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Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2953-2959页

作者： Sihui Luo Xueying Zheng Wei Bao Sheng Nie Yu Ding Tong Yue Yilun Zhou ying hu hua Li Qiongqiong Yang Qijun Wan Bicheng Liu Hong Xu Guisen Li Gang Xu Chunbo Chen huafeng Liu Yongjun Shi Yan Zha Yaozhong Kong Guobin Su ying Tang Mengchun Gong Linong ji Fan Fan Hou jianping weng Department of Endocrinology First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHeifeiChina Institute of Public Health Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Division of Nephrology National Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Nephrology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina The Second Affiliated Hospital of Zhejiang university School of Medicine HangzhouChina Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhouChina Department of Nephrology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina The Second People’s Hospital of Shenzhen Shenzhen UniversityShenzhenChina Institute of Nephrology Zhongda HospitalSoutheast University School of MedicineNanjingChina Children’s Hospital of Fudan university ShanghaiChina Renal Department and Institute of Nephrology Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaSichuan Clinical Research Center for Kidney DiseasesChengduChina Division of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Critical Care Medicine Maoming People’s HospitalMaomingChina Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City Institute of NephrologyAffiliated Hospital of Guangdong Medical UniversityZhanjiangChina huizhou Central People’s Hospital Sun Yat-Sen UniversityHuizhouChina Guizhou Provincial People’s Hospital Guizhou UniversityGuiyangChina Department of Nephrology the First People’s Hospital of FoshanFoshanChina Department of Nephrology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospitalthe Second Clinical CollegeGuangzhou University of Chinese Medicin

Early insulin therapy is capable to achieve glycemic control and restoreβ-cell function in newly diagnosed type 2 diabetes(T2D),but its effect on cardiovascular outcomes in these patients remains *** this nationwide real-world study,we analyzed electronic health record data from 19 medical centers across china between 1 January 2000,and 26 May *** included 5424 eligible patients(mean age 56 years,2176 women/3248 men)who were diagnosed T2D within six months and did not have prior cardiovascular *** Cox regression models were used to estimate the associations of early insulin therapy(defined as the first-line therapy for at least two weeks in newly diagnosed T2D patients)with the incidence of major cardiovascular events including coronary heart disease(CHD),stroke,and hospitalization for heart failure(HF).During 17,158 persons years of observation,we documented 834 incident CHD cases,719 stroke cases,and 230 hospitalized cases for *** diagnosed T2D patients who received early insulin therapy,compared with those who did not receive such treatment,had 31%lower risk of incident stroke,and 28%lower risk of hospitalization for *** significant difference in the risk of CHD was *** found similar results when repeating the aforesaid analysis in a propensity-score matched population of 4578 patients and with inverse probability of treatment weighting *** findings suggest that early insulin therapy in newly diagnosed T2D may have cardiovascular benefits by reducing the risk of incident stroke and hospitalization for HF.

关键词： cardiovascular treatment nationwide

Liver injury in COVID-19:A minireview

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World Journal of Gastroenterology 2022年第47期28卷 6716-6731页

作者： wen-Shu hu Fang-ying jiang wen Shu Rong Zhao ji-Min Cao De-Ping Wang Key Laboratory of Cellular Physiology at Shanxi Medical university Ministry of EducationShanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Physiology Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

Coronavirus disease 2019(COVID-19),caused by infection with the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),has escalated into a global tragedy afflicting human health,life,and social *** the increasing depth of research and a better understanding of this disease,it has been ascertained that,in addition to the lungs,SARS-CoV-2 can also induce injuries to other organs including the *** injury is a common clinical manifestation of COVID-19,particularly in severe cases,and is often associated with a poorer prognosis and higher severity of *** review focuses on the general existing information on liver injury caused by COVID-19,including risk factors and subpopulations of liver injury in COVID-19,the association between preexisting liver diseases and the severity of COVID-19,and the potential mechanisms by which SARS-CoV-2 affects the *** review may provide some useful information for the development of therapeutic and preventive strategies for COVID-19-associated liver injury.

