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Curcumin inhibits colorectal cancer development by blocking the YAP/TAZ signaling axis

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BIOCELL 2024年第3期48卷 443-451页

作者： FEI SHA DAISHAN XIN JUN XU ZHIWEI ZHENG wenxin lin XIAORUI CAI FEI lin MINGHAO ZHENG JIAOlinG CHEN Department of Pharmacy Affiliated Cancer Hospital of Shantou University School of MedicineShantouChina Department of Pharmacy Shantou University Mental Health CenterShantouChina Static Distribution Center Affiliated Cancer Hospital of Shantou University School of MedicineShantouChina

Background:Curcumin is a plant polyphenol with antitumor properties and inhibits the development of colorectal cancer(CRC).However,as the molecular mechanism associated is still unclear,our study aimed to explore the underlying molecular mechanisms by which curcumin inhibits ***:HT29 and SW480 cells were treated with curcumin or/and Doxycycline(DOX),and cell viability,colony forming ability,migration and invasion were conﬁrmed by cell counting kit-8(CCK-8),colony forming,Transwell *** Yes-associated protein 1(YAP)and PDZ-binding motif(TAZ)signaling-related genes or proteins were analyzed using reverse transcription quantitative real-time PCR(RT-qPCR),western blot,and immunoﬂuorescence *** nude mice xenograft tumor model was constructed,YAP and Ki67 expressions were tested by immunohistochemistry(IHC)***:In our study,we proved that curcumin signiﬁcantly inhibited the CRC cell viability,cell migration,and cell invasion *** addition,curcumin inhibited YAP and Transcriptional coactivator with TAZ or the YAP/TAZ signaling axis in CRC ***,in the nude mice model,curcumin treatment signiﬁcantly decreased the size and weight of xenotransplant ***:Therefore,curcumin signiﬁcantly inhibited CRC development and invasion by regulating the YAP/TAZ signaling axis.

关键词： Curcumin Colorectal cancer YAP/TAZ signaling axis

Expressing a human RNA demethylase as an assister improves gene-editing efficiency in plants

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Molecular Plant 2024年第3期17卷 363-366页

作者： Mengyan Bai wenxin lin Chunyan Peng Peizhe Song Huaqin Kuang Jieni lin Jieping Zhang Jiyao Wang Bo Chen Huarong Li Fanjiang Kong Guifang Jia Yuefeng Guan Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design Innovative Center of Molecular Genetics and EvolutionSchool of Life SciencesGuangzhou UniversityGuangzhou 510006China College of Agronomy China Agricultural UniversityBeijing 100193China College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhouFujian 350002China Synthetic and Functional Biomolecules Center Bejing National Laboratory for Molecular SciencesKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Kingagroot Co. Ltd.QingdaoShandong 266000China Tsinghua University-Peking University Joint Center for Life Sciences Bejing 100871China

Dear Editor,Despite myriad successful applications of gene editing in plant functional genomics research and precision breeding,many challenges persist around the efficiency of gene-editing tools for many plant *** instance,soybean(Glycine max)is a major crop providing oil and protein to human diets and feedstock,but its gene-editing efficiency remains relatively low(Bai et al.,2019).

关键词： editing breeding

艾司氯胺酮联合纳布啡用于剖宫产术后的镇痛效果及其对产后抑郁的影响

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实用药物与临床 2024年第3期27卷 197-201页

作者：郑青麒林全阳马保新林文新厦门大学附属中山医院手术麻醉科福建厦门361004

目的探讨艾司氯胺酮联合纳布啡用于择期剖宫产术后镇痛效果,及其对产后抑郁(PPD)发生率的影响,评价联合用药的有效性和安全性。方法选择我院择期行剖宫产术的产妇60例,随机分为艾司氯胺酮+纳布啡组(EN组)和纳布啡组(N组),每组30例。所... 详细信息

目的探讨艾司氯胺酮联合纳布啡用于择期剖宫产术后镇痛效果,及其对产后抑郁(PPD)发生率的影响,评价联合用药的有效性和安全性。方法选择我院择期行剖宫产术的产妇60例,随机分为艾司氯胺酮+纳布啡组(EN组)和纳布啡组(N组),每组30例。所有产妇均采用腰-硬联合麻醉,术后均给予自控静脉镇痛(PCIA)。EN组镇痛方案:艾司氯胺酮0.5 mg/kg+纳布啡1.5 mg/kg,用生理盐水稀释至150 ml;N组镇痛方案:纳布啡2.0 mg/kg用生理盐水稀释至150 ml。记录两组患者术后4 h、8 h、12 h、24 h、36 h、48 h的静息、运动视觉模拟评分法(VAS)评分,记录PCIA总用量;记录产前1 d以及术后第3天、第5天、第14天、第28天爱丁堡产后抑郁量表(EPDS)得分和产后抑郁发生率;记录其他情况和不良反应。结果EN组术后8 h、12 h、24 h、36 h的静息和运动VAS评分低于N组(P0.05)。结论艾司氯胺酮联合纳布啡用于剖宫产术后镇痛,可明显减轻产妇静息和运动时疼痛,降低术后14 d内产后抑郁的发生率,利于产妇早期康复和母乳喂养,且无明显不良反应。

