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Endoscopic band ligation and endoscopic hemoclip placement for patients with Mallory-Weiss syndrome and active bleeding

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World Journal of Gastroenterology 2008年第13期14卷 2080-2084页

作者： Young-seok Cho Hiun-Suk Chae Hyung-Keun Kim Jin-Soo Kim Byung-Wook Kim Sung-Soo Kim Sok-won han Kyu-Yong Choi Department of Internal Medicine Uijeongbu St. Mary's Hospital The Catholic University of Korea Ujeongbu 480-717 Korea Department of Internal Medicine Our Lady Mercy Hospital The Catholic University of Korea Bupyeong 403720 Korea Department of Internal Medicine Uijeongbu St. Mary’s Hospital The Catholic University of Korea Ujeongbu 480-717 Korea Department of Internal Medicine Holy Family Hospital The Catholic University of Korea Bucheon 420717 Korea

AIM: To compare the hemostatic efficacy and safety of two mechanical endoscopic methods: endoscopic band ligation (EBL) and endoscopic hemoclip placement (EHP) in patients with actively bleeding Mallory-Weiss syndrome (MWS). METHODS: A prospective randomized study to compare the efficacy and safety of EHP with EBL was performed from January 2002 to August 2005. Forty-one patients with active bleeding from MWS were treated with EHP (n = 21) or EBL (n = 20). RESULTS: There were no significant differences between groups with respect to clinical and endoscopic characteristics. The mean number of hemoclips applied was 3.2 ± 1.5 and the mean number of bands applied was 1.2 ± 0.4. Primary hemostasis was achieved in all patients. Recurrent bleeding was observed in one patient from the EHP group and two from the EBL group. Patients with recurrent bleeding were treated by the same modality as at randomization and secondary hemostasis was achieved in all. There were no significant differences between the two groups in total transfusion amount or duration of hospital stay. No complications or bleeding-related death resulted. CONCLUSION: EHP and EBL are equally effective and safe for the management of active bleeding in patients with Mallory-Weiss syndrome, even in those with shock or comorbid diseases.

关键词： Mallory-Weiss syndrome Hemostasis Endoscopic band ligation Endoscopic clipping

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Establishment of a chronic biliary disease mouse model with cholecystoduodenal anastomosis for intestinal microbiome preservation

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World Journal of Gastroenterology 2024年第46期30卷 4937-4946页

作者： Yunseon Jang Jung Yeon Kim Song Yeon han Arum Park So Jeong Baek Gyurim Lee Jihee Kang Hyewon Ryu seok-Hwan Kim Translational Immunology Institute Chungnam National University School of MedicineDaejeon 35015South Korea Department of Medical Science Chungnam National University School of MedicineDaejeon 35015South Korea AtoGen Co. Ltd.Techno 1-roDaejeon 35015South Korea Department of Internal Medicine Chungnam National University HospitalDaejeon 35015South Korea Department of Surgery Chungnam National University HospitalDaejeon 35015South Korea Research Institute for Medical Science Chungnam National University School of MedicineDaejeon 35015South Korea

BACKGROUND Chronic biliary disease,including cholangitis and cholecystitis,is attributed to ascending infection by intestinal *** of a mouse model for bile duct inflammation is imperative for the advancement of novel therapeutic *** models fail to replicate the harmful bacterial influx to the biliary tract observed in humans and spread of inflammation to the ***,we aimed to establish an animal model of biliary disease that faithfully replicates the mechanisms of human *** To establish a cholecystoduodenal anastomosis model capable of mimicking the mechanisms of ascending infection and inflammation observed in human biliary *** We established a mouse biliary disease model by directly connecting the gallbladder and duodenum,enabling ascending infection into the biliary tract without traversing the sphincter of *** In the cholecystoduodenal anastomosis mouse model,we observed impaired epithelial structure,wall thickening,and macrophage recruitment in the *** the absence of postoperative antibiotics,we detected no changes in serum proinflammatory cytokine levels,indicating no systemic ***,patency between the gallbladder and duodenum was confirmed via common bile duct *** of patient-derived pathogenic bacteria into bile duct-ligated mice led to ascending infection,which significantly increased proinflammatory cytokine mRNA expression in the liver,duodenum,and *** results indicate that our mouse model exhibited a direct connection between the gallbladder and duodenum,leading to ascending infection and closely mimicking the clinical features of biliary diseases observed in *** The cholecystoduodenal anastomosis mouse model is an effective chronic biliary disease model with significant relevance in the development of microbiome-based therapies for the prevention and treatment of biliary disease.

