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Cost-Effective Approaches of Circumferential Electro Wedge Brake for Reducing Unbalance-Wears

Journal of Mechanics Engineering and Automation 2012年第4期2卷 208-212页

作者： Dong-Hwan Shin Oh-seok Kwon Jeon-Il Moon Seung-han Yang Division of Robot System Daegu Gyeongbuk Institute of Science and Technology Daegu 711-873 South Korea Department of Mechanical Engineering Kyungpook National University Daegu 702-701 South Korea

Existing hydraulic braking systems in the vehicle is composed of the brake pedal, the hydraulic booster and the hydraulic caliper. The driver transmits one＇s breaking intent through the brake pedal stroke and force. The hydraulic booster can amplify the pedal force, only when the engine operates. The hydraulic caliper is composed of cylinders, pistons. There are also hydraulic pipes from the booster to the caliper. Currently, X-By-Wire technology is researched actively due to the exhaustion of fuel and the regulation of CO2. As a chain of this trend, the e-pedal and an electric mechanical brake （EMB） also are highlighted. At the beginning of EMB development, high-torque and high-power motors are required in order to implement the existing hydraulic calipers＇ clamping force. This has some limits as the need of big spaces and high costs. Then the electro wedge brake （EWB） is launching with self-reinforcement features of the wedge structure. EWB can generate big clamping forces with small size and low-torque motors with good braking-efficiency. In recent, the disc＇s circumferential face clamping one has been researched, for better heat-emission ability and better braking-efficiency compared to the existing disc＇s lateral face clamping method. But, this circumferential face clamping method can have worse unbalance-wear features compared to lateral face clamping one. In this study, the authors describe their circumferential EWB concepts, the method for reducing unbalance-wear feature of circumferential EWB, and the cost-effective implementation of circumferential EWB, in particular focused on nonlinear counter-wedge profile which is appropriate to reduce unbalance-wear.

关键词： Electro wedge brake circumferential unbalance-wear counter-wedge profile.

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Antimicrobial effect of alexidine and chlorhexidine against Enterococcus faecalis infection

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International Journal of Oral Science 2013年第1期5卷 26-31页

作者： Hyun-Shik Kim seok Woo Chang Seung-Ho Baek Seung Hyun han Yoon Lee Qiang Zhu Kee-Yeon Kum Department of Conservative Dentistry Dental Research Institute and BK21 ProgramSeoul National University Dental HospitalSeoul National University School of Dentistry Department of Conservative Dentistry School of DentistryKyung Hee University Department of Oral Microbiology and Immunology Dental Research Institute and BK21 ProgramSeoul National University Dental HospitalSeoul National University School of Dentistry Department of Dentistry wonju College of Medicine Yonsei University Division of Endodontology School of Dental MedicineUniversity of Connecticut Health Center

A previous study demonstrated that alexidine has greater affinity for the major virulence factors of bacteria than *** aim of this study was to compare the antimicrobial activity of 1%alexidine with that of 2%chlorhexidine using Enterococcus faecalis-infected dentin *** bovine dentin blocks were prepared and randomly divided into six groups of 10 *** was inoculated on 60 dentin blocks using the Luppens apparatus for 24 h and then the dentin blocks were soaked in 2%chlorhexidine or 1%alexidine solutions for 5 and 10 min,*** saline was used as a *** antimicrobial efficacy was assessed by counting the number of bacteria adhering to the dentin surface and observing the degradation of bacterial shape or membrane rupture under a scanning electron *** fewer bacteria were observed in the 2%chlorhexidine-or 1%alexidine-soaked groups than in the control group(P0.05).Ruptured or antiseptic-attached bacteria were more frequently observed in the 10-min-soaked chlorhexidine and alexidine groups than in the 5-min-soaked chlorhexidine and alexidine *** conclusion,10-min soaking with 1%alexidine or 2%chlorhexidine can be effective against *** infection.

关键词： alexidine antibacterial effect chlorhexidine Enterococcus faecalis Luppens apparatus root canal soaking scanning electron microscope

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Electrostatic spraying for fine-tuning particle dimensions to enhance oral bioavailability of poorly water-soluble drugs

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Asian Journal of Pharmaceutical Sciences 2024年第5期19卷 139-151页

作者： Jung Suk Kim Seunghyun Cheon Mi RanWoo Sanghyun Woo Jee-Eun Chung Yu seok Youn Kyung Taek Oh Soo-Jeong Lim Sae Kwang Ku Bao LoNguyen Jong Oh Kim Sung Giu Jin han-Gon Choi College of Pharmacy Hanyang UniversityAnsan 15588South Korea School of Pharmacy Sungkyunkwan UniversitySuwon 440746South Korea College of Pharmacy Chung-Ang UniversitySeoul 156-756South Korea Department of Bioscience and biotechnology Sejong UniversitySeoul 143747South Korea Department of Anatomy and Histology College of Korean MedicineDaegu Haany UniversityGyeongsan 38610South Korea College of Pharmacy Yeungnam UniversityGyongsan 712749South Korea Department of Pharmaceutical Engineering Dankook UniversityCheonan 31116South Korea

