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考虑运输时间的多资源工序的资源分配优化

福州大学学报（哲学社会科学版） 2024年第4期38卷 72-80,171页

作者：翁武燕储诚斌吴鹏福州大学经济与管理学院福建福州350108

针对制造业和服务业等领域中广泛存在的多资源工序资源分配问题,考虑工件和可移动类资源的运输时间,以最小化最长完工时间为优化目标,构建一类新的资源分配混合整数线性规划模型。针对该问题特性,提出变邻域搜索模拟退火的混合算法。该... 详细信息

针对制造业和服务业等领域中广泛存在的多资源工序资源分配问题,考虑工件和可移动类资源的运输时间,以最小化最长完工时间为优化目标,构建一类新的资源分配混合整数线性规划模型。针对该问题特性,提出变邻域搜索模拟退火的混合算法。该算法结合变邻域搜索算法局部搜索能力强和模拟退火算法全局寻优的优势,同时克服前者容易陷入局部最优而后者局部收敛不佳的问题。在算法的设计中,引入自适应邻域结构和改进降温函数以提高算法的收敛效率。300个不同规模的仿真算例实验结果表明,在求解大规模实例中,所提算法的性能均优于CPLEX求解器、变邻域搜索算法和模拟退火算法,能提供更好的资源分配方案。

关键词：资源分配多资源工序运输时间变邻域算法模拟退火算法

Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei weng Guijun Bi Youxiang Chew Shang Sui Chaolin Tan Zhenglin Du Jinlong Su Fern Lan Ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao weng Adam M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Systemic thrombosis with prothrombin Belgrade mutation in a Chinese patient:A case report

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World Journal of Clinical Cases 2025年第10期13卷 35-39页

作者： Yan-Feng Wu Yan Huang Bao-Hui weng Shan Deng Li-Ya Pan Zhen Li Department of Neurology Liuzhou Worker’s HospitalLiuzhou 545007Guangxi Zhuang Autonomous RegionChina Department of Neurology Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND Thrombophilia contributes to a significant increased risk of venous thromboembolism and can be either inherited or *** thrombophilia may arise from various gene mutations,some of which have not even been adequately reported or poorly *** studies reported a rare and novel missense mutation in the prothrombin gene(***596Gln),known as prothrombin *** mechanisms and therapeutic strategies associated with prothrombin Belgrade mutation have not been fully *** SUMMARY We present the case of a 26-year-old woman with recurrent systemic thrombosis induced by prothrombin Belgrade *** patient suffered from cerebral venous sinus thrombosis that rapidly progressed to systemic thrombosis,alongside a family history of cerebral thrombosis,and no traditional risk factors or abnormal coagulation ***-genome sequencing detected a novel and rare heterozygous prothrombin missense mutation,c.1787G>T(***596Gln),which was responsible for the major etiology of the systemic *** This case strengthens our understanding about hereditary basis of thrombophilia and provokes considerations for therapeutic options on prothrombin Belgrade mutation.

关键词： Arg596Gln Belgrade mutation Thrombophilia Prothrombin Case report

维普期刊数据库评论

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外泌体miRNA参与肿瘤化疗耐药的机制

中国组织工程研究 2025年第7期29卷 1504-1511页

作者：翁宗琴赵海龙遵义医科大学病理生理学教研室贵州省遵义市563000

背景:化疗作为癌症治疗的常见手段,前期具有一定的治疗效果,但随着化疗次数增加,肿瘤细胞对药物的抵抗性也逐渐增加,即化疗耐药性。目前化疗耐药性产生的主要机制包括化疗药物未能达到肿瘤部位,药物活性丧失导致药效下降,肿瘤细胞通过... 详细信息

背景:化疗作为癌症治疗的常见手段,前期具有一定的治疗效果,但随着化疗次数增加,肿瘤细胞对药物的抵抗性也逐渐增加,即化疗耐药性。目前化疗耐药性产生的主要机制包括化疗药物未能达到肿瘤部位,药物活性丧失导致药效下降,肿瘤细胞通过重塑代谢功能、基因表型和微环境逃避药物攻击等,但具体机制还有待深入探讨。目的:归纳并总结不同肿瘤中外泌体miRNA参与耐药的机制,提出潜在靶点。方法:以“hematological malignancies,liver cancer,lung cancer,breast cancer,melanoma,colorectal cancer,drug resistance,exosomal miRNAs”为英文检索词,检索PubMed数据库。检索时间范围为2013年1月至2023年8月。通过阅读文题和摘要进行初步筛选,排除与此次研究内容相关性差或内容重复的文献,最后纳入60篇文献进行综述。结果与结论:(1)外泌体miRNA进入细胞间质和循环,通过发挥局部旁分泌或远端效应,参与不同肿瘤生物进程的形成和发展,包括肿瘤微环境重塑、血管生成和耐药性产生;(2)外泌体miRNA可以透过细胞膜进入另一个细胞的胞浆内,通过传递miRNA启动或抑制受体细胞中的信号通路,在化疗过程中维持细胞存活、增殖和转移能力,从而导致耐药产生;(3)目前已经鉴定出许多与化疗耐药有关的外泌体miRNA,并将其作为常见肿瘤治疗靶点来开展研究;(4)虽然外泌体miRNA作为潜在的生物标志物和治疗靶点具有很大的前景,但仍有一些研究缺陷需要解决:一是缺乏用于外泌体分离和表征的标准化方案,导致不同研究中使用的方法存在差异;二是虽然外泌体中miRNA的存在和丰度已被广泛研究,但其功能作用和作用机制尚不完全清楚,阐明外泌体miRNA调控的特定靶点和途径可以为它们的生物学意义和潜在的治疗应用提供有价值的见解。解决这些研究缺陷将有助于更全面了解外泌体miRNA及其在各个领域的潜在应用,包括诊断、治疗和个性化医疗。

