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Combined effects of physical activity and calcium on bone health in children and adolescents:a systematic review of randomized controlled trials

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World Journal of Pediatrics 2020年第4期16卷 356-365页

作者： Xi Yang Yi Zhai Jian Zhang Jing-Yi Chen Dan Liu wen-hua zhao National Institution for Nutrition and Health Chinese Center for Disease Control and Prevention27 Nanwei RoadWest DistrictBeijingChina Department of Science and Technology Management Chinese Center for Disease Control and Prevention155 Changbai RoadChangping DistrictBeijingChina China National Clinical Research Center for Neurological Diseases Capital Medical UniversityNo.119 South Fourth Ring West RoadFengtai DistrictBeijingChina

Background A better understanding of the role of exercise and nutrition in bone health is significant for preventing *** aim of this review was to assess the combined effects of physical activity and calcium intake on improving bone mineral density in children and *** A search of electronic databases(MedLine,ISI Web of Science,Science Direct)and the literature references were *** controlled trials published between 1997 and 2017,evaluating the effect of both physical activity and calcium intake intervention on bone mineral density or bone mineral content among children aged 3–18 years were *** Improved Jadad Rating Scale was used to assess the methodological quality of the included *** characteristics were summarized in accordance with the review’s PICO *** in bone mineral content were detected at several different bone *** A total of nine studies involving 908 participants were included in this *** combined intervention of physical activity and calcium increased bone mineral in children and adolescents,especially when baseline calcium intake level was low and among participants on the stage of early *** Regular physical activity combined with high level of calcium intake is beneficial for bone health in young *** research is needed to evaluate the dose–response associations and long-term effects of the interaction between physical activity and calcium intake.

关键词： Adolescents Bone health Calcium Children Physical activity

Disease Risks of Childhood Obesity in China

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Biomedical and Environmental Sciences 2005年第6期18卷 401-410页

作者： YAN-PING LI XIAO-GUANG YANG FENG-YING ZHAI JIAN-hua PIAO wen-hua zhao JIAN ZHANG GUAN-SHENG MA National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention 29 Nanwei Road Beijing 100050 China

Objective To estimate the relative risks of dyslipidemia, hypertension, diabetes mellitus, and metabolic syndromes among overweight and obese Chinese children compared with their normal weight counterparts. Methods Overweight and obesity were defined by age- and sex-specific BMI classification reference for Chinese children and adolescents. Pediatric metabolic syndrome （MetS） and each risk factor for MetS were defined using the criteria for US adolescents. Definition of hyper-TC, LDL, and dyslipidemia for adults was applied as well. General linear model factor analysis and chi-square test were used to compare the difference in metabolic indicators among normal weight, overweight, and obese groups. Multiple logistic regression analysis was performed to estimate the odds ratio of metabolic abnormalities between obesity, overweight, and normal weight children, after adjustment for living area, family economic level, age, sex, and daily exercise time and TV watching time, as well as different dietary indices in the model. Results Significant increases in blood lipids, glucose, and blood pressure were found among overweight and obese children as compared with their counterparts with normal weight. By applying WGOC-recommended BMI classification, the risks for hypertriglyceridemia, low HDL and dyslipidemia among overweight children were 1.9, 1.4, and 1.5 times, and was 3.3, 1.5, and 1.8 times among obese groups compared to their counterparts with normal weight after adjustment for age, sex, region, socioeconomic status, physical activity, and dietary intakes. The overweight and obese children （15-17.9 years） had a high-risk of developing hypertension, which was 2.3 and 2.9 times higher than their counterparts with normal weight. Above 90% obese adolescents had abdominal obesity, while less than 1% normal weight ones had abdominal obesity. No obese adolescents were free from any risk factors for MetS, while 36.9% of normal weight adolescents were from the risk factors. 83.

