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Lysine demethylase 5B transcriptionally regulates TREM1 in human cardiac fibroblasts

BIOCELL 2024年第7期48卷 1105-1113页

作者： CHUNLING LIANG JING chen XIAOjie chen WEI YAN jie YU Department of Emergency Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of Cardiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100102China Department of Radiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of Cardiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China

Background:A differential gene,triggering receptor expressed on myeloid cells 1(TREM1),was identiﬁed in blood sequencing datasets from myocardial infarction patients and healthy ***ﬁbrosis following myocardial infarction signiﬁcantly contributes to cardiac ***:This study aimed to unveil the intrinsic regulatory mechanism of TREM1 in myocardialﬁ***:Mimicking pathology by angiotensin II(Ang II)treatment of human cardiacﬁbroblasts(HCFs),the impacts of TREM1 knockdown on its proliferation,migration,and secretion of the pro-ﬁbrotic matrix were identiﬁ*** the Human Transcription Factor Database(HumanTFDB)website,lysine-speciﬁc demethylase 5B(KDM5B)was found to bind to the TREM1 promoter,which was further validated through luciferase reporter and chromatin immunoprecipitation(ChIP).By promoting KDM5B overexpression,its effect on the regulation of TREM1 was ***:TREM1 knockdown suppressed the proliferation,migration,and secretion of the pro-ﬁbrotic matrix in HCFs upon Ang II ***5B bound to the TREM1 promoter and upregulated its transcriptional ***,KDM5B overexpression reversed the regulation of the above cellular phenotypes by TREM1 ***:This study sheds light on the positive regulation of TREM1 by KDM5B,demonstrating their role in promoting myocardialﬁ***ﬁnding provides a theoretical foundation for understanding disease pathology and potentially advancing the development of new targeted therapies.

关键词： Cardiac fibroblasts Fibrosis Myeloid cell receptor Migration Proliferation

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Meibomian glands segmentation in infrared images with limited annotation

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 401-407页

作者： Jia-wen Lin Ling-jie Lin Feng Lu Tai-chen Lai Jing Zou Lin-Ling Guo Zhi-Ming Lin Li Li College of Computer and Data Science Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Fujian Provincial Key Laboratory of Networking Computing and Intelligent Information Processing Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Shengli Clinical Medical College of Fujian Medical University Fuzhou 350001Fujian ProvinceChina Department of Ophthalmology Fujian Provincial Hospital South BranchFujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

●AIM:To investigate a pioneering framework for the segmentation of meibomian glands(MGs),using limited annotations to reduce the workload on ophthalmologists and enhance the efficiency of clinical diagnosis.●METHODS:Totally 203 infrared meibomian images from 138 patients with dry eye disease,accompanied by corresponding annotations,were gathered for the study.A rectified scribble-supervised gland segmentation(RSSGS)model,incorporating temporal ensemble prediction,uncertainty estimation,and a transformation equivariance constraint,was introduced to address constraints imposed by limited supervision information inherent in scribble *** viability and efficacy of the proposed model were assessed based on accuracy,intersection over union(IoU),and dice coefficient.●RESULTS:Using manual labels as the gold standard,RSSGS demonstrated outcomes with an accuracy of 93.54%,a dice coefficient of 78.02%,and an IoU of 64.18%.Notably,these performance metrics exceed the current weakly supervised state-of-the-art methods by 0.76%,2.06%,and 2.69%,***,despite achieving a substantial 80%reduction in annotation costs,it only lags behind fully annotated methods by 0.72%,1.51%,and 2.04%.●CONCLUSION:An innovative automatic segmentation model is developed for MGs in infrared eyelid images,using scribble annotation for *** model maintains an exceptionally high level of segmentation accuracy while substantially reducing training *** holds substantial utility for calculating clinical parameters,thereby greatly enhancing the diagnostic efficiency of ophthalmologists in evaluating meibomian gland dysfunction.