关键词：艾司氯胺酮纳布啡术后镇痛产后抑郁

Multiplex genome editing targeting soybean with ultra-low anti-nutritive oligosaccharides

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The Crop Journal 2023年第3期11卷 825-831页

作者： wenxin lin Huaqin Kuang Mengyan Bai Xiaomeng Jiang Pengfei Zhou Yinghua Li Bo Chen Huarong Li Yuefeng Guan College of Resources and Environment Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design Guangzhou Key Laboratory of Crop Gene EditingInnovative Center of Molecular Genetics and EvolutionSchool of Life SciencesGuangzhou UniversityGuangzhou 510006GuangdongChina FAFU-UCR Joint Center for Horticultural Biology and Metabolomics Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Bioinformatics Department School of Life Sciences and TechnologyTongji UniversityShanghai 200092China KingAgroot CropScience Co. Ltd.Qingdao 266500ShandongChina

Soybean is the primary source of plant protein for *** to the indigestibility of the raffinose family of oligosaccharides(RFO),raffinose and stachyose are considered anti-nutritive factors in soybean ***-RFO soybean cultivars are generated by mutagenesis of RFO biosynthesis genes,but the carbohydrate profiles invite further modification to lower *** study employed a pooled multiplex genome editing approach to target four seed-specifically expressed genes mediating RFO biosynthesis,encoding three raffinose synthases(RS2,RS3,and RS4)and one stachyose *** T1progeny,rs2/rs3 and rs4/sts homozygous double mutants and a rs2/rs3/rs4/sts quadruple mutant(rfo-4m)were *** rs2/rs3 mutant showed reduced raffinose and stachyose contents,but the rs4/sts mutant showed only reduced stachyose in *** RFO contents in the rfo-4m mutant were almost *** analysis showed that the mutation of four RFO biosynthesis genes led to a shift of metabolic profile in the seeds,including the accumulation of several oligosaccharides-related *** mutants could contribute to precision breeding of soybean cultivars for soy food production.

关键词： Soybean Genome editing Raffinose family of oligosaccharides Raffinose Stachyose Precision breeding

Light-triggered fluorochromic cholesteric liquid crystal elastomer with hydrogen-bonded fluorescent switch: dualmodal-switchable circularly polarized luminescence

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Science China Chemistry 2024年第8期67卷 2719-2727页

作者： Siyang lin Tianqi Ren Xianyu Meng wenxin Kang Jinbao Guo Key Laboratory of Carbon Fibers and Functional Polymers Ministry of EducationCollege of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Solid materials with dynamically tunable circularly polarized luminescence(CPL) feature higher security levels and devicefriendly characteristics, showing great superiority in the field of information technology and anti-counterfeiting. To address the limited photoisomerization of fluorescent photoswitch in CPL-active solid materials, here a cholesteric liquid crystal elastomer(CLCE) containing a hydrogen-bonded(H-bonded) polymerizable fluorescent switch AHBA-PSD is prepared. Owing to the good flexibility and low glass-transition temperature of CLCE, AHBA-PSD shows a fast and fully reversible photocyclization/cycloreversion with fluorochromic behavior in CLCE. Further, by controlling the spectral overlapping area between the emission and reflection bands, the CLCE exhibits a strong CPL with a g_(lum) value of up to 0.76 accompanied by a reversible phototunable CPL signal. Meanwhile, the H-bond helps to stabilize the mechanical property, and the force-induced switching-off of CPL signal could be achieved due to the destroyed helical structures by external force. Finally, an automatically-recognized identification card with abundant chiroptical information is demonstrated.

