone(UPy)functionalized polysiloxanes were covalently appended onto the UiO-66 nanoparticles via a postsynthetic approach,which were further anchored onto different porous films through multivalent hydrogen bonding of the UPy *** hydrophobic MOF coating can preserve the porosity of the solid substrates,enable rapid liquid superwetting and confinement within the porous *** the Knoevenagel condensation as a modeled system,robust and highly catalytic performances of the MOF coating were observed on a range of aldehyde ***-scale production of chromene,a pharmaceutical which is typically synthesized via expensive catalysis,was successfully demonstrated on the MOF coating with high yielding rates,demonstrating the great potential of the MOF coating in pharmaceutical synthesis.

关键词： metal–organic framework postsynthetic modification hydrogen bonding superwetting liquid confinement

Temperature-and thickness-dependence of robust out-of-plane ferroelectricity in CVD grown ultrathin van der Waals a-In2Se3 layers

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Nano Research 2020年第7期13卷 1897-1902页

作者： Weng Fu Io Shuoguo Yuan Sin yi Pang Lok Wing wong Jiong Zhao Jianhua Hao Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina

Two-dimensional(2D)ferroelectric materials with unique structure and extraordinary optoelectrical properties have attracted intensive research in the field of nanoelectronic and optoelectronic devices,such as optical sensors,transistors,photovoltaics and non-volatile memory ***,the transition temperature of the reported ferroelectrics in 2D limit is generally low or slightly above room temperature,hampering their applications in high-temperature electronic ***,we report the robust high-temperature ferroelectricity in 2D a-In2Se3,grown by chemical vapor depostion(CVD),exhibiting an out-of-plane spontaneous polarization reaching above 200℃.The polarization switching and ferroelectric domains are observed in In2Se;nanoflakes in a wide temperature *** coercive field of the CVD grown ferroelectric layers ilustrates a room-temperature thickness dependency and increases drastically when the film thickness decreases;whereas there is no large variance in the coercive field at dfterent termperature from the samples with identical *** results show the stable ferroelectricit of In2Se3 nanoflakes maintained at high temperature and open up the opportunities of 2D materials for novel applications in high-temperature nanoelectronic devices.

关键词： ln2Se3 two-dimensional(2D)materials ferroelectricity high-temperature coercive field

CD137L,a driver of harmful inflammation in the nervous system

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Neural Regeneration Research 2023年第11期18卷 2387-2388页

作者： Hiu yi wong Amanda C.Y.Chan Anselm Mak Herbert Schwarz Division of Life Science State Key Laboratory of Molecular NeuroscienceMolecular Neuroscience CenterThe Hong Kong University of Science and TechnologyHong Kong Special Administrative RegionChina Hong Kong Center for Neurodegenerative Diseases Hong Kong Special Administrative RegionChina Division of Neurology University Medicine ClusterNational University HospitalSingapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore Division of Rheumatology University Medicine ClusterNational University Health SystemDepartment of MedicineYong Loo Lin School of MedicineNational Univesity of SingaporeSingapore Department of Physiology and Immunology ProgrammeYong Loo Lin School of MedicineNational University of SingaporeSingapore Integrative Sciences and Engineering Programme NUS Graduate SchoolNational University of SingaporeSingapore

CD137 (TNFRSF9,4-1BB) is a member of the tumor necrosis factor (TNF) receptor family and a potent costimulatory *** levels of CD137 are expressed on T cells upon ***137 signaling in T cells,either by cognate interaction with antigen-presenting cells (APC)or by agonistic anti-CD137 antibodies,strongly enhances proliferation,interferon-y secretion,and cytolytic activity of T ***,CD137 signaling is a main driver of cellular,type 1 helper T cells (Th1)and type 1 cytolytic T cells (Tc1) polarised immune responses.