关键词： infrared meibomian glands images meibomian gland dysfunction meibomian glands segmentation weak supervision scribbled annotation

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Analytical libration control law for electrodynamic tether system with current constraint

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Astrodynamics 2024年第2期8卷 237-246页

作者： Shidong Xu Ti chen Hao wen Dongping Jin State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China

This study focuses on stabilizing the libration dynamics of an electrodynamic tether system(EDTS)using generalized torques induced by the Lorentz *** contrast to existing numerical optimization methods,a novel analytical feedback control law is developed to stabilize the in-plane and out-of-plane motions of a tether by modulating the electric current *** saturation constraint on the current is accounted for by adding an auxiliary dynamic system to the *** enhance the robustness of the proposed controller,multiple perturbations of the orbital dynamics,modeling uncertainties,and external disturbances are approximated using a neural network in which the weighting matrix and approximation error are estimated simultaneously,such that these perturbations are well compensated for during the control design of the ***,a dynamically scaled generalized inverse is utilized to address the singular matrix in the control *** closed-loop system is proven to be ultimately bounded based on Lyapunov stability ***,numerical simulations are performed to demonstrate the effectiveness of the proposed analytical control law.

关键词： electrodynamic tether system(EDTS) libration dynamics analytical control current constraint

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QoS-Aware Computation Offloading in LEO Satellite Edge Computing for IoT:A Game-Theoretical Approach

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Chinese Journal of Electronics 2024年第4期33卷 875-885页

作者： Ying chen Jintao HU jie ZHAO Geyong MIN School of Computer Science Beijing Information Science and Technology University University of Exeter

Low earth orbit(LEO) satellite edge computing can overcome communication difficulties in harsh environments, which lack the support of terrestrial communication infrastructure. It is an indispensable option for achieving worldwide wireless communication coverage in the future. To improve the quality-of-service(QoS) for Internet-of-things(IoT) devices, we combine LEO satellite edge computing and ground communication systems to provide network services for IoT devices in harsh environments. We study the QoS-aware computation offloading(QCO) problem for IoT devices in LEO satellite edge computing. Then we investigate the computation offloading strategy for IoT devices that can minimize the total QoS cost of all devices while satisfying multiple constraints, such as the computing resource constraint, delay constraint, and energy consumption constraint. We formulate the QoSaware computation offloading problem as a game model named QCO game based on the non-cooperative competition game among IoT devices. We analyze the finite improvement property of the QCO game and prove that there is a Nash equilibrium for the QCO game. We propose a distributed QoS-aware computation offloading(DQCO) algorithm for the QCO game. Experimental results show that the DQCO algorithm can effectively reduce the total QoS cost of IoT devices.

关键词： Satellites Costs Computational modeling Low earth orbit satellites Quality of service Games Nash equilibrium

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Prediction for permeability index of blast furnace based on VMD-PSO-BP model

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Journal of Iron and Steel Research(International) 2024年第3期31卷 573-583页

作者： Xiao-jie Liu Yu-jie Zhang Xin Li Zhi-feng Zhang Hong-yang Li Ran Liu Shu-jun chen School of Metallurgy and Energy North China University of Science and TechnologyTangshan 063210HebeiChina chengde Branch HBIS Group Co.Ltd.Chengde 067000HebeiChina

The permeability index is one of the important production indicators to monitor the operation of blast *** is crucial to grasp the trends of changes in the new permeability index in *** the complex vibration spectrum of the permeability index,a prediction model of the permeability index based on the VMD-PSO-BP(variational mode decomposition-particle swarm optimization-back propagation)method was ***,the key factors that affect the permeability index of blast furnace were studied from multiple ***,the permeability index was divided into multiple sub-modes based on the difference of frequency bands by the VMD algorithm,and a PSO-BP prediction model was established for each ***,the prediction results of each sub-mode were summed to obtain the final *** results show that the composite prediction accuracy by using the VMD algorithm is 3%higher than that of the traditional prediction method,which has better applicability.

关键词： Big data-Blast furnace Air permeability Variational mode decomposition Particle swarm optimization Back propagation Model prediction

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Revealing Al-O/Al-F reaction dynamic effects on the combustion of aluminum nanoparticles in oxygen/fluorine containing environments:A reactive molecular dynamics study meshing together experimental validation

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Defence Technology（防务技术） 2024年第4期34卷 313-327页

作者： Gang Li Chuande Zhao Qian Yu Fang Yang jie chen Institute of Chemical Materials China Academy of Engineering Physics(CAEP)P.O.Box 919-311Mianyang 621900SichuanChina