关键词： Liver SARS-CoV-2 Angiotensin-converting enzyme 2 Transmembrane serine protease 2 Chronic liver disease

Manipulation of successive crystalline transformations to control electron transfer and switchable functions

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National Science Review 2018年第4期5卷 507-515页

作者： Cheng-Qi jiao wen-jing jiang Yin-Shan Meng wen wen Liang Zhao Jun-Li Wang ji-Xiang hu Gagik G.Gurzadyan Chun-ying Duan Tao Liu State Key Laboratory of Fine Chemicals Dalian University of Technology Institute of Artificial Photosynthesis State Key Laboratory of Fine Chemicals Dalian University of Technology

Electron transfer in solid is crucial to switchable magnetic,electrical,optical and mechanical ***,it is a formidable challenge to control electron-transfer behaviors via manipulation of crystalline phases,especially through dynamic crystalline ***,three crystalline phases of an{Fe2Co2}compound were obtained via enhancement of intermolecularπ···πinteractions inducingsuccessive single-crystal-to-single-crystal transformations,from solvated 1·2CH3OH·4H2O,to desolvated1 and its polymorph 1a accompanying electron transfer.1·2CH3OH·4H2O showed thermally inducedreversible intermetallic electron transfer in mother *** electron-transfer behavior was observed in 1.1a showed reversible intermetallic electron transfer upon thermal treatment or alternative irradiation with808-and 532-nm lasers at cryogenic *** electron-transfer behaviors significantly change the magnetic and optical properties,providing a strategy to realize different electron-transfer behaviors andswitchable functions viaπ···πinteractions manipulated dynamic crystalline transformation.

关键词： electron-transfer dynamic structural transformation successive crystalline transformations reversible polymorphs

^(18)F-FDG PET/CT in differentiating malignant from benign origins of obstructive jaundice

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Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 516-522页

作者： Shao-Bo Wang hu-Bing Wu Quan-Shi Wang wen-Lan Zhou ying Tian Yun-Hai ji Liang Lv Nanfang PET Center Nanfang Hospital Southern Medical University Department of Radiology First People's Hospital of Yunnan Province

BACKGROUND： The various origins of obstructive jaundice make the diagnosis of the disease difficult. This study was undertaken to evaluate the role of 18F-FDG PET/CT in differentiating malignant from benign origins of obstructive jaundice and to quantify the added value of 18F-FDG PET/CT over conventional imaging（enhanced CT and/or MRI）.METHODS： Eighty-five patients with obstructive jaundice who underwent 18F-FDG PET/CT within 2 weeks after enhanced CT and/or MRI were reviewed retrospectively. All 18F-FDG PET/CT images were independently evaluated by 2 nuclear medicine physicians who were unaware of other imaging data; differences were resolved by consensus of the physicians. All conventional imaging interpretations, according to the medical records, were reviewed by 2 radiologists to determine the potential value. Final diagnoses were based on histological or surgical ***： Sixty-six patients were diagnosed with malignancies, and 19 patients with benign lesions. The maximum standardized uptake values for malignant and benign lesions causing biliary obstruction were 8.2±4.4 and 4.0±5.0, respectively（P〈0.05）. The sensitivity, specificity, and overall accuracy for differentiating malignant from benign origins with 18F-FDG PET/CT were 86.4%（57/66）, 73.7%（14/19）, and 83.5%（71/85）, respectively. 18F-FDG PET/CT in conjunction with conventional imaging changed the sensitivity, specificity, and overall accuracy of conventional imaging alone from 75.8%（50/66） to 95.5%（63/66）（P〈0.05）, 68.4%（13/19） to 57.9%（11/19）（P〉0.05）, and 74.1%（63/85） to 87.1%（74/85）（P〈0.05）, ***： 18F-FDG PET/CT is of great value in differentiating malignant from benign origins of obstructive jaundice and is a useful adjuvant to conventional imaging. 18F-FDG PET/CT should be recommended for further etiological clarification.