关键词： cholesteric liquid crystal elastomer circularly polarized luminescence fluorescent photoswitch diarylethene photoismerization

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Combination of two multiplex genome-edited soybean varieties enables customization of protein functional properties

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Molecular Plant 2022年第7期15卷 1081-1083页

作者： Mengyan Bai Cuicui Yuan Huaqin Kuang Qian Sun Xinchen Hu Luning Cui wenxin lin Chunyan Peng Peng Yue Shikui Song Zebin Guo Yuefeng Guan College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhouFujian 350002China FAFU-UCR Joint Center for Horticultural Biology and Metabolomics Haixia Institute of Science and TechnologyFujian Agriculture and Forestry UniversityFuzhou 350002China Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design Innovative Center of Molecular Genetics and EvolutionSchool of Life SciencesGuangzhou UniversityGuangzhou 510006China College of Food Sciences Fujian Agriculture and Forestry UniversityFuzhouFujian 350002China Shofine Seeds Co. Ltd.JiningShandong 272400China College of Resources and Environment Fujian Agriculture and Forestry UniversityFuzhouFujian 350002China

Dear Editor,Soybean(Glycine max)is a major source of plant-based protein for people worldwide,providing a healthy,affordable,and environmentally friendly alternative to animal-based protein(Montgomery,2003).It has been estimated that there are currently over 12000 food products that contain soy protein(Montgomery,2003).Different food applications of soy protein require distinct properties that affect its function and sensory *** instance,the sensory quality of soymilk is significantly affected by protein emulsibility,whereas tofu quality is determined by protein-gelling ability(Kinsella,1979).

关键词： Montgomery enable soybean

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有机发光二极管老化机制

发光学报 2023年第1期44卷 186-197页

作者：牛泉郝洪敏林雯欣黄江夏华南理工大学发光材料与器件国家重点实验室广东广州510640

有机发光二极管(OLEDs)因在照明和显示领域的巨大潜在应用备受人们关注。在过去的三十年里,OLED器件的效率和寿命有了很大的提高,但对于商业应用而言提高器件寿命仍然是亟待解决的问题之一。为了进一步提升器件稳定性,则需要深入地研究O... 详细信息

有机发光二极管(OLEDs)因在照明和显示领域的巨大潜在应用备受人们关注。在过去的三十年里,OLED器件的效率和寿命有了很大的提高,但对于商业应用而言提高器件寿命仍然是亟待解决的问题之一。为了进一步提升器件稳定性,则需要深入地研究OLED内部存在的老化机理。本文以小分子和聚合物OLEDs为例,综述了两种器件的老化机制。概括了OLED的一些外在和内在老化机制,并介绍了小分子和聚合物OLEDs老化机理的研究进展。对于小分子OLEDs,有研究提出其老化机理是激子与极化子的相互作用,形成陷阱导致器件老化。另一种理论认为激子与极化子的作用诱导分子聚集,促进界面老化。而对于聚合物OLEDs老化机理是激子与空穴相互作用,诱导空穴陷阱产生,导致了亮度、效率损失和驱动电压上升的现象。同时综述了目前一部分延长器件寿命的方案,为后续开发效率更高、寿命更长的OLED器件提供积极作用。

关键词：有机发光二极管退化机制器件寿命稳定性

Photosensitized damage to telomere overhang and telomerase RNA by riboflavin

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Progress in Natural Science:Materials International 2008年第4期18卷 401-404页

作者： Yuxia Liu, Fuqiang Du, Weizhen lin , Tiecheng Tu, wenxin Li, Nianyun lin Key Laboratory of Nuclear Analysis Techniques, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China Key Laboratory of Nuclear Analysis Techniques Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China

By ESR spin elimination and photocleavage assay, the mechanisms of one-electron oxidation damage of oligonucleotides by excited triplet state of riboflavin (Rb) have been elucidated. The results demonstrate that Rb, an endogenous photosensitizer, is capable of cleav- ing single-stranded telomeric overhang and the template region of telomerase RNA under UVA irradiation, resulting in blocking of reverse transcription of telomeric DNA which leads to the apoptosis of cancer cells ultimately.

关键词： Telomere Telomerase Riboflavin ESR spin elimination Excited triplet state

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基于AE信号的切入式磨削模型及工艺试验

农业装备与车辆工程 2022年第3期60卷 83-86,91页

作者：林文鑫上海理工大学机械工程学院上海市200093

针对切入式磨削数控机床的在线监测需求,根据声发射信号强度与磨削力的关系以及传统磨削力理论模型,建立了基于AE信号的切入式磨削均方根曲线理论模型。开展了基于AE信号的磨削工艺试验,分析了不同工装方式、不同加工位置、不同工件材... 详细信息

针对切入式磨削数控机床的在线监测需求,根据声发射信号强度与磨削力的关系以及传统磨削力理论模型,建立了基于AE信号的切入式磨削均方根曲线理论模型。开展了基于AE信号的磨削工艺试验,分析了不同工装方式、不同加工位置、不同工件材质等磨削重要因素对磨削过程中AE信号的影响规律。对AE信号均方根曲线理论模型进行了试验验证。试验结果表明,所建立的基于AE信号的切入式磨削曲线模型对磨削过程中的AE信号具有良好的预测精度。

关键词：声发射信号切入式磨削在线监测磨削试验陶瓷材料