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Nano polystyrene microplastics could accumulate in Nile tilapia(Oreochromis niloticus):Negatively impacts on the intestinal and liver health through water exposure

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Journal of Environmental Sciences 2024年第3期137卷 604-614页

作者： di Wu Xing Lu Li-Xue Dong Juan Tian Jin Deng Lei Wei Hua wen Shan Zhong Ming Jiang School of Basic Medical Sciences Wuhan UniversityWuhan 430071China Key Laboratory of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural AffairsYangtze River Fisheries Research InstituteChinese Academy of Fishery SciencesWuhan 430223China Hubei Province Key Laboratory of Allergy and Immunology Wuhan 430071China

Microplastics(MPs)have become a significant concern for their potential ***,the correlation between the size of plastic particles and their toxicity remains ***,we investigate the toxic effects of different sizes(80 nm,800 nm,8μm and 80μm)polystyrene MPs(PS-MPs)on the model organism Nile tilapia(Oreochromis niloticus).The results of bioluminescent imaging indicate that the 80 nm PS-MPs are more likely to invade the body.H&E staining shows severe damage on the intestinal villi and distinct hepatic steatosis in the 80 nm *** U labeling shows that the proliferation activity of intestinal and liver cells reduces significantly in the 80 nm *** gut microbiome analysis shows a severe imbalance of gut microbiota homeostasis in the 80 nm *** analysis of liver transcriptomics and metabolomics shows that the liver lipid metabolism is disordered in the 80 nm *** conclusion,this study confirms that the 80 nm PS-MPs are more likely to induce intestinal and liver *** the above lay the foundation for further study on the pathological damage of MPs to other organisms.

关键词： Microplastics(MPs) Intestinal toxicity Liver toxicity Gut microbiome Lipid metabolism

High performance 2T0C DRAM cells based on atomic-layer-deposited InAlZnO FETs

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Science China(Information Sciences) 2024年第9期67卷 344-345页

作者： wen XIONG Binbin LUO Wei MENG Bao ZHU Xiaohan WU shi-Jin diNG School of Microelectronics Fudan University

Recently, the oxide semiconductor-based 2T0C dynamic random-access memory(DRAM) has shown great potential in monolithic three-dimensional(M3D)-integrated memory,owing to some unique advantages of oxide semiconductors,such as high electron mobility, wide band gap, and compatibility with back-end-of-line(BEOL) processes [1, 2].

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A tectono-thermal perspective on the petroleum generation,accumulation and preservation in the southern Ordos Basin, North China

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Petroleum Science 2024年第3期21卷 1459-1473页

作者： Peng Yang Zhan-Li Ren Jin-Hua Fu Hong-Ping Bao Hui Xiao Zheng shi Kun Wang Yuan-Yuan Zhang wen-Hui Liu wen-Hou Li State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an710069ShanxiChina National Engineering Laboratory for Exploration and Development of Low-Permeability Oil and Gas Fields Exploration and Development Research Institute of PetroChina Changqing Oilfield CompanyXi'an710018ShaanxiChina Shaanxi Key Lab of Petroleum Accumulation Geology School of Earth Science and EngineeringXi'an Shiyou UniversityXian710065ShaanxiChina Wuxi Research Institute of Petroleum Geology Petroleum Exploration and Production Research InstituteSINOPECWuxi214126JiangsuChina

The southern Ordos Basin has excellent petroleum exploration ***,the tectono-thermal history and the controls on petroleum generation,accumulation and preservation conditions in southern basin are *** this study,we analyzed the present geothermal field,paleo-geothermal gradient,maturity of the hydrocarbon source rocks,uplift and cooling process and tectono-thermal evolution *** the study area,for the Ordovician,Permain and the Triassic strata,the present temperature is low(3070℃)in the southeastern area but high(80140℃)in the northwestern *** paleogeothermal gradient varied from 24℃/km to 30℃/km with a heat flow of 58—69 m W/m^(2)(i.e.,a medium-temperature basin).The paleo-temperatures are higher than the present temperatures and the maximum paleo-temperatures controlled the thermal maturity of the source *** vitrinite reflectance(Ro)values of the Triassic strata are>0.7%and the thermal maturity reached the middlemature oil generation *** Rovalues of the Permian-Ordovician strata are>1.8%and the thermal maturity reached the over-mature gas generation *** southern Ordos Basin has experienced the multiple tectonic events at the Late Ordovician Caledonian(452 Ma),Late Triassic(215 Ma),Late Jurassic(165160 Ma),End-Early Cretaceous(110100 Ma)and Cenozoic(since 40 Ma).A large-scale tectonothermal event occurred at the End-Early Cretaceous(110100 Ma),which was controlled by lithospheric extension,destruction and *** event led to the highest paleo-temperatures and thermal maturities and coeval with the peak period of petroleum generation and *** southern Ordos Basin has undergone rapid and large-scale uplift since the Late Cretaceous due to expansion of the northeastern margin of the Tibetan Plateau,uplift of the Qinling orogenic belt and thrust faulting in the Liupanshan tectonic *** southern Ordos Basin experienced tectonic overprinting that was strong in the south and weak in the *** str