关键词： obstructive jaundice fluorodeoxyglucose positron emission tomography/ computed tomography computed tomography magnetic resonance imaging

基于ERK/NF-κB/COX-2信号通路研究珠子参总皂苷改善对乙酰氨基酚致小鼠肝损伤的作用机制

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中国中药杂志 2024年第10期49卷 2585-2596页

作者：石孟琼张继红周刚郭巍刘英包中文陈茂华谈发明胡慧泉汪鋆植任剑峡唐海明三峡大学基础医学院&肿瘤微环境与免疫治疗湖北省重点实验室湖北宜昌443002 三峡大学中医医院&湖北省功能性消化系统疾病中医临床医学研究中心湖北宜昌443002 湖北鄂州二医院药剂科湖北鄂州436000 宜昌市第二人民医院湖北宜昌443002 湖北恒安芙林药业股份有限公司湖北宜昌443199

研究珠子参总皂苷(total saponins of Panax japonicus,TSPJ)对对乙酰氨基酚(acetaminophen,APAP)诱导小鼠肝损伤的影响及作用机制。将雄性昆明小鼠随机分为空白组、TSPJ组(200 mg·kg^(-1),ig)、模型组、APAP+TSPJ低剂量组(50 mg·kg^(-1),ig)、APAP+TSPJ中剂量组(100 mg·kg^(-1),ig)、APAP+TSPJ高剂量组(200 mg·kg^(-1),ig)和APAP+N-乙酰半胱氨酸组(200 mg·kg^(-1),ip)。给药组每天ig或ip相应的药物,每天1次,连续14 d。末次给药1 h后,除空白组和TSPJ组外,各组小鼠均灌胃给予500 mg·kg^(-1) APAP,24 h后收集小鼠血清与肝脏组织进行血清中丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)、活性氧(reactive oxygen species,ROS)、肿瘤坏死因子(tumor necrosis factor,TNF)-α、白细胞介素(interleukin,IL)-1β、环氧合酶(cyclooxygenase,COX)-2、IL-6、IL-4、IL-10及肝组织中乳酸脱氢酶(lactate dehydrogenase,LDH)、谷胱甘肽(glutathione,GSH)、超氧化物歧化酶(superoxide dismutase,SOD)、过氧化氢酶(catalase,CAT)、总抗氧化能力(total antioxidant capacity,T-AOC)、丙二醛(malondialdehyde,MDA)、髓过氧化物酶(myeloperoxidase,MPO)的水平,苏木精-伊红染色观察肝组织形态学改变;实时定量PCR法测定肝组织中淋巴细胞抗原6G(lymphocyte antigen 6G,Ly6G)、半乳糖凝集素3(galectin 3,Mac-2)、TNF-α、IL-1β、COX-2、IL-6、IL-4、IL-10 mRNA表达,Western blot法测定肝组织中Ly6G、Mac-2、细胞外调节蛋白激酶(extracellular regulated protein kinase,ERK)、磷酸化细胞外信号调节激酶(phosphorylated extracellular regulated protein kinase,p-ERK)、COX-2、核因子κB抑制因子α(inhibitor of nuclear factorκB protein α,IκBα)、磷酸化核因子κB抑制因子α(phosphorylated inhibitor of nuclear factorκB protein α,p-IκBα)、胞浆和胞核中核因子κB亚基p65(nuclear factorκB subunit p65,NF-κB p65)蛋白表达。结果显示,TSPJ可显著降低APAP诱导小鼠肝脏系数、血清中ALT、AST、ROS、TNF-α、IL-1β、IL-6、COX-2水平及肝组织LDH、MPO、MDA水平和肝组织中TNF-α、IL-1β、IL-6 mRNA表达,升高血清中IL-4、IL-10含量及肝组织中GSH、CAT、SOD、T-AOC水平和肝组织中IL-4、IL-10 mRNA表达;改善肝脏病理损伤程度,抑制肝组织中性粒细胞浸润和巨噬细胞募集;降低肝组织中中性粒细胞标记物Ly6G、巨噬细胞标记物Mac-2和COX-2 mRNA和蛋白表达,降低p-ERK、p-IκBα、胞核NF-κB p65蛋白表达和p-ERK/ERK、p-IκBα/IκBα比率,升高胞浆NF-κB p65蛋白表达。以上结果表明,TSPJ对APAP诱导的小鼠肝损伤有显著保护作用、可减轻APAP引起的氧化损伤与炎症反应,其作用机制与抑制ERK/NF-κB/COX-2信号通路激活,进而抑制炎性细胞浸润、炎症因子生成和抑制肝细胞损伤密切相关。

