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Effects of Buyang Huanwu Decoction on Intestinal Barrier, Intestinal Flora, and Trimethylamine Oxide in Rats with Heart Failure

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Chinese Journal of Integrative Medicine 2023年第2期29卷 155-161页

作者： weng jie-qiong LI jie-bai YUAN Meng-fei YAO Ting-ting ZHANG Jing-fang ZENG Yuan-yuan ZHAO Jing LI Ying XU Ke SHEN Xiao-xu Department of Cardiology Dongzhimen Hospital of Beijing University of Chinese MedicineBeijing 100700China Department of Nuclear Medicine Dongzhimen Hospital of Beijing University of Chinese MedicineBeijing 100700China Peking University Sixth Hospital Beijing 100700China

Objective: To explore the mechanisms of Buyang Huanwu Decoction(BYHWD) modulating the gut microbiome and trimethylamine oxide(TAMO) to exert cardioprotective effects. Methods: Ligation of the left anterior descending coronary artery was performed in rats to induce heart failure(HF). Except for the shamoperation group(n=10), 36 operation-induced models were randomized into 3 groups using a random number table(n=12 in each group): the model group, the BYHWD group(15.02 g/kg BYHWD), and the positive group(4.99 g/kg metoprolol succinate). After 4-week treatment(once daily by gavage), echocardiography was applied to evaluate the cardiac function and the Tei index(the ratio of ventricular isovolumic contraction time(IVCT)and isovolumic diastolic time(IVRT) to ejection time(ET)) was calculated;hematoxylin-eosin(HE) staining was observed to characterize the pathology of the myocardium and small intestinal villi. D-lactic acid was detected by an enzyme-linked immunosorbent assay(ELISA). Expressions of occludin, claudin-1, and zonula occludens(ZO-1) were detected by Western blot. 16S ribosomal ribonucleic acid(16S rRNA) sequencing was used to explore the changes in the intestinal flora. TMAO was detected via liquid chromatography-tandem mass spectrometry(LC-MS/MS). Results: In the echocardiography, the Tei index was considerably lower in the positive and BYHWD groups compared with the model group(P<0.05). Besides, BYHWD improved the pathology of myocardium and small intestine of HF rats and lowered the D-lactic acid content in the serum, when compared with the model group(P<0.05). BYHWD also improved the expression of occludin and claudin-1(P<0.05);in the gut microbiota analysis, BYHWD slowed down modifications in the structure distribution of gut microbiota and regulated the diversity of intestinal flora in HF rats. The content of TMAO in the serum was significantly lowered by BYWHT compared with the model group(P<0.05). Conclusion: BYHWD may delay progression of HF by enhan

关键词： Buyang Huanwu Decoction heart failure intestinal flora trimethylamine oxide

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一种复合型自适应数字水印算法

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计算机应用 2005年第3期25卷 557-559,562页

作者：翁洁琼张志浩来可伟同济大学计算中心上海200092

提出一种同时嵌入鲁棒性水印和易损性水印的复合型数字水印算法。其中鲁棒性水印的算法,利用图像小波系数的零树结构,基于零树小波编码,构造出重要系数小波树,将水印信息自适应地以不同强度嵌入载体图像的合适位置。实验结果表明,本算... 详细信息

提出一种同时嵌入鲁棒性水印和易损性水印的复合型数字水印算法。其中鲁棒性水印的算法,利用图像小波系数的零树结构,基于零树小波编码,构造出重要系数小波树,将水印信息自适应地以不同强度嵌入载体图像的合适位置。实验结果表明,本算法在用于版权认证的同时还能对篡改进行有效的检测,具有较好的双重保护性能。

关键词：数字水印小波变换零树小波鲁棒性水印易损性水印

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Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期 46-95页

作者： Zhong-Liang Gong Hong-jie Zhang Yan Cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng qiong Zhang Shaolong Gong Yong Chen Chang-Jiang Yao Yuan-Yuan Zhu Liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

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基于Wnt/β-catenin通路探讨西黄丸对三阴乳腺癌细胞4T1增殖及干性成球能力的影响

