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Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin

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Cellular & Molecular Immunology 2020年第4期17卷 380-394页

作者： Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz yvonne Samstag Institute of Immunology Section Molecular ImmunologyHeidelberg UniversityIm Neuenheimer Feld 30569120 HeidelbergGermany Institute of Human Genetics Department of Human Molecular Geneticsand nCounter Core FacilityHeidelberg UniversityIm Neuenheimer Feld 36669120 HeidelbergGermany Department of Dermatology Heidelberg UniversityIm Neuenheimer Feld 44069120 HeidelbergGermany

The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin *** psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal ***,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the ***,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains ***,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T *** activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/*** T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 *** particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/*** latter molecule initiated STAT1 signaling and IFN γproduction in T *** of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin ***,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases.

关键词： keratinocytes inflammatory skin diseases psoriasis human T cells costimulation CD2 LFA-1 nonprofessional antigenpresenting cells Th1 cells Th17 cells

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Examining Pet Attitude in Relationship to Loneliness and Parenthood Motivation in Pet-Owning Adults

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Health 2014年第7期6卷 598-606页

作者： Cheryl A. Krause-Parello yvonne Wesley Minnie Campbell College of Nursing Seton Hall University South Orange USA College of Nursing University of Colorado Denver Anschutz Medical Campus Aurora USA Independent Health Consultant Rahway USA

Pets’ growing role in family dynamics creates questions about resources pets may provide in parenthood motivation. Pet ownership has been suggested in the literature as an antecedent to parenthood in terms of developing skills needed to rear offspring, nurturance, and responsibility. Participants (N = 118) who were pet owners, completed an online survey that recorded demographics and consisted of loneliness, pet attitude, and parenthood motivation scales. Results supported that loneliness and pet attitude were positively related to parenthood motivation (all p’s < 0.05). Loneliness and parenthood motivation did not vary by pet species. Pet attitude varied by pet species;dog owners had the most positive attitude. Pets were shown to be a valuable resource in alleviating feelings of loneliness and parenthood preparation in this sample. Implications for nursing practice and future research are discussed.

关键词： Pet Attitude Loneliness Pets Parenthood

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IASP关节痛文献资料,《中国疼痛医学杂志》组织翻译第十篇:炎性疼痛:类风湿关节炎痛

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中国疼痛医学杂志 2016年第7期22卷 561-562页

作者： yvonne Lee 陈文赵华

发生炎性细胞因子激活级联反应和周围末梢神经敏化时会出现关节炎性疼痛。很多疾病可以导致关节炎性疼痛,其中最常见的是类风湿关节炎(RA),它是一种以四肢小关节疼痛肿胀为特征的系统性炎症性疾病。病理生理·炎症细胞被前炎性细胞因子... 详细信息

发生炎性细胞因子激活级联反应和周围末梢神经敏化时会出现关节炎性疼痛。很多疾病可以导致关节炎性疼痛,其中最常见的是类风湿关节炎(RA),它是一种以四肢小关节疼痛肿胀为特征的系统性炎症性疾病。病理生理·炎症细胞被前炎性细胞因子趋化到关节周围的滑膜。·滑膜组织中的前列腺素、缓激肽直接激活神经末梢。·细胞因子、趋化因子及生长因子敏化周围神经末梢。·疼痛信号传递中的兴奋性神经递质谷氨酸作用于关节的受体,进一步导致疼痛的级联反应。

关键词：类风湿关节炎敏化周围类风湿性关节炎 IASP 炎性疼痛

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Hepatocellular carcinoma diagnosis and treatment: An overview

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Liver Research 2020年第4期4卷 159-160页

作者： Steven D.Colquhoun Yu-Jui yvonne Wan Department of Surgery University of California DavisSacramentoCAUSA Department of Pathology and Laboratory Medicine University of California DavisSacramentoCAUSA

For decades,chronic liver disease has remained an increasing global health *** vaccines and antiviral therapies,both hepatitis B and C remain enormous clinical *** steatosis has become a rapidly increasing worldwide concern that can be appropriately characterized as an evolving epidemic.1 Aroundtheworld alcohol consumption is onthe rise,while autoim-mune conditions and environmental toxins all continue contrib-uting to this seemingly universal health *** common denominator of chronic liver disease is progressive hepatic inflam-mation leading to fibrosis and cirrhosis.