关键词：珠子参总皂苷对乙酰氨基酚氧化损伤炎症反应细胞外调节蛋白激酶/核因子κB/环氧合酶-2信号通路

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早产儿初乳口腔免疫疗法的最佳证据总结

护理学报 2024年第8期31卷 37-42页

作者：纪锐婷林丹娜刘小成李婷婷谢映梅胡冰应文娟汕头大学医学院广东汕头515000 深圳市龙华区妇幼保健院护理部广东深圳518000 深圳市龙岗区妇幼保健院新生儿科广东深圳518000 深圳市龙岗区妇幼保健院护理部广东深圳518000

目的检索、评价国内外早产儿行初乳口腔免疫疗法的证据,为开展早产儿初乳口腔免疫疗法提供临床实践依据。方法根据“6S”证据模型,系统检索国内外数据库中关于早产儿运用初乳口腔免疫疗法的文献。由2名研究者独立对文献进行质量评价并... 详细信息

目的检索、评价国内外早产儿行初乳口腔免疫疗法的证据,为开展早产儿初乳口腔免疫疗法提供临床实践依据。方法根据“6S”证据模型,系统检索国内外数据库中关于早产儿运用初乳口腔免疫疗法的文献。由2名研究者独立对文献进行质量评价并提取整合证据。结果共纳入11篇文献,其中指南3篇、专家共识1篇、临床决策1篇和系统评价6篇。从适宜对象、干预方法、初乳管理以及健康教育4个方面,共获得15条最佳证据。结论本研究从适宜对象、干预方法、初乳管理及健康教育这4个方面归纳分析早产儿初乳口腔免疫疗法的最佳证据,医护人员可结合临床现有条件和患儿的实际情况开展初乳口腔免疫疗法,以促进患儿免疫系统的成熟及尽早达到出院标准。

关键词：早产儿初乳口腔免疫疗法循证护理最佳证据

Effect of DPC4 Gene on Invasion and Metastasis of Colorectal Carcinoma Cells

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Acta Biochimica et Biophysica Sinica 2006年第12期38卷 883-892页

作者： De-Sheng XIAO ji-Fang wen* jing-He LI Kuan-Song WANG Zhong-Liang hu jian-hua ZHOU Zheng-Hao DENG ying LIU Department of Pathology,Xiangya School of Medicine,Central South university,Changsha 410078,china DepartmentofPathology XiangyaSchoolofMedicineCentralSouthUniversityChangsha410078China

