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Screening COVID-19 from chest X-ray images by an optical diffractive neural network with the optimized F number

Photonics Research 2024年第7期12卷 1410-1426页

作者： JIALONG WANG SHOUYU CHAI wenting gu BOYI LI XUE JIANG YUNXIANG ZHANG HONGEN LIAO XIN LIU DEAN TA Academy for Engineering and Technology Fudan UniversityShanghai 200433China Center for Biomedical Engineering Fudan UniversityShanghai 200433China Department of Chemistry Fudan UniversityShanghai 200433China Department of Biomedical Engineering School of MedicineTsinghua UniversityBeijing 100084China

The COVID-19 pandemic continues to significantly impact people's lives worldwide, emphasizing the critical need for effective detection methods. Many existing deep learning-based approaches for COVID-19 detection offer high accuracy but demand substantial computing resources, time, and energy. In this study, we introduce an optical diffractive neural network(ODNN-COVID), which is characterized by low power consumption, efficient parallelization, and fast computing speed for COVID-19 detection. In addition, we explore how the physical parameters of ODNN-COVID affect its diagnostic performance. We identify the F number as a key parameter for evaluating the overall detection capabilities. Through an assessment of the connectivity of the diffractive network, we established an optimized range of F number, offering guidance for constructing optical diffractive neural networks. In the numerical simulations, a three-layer system achieves an impressive overall accuracy of 92.64% and 88.89% in binary-and threeclassification diagnostic tasks. For a single-layer system, the simulation accuracy of 84.17% and the experimental accuracy of 80.83% can be obtained with the same configuration for the binary-classification task, and the simulation accuracy is 80.19% and the experimental accuracy is 74.44% for the three-classification task. Both simulations and experiments validate that the proposed optical diffractive neural network serves as a passive optical processor for effective COVID-19 diagnosis, featuring low power consumption, high parallelization, and fast computing capabilities. Furthermore, ODNN-COVID exhibits versatility, making it adaptable to various image analysis and object classification tasks related to medical fields owing to its general architecture.

关键词： neural network offering

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动力短舱多点气动优化设计

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航空科学技术 2024年第2期35卷 23-30页

作者：顾文婷马坤韩杰航空工业第一飞机设计研究院陕西西安710089

跨声速发动机短舱的设计过程十分复杂,其设计往往需要在相互矛盾的设计要求中进行权衡。本文针对带动力短舱多点气动设计问题,采用类别形状函数变换法(CST)进行几何外形参数化,结合Kriging代理模型、Pareto遗传算法和松散式代理模型管... 详细信息

跨声速发动机短舱的设计过程十分复杂,其设计往往需要在相互矛盾的设计要求中进行权衡。本文针对带动力短舱多点气动设计问题,采用类别形状函数变换法(CST)进行几何外形参数化,结合Kriging代理模型、Pareto遗传算法和松散式代理模型管理框架,构建了动力短舱多点优化设计平台。在巡航状态,优化目标是降低短舱外表面最大马赫数使短舱阻力减小,提高外流性能;在最大推力状态,优化目标是降低进气道最大马赫数使进气品质提升,提高内流性能。与初始短舱相比,优化设计结果在两个设计点性能上均有所提高,最大马赫数在巡航状态最多降低5%,而在最大推力状态最多降低10%。参数影响规律表明,短舱头部参数对外流和内流性能影响较大,且影响规律不同,应作为短舱综合优化设计的主要参数,并采用不同的优化设计策略。Pareto前沿阵面可以给出满足不同工程设计要求的最优方案。研究结果表明,本文建立的优化设计平台为动力短舱设计提供了有效工具,优化设计结果具有工程参考价值。

关键词：动力短舱类别形状函数变换法 Pareto遗传算法 Kriging代理模型多点优化

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血必净联合血液净化治疗重症急性胰腺炎合并MODS的效果分析

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系统医学 2024年第11期9卷 73-76,83页

作者：缪翠维殷韵顾雯婷南通市中医院重症监护室江苏南通226000

目的探讨血必净联合血液净化治疗在重症急性胰腺炎(Severe Acute Pancreatitis, SAP)合并多器官功能障碍综合征(Multiple Organ Dysfunction Syndrome, MODS)患者中的应用价值。方法回顾性选取2020年10月—2023年10月南通市中医院收治... 详细信息