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北京中医药 2021年第9期40卷 968-972页

作者：翁洁琼卢雯平崔莎莎赵志正中国中医科学院广安门医院肿瘤科北京100053

目的基于Wnt/β-catenin信号通路评价西黄丸对三阴乳腺癌细胞4T1的增殖及干性成球能力的影响。方法制备西黄丸浸提液,采用CCK8的方法,筛选最佳给药浓度,检测其对4T1细胞增殖能力的影响,采用无血清干细胞成球实验检测其对4T1细胞干性成... 详细信息

目的基于Wnt/β-catenin信号通路评价西黄丸对三阴乳腺癌细胞4T1的增殖及干性成球能力的影响。方法制备西黄丸浸提液,采用CCK8的方法,筛选最佳给药浓度,检测其对4T1细胞增殖能力的影响,采用无血清干细胞成球实验检测其对4T1细胞干性成球能力的影响,通过Transwell实验检测其对4T1细胞的迁移和侵袭能力的影响,RT-PCR实验检测Wnt/β-catenin信号通路介导的上皮细胞间充质转化(EMT)的相关mRNA的表达。结果西黄丸可以抑制细胞的增殖、干细胞成球能力和肿瘤细胞的迁移侵袭,RT-PCR结果显示E-cadherin相对上调,Vimentin、β-catenin表达下调,且西黄丸可协同Wnt/β-catenin通路活性抑制剂XAV939抑制细胞的增殖、干细胞成球能力和肿瘤细胞的迁移侵袭。结论西黄丸可能通过抑制Wnt/β-catenin信号通路介导的EMT,干预肿瘤细胞的"干性",从而防治肿瘤转移。

关键词：西黄丸三阴乳腺癌 4T1细胞 Wnt/β-catenin信号通路细胞增殖细胞迁移细胞侵袭干性成球能力

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白头翁汤通过HMGB1调控Nrf-2/HO-1信号通路缓解溃疡性结肠炎

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中国药理学通报 2025年第1期41卷 186-192页

作者：朱维娜马春华阮杰周芙琼张亚杰隆红艳南京中医药大学附属南京中医院南京210022 南京中医药大学附属南京中医院生物样本库南京210022

目的探讨白头翁汤对葡聚糖硫酸钠所致小鼠炎症性肠病的干预作用,并初步阐明其作用机制。方法将50只C57BL/6小鼠随机分为正常组、模型组、白头翁汤高、中、低剂量组(20、10、5 g·kg^(-1)),美沙拉嗪组(5-ASA)(800 mg·kg^(-1)),采用3%葡... 详细信息

目的探讨白头翁汤对葡聚糖硫酸钠所致小鼠炎症性肠病的干预作用,并初步阐明其作用机制。方法将50只C57BL/6小鼠随机分为正常组、模型组、白头翁汤高、中、低剂量组(20、10、5 g·kg^(-1)),美沙拉嗪组(5-ASA)(800 mg·kg^(-1)),采用3%葡聚糖硫酸钠(DSS)7 d构建UC模型,造模d 5开始灌胃给药,连续7 d。观察小鼠体质量,肠道大体观形态、结肠长度、生存率、结肠质量、HE染色观察结肠组织病理学改变,ELISA检测小鼠血清IL-6、IL-1β、高迁移率族蛋白B1(HMGB1)含量;比色法检测髓过氧化物酶(MPO)含量,超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量,Western blot检测肠道HMGB1、免疫球蛋白血管细胞粘附分子1(VCAM)、细胞间粘附分子(ICAM)、金属蛋白酶基质金属肽酶9(MMP-9)、核因子相关因子2(Nrf2)、血红素加氧酶1(HO-1)蛋白表达。结果白头翁汤有效减轻UC小鼠的症状和组织病理学评分。下调炎症因子IL-6和IL-1β、VCAM和ICAM、MMP-9,下调HMGB1。此外,它还抑制核Nrf2/HO-1通路。结论白头翁汤对炎症性肠病模型小鼠的一般情况、炎症指标及氧化应激水平有较好的改善作用,其作用机制可能与抑制HMGB1水平调控Nrf-2/HO-1信号通路,增强结肠黏膜的屏障作用有关。