关键词： diagnosis clinical treatment

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听神经病谱系障碍：挑战和问题

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听力学及言语疾病杂志 2012年第1期20卷 70-74页

作者： yvonne Sininger 聂文英

1996年,Starr将具有"听性脑干反应不能引出或严重异常,耳声发射能引出,言语识别率相对听力不成比例下降"等特殊临床表现的一组听力障碍患者,命名为"听神经病(auditory neuropathy,AN)",受到医学界的广泛关注。10多年来,从基础研究到临... 详细信息

1996年,Starr将具有"听性脑干反应不能引出或严重异常,耳声发射能引出,言语识别率相对听力不成比例下降"等特殊临床表现的一组听力障碍患者,命名为"听神经病(auditory neuropathy,AN)",受到医学界的广泛关注。10多年来,从基础研究到临床研究,国内外对该病的认识不断加深。2008年6月,意大利科莫举行的国际新生儿听力筛查会上,美国科罗拉多州儿童医院的Deborah Hayes教授组织专家对该病进行了热烈讨论,专家们一致认为将听神经病改称为听神经病谱系障碍(auditory neuropathy spectrum disorder,ANSD)更能代表本病的特征。会后Deborah Hayes教授组织专家们编写和出版了《婴幼儿听神经病谱系障碍诊疗指南》一书,书中还编入了专家们从不同角度对该病认识的阐述。为了让大家能够更深入细致地了解婴幼儿听神经病,规范我国婴幼儿听神经病的诊疗工作,经与DeborahHayes教授协商,该书的翻译和出版权被授予首都医科大学附属北京同仁医院和北京市耳鼻咽喉科研究所,由中华医学会耳鼻咽喉头颈外科学分会听力学组组织有关专家对指南进行了翻译。现将《婴幼儿听神经病谱系障碍诊疗指南》翻译稿刊登于《听力学及言语疾病杂志》。在指南的翻译过程中,得到了倪道凤、卜行宽和李兴启等教授的大力支持和指导,参与此项工作的中华医学会耳鼻咽喉头颈外科学分会听力学组的同仁们尽心尽力,付出了大量的辛勤劳动,指南的翻译和审校工作得到了武汉大学人民医院吴展元教授耐心和细致的指导,在此一并表示感谢!

关键词：谱系障碍听神经病听觉障碍听力损失 Eve 患者

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Reduction of Native Diversity by Invasive Plants Depends on Habitat Conditions

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American Journal of Plant Sciences 2015年第17期6卷 2718-2733页

作者： yvonne Künzi Daniel Prati Markus Fischer Steffen Boch Institute of Plant Sciences and Botanical Garden University of Bern Bern Switzerland

Invasions by exotic plant species and their impacts on invaded communities are a highly topical field of research because it provides a basis for the management of neophyte populations. However, for many invasive neophyte species in Central Europe little is known about their impacts on invaded plant communities. Moreover, it has hardly been considered whether effects vary among habitat conditions. Here, we selected each ten sites with different habitat conditions invaded by Erigeron annuus, Fallopia japonica, Impatiens glandulifera and Solidago canadensis which were listed as invasive in Switzerland. At each site, we established four 4 m × 1 m subplots covering a gradient from very low to very high cover of the particular neophyte species to investigate the effect of increasing neophyte cover on the species richness, Shannon diversity and evenness of the invaded plant communities. Moreover, we measured soil pH and characterized habitat conditions using Ellenberg indicator values to light and soil fertility. Whereas increasing cover of I. glandulifera had no effect on the diversity of invaded plant communities, an increasing cover of E. annuus negatively affected Shannon diversity. An increasing cover of F. japonica combined with a decreasing soil pH negatively affected the Shannon diversity of invaded plant communities. Similarly, an increasing cover of S. canadensis in combination with decreasing soil fertility negatively affected the Shannon diversity and evenness of invaded communities. Our results indicate that significant effects of increasing neophyte cover are mostly coupled to particular habitat conditions and then rather suppress than eliminate native plant species in invaded communities. We therefore suggest including abiotic variables in further impact studies on biotic invasions. Furthermore, adapting measures to the respective environmental context can be a useful tool in priority setting for the management of invasive neophyte populations and the resto

关键词： Diversity Impact of Neophytes Indicator Values Plant Species Richness

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Investigating the Physiological Mechanisms between Resistance Training and Pain Relief in the Cancer Population: A Literature Review

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Journal of Cancer Therapy 2023年第2期14卷 80-101页

作者： yvonne Jiang Peter C. Angeletti Amy J. Hoffman College of Arts and Sciences University of Nebraska-Lincoln Lincoln NE USA Nebraska Center for Virology University of Nebraska-Lincoln Lincoln NE USA College of Nursing University of Nebraska Medical Center Omaha Nebraska USA

This literature review examines the mechanisms of how exercise, specifically in the form of resistance training, may lead to pain relief in the cancer population. Primary data from three different cancer populations: breast, prostate, and lung, will be examined. A number of experimental studies have been conducted to confirm the effectiveness of resistance training on pain relief as well as the biochemical pathways that relate to this process. In this review, we will examine 5 randomized controlled trials. For the purposes of this review, pain is defined as physical suffering or discomfort associated with illness. Pain is the body’s natural signal, bringing attention to damage that has been sustained by tissues. However, chronic pain is common in the cancer population, and often serves no good purpose but instead will negatively impact both physical and mental health. The three types of pain: nociceptive, neuropathic, and inflammatory pathways have been investigated, and the knowledge of pain mechanisms allows for the understanding of how it is associated with pain. The purpose of this exploratory literature review is to give insight on how to maximize pain-relieving effects of resistance training. Research has indicated that resistance training modulates pain pathways by upregulating the release of pain-relieving substances including beta-endorphins, anti-inflammatory cytokines, and endocannabinoids. Understanding of the benefits of resistance training may be useful in relieving cancer pain, and reproducing effects of pain-relieving strategies while minimizing the symptoms related to cancer and its treatment.