目的探讨血必净联合血液净化治疗在重症急性胰腺炎(Severe Acute Pancreatitis, SAP)合并多器官功能障碍综合征(Multiple Organ Dysfunction Syndrome, MODS)患者中的应用价值。方法回顾性选取2020年10月—2023年10月南通市中医院收治的80例SAP合并MODS患者的临床资料,根据治疗方法的差异性进行分组,每组40例,对照组在常规治疗的基础上加用血液净化治疗,观察组在对照组的基础上加用血必净。比较两组临床症状缓解情况、MODS评分、急性胰腺炎床边严重度指数(Bedside Index for Severity in Acute Pancreatitis, BISAP)、C-反应蛋白(C-reactive Protein, CRP)、白细胞介素-6(Interleukin-6, IL-6)、氧合指数与血清肌酐水平。结果观察组BISAP评分、MODS评分为(1.44±0.47)分、(2.95±0.95)分,低于对照组的(2.06±0.54)分、(3.97±0.97)分,差异有统计学意义(t=5.477、4.751,P均<0.05)。观察组的临床症状缓解时间均短于对照组,氧合指数高于对照组,CRP、IL-6与肌酐水平低于对照组,差异有统计学意义(P均<0.05)。结论在SAP合并MODS患者治疗中,采用血必净联合血液净化治疗,能够缩短主要症状的缓解时间,改善患者的病情,减轻炎症反应,对呼吸、肾脏损伤也有一定的保护作用。

关键词：急性胰腺炎多器官功能障碍血必净临床症状炎症反应

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Nacelle-airframe integration design method for blended-wing-body transport with podded engines

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Chinese Journal of Aeronautics 2019年第8期32卷 1860-1868页

作者： Zhenqing XIN Zhenli CHEN wenting gu Gang WANG Zhaoguang TAN Dong LI Binqian ZHANG School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Shanghai Aircraft Design and Research Institute Commercial Aircraft Corporation of ChinaLtd.Shanghai 200232China

Strong shock waves and flow separation often occur during the integration of nacelle and airframe for blended-wing-bodies with podded engines. To address this problem, this paper presents an integration method with numerical simulations. The philosophy of channeling flow and avoiding the throat effect on the nacelle and airframe is established based on the analysis of flow interference in the initial configuration. A parametric integration design method is proposed from twodimensional plane to three-dimensional space with control mechanisms and selection principles of the key parameters determined by their influences. Results show that strong shock waves and flow separation can be successfully eliminated under the influence of both the reshaped channel and decelerated inflow below the nacelle. Supersonic regions around the nacelle are effectively reduced, concentrating mainly on the lip position. Thus, a significant cruise drag reduction(8.7%) is achieved though the pressure drag of the nacelle increases.

关键词： Blended-wing-body Computational fluid dynamics Drag reduction Flow interference Nacelle-airframe integration

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Effects of stability margin and thrust specific fuel consumption constrains on multi-disciplinary optimization for blended-wing-body design

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Chinese Journal of Aeronautics 2019年第8期32卷 1847-1859页

作者： Minghui ZHANG Zhenli CHEN Zhaoguang TAN wenting gu Dong LI Changsheng YUAN Binqian ZHANG School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Shanghai Aircraft Design and Research Institute Commercial Aircraft Corporation of ChinaLtd.Shanghai 200232China

Blended-Wing-Body(BWB) configuration, as an innovative transport concept, has become a worldwide research focus in the field of civil transports development. Relative to the conventional Tube-And-Wing(TAW) configuration, the BWB shows integrated benefits and serves as a most promising candidate for future ‘‘green aviation'. The objective of the present work is to figure out the effects of the stability margin and Thrust Specific Fuel Consumption(TSFC) on the BWB design in the framework of Multi-Disciplinary Optimization(MDO). A physically-based platform was promoted to study the effect static stability margin and engine technology level. Low-order physically based models are applied to the evaluation of the weight and the aerodynamic performance. The modules and methods are illustrated in detail, and the validation of the methods shows feasibility and confidence for the conceptual design of BWB aircrafts. In order to find out the relation between planform changes and the selection of stability and engine technology level, two sets of optimizations are conducted separately. The study proves that these two factors have dominant effects towards the optimized BWB designs in both aerodynamic shapes, weight distribution, which needs to be considered during the MDO design process. A balance diagram analysis is applied to find out a reasonable static stability margin range. It can be concluded that a recommended stability margin of a practical BWB commercial aircraft can be half of that of a conventional TAW design.

