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Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma

Cellular & Molecular Immunology 2022年第2期19卷 245-259页

作者： Xun Gao Ting-Fan Leung Gary Wing-Kin wong Wing-hung Ko Mengyun Cai Ellie Jiayi He Ida Miu-Ting Chu Miranda Sin-Man Tsang Ben Chung-Lap Chan Jiawei Ling Xiao Fan Liwei Lu Christopher Wai-Kei Lam Chun-Kwok wong Department of Chemical Pathology The Chinese University of Hong KongHong KongChina Department of Paediatrics The Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Emory College of Arts and Sciences Emory UniversityAtlantaGAUSA Institute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina Faculty of Medicine and State Key Laboratory of Quality Research in Chinese Medicines Macao University of Science and TechnologyMacaoChina Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong KongHong KongChina

We sought to examine the regulatory effect of Meteorin-β(Metrnβ)/Meteorin like(Metrnl)/IL-41 on lung inflammation in allergic *** found that Metrnβwas elevated significantly in asthmatic patients and in mice with allergic asthma induced by house dust mite(HDM)*** exposure to HDM,Metrnβwas secreted predominantly by airway epithelial cells and inflammatory cells,including macrophages and *** increased Metrnβeffectively blocked the development of airway hyperreactivity(AHR)and decreased inflammatory cell airway infiltration and type 2 cytokine production,which was associated with downregulated DC-mediated adaptive immune ***,Metrnβimpaired the maturation and function of bone marrow-derived dendritic cells in *** mice adoptively transferred with dendritic cells isolated from Metrnβ-treated allergic mice displayed decreased AHR,airway inflammation,and lung ***βalso displayed anti-inflammatory properties in immunodeficient SCID mice with allergic asthma and in in vitro 3D ALI airway ***,blockade of Metrnβby anti-Metrnβantibody treatment promoted the development of allergic *** results revealed the unappreciated protective roles of Metrnβin alleviating DC-mediated Th2 inflammation in allergic asthma,providing the novel treatment strategy of therapeutic targeting of Metrnβin allergic asthma.

关键词： Metrnβ Eosinophils Dendritic cells Allergic asthma Air-liquid interface

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Arbuscular mycorrhizal fungi induce lower concentration but higher acquisition of Cd in cucumber(Cucumis sativus L.) plant cultivated on a Cd-contaminated soil

Arbuscular mycorrhizal fungi induce lower concentration but ...

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第八次全国土壤生物与生物化学学术研讨会暨第三次全国土壤健康学术研讨会

作者： Junli Hu Wing Tsang Fuyong Wu Shengchun Wu Junhua Wang Xiangui Lin ming hung wong State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of Sciences Croucher Institute for Environmental Sciences Department of BiologyHong Kong Baptist University Joint Open Laboratory of Soil and the Environment Hong Kong Baptist University & Institute of Soil ScienceChinese Academy of Sciences College of Natural Resources and Environment Northwest A&F University School of Environmental and Resource Sciences Zhejiang A&F University Consortium on Health EnvironmentEducation and ResearchDepartment of Science and Environmental StudiesThe Hong Kong Institute of Education

The trasfer risk of cadmium(Cd) accumulated in stems and leafs of fruiting vegetables,which are generally considered to be more suitable to plant on Cd-contaminated farms,is a major issue encountered with the usage of such non-edible *** 8-week pot experiment was conducted to investigate the acquisition and translocation of Cd by cucumber(Cucumis sativus L.) plant on an unsterilized Cd-contaminated(1.6 mg kg) soil in response to inoculating arbuscular mycorrhizal(AM)fungus,Funneliformis caledonium(Fc) or Glomus versiforme(Gv).Compared with the non-inoculated control,both Fc and Gv inoculations significantly increased(P<0.05) root mycorrhizal colonization rates and phosphorus(P) acquisition efficiencies,and total P acquisitions and biomasses of cucumber plants,while only Fc inoculation significantly increased(P<0.05) soil acid phosphatase activity and available P *** Fc and Gv inoculations significantly increased(P<0.05) P translocation factors from root to shoot,inducing significantly higher(P<0.05) shoot P concentrations and shoot/root biomass ratios relative to the *** contrast,both Fc and Gv inoculations significantly decreased(P<0.05) root and shoot Cd concentrations,causing significantly increased(P<0.05) P/Cd concentration ratios in both root and shoot,while only Gv inoculation significantly decreased(P<0.05) root Cd acquisition efficiency and increased(P<0.05) Cd translocation factor from root to *** addition,AM fungal inoculations also tended to decrease soil total and phytoavailable Cd concentrations via elevating plant total Cd acquisitions and soil pH,*** results demonstrated the potential application of AM fungi in the production of low-Cd vegetables,including the non-edible parts,in Cd-contaminated soils.