关键词： CD137 CD137L inflammation

One-step fabrication of moon-shaped microrobots through in situ solidification of magnetic Janus droplets in microchannels

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Droplet 2023年第2期2卷 105-111页

作者： yi Huang Shuai yin Haiwang Li Sihang Liu Teck Neng wong Research Institute of Aero-Engine Beihang UniversityBeijingChina School of Mechanical and Power Engineering Nanjing Tech UniversityNanjingChina School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingaporeSingapore

Special-shaped microscale structures have shed light on new possibilities in key fields of chemistry,medicine,and *** microrobots with sensitive magnetic responses can be useful tools in controlled chemical reactions,drug delivery,and functional material ***-based emulsion generation technology is adopted as a powerful platform for the fabrication of steerable microrobots with refined ***,Janus droplets are generated in microfluidic chips featuring a flow-focusing *** morphologies of the Janus droplets are achieved by balancing the interfacial tensions,where the portion containing magnetic nanoparticles is solidified through the UV-initiated polymerization process right after the formation while the Janus structure is left *** succeed in controlling the morphology of the Janus droplet along with the moon-shaped robots hydrodynamically and applying them in flow control at the microscale under external magnetic fields,which are characterized and quantified by three-dimensional profile measurement and high-speed microparticle velocimetry *** proposed on-chip fabrication method using a microfluidic platform not only provides a method for fabricating magnetic robots but also enables tuning the complex morphologies and functionalities at the microscale,which could shed light on new possibilities in key fields of controlled chemistry reaction,medicine synthesis,and energy generation.

关键词： solidification shaped magnetic

Feasibility and safety of minimally invasive multivisceral resection for T4b rectal cancer:A 9-year review

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 777-789页

作者： Kai Siang Chan Biquan Liu Ming Ngan Aloysius Tan Kwang yeong How Kar Yong wong Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore

BACKGROUND Colorectal cancer is the third most common cancer and the second highest cause of cancer-related mortality *** 5%-10%of patients are diagnosed with locally advanced rectal cancer(LARC)on *** LARC invading into other structures(i.e.T4b),multivisceral resection(MVR)and/or pelvic ex-enteration(PE)remains the only potential curative surgical *** and/or PE is a major and complex surgery with high post-operative *** invasive surgery(MIS)has been shown to improve short-term post-operative outcomes in other gastrointestinal malignancies,but there is little evi-dence on its use in MVR,especially so for robotic *** is a single-center retrospective cohort study from 1st January 2015 to 31st March *** criteria were patients diagnosed with cT4b rectal cancer and underwent MVR,or stage 4 disease with resectable systemic ***-tients who underwent curative MVR for locally recurrent rectal cancer,or me-tachronous rectal cancer were also *** criteria were patients with systemic metastases with non-resectable *** patients planned for elective surgery were enrolled into the standard enhanced recovery after surgery pathway with standard peri-operative management for colorectal *** sur-gery was defined based on technical difficulty of surgery(*** PE,bladder-sparing prostatectomy,pelvic lymph node dissection or need for flap creation).Our primary outcomes were the margin status,and complication ***-gorical values were described as percentages and analysed by the chi-square *** variables were expressed as median(range)and analysed by Mann-Whitney U *** overall survival(OS)and recurrence-free survival(RFS)were analysed using Kaplan-Meier estimates with life table ***-rank test was performed to determine statistical significance between cumulative *** significance was defined as P<*** estimates with li

关键词： Laparoscopy Minimally invasive surgical procedures Multivisceral resection Pelvic Exenteration Rectal neoplasms Robotic surgical procedures

Efficient page layout analysis on small devices

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第6期10卷 800-804页

作者： Eun-jung HAN Chee-onn wong Kee-chul JUNG Kyung-ho LEE Eun-yi KIM Department of Naval Architecture and Ocean Engineering Inha University Human-Centered Interfaces Lab Department of Digital MediaSoongsil University Internet and Media Engineering Konkuk University

Previously we have designed and implemented new image browsing facilities to support effective offiine image contents on mobile devices with limited capabilities： low bandwidth, small display, and slow processing. In this letter, we fulfill the automatic production of cartoon contents fitting small-screen display, and introduce a clustering method useful for various types of cartoon images as a prerequisite stage for preserving semantic meaning. The usage of neural networks is to properly cut the various forms of pages. Texture information that is useful for grayscale image segmentation gives us a good clue for page layout analysis using the multilayer perceptron （MLP） based x-y recursive algorithm. We also automatically frame the segment MLP using agglomerative segmentation. Our experimental results show that the combined approaches yield good results of segmentation for several cartoons.

关键词： Efficient page layout analysis MLP-based segmentation Mobile devices Image segmentation Neural network