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Long noncoding RNA protein-disulfide isomerase-associated 3 regulated high glucose-induced podocyte apoptosis in diabetic nephropathy through targeting miR-139-3p

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World Journal of Diabetes 2024年第2期15卷 260-274页

作者： Yin-Xi He Ting Wang wen-xian li Yan-Xia Chen Department of Orthopaedic Trauma The Third Hospital of ShijiazhuangShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The First Hospital of ZhangjiakouZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Podocyte apoptosis plays a vital role in proteinuria pathogenesis in diabetic nephropathy(DN).The regulatory relationship between long noncoding RNAs(lncRNAs)and podocyte apoptosis has recently become another research hot spot in the DN *** To investigate whether lncRNA protein-disulfide isomerase-associated 3(Pdia3)could regulate podocyte apoptosis through miR-139-3p and revealed the underlying *** Using normal glucose or high glucose(HG)-cultured podocytes,the cellular functions and exact mechanisms underlying the regulatory effects of lncRNA Pdia3 on podocyte apoptosis and endoplasmic reticulum stress(ERS)were *** Pdia3 and miR-139-3p expression were measured through quantitative real-time polymerase chain *** cell viability was detected through the cell counting kit-8 colorimetric *** podocyte apoptosis rate in each group was measured through flow *** interaction between lncRNA Pdia3 and miR-139-3p was examined through the dual luciferase reporter ***,western blotting was performed to detect the effect of lncRNA Pdia3 on podocyte apoptosis and ERS via *** The expression of lncRNA Pdia3 was significantly downregulated in HG-cultured ***,lncRNA Pdia3 was involved in HG-induced podocyte ***,the dual luciferase reporter assay confirmed the direct interaction between lncRNA Pdia3 and *** Pdia3 overexpression attenuated podocyte apoptosis and ERS through miR-139-3p in HG-cultured *** Taken together,this study demonstrated that lncRNA Pdia3 overexpression could attenuate HG-induced podocyte apoptosis and ERS by acting as a competing endogenous RNA of miR-139-3p,which might provide a potential therapeutic target for DN.

关键词： Long noncoding RNAs Diabetic nephropathy Podocyte apoptosis Endoplasmic reticulum stress Competing endogenous RNA

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Effect of continuous nursing on treatment compliance and side effect management of coronary heart disease

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World Journal of Clinical Cases 2024年第19期12卷 3701-3707页

作者： Juan Wei Bai-wen-xian li Shao-Jie Han Hong-Jie Zhuang wen-Hong Cao Department of Cardiology The First Affiliated Hospital of Hebei North UniversityZhangjiakou 750061Hebei ProvinceChina

BACKGROUND There are relatively few studies on continuing care of coronary heart disease(CHD),and its research value needs to be further *** To investigate the effect of continuous nursing on treatment compliance and side effect management in patients with *** This is a retrospective study with patients from January 2021 to *** study was divided into two groups with 30 participants in each ***-rating anxiety scale(SAS)and Self-rating depression scale(SDS)were used to assess patients'anxiety and depression,and medical coping questionnaire was used to assess patients'coping *** pelvic floor dysfunction questionnaire(PFDI-20)was used to assess the status of pelvic floor function,including bladder symptoms,intestinal symptoms,and pelvic *** SAS score decreased from 57.33±3.01before treatment to 41.33±3.42 after treatment,SDS score decreased from 50.40±1.45 to 39.47±*** decrease of these two indexes was statistically significant(Pliance,reducing anxiety and depression levels,and improving coping styles and pelvic floor functional status.

关键词： Coronary heart disease Continuing care Treatment compliance Anxiety and depression Coping style Pelvic floor function status Pioneering study

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Scattering of Water Waves by Dual Symmetric Inclined Floating Porous Barriers Using the DBEM

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China Ocean Engineering 2024年第1期38卷 156-168页

作者： WANG li-xian DENG Yan-wen YE Yang-sha DENG Zheng-zhi Key Laboratory of High Performance Ship Technology(Wuhan University of Technology) Ministry of EducationWuhan 430063China School of Naval Architecture Ocean and Energy Power EngineeringWuhan University of TechnologyWuhan 430063China Key Laboratory of Water-Sediment Sciences and Water Disaster Prevention of Hunan Province Changsha 410114China Institute of Port Coastal and Offshore EngineeringZhejiang UniversityZhoushan 316021China