关键词： Aerodynamic design Blended-wing-body Multi-disciplinary optimization Optimization design Thrust specific fuel consumption

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老年冠心病患者心脏康复运动依从性调查及影响因素分析

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老年医学与保健 2024年第2期30卷 320-324,342页

作者：梁晓慧谷文婷王晓华李翠秦皇岛市第一医院全科医疗科河北秦皇岛066000

目的调查老年冠心病(CHD)患者心脏康复运动依从性并分析影响因素。方法选取2022年1月-2022年12月秦皇岛市第一医院收治的老年CHD患者200例,使用一般资料调查表、心脏康复运动依从性问卷进行调查,Logistic回归方法分析相关因素。结果200... 详细信息

目的调查老年冠心病(CHD)患者心脏康复运动依从性并分析影响因素。方法选取2022年1月-2022年12月秦皇岛市第一医院收治的老年CHD患者200例,使用一般资料调查表、心脏康复运动依从性问卷进行调查,Logistic回归方法分析相关因素。结果200例老年CHD患者心脏康复运动依从性评分为(37.58±5.31)分,其中主动寻求运动建议维度条目均分最低,即(2.84±0.59)分;200例老年CHD患者中,75例(37.50%)运动依从性较差,125例(62.50%)运动依从性良好;心脏康复运动依从性较差组及良好组在受教育程度、合并症、家庭支持度、社会支持度、运动恐惧等方面比较存在明显差异(P<0.05);Logistic回归模型分析显示,受教育程度为初中及以下[OR(95%CI):1.879(1.269,2.792),P=0.002]、有合并症[OR(95%CI):2.784(1.490,5.203),P=0.001]、家庭支持度差[OR(95%CI):2.309(1.382,3.859),P=0.002]、社会支持度差[OR(95%CI):2.020(1.338,3.048),P=0.001]、运动恐惧[OR(95%CI):2.119(1.340,3.352),P=0.001]均为影响老年CHD患者心脏康复运动依从性的独立危险因素。结论老年CHD患者心脏康复运动依从性处于中等水平,受教育程度、合并症、家庭支持度、社会支持度及运动恐惧可能是影响心脏康复运动依从性的主要因素。

关键词：老年冠心病心脏康复运动依从性影响因素

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一种高效的持续有向栅栏覆盖算法

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浙江工业大学学报 2024年第4期52卷 457-464页

作者：范兴刚廉晓聪贾立刚马天乐谷文婷姜新阳刘贾贤浙江工业大学计算机科学与技术学院浙江杭州310023 浙江工业大学之江学院浙江绍兴312030 绍兴中科移联信息科技有限公司浙江绍兴312030

如何高效实现持续有向栅栏覆盖是无线充电传感器网络的研究热点,采用射频能量捕获技术可以解决栅栏中节点能量受限的问题。在已知网络区域中构建栅栏的节点分布和候选部署位置的情况下,研究射频能量源(Energy source,ES)的部署方案,从... 详细信息

如何高效实现持续有向栅栏覆盖是无线充电传感器网络的研究热点,采用射频能量捕获技术可以解决栅栏中节点能量受限的问题。在已知网络区域中构建栅栏的节点分布和候选部署位置的情况下,研究射频能量源(Energy source,ES)的部署方案,从而满足所有节点的充电需求。首先,确定网络区域中的栅栏矩形;然后,提出一种基于有向发射的射频能量源最优部署算法(OdepD算法),根据候选位置与栅栏矩形的位置关系得到各个ES的射频能量发射方向和角度,根据有向能量发送模型和充电需求计算各个ES的发射功率;最后,以最小化网络充电总能耗为目标,通过离散粒子群优化充电部署位置,确定最终部署策略。仿真结果证明:OdepD算法可以明显降低网络充电总能耗,高效地实现持续栅栏覆盖。