关键词： Chinese obese children Metabolic syndrome (MetS) Hypertension Lipids Relative risk

Cation-Dipole Interaction-Induced Coacervate Underwater Adhesives in Natural Seawater

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Chinese Journal of Polymer Science 2024年第7期42卷 984-991,I0009页

作者： Xu-Fei Liu Chong-Rui Zhang hua-wen Peng Qiang zhao Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan430074China

Significant progress has been made in wet adhesives for low salinity water,but exploration of general ionic adhesives for natural seawater is less developed because the high salinity could weaken interfacial bonding and shields electrostatic interactions,resulting in adhesion ***,the design of adhesives for natural seawater represents challenges less ***,a cationic polyelectrolyte(PECHIA)containing imidazolacetonitrile unit was explored to prepare adhesives enabled by natural *** combining the ion shielding effect with the“cation-dipole”interactions between PECHIA chains,aqueous solution of the PECHIA underwent coacervation and self-crosslinking in natural seawater,allowing for underwater adhesion to various substrates in *** instantaneous lap-shear and tensile adhesion strengths are 47 and 119 kPa,respectively,while the cured adhesive shows~739 k Pa tensile adhesion in natural *** design of PECHIA enables wet adhesives viable for applications in the diversified scenarios of natural seawater.

关键词： Coacervate Underwater adhesives Seawater Cation-dipole interaction

Effect of 5-LOX/COX-2 common inhibitor DHDMBF30 on pancreatic cancer cell Capan2

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World Journal of Gastroenterology 2008年第16期14卷 2494-2500页

作者： Bo Zhang Chang-Liang Wang wen-hua zhao Ming Lv ChunoYing Wang Wei-Xia Zhong WuoYuan Zhou wen-Sheng Yu Yan Zhang Sheng Li Shandong Tumor Hospital Jinan 250117 ShandongProvince China Zibo central hospital Zibo 255001 Shandong ProvinceChina Qilu hospital of Shandong University Jinan 250011Shandong Province China

AIM: To study the effect of 5-lipoxygenase/cyclooxy- genase-2 (5-LOX/COX-2) dual inhibitor 7-tert-butyl-2, 3-dihydro-3, 3-dimethyl substituted dihydrofuran 30 (DHDMBF30) on proliferation and apoptosis of the pancreatic cancer cell line Capan-2 and the effect of DHDMBF30 on human pancreatic cancer in a nude mouse model. METHODS: Investigate the effect of 5-LOX/COX-2 dual inhibitor DHDMBF30 on proliferation and apoptosis of the pancreatic cancer cell line Capan-2 by RT-PCR, MTT assay, FCM and electron microscope. Cell line Capan-2 was inoculated percutaneously on the outer thigh of 12 nude mice. The VEGF mRNA of transplantation tumor was detected by RT-PCR. RESULTS: DHDMBF30 inhibits the proliferation of cell line Capan2, reduces the expression of 5-LOX, COX-2 and VEGF. After Capan2 was treated with DHDMBF30, we found that the apoptosis peak of the experimental group was significantly higher than that of the contrast group (3.08 ± 1.89 vs 27.67 ± 0.52, P < 0.001). The tumor weight of the DHDMBF30 group was significantly lower than PBS control groups (1.35 ± 0.47 vs 2.92 ± 0.73, P < 0.01). Expression of VEGF in the DHDMBF30 group was significantly decreased. CONCLUSION: DHDMBF30 inhibits the proliferation ofthe pancreatic cell line Capan2, and induces apoptosis and inhibits the growth of pancreatic cancer in nude mice.

关键词： 5-lipoxygenase pancreatic tumor Cyclooxygenase2 DHDMBF30 Carcinoma in nude mice

Goal-Oriented Control Systems(GOCS):From HOW to WHAT

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 816-819页

作者： wen-hua Chen the Department of Aeronautical and Automotive Engineering Loughborough UniversityLeicestershireLE113TUU.K.