关键词： Lung Cancer Breast Cancer Prostate Cancer Exercise Physical Activity Cancer Pain Symptoms Pain Relief Resistance Training Pain Relief Biochemical Pathway

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Dental pain

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英国医学杂志中文版 2014年第2期17卷 131-133页

作者： yvonne MacAuley Patrick O'Donnell Henry F Duncan Dublin Dental University Hospital Lincoln Place Dublin Ireland 2Graduate Entry Medical School University of Limerick Limerick Ireland Division of Restorative Dentistry and Periodontology Dublin Dental University Hospital Trinity College Dublin Ireland

A 40 year old woman presents complaining of severe dental pain and swelling,and is unable to contact her *** reports that the pain started three days ago and has increased in intensity since,with her face becoming swollen in the last 24 *** you should cover Nature and severity of the painDental pain occurs as a result of inflammation of the pulp (pulpitis) (see figure 1).This is generally caused by bacteria from decayed teeth or defective dental *** pain can be practically grouped into five progressive pain categories.A short pain history and examination is required to categorise this pain.1.A short,sharp pain lasting only a few seconds and occurring in response to a cold or ' sweet' stimulus is likely to be reversible *** is generally not a severe problem,and the pulp of the tooth can be *** and analgesics are not required,but the patient should be advised to attend a dentist.

关键词：口腔科学口腔疾病临床牙齿

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The Smart Grid Technology Development Strategy of Taiwan

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Smart Grid and Renewable Energy 2016年第5期7卷 155-163页

作者： Faa-Jeng Lin Yenhaw Chen Su-Ying Lu yvonne Hsu Department of Electrical Engineering National Central University Taiwan Research Division 1 Taiwan Institute of Economic Research Taiwan

In Taiwan, in corresponding to the policy of reducing CO2 emission, reforming current energy structure, and saving energy, the National Energy Program (NEP)-Smart Grid General Project Phase 1 was implemented. The objectives of this project are meant to enhance the robustness of the power grid, reduce greenhouse gas emission, increase the penetration rate of renewable energy and develop smart grid industry in Taiwan. This study will introduce the positioning of the Smart Grid General Project among overall smart grid development, the results of Phase 1, the smart grid technology commercialization process of Phase 2, and the promotion model with collaboration between industry, universities and research units.

关键词： Grid National Energy Program Demonstration Site Technology Commercialization Taiwan

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Dynamic interplay between adhesion surfaces in carcinomas:Cell-cell and cell-matrix crosstalk

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World Journal of Biological Chemistry 2016年第1期7卷 64-77页

作者： yvonne E Smith Sri HariKrishna Vellanki Ann M Hopkins Department of Surgery Royal College of Surgeons in IrelandRCSI Education and Research CentreSmurfit BuildingBeau-mont Hospital

Cell-cell and cell-matrix signaling and communication between adhesion sites involve mechanisms which are required for cellular functions during normal development and homeostasis; however these cellular functions and mechanisms are often deregulated in cancer. Aberrant signaling at cell-cell and cell-matrix adhesion sites often involves downstream mediators including Rho GTPases and tyrosine kinases. This review discusses these molecules as putative mediators of cellular crosstalk between cell-cell and cell-matrix adhesion sites, in addition to their attractiveness as therapeutic targets in cancer. Interestingly, inter-junctional crosstalk mechanisms are frequently typified by the way in which bacterial and viral pathogens opportunistically infect or intoxicate mammalian cells. This review therefore also discusses the concept of learning from pathogen-host interaction studies to better understand coordinated communication between cell-cell and cell-matrix adhesion sites, in addition to highlighting the potential therapeutic usefulness of exploiting pathogens or their products to tap into inter-junctional crosstalk. Taken together, we feel that increased knowledge around mechanisms of cell-cell and cell-matrix adhesion site crosstalk and consequently a greater understanding of their therapeutic targeting offers a unique opportunity to contribute to the emerging molecular revolution in cancer biology.

关键词： Cell-cell Cell-matrix Adhesion Cancer Crosstalk Pathogens Epithelial Barrier function Tight junction Cell migration Apical junctional complex Adherens junction Adhesion molecules Extracellular matrix Tyrosine kinases GTPases Rho

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