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Chinese Journal of Natural Medicines 2019年第3期17卷 187-197页

作者： CHEN Mei-Yu LI hong LU Xiao-Xiao LING Li-Jun weng hong-bo SUN Wei CHEN Dao-Feng ZHANG Yun-Yi Department of Pharmacology School of Pharmacy Fudan University Department of Pharmacognosy School of Pharmacy Fudan University

Houttuynia cordata polysaccharide(HCP) is extracted from Houttuynia cordata, a key traditional Chinese medicine. The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infected mice. Mice were infected with H1N1 virus and orally administrated HCP at a dosage of 40 mg×kg^(–1)×d^(–1). H1N1 infection caused pulmonary and intestinal injury and gut microbiota imbalance. HCP significantly suppressed the expression of hypoxia inducible factor-1α and decreased mucosubstances in goblet cells, but restored the level of zonula occludens-1 in intestine. HCP also reversed the composition change of intestinal microbiota caused by H1N1 infection, with significantly reduced relative abundances of Vibrio and Bacillus, the pathogenic bacterial genera. Furthermore, HCP rebalanced the gut microbiota and restored the intestinal homeostasis to some degree. The inhibition of inflammation was associated with the reduced level of Toll-like receptors and interleukin-1β in intestine, as well as the increased production of interleukin-10. Oral administration of HCP alleviated lung injury and intestinal dysfunction caused by H1N1 infection. HCP may gain systemic treatment by local acting on intestine and microbiota. This study proved the high-value application of HCP.

关键词： H1N1 influenza virus Houttuynia cordata Inflammation Intestinal Barrier Microbiota Polysaccharide

Taxus chinensis ameliorates diabetic nephropathy through down-regulating TGF-β1/Smad pathway

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Chinese Journal of Natural Medicines 2018年第2期16卷 90-96页

作者： weng hong-bo HAN Wen-Ke XIONG Yan-Wen JIN Zhou-Hui LAN Zhen LIU Cheng ZHANG Xue-Mei PENG Wen Department of Pharmacology School of Pharmacy Fudan University Department of Nephrology Putuo Hospital Shanghai University of Traditional Chinese Medicine Liqun Hospital Shanghai

Diabetic nephropathy(DN) is one of the common microvascular complications of diabetes mellitus. Renal fibrosis is closely related to the deterioration of renal function. The present study aimed to investigate protective effect of Taxus chinensis on high-fat diet/streptozotocin-induced DN in rats and explore the underlying mechanism of action. The rat DN model was established via feeding high fat diet for 4 weeks and subsequently injecting streptozotocin(30 mg·kg^(-1) body weight) intraperitoneally. The rats with blood glucose levels higher than 16.8 mmol·L^(-1) were selected for experiments. The DN rats were treated with Taxus chinensis orally(0.32, 0.64, and 1.28 g·kg^(-1)) once a day for 8 weeks. Taxus chinensis significantly improved the renal damage, which was indicated by the decreases in 24-h urinary albumin excretion rate, blood serum creatinine, and blood urea nitrogen. Histopathological examination confirmed the protective effect of Taxus chinensis. The thickness of glomerular basement membrane was reduced, and proliferation of mesangial cells and podocytes cells and increase in mesangial matrix were attenuated. Further experiments showed that Taxus chinensis treatment down-regulated the expression of TGF-β1 and α-SMA, inhibited phosphorylation of Smad2 and Smad3. These results demonstrated that Taxus chinensis alleviated renal injuries in DN rats, which may be associated with suppressing TGF-β1/Smad signaling pathway.

关键词： Diabetic nephropathy Taxus chinensis TGF-βl/Smad signaling pathway

Bupleurum polysaccharides ameliorated renal injury in diabetic mice associated with suppression of HMGB1-TLR4 signaling

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Chinese Journal of Natural Medicines 2019年第9期17卷 641-649页

作者： LIU Zhen-Zhen weng hong-bo ZHANG Li-Jie PAN Ling-Yu SUN Wei CHEN Hai-Xia CHEN Mei-Yu ZENG Tao ZHANG Yun-Yi CHEN Dao-Feng LI hong Department of Pharmacology School of PharmacyFudan UniversityShanghai 201203China Department of Pharmacognosy School of PharmacyFudan UniversityShanghai 201203China Clinical trial institution Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 201203China

