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Advancements in personalized stem cell models for aging-related neurodegenerative disorders

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Neural Regeneration Research 2024年第11期19卷 2333-2334页

作者： mingxi weng Ralf Jauch School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Translational Stem Cell Biology Hong Kong Special Administrative RegionChina

Neurodegenerative diseases(NDDs)are a class of disorders characterized by the gradual loss or malfunction of specific cell populations in the nervous system,which can be triggered by genetic or environmental *** a result,patients often experience a decline in mobility,sensation,memory,and cognition,which can ultimately lead to a fatal *** global incidence of NDDs,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,amyotrophic lateral sclerosis(ALS),and multiple sclerosis,is increasing.

关键词： degenerative Huntington sensation

Supposition of graphene stacks to estimate the contact resistance and conductivity of nanocomposites

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Applied mathematics and mechanics(English Edition) 2024年第4期45卷 663-676页

作者： Y.ZARE m.T.mUNIR G.J.weng K.Y.RHEE Biomaterials and Tissue Engineering Research Group Department of Interdisciplinary TechnologiesBreast Cancer Research CenterMotamed Cancer InstituteTehran ***Iran College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait Department of mechanical and Aerospace Engineering Rutgers UniversityNew BrunswickNJ 08903U.S.A. Department of mechanical Engineering(BK21 Four) College of EngineeringKyung Hee UniversityYongin 446701Republic of Korea

In this study,the effects of stacked nanosheets and the surrounding interphase zone on the resistance of the contact region between nanosheets and the tunneling conductivity of samples are evaluated with developed equations superior to those previously *** contact resistance and nanocomposite conductivity are modeled by several influencing factors,including stack properties,interphase depth,tunneling size,and contact *** developed model's accuracy is verified through numerous experimental *** further validate the models and establish correlations between parameters,the effects of all the variables on contact resistance and nanocomposite conductivity are ***,the contact resistance is primarily dependent on the polymer tunnel resistivity,contact area,and tunneling *** dimensions of the graphene nanosheets significantly influence the conductivity,which ranges from 0 S/m to90 S/*** increased number of nanosheets in stacks and a larger gap between them enhance the nanocomposite's ***,the thicker interphase and smaller tunneling size can lead to higher sample conductivity due to their optimistic effects on the percolation threshold and network efficacy.

关键词： graphene polymer composite stacked nanosheet tunneling conductivity contact resistance interphase

SETD2 in cancer:functions,molecular mechanisms,and therapeutic regimens

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Cancer Biology & medicine 2024年第9期21卷 725-730页

作者： Yawen weng Jing Xue Ningning Niu State Key Laboratory of Systems medicine for Cancer Stem Cell Research CenterRen Ji HospitalShanghai Cancer InstituteShanghai Jiao Tong University School of MedicineShanghai 200127China

In recent years,the histone methyltransferase SET domain containing 2(SETD2)has garnered significant attention for its involvement in *** we aim to summarize the research advances regarding SETD2 in tumors,elucidate the role in global epigenetic regulation,highlight potential therapeutic regimens for patients with SETD2 deficiency,and outline future research directions.

关键词： SETD2 regimen therapeutic

Vector Radiative Transfer in a Vertically Inhomogeneous Scattering and Emitting ***Ⅰ:A New Discrete Ordinate method

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Journal of meteorological Research 2024年第2期38卷 209-224页

作者： Ziqiang ZHU Fuzhong weng Yang HAN Chinese Academy of meteorological Sciences China Meteorological AdministrationBeijing 100081 University of Chinese Academy of Sciences Beijing 100049 CmA Earth System modeling and Prediction Centre China Meteorological Administration(CMA)Beijing 100081 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081