Brief:New control theory is required to underpin safe design and deployment of future highly automated systems to deal with uncertain environments and complicated tasks,enabled by AI and other advanced ***-Oriented Control Systems offer potential to transform the control system design from currently instructing a control system how to perform a task to specifying what is to be achieved.

关键词： automated instru system

Triple-transforming gel prepared byβ-cyclodextrin,diphenylamine and lithium chloride in N,N-dimethylacetamide

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Chinese Chemical Letters 2010年第10期21卷 1251-1254页

作者： Yuan Yuan Li wen Jing zhao hua Cheng Zhang Tao Sun Wei An Fei Fei Xin Ai You Hao School of Chemistry and Chemical Engineering Shandong University Jinan 250100 China

This paper describes a triple-transforming gel system （gel-sol-gel＇） for the first time, which is a thermo-responsive and multi- component organogel prepared by β-cyclodextrin （β-CD）, diphenylamine （DPA） and lithium chloride （LiCl） in N,N-dimethyla- cetamide （DMAC） in a suitable proportion based on the supramolecular interactions. In the triple-transfomaing gel system, a gel （gel A） could be formed by β-CD, DPA and LiCl in DMAC at room temperature based on stirring, then the gel could transform into a clear solution based on heating, and then the other gel （gel B） can be formed at a relatively high temperature （Tget, the gelation temperature by heating）. The two gel states in the triple-transforming gel system have different microstructures. This gel system was characterized by OM, SEM, IR and theology.

关键词： Gel Triple-transforming β-Cyclodextrin Lithium N,N-Dimethylacetamide

Enhancement of CD4^+ T cell activities and modulation of Th1/Th2 lineage development in radiated tumor-bearing rats treated with male zooid of Antheraea pernyi extracts

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World Journal of Gastroenterology 2008年第13期14卷 2094-2099页

作者： wen-hua zhao Ling Li Bo Zhang Wei-Dong Zhang Min Zong Ji-Dong Tang Hong-Yu Zhang Sheng Li Shandong Tumor Hospital Jinan 250117 Shandong Province China Shandong Academy of Medical Sciences Jinan 250062 Shandong Province China Institute of of Basic Medicine Shandong Academy of Medical Sciences Jinan 250062 Shandong Province China Qilu Hospital of Shandong University Jinan 250011 Shandong Province China

AIM： To investigate whether supplementation of male zooid of Antheraea pernyi extracts （MZAPE） could enhance immune function of radiated tumor-bearing rats. METHODS： Eighty male Wistar rats were randomly divided into a control group, a simple radiation group, a MZAPE group, and a radiation plus MZAPE group. With the tumor model established by implanting Walker-256 ascites tumor cells, tumor weight and tumor control rate were calculated. The rats in the simple radiation and radiation plus MZAPE groups were underwent to radiation at 10 Gy within 2 d. In the MZAPE and radiation plus MZAPE groups, the MZAPE was gavaged at a dose of 16.53 mg/kg once a day for 7 d. T cell subsets in peripheral blood were determined by flow cytometry and the expression of IL-2, IFN-γ, IL-4 and IL-10 in sera were determined by ELISA on the 8th d. RESULTS： The tumor weight of simple radiation group, MZAPE group and radiation plus MZAPE group was lower than that of control group （P 〈 0.01） and tumor control rates were 63.08% ± 6.43%, 69.86%± 7.12% and 35.30% ± 7.67%, respectively. CD^4＋ T and CD^8＋ T cells in the peripheral blood of the simple radiation group were fewer than in control group. In the MZAPE and radiation plus MZAPE groups, the number of CD^4＋ T cells was higher while CD^8＋ T cells was lower than in the control and simple radiation groups. Expression of IL-2 and INF-y in the radiation group was lower than in control group, and significantly enhanced during MZAPE therapy （P 〈 0.05）. Expression of IL-4 and IL-10 in the radiation group had no significant changes compared with the control group, and decreased significantly after MZAPE treatment （P 〈 0.01）. CONCLUSION： MZAPE administration may help improve the immune function of the radiated tumor-bearing rats and reverse the radiation-induced immune inhibition by promoting the proliferation of T helper cells and inducing the transdifferentiation from Th2 to Th1.