关键词：栅栏覆盖有向能量发送模型发送能耗能量源部署充电效率

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Depletion of anti-CD47mAb in plasma by genetically modified cells for pre-transfusion testing

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Genes & Diseases 2024年第5期11卷 102-104页

作者： Fei Wang wenting Wang Xiaoshuang Wu Zhixin Liu Yafen Wang Rong Zhang Shunli gu Qunxing An Yaozhen Chen Xingbin Hu Department of Transfusion Medicine Xijing HospitalFourth Military Medical UniversityXi’anShaanxi 710032China Xi’an Medical University Xi’anShaanxi 710021China

Allogeneic red blood cell(RBC)transfusion is commonly performed in medical practice because of its efficacy and low-risk ***,pre-transfusion tests are susceptible to monoclonal antibody(mAb)interference.1 Currently,mAb therapies are being developed to treat many diseases,such as ***,certain mAbs,such as anti-CD38mAb and anti-CD47mAb,can bind to RBC membranes;this binding interferes with pre-transfusion tests.2 CD47 has gained considerable attention in recent years because of its potential as a therapeutic target for hematologic malignancies and solid tumors.3 The binding of anti-CD47mAb to RBCs may lead to false-positive results in pan-agglutination tests and cause delays and risks in establishing compatible RBCs for transfusion.

关键词： CD47 transfusion diseases

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3 - 37 Molecular Mechanism of an Early-maturity Mutant Induced by Carbon Ion Beam Irradiation in Sweet Sorghum

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IMP & HIRFL Annual Report 2013年第1期 106-107页

作者： Dong Xicun Liu Ruiyuan Li Wenjian gu wenting Jin Wenjie

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Identification of flavonoids and expression of anthocyanin biosynthetic genes in leaf color mutant induced by carbon ion beam in Wandering jew(Tradescantia fluminensis)

Identification of flavonoids and expression of anthocyanin b...

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2016年全国植物生物学大会

作者： Ruiyuan Liu wenting gu Wenjie Jin Xicun Dong Department of Biophysics Institute of Modern PhysicsChinese Academy of Sciences

Leaf color mutants are ideal materials for studying physiological processes in plants. Here,a thermossensitive leaf-color mutant of Green wandering jew was isolated after carbon ions irradiation,which was designated as mt. The color of young mutant leaves was more sensitive to variations of temperature,however,the young leaves of wild type remained green under low-temperature conditions(6°C-20°C). To elucidate the characteristics of pigmentation in mutant leaves under room temperature conditions(25°C) and low-temperature conditions(7°C),the ultra-structural,pigment composition,molecular mechanisms and anthocyanin accumulation involved in this phenomenon have been investigated in four independent experiments. The results showed that chloroplas ts of mutants exhibited abnormal morphology and distribution at 25 °C,and under low-temperature conditions(7°C),the chloroplasts converted into leucoplast in leaves on mutants. Temperature change affected the rate of color transition,chlorophyll and anthocyanin concentrations in leaves on mutants. Molecular analysis indicated that all the anthocyanin biosynthetic genes and regulatory genes were constitutively up-regulated in mutant leaves at 7°C. The other anthocyanin biosynthesis and regulatory genes showed similar expression levels between mutant and wild type except PAL,CHS,ANS were up-regulated at 25°C. HPLC analysis of anthocyanins in mutant and wild type leaves revealed that the contents of cyanidin,petunidin and delphinidin were significantly lower than those of under lowtemperature conditions(7°C) except pelargonidin was not detected in mutant leaves under room-temperature conditions(25°C). The HPLC profile also indicated the highest levels of flavonols in mutant leaves at 7°C significantly. Overall,above results indicated a close similarity among ultra-structures,pigment compositions,transcript amount and anthocyanin accumulation were tightly associated with temperature variation in leaves of leaf color mutant. These f

关键词： Wandering jew anthocyanin flavonols gene expression HPLC

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