The original vector discrete ordinate radiative transfer(VDISORT)model takes into account Stokes radiance vector but derives its solution assuming azimuthal symmetric surface reflective matrix and atmospheric scattering phase matrix,such as the phase matrix derived from spherical particles or randomly oriented non-spherical *** this study,a new VDISORT is developed for general atmospheric scattering and boundary *** vector is decomposed into both sinusoidal and cosinusoidal harmonic modes,and the radiance at arbitrary viewing geometry is solved directly by adding two zero-weighted points in the Gaussian quadrature *** complex eigenvalues in homogeneous solutions are also taken into full *** accuracy of VDISORT model is comprehensively validated by four cases:Rayleigh scattering case,the spherical particle scattering case with the Legendre expansion coefficients of 0th-13th orders of the phase matrix(hereinafter L13),L13 with a polarized source,and the randomoriented oblate particle scattering case with the Legendre expansion coefficients of 0th-11th orders of the phase matrix(hereinafter L11).In all cases,the simulated radiances agree well with the benchmarks,with absolute biases less than 0.0065,0.0006,and 0.0008 for Rayleigh,unpolarized L13,and L11,*** a polarized bidirectional reflection distribution function(pBRDF)matrix is used as the lower boundary condition,VDISORT is now able to handle fully coupled atmospheric and surface polarimetric radiative transfer processes.

关键词： radiative transfer discrete ordinate polarization Stokes vector vector discrete ordinate radiative transfer(VDISORT)

Intracellular RNA Labeling Technologies for the Analysis of RNA Biology

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Chinese Journal of Chemistry 2024年第7期42卷 790-801页

作者： Ruiqi Zhao Xin Fang Xiaocheng weng Department of Clinical Laboratory Center for Gene DiagnosisDepartment of NeurosurgeryZhongnan Hospital of Wuhan UniversityWuhanHubei 430071China College of Chemistryand molecular Sciences Key Laboratory of Biomedical Polymers-Ministry of EducationWuhan UniversityWuhan Hubei 430072China

As a cornerstone of the central dogma of molecular biology,RNA plays vital roles in living *** the past few decades,many RNA labeling technologies have been developed to elucidate the biological function of *** technologies have signifi-cantly advanced our understanding of RNA secondary structure,localization,and ***,taking advantage of these innovative RNA labeling approaches,plenty of tool kits have been devised for the regulation of RNA-related biological process,such as gene expression and gene *** this review,we primarily focus on an array of intracellular RNA labeling methods,encom-passing chemical probes-based labeling,metabolic labeling,and proximity-dependent *** also provide a brief overview of their applications in the research of RNA ***,the perspectives of RNA labeling are also discussed.

关键词： RNA Chemical probes metabolic labeling Proximity-dependent labeling RNA structures Gene sequencing RNA recognition

mass transfer in heap leaching of weathered crust elution deposited rare earth ore with Al_(2)(SO_(4))_(3) solution

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Journal of Rare Earths 2024年第6期42卷 1175-1181,I0007页

作者： Jingqun Yin Dedong Zeng Jun Tian Yaqing weng Institute of Applied Chemistry Jiangxi Academy of SciencesNanchang330096China School of Chemistry and Chemical Engineering Nanchang UniversityNanchang330031China

In order to increase efficiency and avoid NH^(4+)-N pollution in the leaching process of weathered crust elution-deposited rare earth ores,the mass transfer in heap leaching with Al_(2)(SO_(4))_(3) solution was simulated with column elution and experimentally *** results indicate that the leaching yield is also up to 99%for leaching with aluminum sulfate instead of ammonium *** optimal flow rate is 60 mL/h,the height equivalent to a theoretical plate(HETP)is 1.29 mm *** peak value position of RE^(3+)is 60 mL/h,Fe^(3+)is 100 mL/h,however,Al^(3+)is 150 mL/h,and the heap leaching process has kinetic separation effect.