关键词： Experimental animal model Cholecystoduodenal fistula Anastomosis Biliary Disease Microbiome

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Comparative study of rendezvous techniques in post-liver transplant biliary stricture

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World Journal of Gastroenterology 2012年第41期18卷 5957-5964页

作者： Jae Hyuck Chang In seok Lee Ho Jong Chun Jong Young Choi Seung Kyoo Yoon Dong Goo Kim Young Kyoung You Myung-Gyu Choi Sok won han Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea Department of Radiology College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea Department of Surgery College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

AIM： To investigate the usefulness of a new rendezvous technique for placing stents using the Kumpe （KMP） catheter in angulated or twisted biliary strictures. METHODS： The rendezvous technique was performed in patients with a biliary stricture after living donor liver transplantation （LDLT） who required the exchange of percutaneous transhepatic biliary drainage catheters for inside stents. The rendezvous technique was performed using a guidewire in 19 patients （guidewire group） and using a KMP catheter in another 19 （KMP catheter group）. We compared the two groups retrospectively. RESULTS： The baseline characteristics did not differ between the groups. The success rate for placing insidestents was 100% in both groups. A KMP catheter was easier to manipulate than a guidewire. The mean pro- cedure time in the KMP catheter group （1012 s, range： 301-2006 s） was shorter than that in the guidewire group （2037 s, range： 251-6758 s, P = 0.022）. The cu- mulative probabilities corresponding to the procedure time of the two groups were significantly different （P = 0.008）. The factors related to procedure time were the rendezvous technique method, the number of inside stents, the operator, and balloon dilation of the stric- ture （P 〈 0.05）. In a multivariate analysis, the rendez- vous technique method was the only significant factor related to procedure time （P = 0.010）. The procedural complications observed included one case of mild acute pancreatitis and one case of acute cholangitis in the guidewire group, and two cases of mild acute pancre- atitis in the KMP catheter group. CONCLUSION： The rendezvous technique involving use of the KIVlp catheter was a fast and safe method for placing inside stents in patients with LDLT biliary stric- ture that represents a viable alternative to the guide- wire rendezvous technique,

关键词： Rendezvous Biliary stricture Liver trans-plantation Endoscopic retrograde cholangiography Percutaneous transhepatic biliary drainage

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Nanomolar concentration of alpha-synuclein enhances dopaminergic neuronal survival via Akt pathway

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Neural Regeneration Research 2013年第35期8卷 3269-3274页

作者： Ji-Young Kim Beom seok Jeon han-Joon Kim Tae-Beom Ahn Department of Neurology Inje University Seoul Paik Hospital Department of Neurology College of Medicine Seoul National University Hospital Department of Neurology Kyung Hee University Medical Center

Although alpha-synuclein is generally thought to have a pathological role in Parkinson＇s disease, accumulative evidence exists that alpha-synuclein has a neuroprotective effect. The aim of this study was to evaluate the effect of extracellular alpha-synuclein on dopaminergic cell survival. We assessed cell viability using the 3-（4,5-dimethyt-thiazol-2-yt）-2,5-diphenyltertazolium bromide （MTT） assay both in undifferentiated SH-SY5Y （SHSY） cells and neuronally-differentiated SH-SY5Y （ndSHSY） cells after 24 hour treatment with monomeric alpha-synuclein at various concentrations （0 [control], 50, 100 nmol/L, 1 IJmol/L）. To determine whether cell viability assessed by MTT assay was affected by cell proliferation, 5-bromo-2＇-deoxyuridine （BrdU） incorporation assay was per- formed. Level of both Akt and phosphorylated Akt was measured using western blot method in ndSHSY cells with or without 24 hour alpha-synuclein treatment. Cell viability was increased in ndSHSY cells at the nanomolar concentration of alpha-synuclein, but not in SHSY cells. Proportion of BrdU-positive ndSHSY cells was decreased in alpha-synuclein-treated group compared with control group. Level of phosphorylated Akt in alpha-synuclein-treated group was higher compared with the control group. Our study shows that extracellular alpha-synuclein at nanomolar concentra- tion benefits dopaminergic cell survival via Akt pathway.

