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Serum from Acute-on-chronic Liver Failure Patients May Affect Mesenchymal Stem Cells Transplantation by Impairing the Immunosuppressive Function of Cells

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Journal of Clinical and Translational Hepatology 2021年第4期9卷 503-513页

作者： Yongyuan Zheng Shu Zhu Xingrong Zheng wenxiong xu xuejun Li Jianguo Li Zhiliang Gao Chan Xie Liang Peng Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Province Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

Background and Aims:The safety and efficacy of mesenchymal stem cells(MSCs)in the treatment of acute-onchronic liver failure(ACLF)have been ***,the impact of the pathological ACLF microenvironment on MSCs is less well *** study was designed to explore the changes in the functional properties of MSCs exposed to ACLF ***:MSCs were cultured in the presence of 10%,30%and 50%serum concentrations from ACLF patients and healthy ***,the cell morphology,phenotype,apoptosis and proliferation of MSCs were evaluated,including the immunosuppressive ***,mRNA sequencing analysis was used to identify the molecules and pathways involved in MSC functional changes in the context of ***:In the presence of ACLF serum,MSC morphology significantly changed but phenotype did ***,MSC proliferation activity was weakened,while the apoptosis rate was lightly *** importantly,the immunosuppressive function of MSCs was enhanced in a lowconcentration serum environment but transformed into a proinflammatory response in a high-concentration serum *** sequencing indicated that 10%serum concentration from ACLF patients mediated the PI3K-Akt pathway to enhance the anti-inflammatory effect of MSCs,while the 50%serum concentration from ACLF patients promoted the conversion of MSCs into a proinflammatory function by affecting the cell ***:The 50%ACLF serum concentration is more similar to the environment in the human body,which means that direct peripheral blood intravenous infusion of MSCs may reduce the effect of *** treatments of plasma exchange to reduce harmful substances in serum may promote MSCs to exert a stronger anti-inflammatory effect.

关键词： Mesenchymal stem cells Acute-on-chronic liver failure Immu-nomodulatory Cell therapy Microenvironment

The relationship between zinc deficiency and infectious complications in patients with hepatitis B virus-related acute-on-chronic liver failure

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Gastroenterology Report 2022年第1期10卷 552-558页

作者： Xinhua Li Lu Wang Na He Yeqiong Zhang Jiahui Pang Heping Wang Meng Yu Yongyu Mei Liang Peng wenxiong xu Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Key Laboratory of Tropical Disease Control(Sun Yat-sen University) Ministry of EducationGuangzhouGuangdongP.R.China Department of Diagnostics Second School of Clinical MedicineBinzhou Medical UniversityYantaiShandongP.R.China

Background The prevalence of zinc deficiency is high in patients with chronic liver disease,but few studies have hitherto explored the relationship between the serum zinc level and hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACLF).This study aimed to assess the association between zinc deficiency and infectious complications,and model for end-stage liver disease(MELD)score in patients with HBV-related *** Patients with HBV-related ACLF from the Department of Infectious Diseases of the Third Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)between January 2019 and December 2019 were retrospectively analysed in this *** demographic,clinical,and laboratory data were retrieved from the hospital information system and *** Student’s t-test was used for normally distributed continuous variables between two groups and the Chi-square test was used for categorical *** and multivariate logistic regression analyses were applied to identify independent *** A total of 284 patients were included in this study,including 205 liver cirrhosis and 79 non-cirrhosis *** proportion of patients with zinc deficiency was the highest(84.5%),followed by subclinical zinc deficiency(14.1%)and normal zinc level(1.4%).Patients in the zinc deficiency group had a higher MELD score than the subclinical zinc deficiency or normal zinc group(P=0.021).Age,total bilirubin,and serum zinc level were independent factors for infection(P_(s)<0.05).The serum zinc level in patients without complications at admission was significantly higher than that in patients with complications(P=0.004).Moreover,the serum zinc level in patients with prothrombin time activity(PTA)of<20%was significantly lower than that in patients with 20%≤PTA<30%(P=0.007)and that in patients with 30%≤PTA<40%(P<0.001).Conclusions Zinc deficiency is common in patients with HBV-related *** deficiency is closely associated with infectious complicati

关键词： hepatitis B virus acute-on-chronic liver failure mortality zinc complications

Analysis of a delayed epidemic model with non-monotonic incidence rate and vertical transmission

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International Journal of Biomathematics 2014年第4期7卷 103-119页

作者： Jinhu xu wenxiong xu Yicang Zhou School of Mathematics and Statistics Xi ' an Jiaotong University Xi'an 710049 P. R. China

A delayed SEIR epidemic model with vertical transmission and non-inonotonic incidence is formulated. The equilibria and the threshold of the model have been determined on the bases of the basic reproduction number. The local stability of disease-free equilib- rium and endemic equilibrium is established by analyzing the corresponding character- istic equations. By comparison arguments, it is proved that, if Ro 〈 1, the disease-free equilibrium is globally asymptotically stable. Whereas, the disease-free equilibrium is unstable if R0 〉 1. Moreover, we show that the disease is permanent if the basic repro- duction number is greater than one. Furthermore, the sufficient conditions are obtained for the global asymptotic stability of the endemic equilibrium when R0 〉 1.

