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Pembrolizumab as a novel therapeutic option for patients with refractory thymic epithelial tumor:A case report

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World Journal of Clinical Cases 2021年第5期9卷 1139-1147页

作者： Jonathan Wong-chong Maureen Bernadach Angeline Ginzac Hugo Veyssière Xavier Durando Département d’Oncologie Médicale Centre Jean PERRINClermont-Ferrand 63011France UFR Médecine UniversitéClermont AuvergneClermont-Ferrand 63011France Division de Recherche Clinique Délégation Recherche Clinique et InnovationCentre Jean PERRINClermont-Ferrand 63011France INSERM U1240 Imagerie Moléculaire et Stratégies ThéranostiquesUniversitéClermont AuvergneClermont-Ferrand 63011France Centre d’Investigation Clinique UMR501Clermont-Ferrand 63011France

BACKGROUND Thymic epithelial carcinomas are rare and have a poor *** of thymic epithelial carcinoma is multimodal and includes surgery,post-operative radiation therapy,adjuvant and neoadjuvant chemotherapy,or exclusive chemotherapy based on disease ***,there is currently no standard treatment regimen for metastatic and recurrent thymic *** SUMMARY A 45-year-old Caucasian male,with no past medical history,presented with hepatalgia and a cervical mass.A computed tomography(CT)scan showed multiple suspect lesions in the lungs,liver,and anterior mediastinum associated with mediastinal and cervical ***-guided percutaneous biopsies of the liver lesions and anterior mediastinal mass were performed,confirming the histopathology of thymic epithelial *** consisted of several chemotherapy regimens and radiation therapy,administered between April 2016 and December *** patient achieved complete metabolic *** positron emission tomography/CT performed in June 2019 showed disease relapse,with reappearance of a large hypermetabolic hepatic mass and involvement of mediastinal and axillary lymph *** pembrolizumab(200 mg,every 3 wk)was administered after two prior systemic *** patient’s response to treatment was last documented on March 5,*** Pembrolizumab was successful in treatment of a patient with programmed deathligand 1-negative metastatic thymic carcinoma,pretreated with chemotherapy.

关键词： Thymic epithelial carcinoma Programmed death-ligand 1 negative Pembrolizumab Immune checkpoint Metastasis Case report

Idiopathic adulthood ductopenia with elevated transaminase only:A case report

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World Journal of Clinical Cases 2020年第24期8卷 6524-6528页

作者： Xiao-Chen Zhang Di Wang Xiang Li Yu-Lin Hu chong Wang Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease ofunknown etiology that usually presents as unexplained jaundice. It ischaracterized by adult onset, lack of autoantibodies, inflammatory bowel diseaseand loss of interlobular bile *** SUMMARY This case presents a 27-year-old woman with elevation of transaminases andalkaline phosphatase without clinical symptoms. Five years ago, the patient hadabnormal transaminases but no cholestasis. Three months before admission,physical examination revealed an increase in transaminases. Oralhepatoprotective drugs did not show any significant improvement, and she wasadmitted to hospital for further diagnosis and treatment. Liver biopsy confirmedIAD. After about 2 wk of ursodeoxycholic acid treatment, serological andhistological examination showed a significant *** IAD is a manifestation of cholestasis, but also may be an abnormal increase intransaminase in the early stage.

关键词： Idiopathic adulthood ductopenia Ductopenic diseases Liver injury Cholestasis Ursodeoxycholic acid Case report

Multiscale cellulose-based fireproof and thermal insulation gel materials with water-regulated forms

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Nano Research 2023年第2期16卷 3379-3386页

作者： chong-Han Yin Huai-Bin Yang Zi-Meng Han Kun-Peng Yang Zhang-Chi Ling Qing-Fang Guan Shu-Hong Yu Department of Chemistry Institute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Different forms of construction materials(e.g.,paints,foams,and boards)dramatically improve the quality of *** the increasing environmental requirements for buildings,it is necessary to develop a comprehensive sustainable construction material that is flexible in application and exhibits excellent performance,such as fireproofing and thermal ***,an adjustable multiform material strategy by water regulation is proposed to meet the needs of comprehensive applications and reduce environmental *** gels are constructed based on multiscale cellulose fibers and hollow glass microspheres,with fireproofing and thermal *** traditional materials,this multiscale cellulose-based gel can change forms from dispersion to paste to dough by adjusting its water content,which can realize various construction forms,including paints,foams,and low-density boards according to different scenarios and corresponding needs.