关键词：白头翁汤溃疡性结肠炎 Nrf-2/HO-1信号通路 HMGB1 氧化应激葡聚糖硫酸钠

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Influence of gonadotropin-releasing hormone agonist on the effect of chemotherapy upon ovarian cancer and the prevention of chemotherapy-induced ovarian damage:an experimental study with nu/nu athymic mice

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第11期13卷 894-903页

作者： qiong-yan LIN Yi-feng WANG Hui-nan weng Xiu-jie SHENG Qing-ping JIANG Zhi-ying YANG Department of Obstetrics and Gynecology Key Laboratory for Major Obstetric Diseases of Guangdong Province the Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510150 China Department of Obstetrics and Gynecology Zhujiang Hospital Nanfang Medical University Guangzhou 510282 China

Background and objective:Gonadotropin-releasing hormone (GnRH) plays an important role in the regulation of ovarian function and ovarian cancer cell growth. In this study, we determined whether administration of the GnRH agonist (GnRHa), triporelin, prior to cisplatin treatment affects cisplatin and/or prevents cisplatin-induced ovarian damage. Methods:nu/nu mice were injected with ovarian cancer OVCAR-3 cells intraperitoneally. After two weeks, the mice were treated with saline (control), cisplatin, GnRHa, or cisplatin plus GnRHa for four weeks. At the end of the experimental protocol, blood, tumor, ovary, and uterine tissues were resected for hematoxylin and eosin (H&E) staining, immunohistochemical analyses of Ki67, nuclear factor-κB (NF-κB), and caspase-3, transmission electron microscopy of apoptosis, or enzyme-linked immunosorbent assay (ELISA) analyses of anti-Mullerian hormone (AMH). Results:Cisplatin treatment effectively inhibited tumor growth in mice treated with human ovarian cancer cells; however the treatment also induced considerable toxicity. Immunohistochemical analyses showed that Ki67 expression was reduced in cisplatin-treated mice compared to control (P0.05), while expressions of NF-κB and caspase-3 were reduced and induced, respectively, in cisplatin-treated mice and cisplatin plus GnRHa-treated mice. Apoptosis occurred in the GnRHa, cisplatin, and cisplatin plus GnRHa-treated mice, but not in control mice. Ovaries exposed to GnRHa in both GnRHa mice and cisplatin-treated mice (combination group) had significantly more primordial and growth follicles and serum levels of AMH than those in the control mice and cisplatin-treated mice (P<0.05). Conclusions:Administration of GnRHa to mice significantly decreased the extent of ovarian damage induced by cisplatin, but did not affect the anti-tumor activity of cisplatin

关键词： Gonadotrophin-releasing hormone Cisplatin Ovarian cancer Animal experiment

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Landscape Changes in Wenchuan ——A Mountainous County in Sichuan, China

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Wuhan University Journal of Natural Sciences 2005年第4期10卷 707-712页

作者： YEYan-qiong CHENGuo-jie EcologyDepartmentofSouthChinaAgricultureUniversity Guangzhou510642GuangdongChina CollegeofEnvironmentandResourceofSouthwestChinaNormalUniversity Chongqing400715China

Based on the collection of land use maps of three representative years (1972,1986 and 1995) with a scale of 1 : 100 000, which were derived from interpreted aerial photographsand field surveys , landscape pattern were studied in Wenchuan County of Aba Prefecture, northwestof Sichuan Province, China. Six land use categories were classified according to the actuality ofthe study area and digitized by manual with the assistance of Geographic Information System (GIS).Landscape spatial and temporal changes were analyzed quanti-ficationally by a series of structure,shape, pattern indices, which indicated that grassland dominates in number of patch while bothgrassland and shrub-land dominate in total area of patch over time. During the last 23 years, thefractal dimension of grassland and shrub-land were decreased while the other types were *** dominance and fragmentation and lowest diversity characterized the landscape of 1972. In1986, the landscape pattern had the highest diversity and lowest dominance and fragmentation, whichis contrary to the pattern in 1972. Slight change of diversity, dominance and fragmentation has beendisplayed from 1986 to 1995.