关键词： Fission-track dating Vitrinitereflectance Geothermal field Tectono-thermal evolution Petroleum geology Ordos Basin

Characterization of the current crowding effect on chip surface using a quantum wide-field microscope

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Chinese Optics Letters 2024年第6期22卷 123-128页

作者： Rui Zhao ding Wang Huan Fei wen Yunbo shi Jun Tang Jun Liu Science and Technology on Electronic Test&Measurement Laboratory North University of ChinaTaiyuan 030051China

We characterize the current crowding effect for microwave radiation on a chip surface based on a quantum wide-field microscope combining a wide-field reconstruction technique. A swept microwave signal with the power of 0–30 d Bm is supplied to a dumbbell-shaped microstrip antenna, and the significant differences in microwave magnetic-field amplitudes attributed to the current crowding effect are experimentally observed in a 2.20 mm ×1.22 mm imaging area. The normalized microwave magnetic-field amplitude along the horizontal geometrical center of the image area further demonstrates the feasibility of the characterization of the current crowding effect. The experiments indicate the proposal can be qualified for the characterization of the anomalous area of the radio-frequency chip surface.

关键词： current crowding effect microwave field on chip surface quantum wide-field microscope nitrogen-vacancy center

Advance in reversible Zn anodes promoted by 2D materials

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Rare Metals 2024年第4期43卷 1350-1369页

作者： Shu-Yuan Lei Jin-Xiu Feng Yu-Chao Chen Dong Zheng wen-Xian Liu wen-Hui shi Fang-Fang Wu Xie-Hong Cao School of Materials Science and Engineering Zhejiang University of TechnologyHangzhou310014China Center for Membrane Separation and Water Science and Technology College of Chemical EngineeringZhejiang University of TechnologyHangzhou310014China

With the growing energy demand associated with high safety and low-cost requirement,aqueous zinc-ion batteries(AZIBs)have been considered as one of the most promising next-generation ***,some key issues,such as uncontrollable dendrites growth,severe corrosion,hydrogen evolution and side reactions of Zn anodes during charge/discharge process,have hindered its pragmatic ***-dimensional(2D)materials hold advantages of unique physical and chemical properties,large surface areas and abundant active sites,which have been successfully used to overcome the above shortcomings of Zn anodes in recent *** this review,the issues and challenges of Zn anodes are ***,the state-of-the-art progress on Zn anodes modification based on 2D materials such as graphene,2D metal carbides and nitrides(MXenes),2D metal-organic frameworks(MOFs),2D covalent organic frameworks(COFs),2D transition metal compounds and other 2D materials is discussed in ***,the perspectives of employing 2D materials in highly reversible Zn anodes are summarized and discussed.

关键词： 2D materials Aqueous zinc-ion battery Zn anodes Dendrites growth

Nanoimprint-induced strain engineering of two-dimensional materials

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Microsystems & Nanoengineering 2024年第2期10卷 323-332页

作者： Chuying Sun Jianwen Zhong Zhuofei Gan Liyang Chen Chuwei Liang Hongtao Feng Zhao Sun Zijie Jiang wen-di Li The University of Hong Kong Hong KongChina

The high stretchability of two-dimensional(2D)materials has facilitated the possibility of using external strain to manipulate their ***,strain engineering has emerged as a promising technique for tailoring the performance of 2D materials by controlling the applied elastic strain *** various types of strain engineering methods have been proposed,deterministic and controllable generation of the strain in 2D materials remains a challenging ***,we report a nanoimprint-induced strain engineering(NISE)strategy for introducing controllable periodic strain profiles on 2D materials.A three-dimensional(3D)tunable strain is generated in a molybdenum disulfide(MoS_(2))sheet by pressing and conforming to the topography of an imprint *** strain profiles generated in MoS_(2)are demonstrated and verified by Raman and photoluminescence(PL)*** strain modulation capability of NISE is investigated by changing the imprint pressure and the patterns of the imprint molds,which enables precise control of the strain magnitudes and distributions in MoS_(2).Furthermore,a finite element model is developed to simulate the NISE process and reveal the straining behavior of MoS_(2).This deterministic and effective strain engineering technique can be easily extended to other materials and is also compatible with common semiconductor fabrication processes;therefore,it provides prospects for advances in broad nanoelectronic and optoelectronic devices.

关键词： strain dimensional molybdenum

CD3ε of a pan T cell marker involved in mouse Aspergillus fumigatus keratitis

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 616-624页

作者： wen-Hao shi Li-Mei Wang Hai-Jing Yan shi-Long Liu Xian Yang Xue-JiaoYang Cheng-Ye Che Department of Ophthalmology the Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Weifang Medical University Weifang 261053Shandong ProvinceChina Eye Hospital of wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina Department of Medical Engineering the Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