To investigate the effect of DPC4 gene on invasion and metastasis of colorectal carcinomacells,the expression of DPC4 was detected in sixty-three samples of colorectal tumors and seven cases ofcolorectal *** biological behavior of tumors expressing DPC4 was evaluated (including tumorstaging,differentiation degree and metastasis).pcDNA3.1-DPC4 plasmid was constructed and transferredinto HCT116 cells not expressing *** cell models (DPC4~+-HCT116) steadily expressing DPC4 *** with HCT116 and pcDNA3.1-HCT116 cells,the doubling time of DPC4~+-HCT116 cellswas lengthened obviously (P1),the apoptosis rate of DPC4~+-HCT 116 cells was significantly increased(P1),the cloning efficiency,cell adherency,migration and invasion ability of DPC4~+-HCT116 cells weredropped obviously (P1).The number of cancer nodules was decreased significantly in abdominal cavityand liver of the nude mice inoculated with DPC4~+-HCT116 *** activity of MMP-9 and MMP-2 wasdetected by gelatin *** comparison with HCT116 and pcDNA3.1-HCT116 cells,the activity ofMMP-9 was decreased in DPC4~+-HCT116 ***,the down-regulation of DPC4 expression may beassociated with the carcinogenesis of colorectal ***4 may inhibit the proliferation of coloncancer cell by restraining growth and inducing apoptosis,and the invasion and metastasis of colorectalcarcinoma ***-9 may be one of the downstream target genes regulated by DPC4.

关键词： DPC4 colorectal carcinoma invasion metastasis MMP9

Insight into the formation mechanism of levoglucosenone in phosphoric acid-catalyzed fast pyrolysis of cellulose

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Journal of Energy Chemistry 2020年第4期29卷 78-89页

作者： Bin hu Qiang Lu Yu-ting Wu wen-luan Xie Min-shu Cui ji Liu Chang-qing Dong Yong-ping Yang National Engineering Laboratory for Biomass Power Generation Equipment North China Electric Power UniversityBeijing 102206China

The catalytic fast pyrolysis of cellulose impregnated with phosphoric acid (H3PO4) offers a promising method for the selective production of levoglucosenone (LGO),a valuable anhydrosugar ***,the fundamental mechanism for selective LGO formation is ***,quantum chemistry calculations and catalytic fast pyrolysis experiments were performed to reveal the formation mechanism of LGO in H3PO4-catalyzed cellulose pyrolysis.H3PO4 significantly decreased the energy barriers of the pyrolytic reactions and altered the competitiveness of the LGO formation pathways,promoting LGO *** different pathways in the non-catalytic and H3P04-catalyzed conditions,LGO is mainly produced from the primary decomposition of glucose units of cellulose and secondary conversion of *** major catalytic formation pathways of LGO comprise similar reactions,with dehydration at the 3-OH+2-H site as the rate-determining ***,secondary conversion of 1,4;3,6-dianhydro-α-D-glucopyranose is not feasible for LGO formation,in contrast to previous *** addition,a high degree of polymerization is beneficial for the selectivity of LGO formation in the catalytic process,because the glycosidic bond is important for the formation of the bicyclic structure (1,5-and1,6-acetal rings).

关键词： Phosphoric acid Levoglucosenone Formation mechanism Density functional theory Py-GC/MS

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广东省公路客运站场发车实载率的特征

暨南大学学报（自然科学与医学版） 2003年第1期24卷 16-21页

作者：胡郁葱徐建闽靳文舟温惠英许继红孙楚文华南理工大学交通学院广东广州510640 广东省交通厅广东广州510000 广东省物价局广东广州510000

　根据在运价研究过程中对广东省公路客运站场发车情况的调查和研究结果,对不同车型、地域等类别的发车实载率特征进行了分析,得到各类班线平均发车实载率为49 82%的结论.与专门组织的实载率抽样调查的结果相对比,对实载率进行了修正,... 详细信息

　根据在运价研究过程中对广东省公路客运站场发车情况的调查和研究结果,对不同车型、地域等类别的发车实载率特征进行了分析,得到各类班线平均发车实载率为49 82%的结论.与专门组织的实载率抽样调查的结果相对比,对实载率进行了修正,最终得出综合认定的基准实载率,为正确评价广东省旅客运输市场供需状况,合理制定运价提供了依据.

关键词：广东公路客动站发车实载率旅客运输市场车型地域运价