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Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology Research 2025年第1期33卷 199-212页

作者： WEN yang BIN TANG DAN XU wenxiu yang Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported ***,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(p<0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCR7 CCL21 ERK1/2 Lenalidomide Diffuse large B-cell lymphoma(DLBCL)

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Recent advances in carbon-based electrocatalysts for oxygen reduction reaction

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Chinese Chemical Letters 2020年第3期31卷 626-634页

作者： Lulu Chen Xiaolong Xu wenxiu yang Jianbo Jia State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China Department of Materials Science&Engineering&Department of Energy and Resources Engineering College of EngineeringPeking UniversityBeijing 100871China School of Chemical and Environmental Engineering Wuyi UniversityJiangmen 529020China

Fuel cells are one of the most promising clean energy devices to substitute for fossil fuel in the future to alleviate energy crisis and environmental *** the key reaction on the cathode in the fuel cells,oxygen reduction reaction(ORR)still requires efficient noble metal catalysts such as the comme rcial Pt/C to boost the reaction for its sluggish ***,it is critical to design earth-abundant carbonbased catalysts with high efficiency and long-term stability to replace the noble metal-based *** review focuses on the recent progress about carbon-based ORR catalysts including non-metal doped carbon materials,transition metal-nitrogen-carbon species,transition metal carbides/carbon,single atom catalysts,and other carbon *** we further infer that the excellent ORR performances can be achieved by the balance of geometric and electronic structures of catalysts such as conductivity,surface area,hierarchical porous structure,defect and doping ***,the perspective development trend is also proposed to guide the rational designation of carbon-based catalysts for ORR and even extend to other energy storage and conversion fields in the future.

关键词： Oxygen reduction reaction Carbon materials Transition metal catalysts Single atom catalysts Fuel cells

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Heat and hyposmotic stimulation increase in [Ca^(2+)]_i by Ca^(2+) influx in rat synoviocytes

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Chinese Science Bulletin 2008年第4期53卷 548-554页

作者： SUN WenWu HU Fen yang wenxiu Biophysics Department in School of Physics Key Laboratory of Bioactive Materials for Ministry of Education Nankai UniversityTianjin 300071 China

Rheumatoid arthritis(RA),which is marked by inflammatory synovitis,is a common,chronic autoim-mune-disease,whose pathogenesis is complex and still *** order to explore the effects of heat and hyposmotic stimuli on synoviocytes in rheumatoid arthritis,the changes of [Ca2+]i induced by heat,hyposmotic and 4α-PDD stimuli were observed in synoviocytes.[Ca2+]i elevation induced by heat ≥ 28℃,hyposmotic and 4α-PDD stimuli is found to be positively relative to increasing temperature,decreasing osmolality and rising concentration of 4α-*** show that there is reciprocity among these stimuli and desensitization,and that [Ca2+]i elevation depends on Ca2+ influx,but not necessarily links to Ca2+ release from intracellular stores and voltage-dependent Ca2+ channel in *** above characteristics of Ca2+ influx are similar to those of TRPV4.A probable mechanism has been suggested that heat and hyposmotic stimulation might increase the level of [Ca2+]i by activating the TRPV4-like channel and Ca2+ influx in the synoviocytes.

关键词：风湿性关节炎热扩散低渗透性钙离子

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Ru-doped functional porous materials for electrocatalytic water splitting

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Nano Research 2024年第3期17卷 982-1002页

作者： Chongao Tian Rui Liu Yu Zhang wenxiu yang Bo Wang Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Advanced Technology Research Institute(Jinan)Advanced Research Institute of Multidisciplinary ScienceSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Library Beijing Institute of TechnologyBeijing 100081China