关键词： SEIR epidemic model basic reproduction number vertical transmission permanent.

ASYMPTOTICAL ANALYSIS OF A REACTIONDIFFUSION EQUATIONS D-SIS EPIDEMIC MODEL

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Annals of Differential Equations 2007年第2期23卷 225-233页

作者： xu wenxiong Yin Hongwei xu Zongben School of Science Xi＇an Jiaolong University Xi＇an 710049

By monotone methods and invariant region theory, a reaction-diffusion equations D-SIS epidemic model with bilinear rate is studied. The existence and uniqueness of the solution of the model are proved. The basic reproductive number which determines whether the disease is extinct or not is found. The globally asymptotical stability of the disease-free equilibrium and the endemic equilibrium are obtained. Some results of the ordinary differential equations model are extended to the present partial differential equations model.

关键词： epidemiology mathematical model reaction-diffusion equations threshold. global stability

Long-term hepatitis B surface antigen kinetics after nucleos(t)ide analog discontinuation in patients with noncirrhotic chronic hepatitis B

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Liver Research 2024年第3期8卷 179-187页

作者： Lina Wu Jiadi Lai Qiumin Luo Yeqiong Zhang Chaoshuang Lin Dongying Xie Youming Chen Hong Deng Zhiliang Gao Liang Peng wenxiong xu Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Key Laboratory of Tropical Disease Control Ministry of EducationSun Yat-sen UniversityGuangzhouGuangdongChina

Background and aim Few studies have reported hepatitis B surface antigen(HBsAg)kinetics after nucleos(t)ide analog(NA)discontinuation in patients with noncirrhotic chronic hepatitis B(CHB).The study specifically investigated long-term HBsAg kinetics after NA *** Between January 2014 to January 2024,this study prospectively enrolled 106 outpatients with noncirrhotic CHB who met the discontinuation criteria after NA consolidation ***,clinical,and laboratory data were collected and analyzed after NA *** Ninety-six patients who finished 5 years of follow-up were *** remained undetectable in 29 patients with end of treatment(EOT)HBsAg *** 67 patients with EOT HBsAg positivity,HBsAg seroclearance occurred in 12(17.9%)patients with an estimated annual incidence of HBsAg seroclearance of 3.6%.Patients with EOT HBsAg levels of≤1000 IU/mL had a higher HBsAg seroclearance rate than those with EOT HBsAg levels of>1000 IU/mL(33.3%vs.5.4%).The proportion of patients with HBsAg≤1000 IU/mL increased during *** regression analysis indicated that the EOT HBsAg level was an independent factor for HBsAg seroclearance and an HBsAg level decline exceeding 1 log10 IU/*** optimal EOT HBsAg cutoff for both HBsAg seroclearance and an HBsAg level decline exceeding 1 log10 IU/mL was 359 IU/*** Patients with EOT HBsAg negativity experienced no relapse and maintained HBsAg seroclearance during 5 years of follow-up after NA discontinuation.A higher HBsAg seroclearance rate can be obtained in patients with EOT HBsAg levels of≤1000 IU/mL during 5 years of follow-up after NA *** monitoring and proper NA retreatment are recommended to guarantee the safety of NA discontinuation.

关键词： Hepatitis B virus(HBV) Chronic hepatitis B(CHB) Hepatitis B surface antigen(HBsAg) Nucleos(t)ide analogs(NAs) Quantitative HBsAg Kinetics

Double Plasma Molecular Adsorption System with Sequential Low-dose Plasma Exchange in Patients with Hepatitis B Virus-related Acute-on-chronic Liver Failure:A Prospective Study

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Journal of Clinical and Translational Hepatology 2023年第4期11卷 908-917页

作者： Lu Wang wenxiong xu Shu Zhu Guoli Lin Jing Lai Yufeng Zhang Ying Liu Lihua Zheng Qiumin Luo Zhiliang Gao Chan Xie Liang Peng Second School of Clinical Medicine Binzhou Medical UniversityYantaiShandongChina Department of Infectious Diseases Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdongChina Key Laboratory of Tropical Disease Control(Sun Yat-sen University) Ministry of EducationGuangzhouGuangdongChina

Background and Aims:To investigate the safety and efficacy of double plasma molecular adsorption system(DPMAS)with sequential low-dose plasma exchange(LPE)in treating early hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF).Methods:Clinical data of patients with HBVACLF were prospectively collected,including patients in a DPMAS with sequential LPE(DPMAS+LPE)group and those in a standard medical treatment(SMT)*** primary endpoint was death or liver transplantation(LT)at 12 weeks of ***-score matching was performed to control the effects of confounding factors on prognosis between the two ***:After 2 weeks,total bilirubin,alanine aminotransferase,blood urea nitrogen levels,and Chinese Group on the Study of Severe Hepatitis B score,were significantly lower in the DPMAS+LPE group than those in the SMT group(p<0.05).After 4 weeks,laboratory parameters of the two groups were *** cumulative survival rate of the DPMAS+LPE group was significantly higher than that of the SMT group at 4 weeks(97.9%vs.85.4%,p=0.027),but not at 12 weeks(85.4%vs.83.3%,p=0.687).Cytokine levels were significantly lower in 12-week survival group than in the death-or-LT group(p<0.05).Functional enrichment analysis showed that downregulated cytokines were mainly involved in positive regulation of proliferation and activation of lymphocytes and monocytes,regulation of immune effect response,regulation of endotoxin response,and glial cell ***:DPMAS+LPE significantly improved the 4-week cumulative survival rate,and ameliorated the inflammatory response in ***+LPE may be a promising modality for patients with early HBV-ACLF.