关键词： Raree arths mass transfer Process optimization Heapleaching Weathered crust elution-deposited rare earth ore

A robust implicit high-order discontinuous Galerkin method for solving compressible Navier-Stokes equations on arbitrary grids

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Acta mechanica Sinica 2024年第8期40卷 96-119页

作者： Jia Yan Xiaoquan Yang Peifen weng Shanghai Institute of Applied mathematics and mechanics Shanghai Key Laboratory of Mechanics in Energy EngineeringSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai200072China College of Energy and mechanical Engineering Shanghai University of Electric PowerShanghai200090China

The primary impediments impeding the implementation of high-order methods in simulating viscous flow over complex configurations are robustness and *** challenges impose significant constraints on computational efficiency,particularly in the domain of engineering *** address these concerns,this paper proposes a robust implicit high-order discontinuous Galerkin(DG)method for solving compressible Navier-Stokes(NS)equations on arbitrary *** method achieves a favorable equilibrium between computational stability and *** solve the linear system,an exact Jacobian matrix solving strategy is employed for preconditioning and matrix-vector generation in the generalized minimal residual(GmRES)*** approach mitigates numerical errors in Jacobian solution during implicit calculations and facilitates the implementation of an adaptive Courant-Friedrichs-Lewy(CFL)number increasing strategy,with the aim of improving convergence and *** further enhance the applicability of the proposed method for intricate grid distortions,all simulations are performed in the reference *** practice significantly improves the reversibility of the mass matrix in implicit calculations.A comprehensive analysis of various parameters influencing computational stability and efficiency is conducted,including CFL number,Krylov subspace size,and GmRES convergence *** computed results from a series of numerical test cases demonstrate the promising results achieved by combining the DG method,GmRES solver,exact Jacobian matrix,adaptive CFL number,and reference domain calculations in terms of robustness,convergence,and *** analysis results can serve as a reference for implicit computation in high-order calculations.

关键词： Discontinuous Galerkin method Exact Jacobian matrix GmRES solver Adaptive CFL number Reference domain High-order

Surface-induced interaction of colloidal particles in isotropic liquid crystals

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Communications in Theoretical Physics 2024年第7期76卷 114-122页

作者： Hualing Zhang Kaifeng weng Rui ma Department of Physics College of Physical Science and TechnologyXiamen UniversityXiamen 361005China Fujian Provincial Key Laboratory for Soft Functional materials Research Research Institute for Biomimetics and Soft MatterXiamen UniversityXiamen 361005China

In this work,we study the interaction between two colloidal particles in a liquid crystal that is in the isotropic *** interaction is caused by surface-induced polarization of the liquid crystal molecules in the vicinity of the *** find that the interaction is short-ranged in both 2D and 3D *** symmetric homeotropic anchoring conditions,the interaction is *** under anti-symmetric homeotropic anchoring conditions,the interaction is repulsive at short distances but attractive at intermediate *** particle size has a strong impact on the effective interaction force.

关键词： surface-induced interaction colloidal particles liquid crystals

Optimal Assimilation of microwave Upper-Level Sounding Data in CmA-GFS

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Advances in Atmospheric Sciences 2024年第10期41卷 2043-2060页

作者： Changjiao DONG Hao HU Fuzhong weng School of Atmospheric Physics Nanjing University of Information Science and TechnologyNanjing 210044China CmA Earth System modeling and Prediction Centre(CEmC) China Meteorological AdministrationBeijing 100081China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China

Various approaches have been proposed to minimize the upper-level systematic biases in global numerical weather prediction(NWP)models by using satellite upper-air sounding channels as ***,since the China meteorological Administration Global Forecast System(CmA-GFS)has a model top near 0.1 hPa(60 km),the upper-level temperature bias may exceed 4 K near 1 hPa and further extend to 5 *** this study,channels 12–14 of the Advanced microwave Sounding Unit A(AmSU-A)onboard five satellites of NOAA and mETOP,whose weighting function peaks range from 10 to 2 hPa are all used as anchor observations in *** is shown that the new“Anchor”approach can effectively reduce the biases near the model top and their downward propagation in three-month assimilation *** bias growth rate of simulated upper-level channel observations is reduced to±0.001 K d^(–1),compared to–0.03 K d^(–1)derived from the current dynamic correction *** relatively stable bias significantly improves the upper-level analysis field and leads to better global medium-range forecasts up to 10 days with significant reductions in the temperature and geopotential forecast error above 10 hPa.

关键词： CmA-GFS upper-level model bias anchoring bias correction satellite microwave data assimilation