Bupleurum polysaccharides(BPs)is isolated from Bupleurum smithii ***,a key traditional Chinese *** study was to investigate the effects of BPs on diabetic kidney *** two intraperitoneal injections of streptozotozin(STZ)100 mg·kg^–1,renal injury in diabetic mice was induced and BPs was orally administrated at dosages of 30 and 60 mg·kg^–1·d^–*** STZ injected mice developed renal function damage,renal inflammation and fibrosis known as diabetic kidney disease(DKD).BPs significantly reduced serum creatinine level and urinary albumin excretion rate,with the attenuated swelling of *** treatment obviously alleviated the pathological damage of renal *** progression of renal injury in BPs treated mice was inhibited with less expression of type IV collagen(Col IV),fibronectin(FN)andα-smooth muscle actin(α-SMA).The inhibition of inflammation in kidney was associated with the reduced level of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6).BPs administration suppressed the over-expression of toll like receptor 4(TLR4)and high-mobility group box 1(HMGB1)with lowered activity of nuclear factor kappa B(NF-κB)in renal tissue of diabetic *** administration of BPs effectively prevented the development of renal injury in diabetic *** study suggested that the protection provided by BPs might affect through the interruption of HMGB1-TLR4 pathway,leading to the inhibition of renal inflammation and fibrotic process.

关键词： Renal injury Bupleurum:High-mobility group box Toll-like receptor 4 Inflammation Renal fibrosis Polysaccharides

Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： Pan Guo hong-bo Jin Cong-Feng Qiao Yue-Liang Wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries

High-dense nanocrystalline W-based alloy prepared by hot isostatic pressing with uniform microstructure, ultrahigh hardness and good thermal stability

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Tungsten 2025年第1期7卷 120-136页

作者： Zao-Ming Wu Lin He Lin-Sen Ye Xiao-Feng Yang Jia-Jia Zhang hong-bo Lei Institute of Materials China Academy of Engineering Physics

High-density uniform microstructure nanocrystalline W-10wt.% Cr-5wt.% Y（W-10Cr-5Y） alloy with an average grain size of 85 nm and a relative density of 99.8% was successfully prepared.W-Cr-Y alloys with different amounts of second-phase particles were prepared by high-energy ball milling and hot isostatic pressing *** effects of composition design,ball milling parameters,and sintering parameters on the microstructure of W-Cr-Y alloys were studied.A feasible technology for controlling the synthesis of high-density nanocrystalline W-based alloys has been *** microstructure analysis of nanocrystalline W-10Cr-5Y alloy shows that there are two types of doping in the second phase:intergranular doping and intragranular *** "uniform distribution YOx-rich particles" effectively suppresses the grain growth of W and leads to the formation of nanocrystalline W-10Cr-5Y alloy.W-10Cr-5Y has an ultra-high hardness,with a Vickers hardness of 1312±12 kgf·***-temperature annealing treatment shows that W-10Cr-5Y has good thermal stability at 1000 and1100℃,as demonstrated by the comparison of Vickers hardness and grain size between annealed and unannealed alloys.

关键词： Hot isostatic pressing Microstructure Nanocrystalline tungsten Thermal stability Vickers hardness

钠-葡萄糖共转运蛋白2抑制剂肾脏保护作用的研究进展

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中国新药与临床杂志 2023年第8期42卷 481-485页

作者：苑艳金子杰翁鸿博复旦大学药学院药理系上海201203

钠-葡萄糖共转运蛋白2抑制剂(SGLT2is)现已广泛用于2型糖尿病治疗。近年临床研究显示,SGLT2is在发挥降血糖作用的同时,还能显著缓解糖尿病肾脏疾病(DKD)的进程。大型临床试验结果提示,SGLT2is恩格列净、达格列净、卡格列净和艾托格列净... 详细信息

钠-葡萄糖共转运蛋白2抑制剂(SGLT2is)现已广泛用于2型糖尿病治疗。近年临床研究显示,SGLT2is在发挥降血糖作用的同时,还能显著缓解糖尿病肾脏疾病(DKD)的进程。大型临床试验结果提示,SGLT2is恩格列净、达格列净、卡格列净和艾托格列净在慢性肾脏病(CKD)患者中也显示出良好疗效,且有研究发现SGLT2is的肾脏保护作用可能独立于其降血糖作用。进一步探讨SGLT2is肾脏保护机制有利于促进SGLT2is与其他肾脏保护治疗相结合的新型临床治疗策略的制定。

关键词：钠-葡萄糖共转运蛋白2抑制剂糖尿病肾功能不全慢性肾脏病临床试验

Relationship Between Developmental Intensity of Landslide and Malan Loess Cohesion at a Regional Horizontal Space Scale

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Journal of Earth Science 2025年

作者： Yongheng Zhou Yaming Tang bo hong Fan Feng Longhui Wang Institute of Geological Survey， China University of Geosciences (Wuhan) Institute of Earth Environment， Chinese Academy of Sciences Xi'an Geological Survey Center China Geological Survey Chinese Academy of Geological Sciences