关键词： neural regeneration alpha-synuclein neuronal survival nanomolar extracellular phosphorylatedAkt SH-SY5Y cell neuronal differentiation proliferation dopaminergic 5-bromo-2'-deoxyuridine grants-supported paper neuroregeneration

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Primary intestinal lymphangiectasia diagnosed by capsule endoscopy and double balloon enteroscopy

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World Journal of Gastrointestinal Endoscopy 2011年第11期3卷 235-240页

作者： Tak Geun Oh Joo won Chung Hee Man Kim seok-Joo han Jin Sung Lee Jung Yeob Park Si Young Song Division of Gastroenterology Department of Internal MedicineYonsei Institute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea epartment of Pediatric Surgery Yonsei University College of MedicineSeoul 120-752South Korea Department of Pediatrics Yonsei University College of MedicineSeoul 120-752South Korea Division of Gastroenterology Department of Internal MedicineBrain Korea 21 Project for Medical Science and Severance Biomedical Science InstituteYonsei University College of MedicineSeoul 120-752South Korea

Primary intestinal lymphangiectasia(PIL)is a rare disorder characterized by dilated intestinal lymphatics and the development of protein-losing *** with PIL develop hypoalbuminemia,hypocalcemia,lymphopenia and hypogammaglobulinemia,and present with bilateral lower limb edema,fatigue,abdominal pain and *** reveals diffusely elongated,circumferential and polypoid mucosae covered with whitish enlarged villi,all of which indicate intestinal *** is conf irmed by characteristic tissue pathology,which includes dilated intestinal lymphatics with diffusely swollen mucosa and enlarged *** prevalence of PIL has increased since the introduction of capsule *** etiology and prevalence of PIL remain *** studies have reported that several genes and regulatory molecules for lymphangiogenesis are related to *** report the case of a patient with PIL involving the entire small bowel that was confirmed by capsule endoscopy and double-balloon enteroscopy-guided tissue pathology who carried a deletion on chromosome *** relationship between this deletion on chromosome 4 and PIL remains to be investigated.

关键词： Capsule endoscopy Double balloon enteroscopy Chromosome deletion Chromosome 4q25 Primary intestinal lymphangiectasia

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A squamous metaplasia in a gastric ulcer scar of the antrum

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World Journal of Gastroenterology 2008年第8期14卷 1296-1298页

作者： Young-seok Cho Jin-Soo Kim Hyung-Keun Kim Jeong-Seon Ji Byung-Wook Kim Hiun-Suk Chae Sok-won han Kyu-Yong Choi In-Sik Chung Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary's Hospital Gyeonggi-do 480-717 Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Our Lady of Mercy Hospital Gyeonggi-do Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Holy Family Hospital Gyeonggi-do Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Kangnam St. Mary’s Hospital Seoul Korea

An 81-year-old man presented with epigastric pain and weight loss for one month. He had a past history of pulmonary tuberculosis, 10 years ago. We performed a gastroscopy, which showed a linear depressed whitish gastric ulcer scar (0.8 cm in length) in the posterior wall of the prepyloric antrum. The result of biopsy was reported as squamous epithelium. Immunohistochemical staining using an antibody to high molecular weight cytokeratin (HMC) revealed positive staining in the squamous epithelium. Two years later, the lesion was followed up. The lesion remained at same site endoscopically, but no squamous epithelium could be seen microscopically.

关键词： Squamous metaplasia Gastric ulcer scar High molecular weight cytokeratin

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Risk prediction platform for pancreatic fistula after pancreatoduodenectomy using artificial intelligence

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World Journal of Gastroenterology 2020年第30期26卷 4453-4464页

作者： In Woong han Kyeongwon Cho Youngju Ryu Sang Hyun Shin Jin seok Heo Dong Wook Choi Myung Jin Chung Oh Chul Kwon Baek Hwan Cho Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Medical Artificial Intelligence Research Center Department of Medical Device Management and ResearchSAIHSTSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Radiology Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Artificial Intelligence Research Center Medical DataBase IncorporatedSeoul 06048South Korea

BACKGROUND Despite advancements in operative technique and improvements in postoperative managements,postoperative pancreatic fistula(POPF)is a life-threatening complication following pancreatoduodenectomy(PD).There are some reports to predict POPF preoperatively or intraoperatively,but the accuracy of those is *** intelligence(AI)technology is being actively used in the medical field,but few studies have reported applying it to outcomes after *** To develop a risk prediction platform for POPF using an AI *** Medical records were reviewed from 1769 patients at Samsung Medical Center who underwent PD from 2007 to 2016.A total of 38 variables were inserted into AI-driven *** algorithms tested to make the risk prediction platform were random forest(RF)and a neural network(NN)with or without recursive feature elimination(RFE).The median imputation method was used for missing *** area under the curve(AUC)was calculated to examine the discriminative power of algorithm for POPF *** The number of POPFs was 221(12.5%)according to the International Study Group of Pancreatic Fistula definition *** median imputation,AUCs using 38 variables were 0.68±0.02 with RF and 0.71±0.02 with *** maximal AUC using NN with RFE was *** risk factors for POPF were identified by AI algorithm:Pancreatic duct diameter,body mass index,preoperative serum albumin,lipase level,amount of intraoperative fluid infusion,age,platelet count,extrapancreatic location of tumor,combined venous resection,co-existing pancreatitis,neoadjuvant radiotherapy,American Society of Anesthesiologists’score,sex,soft texture of the pancreas,underlying heart disease,and preoperative endoscopic biliary *** developed a web-based POPF prediction platform,and this application is freely available at http://*** This study is the first to predict POPF with multiple risk factors using *** platform is reli