Improving the energy conversion efficiency in metallic fuel(e.g.,Al)combustion is always desirable but challenging,which often involves redox reactions of aluminum(Al)with various mixed oxidizing *** instance,Al-O reaction is the most common pathway to release limited energy while Al-F reaction has received much attentions to enhance Al combustion ***,microscopic understanding of the Al-O/Al-F reaction dynamics remains unsolved,which is fundamentally necessary to further improve Al combustion *** this work,for the first time,Al-O/Al-F reaction dynamic effects on the combustion of aluminum nanoparticles(n-Al)in oxygen/fluorine containing environments have been revealed via reactive molecular dynamics(RMD)simulations meshing together combustion *** RMD simulation systems of Al core/O_(2)/HF,n-Al/O_(2)/HF,and n-Al/O_(2)/CF4 with oxygen percentage ranging from 0%to 100%have been *** n-Al combustion in mixed O_(2)/CF_4 environments have been conducted by constant volume combustion *** results show that Al-O reaction exhibits kinetic benefits while Al-F reaction owns thermodynamic benefits for n-Al *** n-Al/O_(2)/HF,Al-O reaction gives faster energy release rate than Al-F reaction(1.1 times).The optimal energy release efficiency can be achieved with suitable oxygen percentage of 10%and 50%for n-Al/O_(2)/HF and n-Al/O_(2)/CF_4,*** combustion experiments,90%of oxygen percentage can optimally enhance the peak pressure,pressurization rate and combustion ***,Al-O reaction prefers to occur on the surface regions while Al-F reaction prefers to proceed in the interior regions of n-Al,confirming the kinetic/thermodynamic benefits of Al-O/Al-F *** synergistic effect of Al-O/Al-F reaction for greatly enhancing n-Al combustion efficiency is demonstrated at atomicscale,which is beneficial for optimizing the combustion performance of metallic fuel.

关键词： Al-O/Al—F reaction Kinetic benefits Thermodynamic benefits Molecular dynamics Combustion

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2D multifunctional devices:from material preparation to device fabrication and neuromorphic applications

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International Journal of Extreme Manufacturing 2024年第3期6卷 91-118页

作者： Zhuohui Huang Yanran Li Yi Zhang jiewei chen Jun He jie Jiang Hunan Key Laboratory of Nanophotonics and Devices School of PhysicsCentral South UniversityChangshaHunanPeople’s Republic of China Department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong Special Administrative Region of ChinaPeople’s Republic of China

Neuromorphic computing systems,which mimic the operation of neurons and synapses in the human brain,are seen as an appealing next-generation computing method due to their strong and efficient computing ***-dimensional (2D) materials with dangling bond-free surfaces and atomic-level thicknesses have emerged as promising candidates for neuromorphic computing *** a result,2D neuromorphic devices may provide an ideal platform for developing multifunctional neuromorphic ***,we review the recent neuromorphic devices based on 2D material and their multifunctional *** synthesis and next micro–nano fabrication methods of 2D materials and their heterostructures are first *** recent advances of neuromorphic 2D devices are discussed in detail using different operating *** importantly,we present a review of emerging multifunctional neuromorphic applications,including neuromorphic visual,auditory,tactile,and nociceptive systems based on 2D *** the end,we discuss the problems and methods for 2D neuromorphic device developments in the *** paper will give insights into designing 2D neuromorphic devices and applying them to the future neuromorphic systems.

关键词： 2D material micro–nano fabrication multifunctional system neuromorphic electronics artificial intelligence

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Kelp Fucoidans Facilitate Vascular Recanalization via Inhibiting Excessive Activation of Platelet in Deep Venous Thrombosis Model of Mouse

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Journal of Ocean University of China 2024年第2期23卷 550-556页

作者： SUN Taohua LIU jie YAN Taishan chen Anjin ZHANG Fang Department of Clinical Drug Trials Qingdao Municipal HospitalQingdao 266100China Department of Pharmacy Qingdao Municipal HospitalQingdao 266100China

This study was carried out explore the mechanism underlying the inhibition of platelet activation by kelp fucoidans in deep venous thrombosis(DVT)*** the control and sham mice,the walls of deep vein were regular and smooth with intact intima,myometrium and *** blood vessel was wrapped with the tissue and there was no thrombosis in the *** the DVT model,the wall was uneven with thicken intima,myometrium and *** treated with fucoidans LF1 and LF2,the thrombus was dissolved and the blood vessel was *** with the control group,the ROS content,ET-1 and VWF content and the expression of PKC-βand NF-κB in the model were significantly higher(P<0.05);these levels were significantly reduced following treatments with LF2 and *** with H_(2)O_(2)treated-HUVECs,combined LF1 and LF2 treatment resulted in significant decrease in the expression of PKC-β,NF-κB,VWF and TM protein(P<0.05).It is clear that LF1 and LF2 reduces DVT-induced ET-1,VWF and TM expressions and production of ROS,thus inhibiting the activation of PKC-β/NF-κB signal pathway and the activation of coagulation system and ultimately reducing the formation of venous thrombus.