关键词： Antheraea pernyi Male zooid Rats Radiotherapy Immune suppression

Report on Childhood Obesity in China (6) Evaluation of a Classroom-based Physical Activity Promotion Program

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Biomedical and Environmental Sciences 2007年第1期20卷 19-23页

作者： AI-LING LIU XIAO-QI HU GUAN-SHENG MA zhao-HUI CUI YONG-PING PAN Su-YING CHANG wen-hua zhao HUN-MING CHEN National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention 29 Nanwei Road Beijing 100050 China Dongcheng School Healthcare Institute Beijing 100007 China International Life Science Institute Focal Point-China Beijing 100050 China

Objectives To evaluate the effect of Happy 10 program on the promotion of physical activity, physical growth and development of primary-school students, and on obesity control and prevention. Methods Two similar primary schools from one district of Beijing, China were selected, one as an intervention school and the other as a control school. Happy 10 program was implemented at least once every school day in the intervention school for two semesters, whereas no intervention was adopted in the control school. The information on energy expenditure and duration of physical activity was collected by a validated 7-day physical activity questionnaire. Height and weight were measured by trained investigators following the standardized procedure. Energy expenditure and intensity of each Happy 10 session was measured by a physical activity monitor. Results The average energy expenditure and duration of total physical activity per day among students in the intervention school increased significantly from 15.0 to 18.2 kcal/kg, and 2.8 to 3.3 h respectively, whereas the figures significantly decreased in the control school. There was a significant difference in change of weight and BMI between girls in the intervention and control school （2.4 kg vs 4.6 kg, -0.47 kg/m^2 vs 0.66 kg/m^2）. The prevalence of overweight and obesity in the intervention school decreased by 0.4%-5.6%, as compared to the increase by 0.6%-4.5% in the control school. The average energy expenditure and intensity per 10-minute session ranged from 25.0-35.1 kcal, 4.8-6.2 kcal/kg/h respectively in grades 1-5. Conclusion Happy 10 program provides a useful strategy to promote physical activity among school children and also plays a positive role in building up physical growth and development of girls.

关键词： Happy 10 Physical activity Obesity Intervention

Confirmed Diagnosis by RT-PCR and Phylogenetic Analysis of Peste des Petits Ruminants Viruses in Tibet, China

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Virologica Sinica 2009年第6期24卷 573-578页

作者： wen-hua zhao Shi-biao YANG Jian-qiang HAN Mei JIANG hua-chun LI Nian-zu ZHANG Qi-han LI Laboratory of Tropical and Subtropical Animal Virology of MOA National Exotic Animal Disease Diagnostic Laboratory Kunming 650224 China Yu Xi Agriculture Vocational Technical College Yu Xi 653100 China Peking Union Medical College Tsinghua University Kunming Jiaoling Road 3 79# Kunming 65011 8 China

This paper reports the confirmed diagnosis by nested RT-PCR of PPR cases in Tibet, China in 2007, and results of phylogenetic analysis. Results showed that the 11 tested samples were PPRV positive by nested RT-PCR, of which 2 samples were genetically close to the X7443 strain (Nigeria 75/1) of lineage I, and 3 samples close to the strain AY560591 (Sungri96) of linage IV with 96.6%、97.3%、97.6% and 98% nucleotide sequence homogeneity respectively, based on partial sequencing of the F gene from 5 samples and complete sequencing of the N/M/F/H genes from one sample. This study suggested that there are at least 2 origins of PPRV in China.

关键词： Peste des petitis ruminants virus (PPRV) Tibet RT-PCR Open reading frame (ORF) Phylogenetic analysis