关键词： bioinspired multiscale structure nanocellulose water regulation gel material

Hemodynamic changes in hepatic sinusoids of hepatic steatosis mice

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World Journal of Gastroenterology 2019年第11期25卷 1355-1365页

作者： Jing Fan chong-Jiu Chen Yu-Chen Wang Wei Quan Jian-Wei Wang Wei-Guang Zhang Department of Anatomy Histology and EmbryologySchool of Basic Medical SciencesPeking University Health Science Center

BACKGROUND Fatty liver(FL) is now a worldwide disease. For decades, researchers have been kept trying to elucidate the mechanism of FL at the molecular level, but rarely involve the study of morphology and medical physics. Traditionally, it was believed that hemodynamic changes occur only when fibrosis occurs, but it has been proved that these changes already show in steatosis stage, which may help to reveal the pathogenesis and its progress. Because the pseudolobules are not formed during the steatosis stage, this phenomenon may be caused by the compression of the liver microcirculation and changes in the *** To understand the pathogenesis of hepatic steatosis and to study the hemodynamic changes associated with hepatic *** Eight-week-old male C57 BL/6 mice were divided into three groups randomly(control group, 2-wk group, and 4-wk group), with 16 mice per group. A hepatic steatosis model was established by subcutaneous injection of carbon tetrachloride in mice. After establishing the model, liver tissue from mice was stained with hematoxylin and eosin(HE), and oil red O stains. Blood was collected from the angular vein, and hemorheological parameters were estimated. A two-photon fluorescence microscope was used to examine the flow properties of red blood cells in the hepatic *** Oil red O staining indicated lipid accumulation in the liver after CCl_4 *** staining indicated narrowing of the hepatic sinusoidal vessels. No significant difference was observed between the 2-wk and 4-wk groups of mice onmorphological examination. Hemorheological tests included whole blood viscosity(mPas, γ = 10 s-1/γ = 100 s-1)(8.83 ± 2.22/4.69 ± 1.16, 7.73 ± 2.46/4.22 ±1.32, and 8.06 ± 2.88/4.22 ± 1.50), red blood cell volume(%)(51.00 ± 4.00, 42.00 ±5.00, and 40.00 ± 3.00), the content of plasma fibrinase(g/L)(3.80 ± 0.50, 2.90 ±0.80, and 2.30 ± 0.70), erythrocyte deformation index(%)(44.49 ± 5.81, 48.00 ±15.29, and 44.36 ± 15.01), eryt

关键词： Hepatic steatosis Hemodynamics Hepatic sinusoids Two-photon fluorescence microscopy Carbon tetrachloride

Application of acellular dermal matrix for intestinal elongation in animal models

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World Journal of Gastroenterology 2010年第16期16卷 2023-2027页

作者： Xu, Hui-Min Wang, Zhen-Jun Han, Jia-Gang Ma, Hua-chong Zhao, Bo Zhao, Bao-Cheng Capital Med Univ Beijing Chaoyang Hosp Dept Gen Surg Beijing 100020 Peoples R China

AIM:To investigate the eff icacy of acellular dermal matrix(ADM) for intestinal elongation in animal ***:Japanese white big-ear rabbits(n = 9) and Wuzhishan miniature pigs(n = 5) were used in the ***-made and commercial ADM materials were used as grafts,respectively.A 3-cm long graft was interposed in continuity with the small bowel and a sideto-side anastomosis,distal to the graft about 3-4 cm,was *** animals were sacrificed at 2 wk,4 wk,8 wk and 3 mo after surgery and the histological changes were evaluated under light microscope and electron ***:The animals survived after the operation with no evidence of peritonitis and *** ad-hesions were found between the graft and surrounding *** grafts were completely absorbed within postoper ative two or three months except *** observ ation showed inflammation in the grafts with fibrinoid necroses,infiltration of a large amount of neutrophils and leukomonocytes,and the degree varied in different *** neointestine with wellformed structures was not observed in the ***:It is not suitable to use acellular dermal matrix alone as a scaffold for the intestinal elongation in animal models.

关键词： Acellular dermal matrix Intestine Elongation

Compound heterozygous mutation of MUSK causing fetal akinesia deformation sequence syndrome: A case report

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World Journal of Clinical Cases 2019年第21期7卷 3655-3661页

作者： Na Li chong Qiao Yuan Lv Tian Yang Hao Liu Wen-Qian Yu Cai-Xia Liu Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Key Laboratory of Maternal-Fetal Medicine of Liaoning Province Key Laboratory of Obstetrics and Gynecology of Higher Education of Liaoning ProvinceShenyang 110004Liaoning ProvinceChina

BACKGROUND Fetal akinesia deformation sequence(FADS)is a broad spectrum disorder with absent fetal movements as the unifying *** etiology of FADS is heterogeneous and mostly still unknown.A prenatal diagnosis of FADS relies on clinical features obtained by ultrasound and fetal muscle ***,the recent advances of next-generation sequencing(NGS)can effectively provide a definitive molecular *** SUMMARY A fetus presented after 24 wk and 6 d of gestation with absent fetal movements and multiple abnormal ultrasonographic *** mother had had a previous abortion due to a similarly affected fetus a year before.A clinical diagnosis of FADS was *** parents refused cord blood examination and chose abortion.A molecular diagnosis of fetal muscle using NGS of genes found a compound heterozygous mutation in the MUSK gene:c.220C>T(chr9:113449410 p.R74W)and c.421delC(chr9:113457745 p.P141fs).CONCLUSION To our knowledge,this is the first report in China showing that a mutation in MUSK is associated with *** supports previous finding that a lethal mutation of MUSK will cause FADS.A precise molecular diagnosis for genetic counseling and options for a prenatal diagnosis of FADS are very important,especially for recurrent FADS;this may also provide evidence for both prenatal and preimplantation genetic diagnoses.