关键词：肿瘤化疗耐药外泌体 miRNA 病理生理学机制转移增殖肿瘤微环境

Multiaxial fatigue life prediction of composite laminates

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Chinese Journal of Aeronautics 2021年第12期34卷 227-237页

作者： Jingmeng weng Tong MENG Weidong WEN Shaodong weng Xi'an Aerospace Propulsion Institute Xi'an 710100China Academy of Space Electronic Information Technology Xi'an 710100China College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China School of Mechcmo-Electronic Engineering Xidian UniversityXi'an 710071China

A study of composite laminates under tension–torsion biaxial loading is *** focus is placed on fatigue lives of composite laminates under different tension–torsion biaxial fatigue loading paths.A macro-meso model used to predict multiaxial fatigue life of composite laminates is also presented in this ***,a macro-scale 3 D RVE corresponding to composite laminates is established to determine strain components in the material principal direction of each layer for each biaxial stress ***,a meso-scale 3 D RVE corresponding to each layer with fibers distributed randomly is established,with progressive damage prediction method,biaxial strength of composite laminates can be predicted,and the final failure layer can be ***,select any one of fatigue loading path at which the final failure of composite laminates is fiber failure(matrix failure)to establish the reference curve for fiber(matrix).Finally,with reference curve,fatigue life of composite laminates under any biaxial loading path can be *** numerical results show good agreements with experimental data.

关键词： Composite laminates Fatigue damage parameter Life prediction Multiaxial fatigue Multiaxial strength

High-pressure opens new windows for topological materials

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Science China(Physics,Mechanics & Astronomy) 2018年第3期61卷 85-86页

作者： HongMing weng Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China Collaborative Innovation Center of Quantum Matter Beijing 100190 China

Recently Guo et al. [1 ] have performed a systematic simulation on the high-pressure phases of the first experimen- tally available Weyl semimetals TaAs family. Through such a cheap but powerful technique, they theoretically found a new topological phase in this family members under high pressure. This article presents a nice example that high-pressure is applicable in tuning the topological phase transition

关键词：拓扑高压窗户材料 TaAs 阶段转变半金属家庭

Impacts of Multi-Scale Solar Activity on *** Ⅱ:Dominant Timescales in Decadal-Centennial Climate Variability

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Advances in Atmospheric Sciences 2012年第4期29卷 887-908页

作者： Hengyi weng State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029

Part II of this study detects the dominant decadal-centennial timescales in four SST indices up to the 2010/2011 winter and tries to relate them to the observed 11-yr and 88-yr solar activity with the sunspot number up to Solar Cycle 24. To explore plausible solar origins of the observed decadal-centennial timescales in the SSTs and climate variability in general, we design a simple one-dimensional dynamical system forced by an annual cycle modulated by a small-amplitude single- or multi-scale ＂solar activity.＂ Results suggest that nonlinear harmonic and subharmonic resonance of the system to the forcing and period-doubling bifurcations are responsible for the dominant timescales in the system, including the 60-yr timescale that dominates the Atlantic Multidecadal Oscillation. The dominant timescales in the forced system depend on the system＇s parameter setting. Scale enhancement among the dominant response timescales may result in dramatic amplifications over a few decades and extreme values of the time series on various timescales. Three possible energy sources for such amplifications and extremes are proposed. Dynamical model results suggest that solar activity may play an important yet not well recognized role in the observed decadal-centennial climate variability. The atmospheric dynamical amplifying mechanism shown in Part I and the nonlinear resonant and bifurcation mechanisms shown in Part II help us to understand the solar source of the multi-scale climate change in the 20th century and the fact that different solar influenced dominant timescales for recurrent climate extremes for a given region or a parameter setting. Part II also indicates that solar influences on climate cannot be linearly compared with non-cyclic or sporadic thermal forcings because they cannot exert their influences on climate in the same way as the sun does.

关键词： sun-climate relationship decadal-centennial climate timescales nonlinear forcing-response res- onant mechanism bifurcation mechanism scale enhancement for extremes

Synchronous Parallel Block Coordinate Descent Method for Nonsmooth Convex Function Minimization

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Journal of Systems Science & Complexity 2020年第2期33卷 345-365页

作者： DAI Yutong weng Yang College of Mathematics Sichuan UniversityChengdu 610064China

This paper proposes a synchronous parallel block coordinate descent algorithm for minimizing a composite function,which consists of a smooth convex function plus a non-smooth but separable convex *** to the generalization of the proposed method,some existing synchronous parallel algorithms can be considered as special *** tackle high dimensional problems,the authors further develop a randomized variant,which randomly update some blocks of coordinates at each round of *** proposed parallel algorithms are proven to have sub-linear convergence rate under rather mild *** numerical experiments on solving the large scale regularized logistic regression with 1 norm penalty show that the implementation is quite *** authors conclude with explanation on the observed experimental results and discussion on the potential improvements.

关键词： Block coordinate descent convergence rate convex functions parallel algorithms