AIM:To explore whether CD3ε is involved in the adaptive immunity of Aspergillus fumigatus(***)keratitis in mice and the role of innate and adaptive immunity in ***:Mice models of *** keratitis were established by intra-stromal injection and corneal epithelial *** injections of natamycin,wedelolactone,LOX-1 inhibitor(poly I)or Dectin-1 inhibitor(laminarin)were used to treat mice with *** *** were pretreated by intraperitoneal injection of anti-mouse CD3ε.We observed the corneal infection of mice under the slit lamp microscope and made a clinical *** protein expression of CD3ε and interleukin-10(IL-10)was determined by Western ***:With the disease progresses,the degree of corneal opacity and edema *** the intrastromal injection models,CD3εprotein expression began to increase significantly on the 2^(nd) ***,in the scraping epithelial method models,CD3ε only began to increase on the 3^(rd) *** natamycin treatment,the degree of corneal inflammation in mice was significantly attenuated on the 3^(rd) *** wedelolactone treatment,the severity of keratitis *** the amount of CD3ε protein was also reduced,compared with the control *** inhibiting LOX-1 and Dectin-1,there was no significant difference in CD3ε production compared with the control *** inhibiting CD3ε,corneal ulcer area and clinical score increased,and IL-10 expression was ***:As a pan T cell marker,CD3ε participate in the adaptive immunity of *** keratitis in *** our mice models,the corneas will enter the adaptive immune stage *** regulating IL-10,CD3ε exerts antiinflammatory and repairs effects in the adaptive immune stage.

关键词： CD3ε adaptive immunity Aspergillus fumigatus keratitis interleukin-10

Lenvatinib combined with sintilimab plus transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma

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World Journal of Clinical Cases 2024年第2期12卷 285-292页

作者： Sha-Sha Sun Xiao-di Guo wen-Dong Li Jing-Long Chen Department of Oncology Capital Medical University Affiliated Beijing Ditan HospitalBeijing 100015China

BACKGROUND Recently,combination therapy has shown a better trend towards improved tumour response and survival outcomes than monotherapy in patients with hepatocellular carcinoma(HCC).However,research on triple therapy[lenvatinib+sintilimab+transarterial chemoembolization(TACE)]as a first-line treatment for advanced HCC is *** To evaluate the safety and efficacy of triple therapy as a first-line treatment for advanced *** HCC patients with Barcelona Clinic Liver Cancer stage C treated with triple therapy were *** patients were treated with lenvatinib every day and sintilimab once every 3 ***,TACE was performed every 4-6 wk if *** primary outcome of the study was overall survival(OS).The secondary outcomes were the objective response rate(ORR),disease control rate(DCR),and incidence of adverse *** Forty HCC patients who underwent triple therapy were retrospectively analysed from January 2019 to January *** a median follow-up of 8.5 months,the 3-,6-,and 12-mo OS rates were 100%,88.5%,and 22.5%,*** ORR and DCR were 45%and 90%,*** median progressive free survival and median OS were not *** complications were observed in 76%of the patients(grade 3,15%;grade 4,2.5%).CONCLUSION Combination therapy comprising lenvatinib,sintilimab and TACE achieved promising outcomes in advanced HCC patients and had manageable effects.

关键词： Lenvatinib Sintilimab Advanced hepatocellular carcinoma Combination therapy Tumor response

Artificial neural network-based method for discriminating Compton scattering events in high-purity germaniumγ-ray spectrometer

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Nuclear Science and Techniques 2024年第2期35卷 64-84页

作者： Chun-di Fan Guo-Qiang Zeng Hao-wen Deng Lei Yan Jian Yang Chuan-Hao Hu Song Qing Yang Hou College of Nuclear Technology and Automation Engineering Chengdu University of TechnologyChengdu 610059China

To detect radioactive substances with low activity levels,an anticoincidence detector and a high-purity germanium(HPGe)detector are typically used simultaneously to suppress Compton scattering background,thereby resulting in an extremely low detection limit and improving the measurement ***,the complex and expensive hardware required does not facilitate the application or promotion of this ***,a method is proposed in this study to discriminate the digital waveform of pulse signals output using an HPGe detector,whereby Compton scattering background is suppressed and a low minimum detectable activity(MDA)is achieved without using an expensive and complex anticoincidence detector and *** electric-field-strength and energy-deposition distributions of the detector are simulated to determine the relationship between pulse shape and energy-deposition location,as well as the characteristics of energy-deposition distributions for fulland partial-energy deposition *** relationship is used to develop a pulse-shape-discrimination algorithm based on an artificial neural network for pulse-feature *** accurately determine the relationship between the deposited energy of gamma(γ)rays in the detector and the deposition location,we extract four shape parameters from the pulse signals output by the *** learning is used to input the four shape parameters into the ***,the pulse signals are identified and classified to discriminate between partial-and full-energy deposition *** partial-energy deposition events are removed to suppress Compton *** proposed method effectively decreases the MDA of an HPGeγ-energy dispersive *** results show that the Compton suppression factors for energy spectra obtained from measurements on ^(152)Eu,^(137)Cs,and ^(60)Co radioactive sources are 1.13(344 keV),1.11(662 keV),and 1.08(1332 keV),respectively,and that the corresponding MDAs are 1.4%,5.

关键词： High-purity germaniumγ-ray spectrometer Pulse-shape discrimination Compton scattering Artificial neural network Minimum detectable activity