Electrolytic water splitting(EWS)is an attractive and promising technique for the production of hydrogen ***,the sluggish kinetic rate of hydrogen/oxygen evolution reactions leads to a high overpotential and low energy *** to date,Pt/Ir-based nanocatalysts have become the state-of-the-art EWS catalysts,but disadvantages such as high cost and low earth abundance greatly limit their applications in EWS *** an attractive candidate for the Pt/Ir catalysts,series of Ru-based nanomaterials have aroused much attention for their low price,Pt-like hydrogen bond strength,and high EWS *** particular,Ru-doped functional porous materials have been becoming one of the most representative EWS catalysts,which can not only achieve the dispersion and adjustment for active Ru sites,but also simultaneously solve the problems of mass transfer and catalytic conversion in *** this review,the design and preparation strategies of Ru-doped functional porous materials toward EWS in recent years are summarized,including Ru-doped metal organic frameworks(MOFs),Ru-doped porous organic polymers(POPs),and their ***,detailed structure–activity relationships induced by the tuned geometric/electronic structures of Ru-doped functional porous materials are further depicted in this *** but not least,the challenges and perspectives of Ru-doped functional porous materials catalysts are reasonably proposed to provide fresh ideas for the design of Ru-based EWS catalysts.

关键词： Ru-based catalyst functional porous materials electrolytic water splitting oxygen evolution reaction hydrogen evolution reaction

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Preparation and adsorption property of novel inverse-opal hierarchical porous N-doped carbon microspheres

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Chinese Chemical Letters 2021年第2期32卷 866-869页

作者： wenxiu yang Guoqing Xu Jingjing Shu Mozhen Wang Xuewu Ge C4S Key Laboratory of Soft Matter Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China

The design of pore structure is the key factor for the performance of porous carbon *** this wo rk,novel micron-sized colloidal crystal microspheres consisting of fibrous silica(F-SiO_(2)) nanoparticles are firstly prepared by water-evapo ration-induced self-assembly of F-SiO_(2) nanoparticles in the droplets of an inverse emulsion system to be used as sacrificial ***(AN) was infiltrated in the voids of the F-SiO_(2) colloidal crystal microspheres,and in-situ induced by ^(60)Co γ-ray to polymerize into polyacrylonitrile(PAN).After the PAN-infiltrated F-SiO_(2) colloidal crystal microspheres were carbonized and etched with HF solution,novel micron-sized inverse-opal N-doped carbon(IO-NC) microspheres consisting of hollow carbon nanoparticles with a hierarchical macro/meso-porous inner surface were *** IO-NC microspheres have a specific surface area as high as 266.4 m^(2)/g and a molar ratio of C/N of *** have a good dispersibility in water,and show a high adsorption capacity towards rhodamine B(RhB) up to 137.28 mg/(g microsphe re).This work offers a way to obtain novel micron-sized hierarchical macro/meso-porous N-doped carbon microspheres,which opens a new idea to prepare high-performance hierarchical porous carbon materials.

关键词： Inverse-opal carbon microspheres N doping Colloidal crystal microsphere Fibrous silica nanoparticles Adsorption

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Synergizing high valence metal sites and amorphous/crystalline interfaces in electrochemical reconstructed CoFeOOH heterostructure enables efficient oxygen evolution reaction

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Nano Research 2022年第10期15卷 8857-8864页

作者： Xiangjian Liu Rui Liu Jinming Wang Yarong Liu Liuhua Li wenxiu yang Xiao Feng Bo Wang Key Laboratory of Cluster Science Ministry of Education Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsAdvanced Technology Research Institute(Jinan)Advanced Research Institute of Multidisciplinary ScienceSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China

Cobalt hydroxide nanosheet is among the most popular oxygen evolution reaction(OER)catalyst yet still suffers from sluggish catalytic kinetics,limited activity,and poor ***,an efficient in situ electrochemical reconstructed CoFe-hydroxides derived OER electrocatalyst was *** introduction of Fe promoted the transformation of Co^(2+)into Co^(3+)in CoFehydroxides nanosheet,along with the formation of abundant amorphous/crystalline *** for the retained nanosheet microstructure,high valence Co^(3+)and Fe^(3+)species,and the amorphous/crystalline heterostructure interfaces,the as-designed electrochemical reconstructed CoFeOOH nanosheet/Ni foam(CoFeOOHNS/NF)electrode delivers 100 mA·cm^(−2) in alkaline at an overpotential of 275 mV and can stably electrocatalyze water oxidation for at least 35 h at 100 mA·cm^(−2).Meanwhile,the alkaline full water splitting electrolyzer achieves a current density of 10 mA·cm^(−2) only at 1.522 V for CoFeOOHNS/NF‖Pt/C/NF,which is much lower than that of Ru/C/NF‖Pt/C/NF(1.655 V@10 mA·cm^(−2)).This work paves the way for in-situ synergetic modification engineering of electrochemical active components.