关键词： MUSK gene Fetal akinesia deformation sequence Joint contractures Casereport

异层等价离子双掺杂策略优化BiCuSeO的热电性能

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无机材料学报 2019年第3期34卷 294-300页

作者：李周肖翀中国科学技术大学化学与材料科学学院合肥230026 中国科学技术大学微尺度物质科学国家研究中心合肥230026

选取BiCuSeO双亚层超晶格热电材料为研究对象,通过La、Ag单掺杂和双掺杂两种方式等价取代[Bi2O2]2+亚层和[Cu2Se2]2–亚层中的Bi、Cu位点,并对其热电输运性能和缺陷调控机理进行研究,结果发现:La-Ag双掺杂可以结合两种单掺杂的优势,在... 详细信息

选取BiCuSeO双亚层超晶格热电材料为研究对象,通过La、Ag单掺杂和双掺杂两种方式等价取代[Bi2O2]2+亚层和[Cu2Se2]2–亚层中的Bi、Cu位点,并对其热电输运性能和缺陷调控机理进行研究,结果发现:La-Ag双掺杂可以结合两种单掺杂的优势,在适度提升载流子浓度的同时保持与纯样相当的载流子迁移率,从而使电导率得到大幅度的提升。与此同时,La-Ag双掺杂可以引发能带收敛效应,有助于同步获得较高的载流子迁移率和Seebeck系数,最终使PF得到了优化;另一方面,由于点缺陷对载热声子的强烈散射作用,样品的晶格热导率和总热导率进一步降低,使最终ZT值也得到了优化。结果,La-Ag双掺杂样品的ZT值在755K下达到0.46,高于原始纯样(ZT=0.27)和单掺杂样品。该项研究表明La、Ag异层等价双掺杂策略可以实现BiCuSeO热电输运参数的协同调控与优化。

关键词：异层双掺杂 BiCuSeO 热电性能电热输运协同调控

Establishment of an orthotopic pancreatic cancer mouse model: Cells suspended and injected in Matrigel

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World Journal of Gastroenterology 2014年第28期20卷 9476-9485页

作者： Yong-Jian Jiang chong-Lek Lee Qiang Wang Zhong-Wen Zhou Feng Yang Chen Jin De-Liang Fu Department of Pancreatic Surgery Huashan HospitalFudan University Department of Pathology Huashan HospitalFudan University

AIM: To establish an orthotopic mouse model of pancreatic cancer that mimics the pathological features of exocrine pancreatic adenocarcinoma.

关键词： Pancreatic cancer Orthotopic mouse model Matrigel C57BL/6 mouse Pan02

Single atom accelerates ammonia photosynthesis

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Science China Chemistry 2018年第9期61卷 1187-1196页

作者： Pengcheng Huang Wei Liu Zhihai He chong Xiao Tao Yao Youming Zou Chengming Wang Zeming Qi Wei Tong Bicai Pan Shiqiang Wei Yi Xie Hefet National Laboratory for Physical Sciences at the Microscale CAS Center for Excellence in Nanoscience iCHEM University of Science and Technology of China Hefei 230026 China National Synchrotron Radiation Laboratory University of Science and Technology of China. Hefei 230029 China High Magnetic Field Laboratory Chinese Academy of Sciences Hefei 230031 China

Atomically dispersed metal has gained much attention because of the new opportunities they offer in catalysis. However, it is still crucial to understand the mechanism of single-atom catalysis at molecular level for expanding them to other more difficult catalytic reactions, such as ammonia synthesis from nitrogen. In fact, developing ammonia synthesis under ambient conditions to overcome the high energy consumption in well-established Haber-Bosch process has fascinated scientists for many ***, we demonstrate that single Cu atom yields facile valence-electron isolation from the conjugated π electron cloud of p-CN. Electron spin resonance measurements reveal that these isolated valence electrons can be easily excited to generate free electrons under photo-illumination, thus inducing high efficient photo-induced ammonia synthesis under ambient *** NH_3 producing rate of copper modified carbon nitride(Cu-CN) reached 186 μmol g^(-1) h^(-1) under visible light irradiation with the quantum efficiency achieved 1.01% at 420 nm monochromatic light. This finding surely offers a model to open up a new vista for the ammonia synthesis at gentle conditions. The introduction of single atom to isolate the valence electron also represents a new paradigm for many other photocatalytic reactions, since the most photoinduced processes have been successfully exploited sharing the same origin.

关键词： single atom photocatalytic ammonia synthesis