关键词： Land use Landscape change GIS

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Origin of the spatial consistency of summer precipitation variability between the Mongolian Plateau and the mid-latitude East Asian summer monsoon region

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Science China Earth Sciences 2020年第8期63卷 1199-1208页

作者： jie CHEN Wei HUANG qiong ZHANG Song FENG Key Laboratory of Western China s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Department of Physical Geography and Bolin Centre for Climate Research Stockholm UniversityStockholm 10691Sweden Department of Geosciences University of ArkansasFayetteville 72701USA

The Mongolian Plateau(MP) is located in the eastern part of arid Central Asia(ACA). Climatically, much of the MP is dominated by the westerly circulation and has an arid and semi-arid climate;however, the eastern part of the MP is also influenced by the East Asian summer monsoon(EASM) and has a humid and semi-humid climate. Several studies have shown that precipitation variability in the MP differs from that in western ACA but is consistent with that in the EASM region. Here we use monthly precipitation data for 1979–2016 to characterize and determine the origin of the summer precipitation variability of the MP and the EASM region. The results show that the MP and the mid-latitude EASM region exhibit a consistent pattern of precipitation variability on interannual and decadal timescales;specifically, the consistent regions are the MP and North and Northeast China. We further investigated the physical mechanisms responsible for the consistent interdecadal precipitation variability between the MP and the mid-latitude EASM region, and found that the mid-latitude wave train over Eurasia, with positive(negative) geopotential height anomalies over the North Atlantic and ACA and negative(positive) geopotential height anomalies over Europe and the MP, is the key factor responsible for the consistency of precipitation variability in the MP and the mid-latitude EASM region. The positive anomalies over the North Atlantic and ACA and negative anomalies over Europe and the MP would enhance the transport of westerly and monsoon moisture to the MP and North and Northeast China. They could also strengthen the Northeast Asian low, enhance the EASM, and trigger the anomalous ascending motion over the MP which promotes precipitation in the MP and in the mid-latitude EASM region. Overall, our results help explain the spatial variations of paleo-precipitation/humidity reconstructions in East Asia and clarify the reasons for the consistency of the regional climate.

关键词： Mongolian Plateau Mid-latitude EASM region Summer precipitation Decadal Consistent variability

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The effects of compressibility and strength on penetration of long rod and jet

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Defence Technology（防务技术） 2018年第2期14卷 99-108页

作者： weng-jie Song Xiao-wei Chen Pu Chen Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing 100871China Centre for Applied Physics and Technology(CAPT) Peking UniversityBeijing 100871China State Key Lab of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

The approximate compressible model is adopted to study the effects of strength and compressibility on the penetration by WHA long rod and copper jet into semi-infinite target in detail. For WHA rod penetrating PMMA at... 详细信息

关键词： Compressibility Strength Long rod Jet Compressible model Virtual origin model

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AutoSeqMan:batch assembly of contigs for Sanger sequences

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Zoological Research 2018年第2期39卷 123-126页

作者： jie-qiong Jin Yan-Bo Sun State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences

With the wide application of DNA sequencing technology, DNA sequences are still increasingly generated through the Sanger sequencing platform. SeqMan （in the LaserGene package） is an excellent program with an easy-to-use graphical user interface （GUI） employed to assemble Sanger sequences into contigs. However, with increasing data size, larger sample sets and more sequenced loci make contig assemble complicated due to the considerable number of manual operations required to run SeqMan. Here, we present the ＇autoSeqMan＇ software program, which can automatedly assemble contigs using SeqMan scripting language. There are two main modules available, namely, ＇Classification＇ and ＇Assembly＇. Classification first undertakes preprocessing work, whereas Assembly generates a SeqMan script to consecutively assemble contigs for the classified files. Through comparison with manual operation, we showed that autoSeqMan saved substantial time in the preprocessing and assembly of Sanger sequences. We hope this tool will be useful for those with large sample sets to analyze, but with little programming experience. It is freely available at https：//***/ Sun-Yanbo/autoSeqMan.

关键词： Batch processing Sanger sequences Contig assembly SeqMan

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