关键词： electrochemical reconstruction high valance transition metal amorphous heterostructure interfaces electrochemical oxygen evolution reaction

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Heterogeneous assembling 3D free-standing Co@carbon membrane enabling efficient fluid and flexible zinc-air batteries

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Nano Research 2023年第7期16卷 9327-9334页

作者： Jinming Wang Xiangjian Liu Liuhua Li Rui Liu Yarong Liu Changli Wang Zunhang Lv wenxiu yang Xiao Feng Bo Wang Key Laboratory of Cluster Science Ministry of Education Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Materials Science and EngineeringAdvanced Technology Research Institute(Jinan)Advanced Research Institute of Multidisciplinary ScienceSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China

Developing an efficient,interface-rich,and free-standing non-noble-metal electrocatalyst is vital for the flexible zinc-air batteries(ZABs).Herein,a three-dimensional(3D)heterogeneous carbon-based flexible membrane was assembled by Co@carbon nanosheets/carbon nanotubes and hollow carbon nanofiber(Co@NS/CNT-CNF)as an efficient oxygen reduction reaction(ORR)catalyst with a positive half-wave potential of 0.846 V and a small Tafel slope of 79 mV·dec^(-1).Meanwhile,the Co@NS/CNT-CNF electrode also exhibits excellent open-circuit voltage,peak power density,and long-time cycling stability in liquid-state ZABs(1.605 V,163 mW·cm^(-2),and 400 h)and flexible ZABs under flat/bending condition(1.47 V,102 mW·cm^(-2),and 80 h).Such heterogeneous flexible membrane architecture not only optimizes the electrolyte infiltration,but also provides capacious possibility for O_(2)and electrolyte ***,work-function analyses coupled with density functional theory(DFT)results demonstrate that the electron transfer capability and metal-support interaction can be well optimized in the obtained Co@NS/CNT-CNF catalyst.

关键词： free-standing membrane electrocatalysts carbon nanomaterials zinc-air batteries

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Detecting HI Galaxies with Deep Neural Networks in the Presence of Radio Frequency Interference

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Research in Astronomy and Astrophysics 2023年第11期23卷 38-50页

作者： Ruxi Liang Furen Deng Zepei yang Chunming Li Feiyu Zhao Botao yang Shuanghao Shu wenxiu yang Shifan Zuo Yichao Li Yougang Wang Xuelei Chen National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China Department of Physics Northeastern UniversityBostonMA 02115USA Biomedical Instrument Institute School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Key Laboratory of Cosmology and Astrophysics(Liaoning) College of SciencesNortheastern UniversityShenyang 110819China Key Laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China

In the neutral hydrogen(H I)galaxy survey,a significant challenge is to identify and extract the H I galaxy signal from the observational data contaminated by radio frequency interference(RFI).For a drift-scan survey,or more generally a survey of a spatially continuous region,in the time-ordered spectral data,the H I galaxies and RFI all appear as regions that extend an area in the time-frequency waterfall plot,so the extraction of the H I galaxies and RFI from such data can be regarded as an image segmentation problem,and machine-learning methods can be applied to solve such *** this study,we develop a method to effectively detect and extract signals of H I galaxies based on a Mask R-CNN network combined with the PointRend *** simulating FAST-observed galaxy signals and potential RFI impact,we created a realistic data set for the training and testing of our neural *** compared five different architectures and selected the best-performing *** architecture successfully performs instance segmentation of H I galaxy signals in the RFI-contaminated time-ordered data,achieving a precision of 98.64%and a recall of 93.59%.