关键词： Funneliformis caledonium Glomus versiforme Root acquisition efficieny Soil acid phosphatase Soil DTPA-extractable Cd Soil pH

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Novel N-heteroaromatic dyes for textile substrates

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Chinese Chemical Letters 2014年第8期25卷 1165-1168页

作者： Kim-hung Lam Sarah Sze-Wah Ho Pik-Ling Lam Johnny Cheuk-On Tang Zhao-Xiang Bian Albert Sun-Chi Chan Hua Li Wai-Yeung wong Chung-Hin Chui Department of Applied Biology and Chemical Technology Institute of Textile and Clothing The Hong Kong Polytechnic University Clinical Division School of Chinese Medicine Hong Kong Baptist University Institute of Molecular Functional Materials Department of Chemistry and Institute of Advanced Materials Hong Kong Baptist University College of Life and Environmental Sciences Minzu University of China HKBU Institute of Research and Continuing Education Shenzhen Virtual University Park

This study reports the synthesis and characterization of quinoline derivatives. The synthesized quinoline compounds were applied to the dyeing treatment of acrylic fabrics. The color fastness to washing and light of quinoline compound-dyed fabrics was examined. Human skin HaCaT cell line was also used for the skin cytotoxicity evaluation of the quinoline compound-dyed acrylic fabrics.

关键词： Acrylic fabrics Fluorescent Quinoline dyes Skin cytotoxicity

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SHIP:Searching Heuristically over the Internet for the Desired Page

SHIP:Searching Heuristically over the Internet for the Desir...

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第二十届全国数据库学术会议

作者： Kam-Fai wong Chun-hung Cheng Department of Systems Engineering and Engineering Management The Chinese University of Hong Kong

In this paper a novel heuristic-based algorithm,SHIP,for deriving a Web address from a given company name is *** enables a user to locate the desired Web pages *** to classical contentbased algorithms for"company sear... 详细信息

关键词： Web page Searching Heuristically Desired page

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Polymetallaynes and Molecular Metallaynes Containing Platinum,Mercury and Gold for Optoelectronic and Magnetic Applications

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Chinese Journal of Chemistry 2023年第17期41卷 2159-2178页

作者： Chen Zhang Linli Xu Wai-Yeung wong Departmentof Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomHong Kongchina

omprehensive Summary,Polymetallaynes are a promising branch of metallopolymers,in which the introduction of metal building blocks to organic conjugated backbones leads to their unique skeletons and versatile ***,the chemical structures,geometric configurations and functional properties in these organometallic systems can be adjusted flexibly by the appropriate selection of metal centers,auxiliary ligands,or bridging *** recent years,both one-dimensional and two-dimensional polymetallaynes have attracted considerable attention owing to their excellent electronic,optical and magnetic ***,the studies on molecular metallaynes provide substantial insights for the exploration of the structure-property-activity relationships in these organometallic acetylide-containing *** recent research progress of polymeric and molecular metallaynes containing platinum,mercury and gold is discussed in this article.A series of functional properties have been realized in these acetylide-containing compounds by the rational structural design and refined synthetic strategies,leading to their emerging applications including energy conversion,nonlinear optics,data storage and memory,as well as chemo/biosensing.