关键词： Postoperative pancreatic fistula Pancreatoduodenectomy Neural networks Recursive feature elimination

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Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model

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World Journal of Gastroenterology 2014年第42期20卷 15703-15714页

作者： Hyeong-Geug Kim Jung-Min Kim Jong-Min han Jin-seok Lee Min-Kyung Choi Dong-Soo Lee Yeon-Hwa Park Chang-Gue Son Liver and immunology research center Daejeon Oriental Hospital of Oriental Medical Collage of Daejeon University NAR center Inc. Daejeon Oriental Hospital of Oriental Medical Collage of Daejeon University Department of Internal Medicine Daejeon St.Mary’s Hospital The Catholic University of Korea

AIM: To evaluate protective effects of Chunggan extract (CGX), a traditional herbal formula, under 4 wk of alcohol consumption-induced liver injury.

关键词： Alcohol abuse Liver injury Traditional Chinese Medicine Fibrogenic cytokines Hepato stellate cell

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Endoscopic band ligation: Beyond prevention and management of gastroesophageal varices

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World Journal of Gastroenterology 2013年第27期19卷 4271-4276页

作者： Jeong-Seon Ji Young-seok Cho Division of Gastroenterology Department of Internal MedicineIncheon St. Mary's HospitalThe Catholic University of Korea College of Medicine Division of Gastroenterology Department of Internal MedicineUijeongbu St. HospitalThe Catholic University of Korea College of Medicine

Endoscopic band ligation (EBL) is the preferred endoscopic technique for the endoscopic treatment of acute esophageal variceal bleeding. EBL has also been used to treat nonvariceal bleeding. Recently, han et al demonstrated that EBL can be a feasible and safe alternate technique for the management of iatrogenic gastric perforation especially in cases in which closure with endoclips is difficult. EBL is technically simpler to perform than other methods and provides a good view of the lesions under direct pressure and suction from the transparent ligation cap. EBL can be used even if the diameter of the perforation is greater than 10 mm or if there is a severe tangential angle. In this commentary, we discuss the efficacy and safety of EBL for the closure of iatrogenic gastrointestinal perforation. We also discuss the advantages and disadvantages of EBL for the treatment of nonvariceal bleeding.

关键词： Band ligation Endoscopy Intestinal perforation Gastrointestinal hemorrhage

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Effects of precipitation strengthening heat treatment for Al-Mg alloy

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Transactions of Nonferrous Metals Society of China 2011年第6期21卷 1218-1224页

作者： Seong-Jong KIM seok-Ki JANG Min-Su han Seong-Kwon KIM Jong-Sin KIM Division of Marine System Engineering Mokpo Maritime University Mokpo City Jeonnam 530-729 Korea Media Engineering Seoul National University of Technology Seoul 139-743 Korea Korean Register of Shipping Tokyo Branch Office 3rd F Sanko BLDG＇ 4-11 Nohonbashi Kodenma-cho Cho-ku 103-0001 Tokyo Japan

The corrosions resulting from defects in painting layers frequently occur in Al alloys, so the application of corrosion preventing systems is also very important. Optimum conditions in terms of electrochemistry in relation to solution treatment, quenching and artificial aging treatment were established in order to optimize precipitation strengthening conditions intended to enhance the strength of Al alloys. Slow strain rate tests （SSRT） at various applied potentials were conducted in potential range from -1.8 to 0.5 V. The results show that the maximum tensile strengths, elongations and time-to-fracture are shown to be high values. After precipitation strengthening heat treatment, a tendency appear that time-to-fracture increases as elongation increases. In the potential range from -1.3 V to -0.7 V, the specimens show excellent mechanical properties, and thus this range is considered to be a corrosion prevention range.

关键词： Al alloy slow strain rate test electrochemistry precipitation strengthening heat treatment mechanical property

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