关键词： methods:data analysis methods:observational techniques:image processing

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Coordination-environment regulation of atomic Co-Mn dual-sites for efficient oxygen reduction reaction

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Nano Research 2024年第8期17卷 6841-6848页

作者： Caiting Sun Yarong Liu Zunhang Lv Rui Liu Changli Wang Liuhua Li Jinming Wang Yu Zhang wenxiu yang Bo Wang Key Laboratory of Cluster Science(Ministry of Education) Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsAdvanced Technology Research Institute(Jinan)Advanced Research Institute of Multidisciplinary ScienceSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Library Beijing Institute of TechnologyBeijing 100081China

Precisely designing atomic metal-nitrogen-carbon(M-N-C)catalysts with asymmetric diatomic configurations and studying their structure–activity relationships for oxygen reduction reaction(ORR)are important for zinc-air batteries(ZABs).Herein,a dualatomic-site catalyst(DASC)with CoN_(3)S-MnN_(2)S_(2) configuration was prepared for the cathodes of *** with Co-N-C(Mn-free)and CoMn-N-C(S-free doping),CoMn-N/S-C exhibits excellent half-wave potential(0.883 V)and turnover frequency(1.54 e·s^(−1)·site^(−1)),surpassing most of the reported state-of-the-art Pt-free ORR *** CoMn-N/S-C-based ZABs achieve extremely high specific capacity(959 mAh·g^(−1))and good stability(350 h@5 mA·cm^(−2)).Density functional theory(DFT)calculation shows that the introduction of Mn and S can break the electron configuration symmetry of the original Co 3d orbital,lower the dband center of the Co site,and optimize the desorption behavior of*OH intermediate,thereby increasing the ORR activity.

关键词： metal organic frameworks oxygen reduction reaction dual-atom catalyst coordination-environment regulation zinc-air batteries

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A highly efficient atomically thin curved Pd Ir bimetallene electrocatalyst

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National Science Review 2021年第9期8卷 100-110页

作者： Fan Lv Bolong Huang Jianrui Feng Weiyu Zhang Kai Wang Na Li Jinhui Zhou Peng Zhou wenxiu yang Yaping Du Dong Su Shaojun Guo School of Materials Science and Engineering Peking University Department of Applied Biology and Chemical Technology Hong Kong Polytechnic University Frontier Institute of Science and Technology jointly with College of Science Xi'an Jiaotong University Center for Functional Nanomaterials Brookhaven National Laboratory School of Materials Science and Engineering & National Institute for Advanced Materials Nankai University College of Engineering Peking University

The multi-metallene with an ultrahigh surface area has great potential in precise tuning of surface heterogeneous d-electronic correlation by surface strain effect for the distinctive surface electronic structure, which is a brand new class of promising 2 D electrocatalyst for sustainable energy device application. However, achieving such an atomically thin multi-metallene still presents a great ***, we present a new synthetic method for an atomic-level palladium-iridium(Pd Ir) bimetallene with an average thickness of only～1.0 nm for achieving superior catalysis in the hydrogen evolution reaction(HER) and the formic acid oxidation reaction(FAOR). The curved Pd Ir bimetallene presents a top-ranked high electrochemical active area of 127.5 ± 10.8 m~2 g Pd+Ir-1in the reported noble alloy materials, and exhibits a very low overpotential, ultrahigh activity and improved stability for HER and FAOR. DFT calculation reveals that the Pd Ir bimetallene herein has a unique lattice tangential strain, which can induce surface distortion while concurrently creating a variety of concave-convex featured micro-active regions formed by variously coordinated Pd sites agglomeration. Such a strong strain effect correlates the abnormal on-site active 4 d10-t2g-orbital Coulomb correlation potential and directly elevates orbital-electronegativity exposure within these active regions, resulting in a preeminent barrier-free energetic path for significant enhancement of FAOR and HER catalytic performance.

关键词： strain metallene PdIr alloy atomically thin electrocatalyst

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