关键词： Polymetallayne Molecular metallayne Metallated graphyne Platinum Mercury Gold

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Synergistic Effect of Graphdiyne-based Electrocatalysts

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Chemical Research in Chinese Universities 2021年第6期37卷 1242-1256页

作者： wong Hon Ho SUN mingzi HUANG Bolong Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARP.R.China

The synergistic effect can help improve the electrocatalyst performances by combining the advantages of individual *** particular,such an effect has been more important in the atomic *** this review,we have summarized the synergistic effect of N,X co-doping graphdiyne[X=B,S,F or transition metal(TM)]electrocatalysts and graphdiyne-based dual-atom catalyst(GDY-DAC).In general,the synergistic cooperation between two different dopants in co-doped GDY and adjacent active sites in GDY-DAC not only promotes their catalytic activity but also greatly enhances the thermodynamic stability of the *** the N,X co-doping GDY electrocatalysts,doping the heteroatoms like boron,sulphur,phosphorus,and fluorine with nitrogen can further tune the charge density distribution and electronic ***,the electron exchange between two doping atoms and GDY substrate has been discussed,where the TM-based GDY-DAC is a very promising catalyst for *** importantly,electronic interactions between different elements on GDY have been carefully *** the end,we have also supplied perspectives to the future developments of the GDY-based electrocatalysts.

关键词： Graphdiyne(GDY) Electrocatalyst Synergistic effect Dual-atom catalyst co-Doped GDY

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Detection of focal liver lesions in cirrhotic liver using contrast-enhanced ultrasound

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World Journal of Radiology 2009年第1期1卷 25-36页

作者： Grace Lai-hung wong Hui-Xiong Xu Xiao-Yan Xie Institute of Digestive Disease Department of Medicine and TherapeuticsThe Chinese University of Hong KongHong KongChina Department of Medical Ultrasonics The First Affiliated HospitalInstitute of Diagnostic and Interventional UltrasoundSun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina

Patients with liver cirrhosis are at increased risk of hepatocellular carcinoma(HCC).Conventional or baseline ultrasound(BUS)is often used as the first-line tool for HCC surveillance or detection,but the accuracy of BUS in HCC detection or differentiation from other focal liver lesions(FLLs)is ***-enhanced ultrasound(CEUS)represents a recent revolution in the field of ultrasonography and it has become increasingly important in the detection and evaluation of *** CEUS,HCC typically exhibits arterial hyper-enhancement and portal-venous washout represented by hypoenhanced lesions in the portal venous and late *** detection rate of HCC was significantly higher with CEUS compared with *** regenerative or some dysplastic nodules may exhibit arterial hyperenhancement as they are differentiated from HCC by its iso-enhancing pattern in portal and late *** contrast-enhancement patterns of other different types of benign and malignant FLLs,as well as their detection rates with CEUS,were also discussed.

关键词： Contrast-enhanced ultrasound Cirrhosis Focal liver lesions Metastatic liver cancer Hepatocellular carcinoma

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Hepatitis B virus genotype has no impact on hepatitis B e antigen seroconversion after lamivudine treatment

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World Journal of Gastroenterology 2003年第12期9卷 2695-2697页

作者： Henry Lik-Yuen Chan May-Ling wong Alex Yui Hui Angel Mei-Ling Chim Ada Mei-Ling Tse Lawrence Cheung-Tsui hung Francis Ka-Leung Chan Joseph Jao-Yiu Sung Department of Medicine and Therapeutics Chinese University of Hong KongHong Kong

AIM: To investigate the association of hepatitis B virus (HBV) genotype and HBeAg seroconversion after nucleotide analogue ***: Chronic hepatitis B patients receiving lamivudine followed up for at least 6 months post-treatment were studied. Consecutive treatment-naive patients who were prospectively followed up in the clinic for at least 18 months were studied as controls. HBeAg seroconversion was defined as loss of HBeAg, appearance of anti-HBe and normalization of alanine aminotransferase for at least 6 ***: Thirty-five patients on lamivudine and 96 control patients followed up for 39 (18-49) months were *** was given for 12 (10-18) months, and patients were followed up for 15 (6-34) months after drug *** B and C HBV were found in 43 and 88 patients and HBeAg seroconversion occurred in 12 (28 %) and 16(18 %) patients, respectively (P=0.30). There was no difference in HBeAg seroconversion between patients infected by genotype B and C HBV in the control (35 % vs 21%, P=0.25) and lamivudine-treated (14 % vs 10 %,P=1.00) ***: HBeAg seroconversion after treatment by lamivudine was not influenced by the HBV genotype.