The scattering of normally incident water waves by two surface-piercing inclined perforated barriers in water with a uniform finite depth is investigated within the framework of linear water wave *** that thin barriers are zero-thickness,a novel numerical method involving the the coupling of the dual boundary element method(DBEM)with damping layers is *** order to effectively damp out the reflected waves,two damping layers,instead of pseudoboundaries are implemented near the two side boundaries of the computational ***,the modified linearized free surface boundary conditions are formulated and used for solving both the ordinary boundary integral equation as well as the hypersingular boundary integral equation for degenerate *** newly developed numerical method is validated against analytical methods using the matched eigenfunction expansion method for the special case of two vertical barriers or the inclined angle to the vertical being *** influence of the length of the two damping layers has been ***,these findings are also validated against previous results for several *** validation,the numerical results for the reflection coefficient,transmission coefficient and dissipation coefficient are obtained by varying the inclination angle and porosity-effect *** effects of both the inclination angle and the porosity on the amplitudes of wave forces acting on both the front and rear barriers are also *** is found that the effect of the inclination angle mainly shifts the location of the extremal values of the reflection and the transmission ***,a moderate value of the porosity-parameter is quite effective at dissipating wave energy and mitigating the wave loads on dual barriers.

关键词： dual boundary element method inclined perforated floating breakwater reflection coefficient transmission coefficient damping layer

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Microstructure Evolution and Nanomechanical Behavior of Micro-Area in Molten Pool of Selective Laser Melting(CoCrNi)_(82)Al_(9)Ti_(9)High-Entropy Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 1019-1033页

作者： Hong-Wei Zhang li-Wei Lan Zhe-Yu Yang Chang-Chun li wen-xian Wang College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024China Ministry of Education Key Laboratory of Interface Science and Engineering in Advanced MaterialsTaiyuan University of TechnologyTaiyuan030024China Shanxi-Zhejiang University New Materials and Chemical Research Institute Taiyuan030032China

In this work,the phase evolution mechanism and nanomechanical properties of(CoCrNi))(82)Al_(9)Ti_(9)high-entropy alloy(HEA)prepared by selective laser melting(SLM)in the molten pool were *** HEA contains multiple primary elements and undergoes high-temperature gradient and rapid cooling during *** leads to significant inhomogeneity of nano-scale microstructure characteristics and instability of *** optimizing process parameters,the microstructure evolution at the optimal parameter volume energy density of 440 J/mm^(3)was studied.A phase transition from BCC to FCC occurred in the melt *** the micro-area of the melt pool results in a temperature rise and the combustion-induced loss of Al ***,the Ni element content increases significantly outside the melt *** process enhances the phase stability of FCC and facilitates phase ***,rapid cooling leads to the formation of distinctive ultrafine equiaxial crystals inside the melt pool,accompanied by the generation of intracrystalline needle-like nano-scale *** the melt pool,the accumulation of energy results in the formation of coarse ***,the nano-hardness inside the molten pool is remarkably high at 11.79 GPa,while the outside the molten pool is reduced to 9.58 *** the fracture toughness outside the melt pool also *** with inside the melt pool,the residual stress outside the melt pool changed from compressive to tensile stress and decreased from 603.28 to 322.84 MPa.

关键词： High-entropy alloys Selective laser melting Microstructure evolution Nanoindentation

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Impact of scandium and terbium on the mechanical properties,corrosion behavior,and biocompatibility of biodegradable Mg-Zn-Zr-Mn alloys

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Journal of Magnesium and Alloys 2024年第2期12卷 546-572页

作者： Khurram Munir Jixing lin xian Tong Arne Biesiekierski Yuncang li Cuie wen School of Engineering RMIT UniversityMelbourneVictoria 3001Australia School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325027China