关键词： kelp fucoidans LF1 LF2 deep vein thrombosis platelet

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Learning Scalable Task Assignment with Imperative-Priori Conflict Resolution in Multi-UAV Adversarial Swarm Defense Problem

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Journal of Systems Science & Complexity 2024年第1期37卷 369-388页

作者： ZHAO Zhixin chen jie XIN Bin LI Li JIAO Keming ZHENG Yifan School of Electronics and Information Engineering Tongji UniversityShanghai 201804China Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghai 201804China School of Automation Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Autonomous Intelligent Unmanned Systems Beijing 100081China Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghai 201804China.

The multi-UAV adversary swarm defense(MUASD)problem is to defend a static base against an adversary UAV swarm by a defensive UAV *** the problem into task assignment and low-level interception strategies is a widely used ***-based approaches for task assignment are a promising *** studies on learning-based methods generally assume decentralized decision-making architecture,which is not beneficial for conflict *** contrast,centralized decision-making architecture is beneficial for conflict resolution while it is often detrimental to *** achieve scalability and conflict resolution simultaneously,inspired by a self-attention-based task assignment method for sensor target coverage problem,a scalable centralized assignment method based on self-attention mechanism together with a defender-attacker pairwise observation preprocessing(DAP-SelfAtt)is ***,an imperative-priori conflict resolution(IPCR)mechanism is proposed to achieve conflict-free ***,the IPCR mechanism is parallelized to enable efficient *** validate the algorithm,a variant of proximal policy optimization algorithm(PPO)is employed for training in scenarios of various *** experimental results show that the proposed algorithm not only achieves conflict-free task assignment but also maintains scalability,and significantly improve the success rate of defense.

关键词： Conflict resolution reinforcement learning scalability task assignment.

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Spray pyrolysis-derived W-doped MoSe2/rGO paper-like microspheres:optimization of microstructure and mesostructure for enhanced lithium storage

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Rare Metals 2024年第7期43卷 3019-3031页

作者： Wei Wang Jun-Yu chen jie Ouyang Hong Yin Ao-jie Li Liang chen Jun-Lin Huang Yu-Can Zhu Gang-Yong Li Zhao-Hui Hou Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Chemistry and Chemical Engineering Hunan Institute of Science and Technology Hunan Province Key Laboratory of Materials Surface & Interface Science and Technology Material Science and Engineering SchoolCentral South University of Forestry and Technology International Iberian Nanotechnology Laboratory (INL)

Two-dimensional MoSe2is a promising candidate for lithium-ion battery ***,its conductivity and lithium storage volumetric effect still need to be *** this work,W-doped MoSe2/rGO paper-like microspheres are successfully prepared through ultrasonic spray pyrolysis,achieving optimization at both the microstructure and mesostructure to enhance the lithium storage performance of the ***,by utilizing the similar two-dimensional structure between MoSe2and rGO,self-assembly is achieved through spray pyrolysis,resulting in a well-defined van der Waals heterostructure at the interface on the microscale,enhancing the electron and ion transfer capability of the ***,the mesoscale paper-like microsphere morphology provides additional volume expansion buffering ***,W-doping not only increases the interlayer spacing of MoSe2（0.73 nm）,thereby reducing the diffusion resistance of Li+,but also allow for the modulation of the energy band structure of the *** functional theory（DFT） calculations confirm that W-doped MoSe2/rGO exhibits the narrowest bandgap（0.892 eV）.Therefore,the composite demonstrates excellent lithium storage performance,maintaining a specific capacity of 732.9 mAh·g-1after 300 cycles at a current density of 1 A·g-1.

关键词： Molybdenum selenide Heterostructure Microspheres Li-ion batteries Kinetics

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