关键词： Plasma exchange Double plasma molecular adsorption system Acute-on-chronic liver failure Prognosis

All-optical generation,detection,and manipulation of picosecond acoustic pulses in 2D semiconductor/dielectric heterostructures

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Photonics Research 2023年第12期11卷 2000-2010页

作者： wenxiong xu YUANYUAN LI QIANNAN CUI HE ZHANG CHUANSHENG XIA HAO GUO GUANGQUAN ZHOU JIANHUA CHANG HUI ZHAO JUN WANG ZHONGZE GU CHUNXIANG xu State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Electronic and Information Engineering Nanjing University of Information Science and TechnologyNanjing 210044China Department of Physics and Astronomy The University of KansasLawrenceKansas 66045USA Laboratory of Micro-Nano Optoelectronic Materials and Devices Key Laboratory of Materials for High-Power LaserShanghai Institute of Opticsand Fine MechanicsChinese Academy of SciencesShanghai 201800China

Launching,tracking,and controlling picosecond acoustic(PA)pulses are fundamentally important for the construction of ultrafast hypersonic wave sources,ultrafast manipulation of matter,and spatiotemporal imaging of ***,we show that GHz PA pulses can be all-optically generated,detected,and manipulated in a 2D layered MoS_(2)∕glass heterostructure using femtosecond laser *** on an interferometric model,PA pulse signals in glass are successfully decoupled from the coexisting temperature and photocarrier relaxation and coherent acoustic phonon(CAP)oscillation signals of MoS_(2)lattice in both time and frequency *** selective interface excitations,temperature-mediated interfacial phonon scatterings can compress PA pulse widths by about 50%.By increasing the pump fluences,anharmonic CAP oscillations of MoS_(2)lattice are *** a result,the increased interatomic distance at the MoS_(2)∕glass interface that reduces interfacial energy couplings can markedly broaden the PA pulse widths by about 150%.Our results open new avenues to obtain controllable PA pulses in 2D semiconductor/dielectric heterostructures with femtosecond laser pump-probe,which will enable many investigations and applications.

关键词： pump heterostructure scattering

Establishment of the Effectiveness of Follow-Up Protocols for Patients under COVID-19 Epidemic

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Open Journal of Nursing 2020年第10期10卷 977-988页

作者： Juan Wang Meiling Zhang Yuanli Chen Lili Li wenxiong xu Liang Peng Deparment of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen University Guangzhou China

Objectives: To control the Corona Virus Disease (COVID-19) epidemic, it is meaningful to improve the home quarantine ability and home-quarantine compliancy of patients released from medical isolation, and to prevent cross-contamination. This study aimed to up protocols for COVID-19 patients released from medical isolation. Methods: A total of 35 patients discharged from the isolation ward of the Third Affiliated Hospital of Guangzhou Sun Yat-sen University from January 22, 2020 to February 18, 2020 were included. The patients received health education through discharge preparation, education leaflets and videos. The patients were followed up on the 2nd, 7th and 14th day after discharge through WeChat and phone call. On the 2nd and 14th day after discharge, the patients completed the knowledge assessment, self-perceived burden survey and satisfaction survey using a self-made home quarantine knowledge paper. Results: There were statistical differences in the knowledge and understanding of home quarantine and self-perceived burden between the 2nd day and 14th day after home quarantine (P Conclusion: By improving the discharge preparation, conducting in-time follow-up after discharge via WeChat and phone call, and performing multi-channel health education, the follow-up researchers could help the patients perform a more effective home quarantine, which could effectively prevent the spread of COVID-19 epidemic.

关键词： Novel Coronavirus Pneumonia (COVID-19) Home Quarantine Discharge Preparation Follow-Up

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积极探索新的途径

高校理论战线 2009年第7期 44-45页

作者：徐文雄西安交通大学学工部部长 710049

新形势下如何利用新媒体为大学生思想政治教育工作服务，这是高校思想政治教育工作者需要迫切解决的问题。总的来说．新媒体时代的大学生思想政治教育必须加强对大学生行为本身的引导、分析和教育，同时也要积极探索新的途径．把握利用... 详细信息

新形势下如何利用新媒体为大学生思想政治教育工作服务，这是高校思想政治教育工作者需要迫切解决的问题。总的来说．新媒体时代的大学生思想政治教育必须加强对大学生行为本身的引导、分析和教育，同时也要积极探索新的途径．把握利用好新媒体．使它为大学生思想政治教育所用．

关键词：思想政治教育工作者大学生思想政治教育新媒体时代大学生行为利用