Magnesium(Mg)-based bone implants degrade rapidly in the physiological environment of the human body which affects their structural integrity and biocompatibility before adequate bone *** earth elements(REEs)have demonstrated their effectiveness in tailoring the corrosion and mechanical behavior of Mg *** study methodically investigated the impacts of scandium(Sc)and terbium(Tb)in tailoring the corrosion resistance,mechanical properties,and biocompatibility of Mg–0.5Zn–0.35Zr–0.15Mn(MZZM)alloys fabricated via casting and hot *** indicate that addition of Sc and Tb improved the strength of MZZM alloys via grain size reduction and solid solution strengthening *** extruded MZZM–(1–2)Sc–(1–2)Tb(wt.%)alloys exhibit compressive strengths within the range of 336–405 MPa,surpassing the minimum required strength of 200 MPa for bone implants by a significant *** polarization tests revealed low corrosion rates of as–cast MZZM(0.25 mm/y),MZZM–2Tb(0.45 mm/y),MZZM–1Sc–1Tb(0.18 mm/y),and MZZM–1Sc–2Tb(0.64 mm/y),and extruded MZZM(0.17 mm/y),MZZM–1Sc(0.15 mm/y),MZZM-2Sc(0.45 mm/y),MZZM-1Tb(0.17 mm/y),MZZM-2Tb(0.10 mm/y),MZZM–1Sc-1Tb(0.14 mm/y),MZZM-1Sc-2Tb(0.40 mm/y),and MZZM–2Sc–2Tb(0.51 mm/y)alloys,which were found lower compared to corrosion rate of high-purity Mg(~1.0 mm/y)reported in the ***,addition of Sc,or Tb,or Sc and Tb to MZZM alloys did not adversely affect the viability of SaOS2 cells,but enhanced their initial cell attachment,proliferation,and spreading shown via polygonal shapes and *** study emphasizes the benefits of incorporating Sc and Tb elements in MZZM alloys,as they effectively enhance corrosion resistance,mechanical properties,and biocompatibility simultaneously.

关键词： Corrosion property In vitro cytotoxicity Magnesium alloys Mechanical property Rare earth elements

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Heteroepitaxial growth of Au@Pd core–shell nanocrystals with intrinsic chiral surfaces for enantiomeric recognition

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Rare Metals 2024年第1期43卷 225-235页

作者： Feng-Xia Wu Feng-Hua li Xia-li Lv Qi-xian Zhang Guo-Bao Xu wen-Xin Niu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Shaoxing Institute of Technology Shanghai UniversityShaoxing 312000China University of Science and Technology of China Hefei 230026China School of Materials Science and Engineering Shanghai UniversityShanghai 200436China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314113China University of Chinese Academy of Sciences Beijing 100039China

Noble metal surfaces with intrinsic chirality serve as an ideal candidate for investigating enantioselective chemistry due to their superior chemical durability and high catalytic ***,significant advance has been made in synthesizing metal nanocrystals with intrinsic ***,the majority reports are limited to ***,through a heteroepitaxial growth strategy,the synthesis of metal nanocrystals with intrinsic chirality to palladium was extended for the first time and their application in enantioselective recognition was *** heteroepitaxial growth strategy allows for transferring the chirality of homochiral Au nanocrystals to Au@Pd core–shell *** employing the chiral Au@Pd nanocrystals as enantiomeric recognizing elements,a series of electrochemical sensors for chiral discrimination were *** optimal conditions,the peak potential between D-dihydroxyphenylalanine(D-DOPA)and L-dihydroxyphenylalanine(L-DOPA)is about 80 m V,and the peak current of D-DOPA is 2 times as much as that of L-DOPA,which enables the determination of the enantiomeric excess(EE,%)of ***,this report not only introduces a heteroepitaxial growth strategy to synthesize metal nanocrystals with intrinsic chirality,but also demonstrates the superior capability of integrating intrinsic chirality and catalytic properties into metal nanocrystals for chiral recognition.

关键词： Core–shell nanostructures Chirality transfer Electrochemical sensors Chiral recognition Chiroplasmonics

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A Time Series Observation of Chinese Children Undergoing Rigid Bronchoscopy for an Inhaled Foreign Body： 3149 Cases in 1991-2010

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Chinese Medical Journal 2015年第4期128卷 504-509页

作者： Xu Zhang wen-xian li Yi-Rong Cai Department of Anesthesiology Eye and ENT Hospital Fudan University Shanghai 200031 China

Background：In China,tracheobronchial foreign body （TFB） aspiration,a major cause of emergency episode and accident death in children,remains a challenge for anesthetic ***,we share our experience and discuss the anesthetic consideration and management of patients with TFB ***：This was a single-institution retrospective study in children with an inhaled foreign body between 1991 and 2010 that focused on the complications following rigid bronchoscopy （RB）.Data including the clinical characteristics of patients and TFB,anesthetic method,and postoperative severe complications were analyzed by different ***：During the 20-year study period,the charts of 3149 patients who underwent RB for suspected inhaled TFB were *** were 2079 male and 1070 female patients （1.94：1）.A nut （84％） was the most commonly inhaled *** study revealed a 9％（n =284） overall rate of severe postoperative complications related to severe hypoxemia,laryngeal edema,complete laryngospasm,pneumothorax,total segmental atelectasis,and death with incidences of 3.2％,0.9％,1.3％,0.3％,0.3％,and 0.1％,*** rates of preoperative airway impairment,negative findings of TFB,and adverse postoperative events have been on the rise in the past 5 ***：The survey results confirmed that hypoxemia remains the most common postoperative complication in different *** controlled ventilation and spontaneous ventilation were effective during the RB extraction of the foreign body at our hospital in the modern technique *** active respiratory symptom was commonly seen in the groups with negative findings.