关键词：乙型肝炎乙型肝炎病毒拉米夫定 HBeAg 基因型抗病毒治疗

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The combined role of MRI prostate and prostate health index in improving detection of significant prostate cancer in a screening population of Chinese men

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Asian Journal of Andrology 2023年第6期25卷 674-679页

作者： Peter KF Chiu Thomas YT Lam Chi-Fai Ng Jeremy YC Teoh Carmen CM Cho Hiu-Yee hung Cindy Hong Monique J Roobol Winnie CW Chu Samuel YS wong Joseph JY Sung SH Ho Urology Centre Department of SurgeryThe Chinese University of Hong KongHong Kong SARChina The Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong SARChina Department of Imaging and Interventional Radiology The Chinese University of Hong KongHong Kong SARChina Erasmus MC Cancer Institute Erasmus Medical UniversityRotterdam 3015The Netherlands Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore

Using prostate-specific antigen(PSA)for prostate cancer(PCa)screening led to overinvestigation and overdiagnosis of indolent *** aimed to investigate the value of prostate health index(PHI)and magnetic resonance imaging(MRI)prostate in an Asian PCa screening *** aged 50–75 years were prospectively recruited from a community-based PSA screening *** with PSA 4.0–10.0 ng ml^(−1) had PHI result *** prostate was offered to men with PSA 4.0–50.0 ng ml−1.A systematic prostate biopsy was offered to men with PSA 4.0–9.9 ng ml^(−1) and PHI≥35,or PSA 10.0–50.0 ng ml^(−1).Additional targeted prostate biopsy was offered if they had PI-RADS score≥*** significant PCa(csPCa)was defined as the International Society of Urological Pathology(ISUP)grade group(GG)≥2 or ISUP GG 1 with involvement of≥30%of total systematic *** total,12.8%(196/1536)men had PSA≥4.0 ng ml^(−1).Among 194 men with PSA 4.0–50.0 ng ml^(−1),187(96.4%)received MRI *** them,28.3%(53/187)had PI-RADS≥3 ***,7.0%(107/1536)men were indicated for biopsy and 94.4%(101/107)men received *** the men received biopsy,PCa,ISUP GG≥2 PCa,and csPCa was diagnosed in 42(41.6%),24(23.8%),and 34(33.7%)men,*** with PSA/PHI pathway in men with PSA 4.0–50.0 ng ml^(−1),additional MRI increased diagnoses of PCa,ISUP GG≥2 PCa,and csPCa by 21.2%(from 33 to 40),22.2%(from 18 to 22),and 18.5%(from 27 to 32),*** benefit of additional MRI was only observed in PSA 4.0–10.0 ng ml^(−1),and the number of MRI needed to diagnose one additional ISUP GG≥2 PCa was 20 in PHI≥35 and 94 in PHI<*** them,45.4%(89/196)men with PSA≥4.0 ng ml^(−1) avoided unnecessary biopsy with the use of PHI and MRI.A screening algorithm with PSA,PHI,and MRI could effectively diagnose csPCa while reducing unnecessary *** benefit of MRI prostate was mainly observed in PSA 4.0–9.9 ng ml^(−1) and PHI≥35 *** was an important risk stratification step for PCa

关键词： magnetic resonance imaging prostate prostate cancer prostate health index prostate-specific antigen screening

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Recent advancement on technical requirements for grid integration of wind power

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Journal of Modern Power Systems and Clean Energy 2013年第3期1卷 216-222页

作者： Xiaoge LIU Zhao XU Kit Po wong The Hong Kong Polytechnic University Hung HomHong Kong

The installation of wind energy has experienced rapid development during recent *** a result,the operation of power system can be greatly ***,the operators of different countries have formulated the grid codes which reinforce technical requirements for wind power *** this paper,recent grid codes published in different countries have been carefully *** basic requirements of active power control and reactive power compensation,both of which have particular influence on wind power plants operation,are focused *** on this review,it is understood that with the increasing integration of wind energy,there is a worldwide trend to regulate the performance of wind power plants so that they can contribute to the stability and reliability of power system.

关键词： Wind power Grid integration requirements Low voltage ride through Active power control

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