While spray-drying has been widely utilized to improve the bioavailability of poorly water-soluble drugs,the outcomes often exhibit suboptimal particle size distribution and large particle sizes,limiting their *** this study,we introduce electrostatic spraying as an advanced technology tailored for poorly water-soluble drugs,enabling the fabrication of nanoparticles with fine and uniform particle size ***(1 g),as a model drug,copovidone(5 g),and sodium dodecyl sulfate(0.1 g)were dissolved in 200 ml ethanol and subjected to conventional-spray-dryer and electrostatic spray *** electrostatic spray-dried nanoparticles(ESDN)showed smaller particle sizes with better uniformity compared to conventional spray-dried nanoparticles(CSDN).ESDN demonstrated significantly enhanced solubility and rapid release in *** vitro studies revealed that ESDN induced apoptosis in HCT-116 cells to a greater extent,exhibiting superior cytotoxicity compared to ***,ESDN substantially improved oral bioavailability and antitumor efficacy compared to *** findings suggest that ESD shows potential in developing enhanced drug delivery systems for poorly water-soluble drugs,effectively addressing the limitations associated with CSD methods.

关键词： Electrostatic spray drying Poorly water-soluble drug Regorafenib Particle size distribution Oral bioavailability Oral antitumor efficacy

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A randomized, prospective, two-center comparison of sirolimus-eluting stent and zotarolimus-eluting stent in acute ST-elevation myocardial infarction： The SEZE trial

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Chinese Medical Journal 2012年第19期125卷 3373-3381页

作者： Woo-Young Chung Jeehoon Kang Young-seok Cho Hae-Jun Park han-Mo Yang Jae-Bin Seo Jung-won Suh Kwang-I1 Kim Tae-Jin Youn Sang-Hyun Kim In-Ho Chae Joo-Hee Zo Myung-A Kim Dong-Ju Choi Seoul National University Boramae Hospital Seoul South Korea Seoul National University Bundang Hospital Seongnam SouthKorea Seoul National University Hospital Seoul South Korea

Background The zotarolimus-eluting stent has shown larger in-stent late lumen loss compared to sirolimus-eluting stents in previous studies. However, this has not been thoroughly evaluated in ST elevation myocardial infarction. Methods This was a prospective, randomized, controlled trial evaluating angiographic outcomes in patients presenting with ST elevation myocardial infarction, treated with zotarolimus-eluting stents or sirolimus-eluting stents. From March 2007 to February 2009, 122 patients were randomized to zotarolimus-eluting stents or sirolimus-eluting stents in a 1：1 fashion. The primary endpoint was 9-month in-stent late lumen loss confirmed by coronary angiography, and secondary endpoints were percent diameter stenosis, binary restenosis rate, major adverse cardiac events （a composite of cardiac death, non-fatal myocardial infarction, and target vessel revascularization）, and late-acquired incomplete stent apposition. Results Angiographic in-stent late lumen loss was significantly higher in the zotarolimus-eluting stent group compared to the sirolimus-eluting stent group （（0.49±0.65） mm vs. （0.10±0.46） mm, P=0.001）. Percent diameter stenosis at 9-month follow-up was also larger in the zotarolimus-eluting stent group （（30.0±17.9）% vs. （17.6±14.0）%, P 〈0.001）. In-segment analysis showed similar findings. There were no significant differences in binary restenosis rate, major adverse cardiac events, and late-acquired incomplete stent apposition. Conclusions Compared to sirolimus-eluting stents, the zotarolimus-eluting stent is associated with significantly higher in-stent late lumen loss at 9-month angiographic follow-up in the treatment of ST elevation myocardial infarction. Although there was no significant difference in 1-year clinical outcomes, the clinical implication of increased late lumen loss should be further studied.

关键词： sirolimus-eluting stent zotarolimus-eluting stent ST elevation myocardial infarction late lumen loss

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Elucidating the photoluminescence-enhancement mechanism in a push-pull conjugated polymer induced by hot-electron injection from gold nanoparticles

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Photonics Research 2021年第2期9卷 131-141页

作者： DONGKI LEE SE GYO han JUNGHO MUN KIHYUK YANG SUNG HYUK KIM JUNSUK RHO KILwon CHO DONGYEOP X.OH MUN seok JEONG Department of Energy Science Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Department of Mechanical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Research Center for Bio-based Chemistry Korea Research Institute of Chemical Technology(KRICT)Ulsan 44429Republic of Korea

Understanding the photophysical interactions between the components in organic-inorganic nanocomposites is a key factor for their efficient application in optoelectronic devices. In particular, the photophysical study of nanocomposites based on organic conjugated polymers is rare. We investigated the effect of surface plasmon resonance(SPR) of gold nanoparticles(Au NPs) on the photoluminescence(PL) property of a push-pull conjugated polymer(PBDB-T). We prepared the hybrid system by incorporating poly(3-hexylthiophene)-stabilized Au NPs(P3 HT-Au NPs) into PBDB-T. The enhanced and blueshifted PL was observed in the hybrid system compared to PL in a neat PBDB-T system, indicating that the P3 HT chains attached to the Au NPs suppressed charge-transfer from PBDB-T to the Au NPs and relayed the hot electrons to PBDB-T(the band-filling effect).This photophysical phenomenon limited the auto-dissociation of PBDB-T excitons. Thus, the radiative recombination of the excitons occurred more in our hybrid system than in the neat system.

关键词： conjugated system polymer

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