关键词： Complication Inhaled Foreign Body Rigid Bronchoscope

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Global output feedback regulation of time-varying nonlinear systems via the dual-gain method

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Science China(Information Sciences) 2024年第5期67卷 333-334页

作者： xian-Long YIN Zong-Yao SUN Changyun wen Institute of Automation Qufu Normal University School of Electrical and Electronic Engineering Nanyang Technological University

Notably, owing to the limited information available, the problem of output feedback stabilization/regulation for nonlinear systems has been explored based on state *** addition, the sensors accounting for state measurement could fail to detect the system states accurately due to the limitations of manufacturing techniques and instruments.

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Clinical effect of laparoscopic radical resection of colorectal cancer based on propensity score matching

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 124-133页

作者： Yang liu xian-Xue Wang Yu-lin li wen-Tao He Hong li Hua Chen Department of General Surgery Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina Department of Anesthesiology Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina

BACKGROUND The incidence of colorectal cancer(CRC)is increasing *** radical resection of CRC is a minimally invasive procedure preferred in clinical *** To investigate the clinical effect of laparoscopic radical resection of CRC on the basis of propensity score matching(PSM).METHODS The clinical data of 100 patients who received inpatient treatment for CRC at Changde Hospital,xiangya School of Medicine,Central South University(The First People’s Hospital of Changde City)were analyzed *** control group included patients who underwent open surgery(n=43),and those who underwent laparoscopic surgery formed the observation group(n=57).The baseline information of both groups was equipoised using 1×1 *** in the perioperative parameters,inflammatory response,immune function,degree of pain,and physical status between the groups were *** Thirty patients from both groups were successfully *** PSM,baseline data showed no statistically significant differences between the groups:(1)Periop-erative parameters:The observation group had a longer surgery time,less intra-operative blood loss,earlier first ambulation and first anal exhaust times,and shorter gastric tube indwelling time than the control group;(2)Inflammatory response:24 h after surgery,the levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)between groups were higher than ***-6,CRP,and TNF-αlevels in the observation group were lower than in the control group;(3)Immune function:At 24 h after surgery,counts of CD4-positive T-lymphocytes(CD4+)and CD4+/CD8-positive T-lymphocytes(CD8+)in both groups were lower than those before surgery,whereas CD8+was higher than that before *** 24 h after surgery,both CD4+counts and CD4+/CD8+in the observation group were higher than those in the control group,whereas CD8+counts were lower;(4)Degree of pain:The visual analog scale scores in the observation gro

关键词： Colorectal cancer Laparoscopic Open surgery Inflammatory reaction Immune function Propensity score

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Delving into high-quality SVBRDF acquisition: A new setup and method

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Computational Visual Media 2024年第3期10卷 523-541页

作者： Chuhua xian Jiaxin li Hao Wu Zisen lin Guiqing li School of Computer Science and Engineering South China University of TechnologyGuangzhou 510006China Guangdong Shidi Intelligence Technology Ltd.Guangzhou 510000China

In this study, we present a new andinnovative framework for acquiring high-qualitySVBRDF maps. Our approach addresses the limitations of the current methods and proposes a newsolution. The core of our method is a simple hardwaresetup consisting of a consumer-level camera, LEDlights, and a carefully designed network that canaccurately obtain the high-quality SVBRDF propertiesof a nearly planar object. By capturing a ﬂexiblenumber of images of an object, our network usesdifferent subnetworks to train different property mapsand employs appropriate loss functions for each ofthem. To further enhance the quality of the maps, weimproved the network structure by adding a novel skipconnection that connects the encoder and decoder withglobal features. Through extensive experimentation usingboth synthetic and real-world materials, our resultsdemonstrate that our method outperforms previousmethods and produces superior results. Furthermore,our proposed setup can also be used to acquire physicallybased rendering maps of special materials.

关键词： acquisition setup SVBRDF acquisition material capture global skip connection

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