Malan loess is highly water-sensitive， with its shear strength， particularly cohesive strength， significantly decreasing under the influence of water. The Western Shanxi Loess Plateau （WSLP） is especially prone to loess landslides， which are closely linked to rainfall infiltration. Understanding the regional variation of Malan loess cohesion (cm) and its distribution in relation to the developmental intensity of landslides in this area can provide essential scientific evidence for effective landslide prevention. Loess landslides and Malan loess were selected as the objects of study for the current research. The regional variation and distribution pattern of the cmwere revealed through undisturbed loess direct shear tests and Inverse Distance Weighting （IDW） interpolation. The relationship between the developmental intensity of landslide and the regional variation of the cmwas explored using the Cumulative Sum Variable Dimension Fractal （CSVDF）， Frequency Ratio （FR） model， and Certainty Factor （CF） model. The following conclusions were drawn: Results from the direct shear tests and IDW method indicate that the cmtends to decrease from south to north and exhibits a positively skewed spatial distribution pattern. The CSVDF results indicates a similarity between the regional variation of the cmand the development intensity of loess landslides. The FR and CF results reveal that loess landslides are more likely to occur when the cmis between 0 and 16.14 kPa.

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Impact of Startup Strategy and Buffer Tank Volume on the Compressor Inlet State for a 3-MW sCO2 Brayton Cycle

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Journal of Thermal Science 2025年第1期34卷 159-175页

作者： ZHAO Decai WANG bo Key Laboratory of Advanced Energy and Power Institute of Engineering Thermophysics(IET)Chinese Academy of Sciences (CAS) University of Chinese Academy of Sciences

The supercritical carbon dioxide（sCO2） Brayton cycle system has become an emerging and highly promising method of thermal power conversion due to its efficiency advantage,system compactness,and excellent adaptability of the heat *** the low carbon sCO2Brayton cycle testbed with cycle output power approaching 3 MW,a relatively detailed dynamic simulation model of the entire system is constructed to explore the dynamic response characteristics of the system with different startup strategies and different buffer tank volumes during the startup *** simulation results indicate that the smaller the volume of the buffer tank,the more rapid and obvious the parameter fluctuation in the buffer tank during the *** the allowable relative deviation limit of density is 5%,then the ratio of the buffer tank volume to the volume of the entire closed loop should not be lower than 36.80%.The strategy of simultaneous temperature and speed increase during turbine bypass start can effectively reduce the fluctuation of compressor inlet parameters and reach the steady-state more *** paper provides the recommended matching table for the opening of the turbine bypass valve（TBV） and the main regulating valve（MGV） to reduce the parameter fluctuation during the bypass *** effectiveness of the proposed turbine bypass and bypass switching startup strategy is verified by simulation,which may be used as a reference for test bench's future debugging and operation.

关键词： buffer tank dynamic characteristic dynamic model sCO2 Brayton cycle startup strategy

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闽牧3号圆叶决明的选育研究

草地学报 2016年第5期24卷 1068-1072页

作者：郑向丽王俊宏翁伯琦徐国忠福建省农业科学院农业生态研究所福建省红壤山地农业生态过程重点实验室福建省山地草业工程技术研究中心福建省丘陵地区循环农业工程技术研究中心福建福州350013

为提高草产量及适口性,2002年由福建省农业科学院农业生态研究所利用^(60) Coγ射线辐射闽引圆叶决明(Chamaecrista rotundifolia‘Minyin’,CPI86134)种子,经多代筛选选育出闽牧3号圆叶决明(Chamaecrista rotundifolia‘Minmu No.3’),并于2011年通过福建省品种认定委员会认定。2005-2010年进行品种比较试验、区域试验和生产试验,结果表明:闽牧3号圆叶决明平均种子产量260.9kg·hm^(-2),比对照增产7.7%,但差异不显著;初花期植株粗蛋白含量为18.84%;平均干草产量11110.4kg·hm^(-2),比对照闽引圆叶决明增产22.05%,差异极显著(P<0.01)。因此,闽牧3号圆叶决明适用于加工草粉饲料。

关键词：闽牧3号圆叶决明辐射品种选育产草量

Traffic safety helmet wear detection based on improved YOLOv5 network

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Optoelectronics Letters 2025年第1期21卷 35-42页

作者： GUI Dongdong SUN bo College of Software Southeast University Quanzhou Equipment Research Centre Haixi Institute Chinese Academy of Sciences

Aiming at the problem that the current traffic safety helmet detection model can't balance the accuracy of detection with the size of the model and the poor generalization of the model, a method based on improving you only look once version 5(YOLOv5) is proposed. By incorporating the lightweight Ghost Net module into the YOLOv5 backbone network, we effectively reduce the model size. The addition of the receptive fields block(RFB) module enhances feature extraction and improves the feature acquisition capability of the lightweight model. Subsequently, the high-performance lightweight convolution, GSConv, is integrated into the neck structure for further model size compression. Moreover, the baseline model's loss function is substituted with efficient insertion over union(EIoU), accelerating network convergence and enhancing detection precision. Experimental results corroborate the effectiveness of this improved algorithm in real-world traffic scenarios.

关键词： Traffic control