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Comparison of different methods of nasogastric tube insertion in anesthetized and intubated patients: A meta-analysis

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World Journal of Clinical Cases 2021年第26期9卷 7772-7785页

作者： Gao-wen ou Heng Li Bing Shao Li-Ming Huang Guo-Min Chen Wei-Chao Li Department of Anesthesiology Qingyuan People’s HospitalThe Six Affiliated Hospital of Guangzhou Medical UniversityQingyuan 511518Guangdong ProvinceChina

BACKGRouND Several techniques of nasogastric tube(NGT)insertion have been described in the literature with different success *** To systematically search the literature and conduct a meta-analysis comparing the success rates,insertion time and complications associated with different techniques of NGT insertion in anesthetized and intubated *** An electronic search of the PubMed,Scopus,CENTRAL(Cochrane Central Register of Controlled Trials),and Google Scholar databases were performed up to October 31,*** included 17 randomized controlled trials with 2500 participants in the *** As compared to the conventional method,successful insertion of the NGT on first attempt was higher with modified techniques such as the reverse Sellick’s maneuver[relative risk(RR)1.94;95%confidence interval(CI):1.62-2.31],use of a frozen NGT(RR 1.55;95%CI:1.13-2.13),inserting the NGT with neck flexion and lateral neck pressure(RR 1.64;95%CI:1.10-2.45),endotracheal tube-assisted(RR 1.88;95%CI:1.52-2.32)and video-assisted placements(RR 1.60;95%CI:1.31-1.95).All the modified techniques also led to comparatively higher insertion success rates than the conventional *** The use of modified techniques of NGT insertion such as the reverse Sellick’s maneuver,neck flexion with lateral neck pressure,frozen NGT,endotracheal tube-guided or video-assisted methods result in a significantly better chance of successful tube insertion at first attempt as compared to the conventional *** modified techniques also significantly improve the overall chance of successful NGT placement as compared to the conventional method.

关键词： Nasogastric tube Anesthetized patient Intubated patients Mucosal bleeding

Knockdown of HE4 suppresses tumor growth and invasiveness in lung adenocarcinoma through regulation of EGFR signaling

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Oncology Research 2024年第6期32卷 1119-1128页

作者： YUE ZHANG wenYU YANG XIAOWANG HAN YUE QIAO HAITAO WANG TING CHEN TIANYING LI wen-BIN ou Department of Biopharmaceutics College of Life Sciences and MedicineZhejiang Provincial Key Laboratory of Silkworm Bioreactor and BiomedicineZhejiang Sci-Tech UniversityHangzhou310018China Department of Thoracic Surgery Zhejiang Provincial People’s HospitalHangzhou310014China

It has been shown that the high expression of human epididymis protein 4(HE4)in most lung cancers is related to the poor prognosis of patients,but the mechanism of pathological transformation of HE4 in lung cancer is still *** current study is expected to clarify the function and mechanism of HE4 in the occurrence and metastasis of lung adenocarcinoma(LUAD).Immunoblotting evaluated HE4 expression in lung cancer cell lines and biopsies,and through analysis of The Cancer Genome Atlas(TCGA)*** HE4 overexpression was demonstrated in LUAD,but not in lung squamous cell carcinoma(LUSC),indicating that HE4 can serve as a biomarker to distinguish between LUAD and ***4 knockdown significantly inhibited cell growth,colony formation,wound healing,and invasion,and blocked the G1-phase of the cell cycle in LUAD cell lines through inactivation of the EGFR signaling downstream including PI3K/AKT/mTOR and RAF/MAPK *** first-line EGFR inhibitor gefitinib and HE4 shRNA had no synergistic inhibitory effect on the growth of lung adenocarcinoma cells,while the third-line EGFR inhibitor osimertinib showed additive anti-proliferative ***,we provided evidence that HE4 regulated EGFR expression by transcription regulation and protein interaction in *** findings suggest that HE4 positively modulates the EGFR signaling pathway to promote growth and invasiveness in LUAD and highlight that targeting HE4 could be a novel strategy for LUAD treatment.

关键词： Lung adenocarcinoma Human epididymis protein 4 Epidermal growth factor receptor Biomarker Targeted therapies

Competence of clinical teachers:A survey on perception of masters of nursing specialist postgraduates, their clinical teachers, and head nurses

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International Journal of Nursing Sciences 2017年第2期4卷 158-163页

作者： Xiao-fen Wang Ling Zhao Hong-juan Hu Gao-wen ou Li Liao School of Nursing University of South ChinaHengyangHunan 421001China XiangYa School of Medicine Central South UniversityChangshaHunan 410013China

Objectives:To explore the current admittance situation of clinical teachers for masters of nursing specialist(MNS)postgraduates and to test the competence of clinical teachers in self-evaluation and other ***:In this cross-sectional study,using a random number table,we chose 80 MNS postgraduates under clinical practice,their clinical teachers,and head nurses each from six hospitals in Hunan and *** participants were tested on the basis of the Clinical Teachers'Competence Inventory of MNS *** competences of clinical teachers were evaluated by the three groups of ***:The aggregated scores of teacher competence as evaluated by the MNS postgraduates(181.33±24.95)were lower than those assigned by both clinical teachers(190.75±24.30)and their head nurses(198.53±18.90),with significant differences in all dimensions except for clinical managing *** five highest rated items from all participants focused on the teachers'clinical nursing ability,and the five lowest rated items were mainly about their clinical research ***:The evaluation from MNS postgraduates is obviously lower than the self-evaluation of clinical teachers,and all participants are aware of the deficiency in research ability of the ***,the admittance and examination of clinical teachers should be controlled *** should be carried out immediately to strengthen their comprehensive abilities,especially their research ability.

关键词： Clinical teachers Education Nursing Graduate Masters of nursing specialist Performance appraisal

Deformation and densification behavior of discrete media filled thin-walled tubes during forward extrusion

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Transactions of Nonferrous Metals Society of China 2016年第8期26卷 2162-2169页

作者： Tong wen Qing LIU Qian HUANG wen-xue ou Jian-qing FENG College of Materials Science and Engineering Chongqing University Chongqing 400044 China Northwest Institute for Nonferrous Metal Research Xi’an 710016 China

Discrete media filled thin-walled hollow profiles are frequently used as integer structures for special purpose, e.g., in certain materials processing or architectural components. To understand the deformation of such composite structures which is a complicate mechanics process, involving coupled elastic-plastic deformation of dense metal, compaction of particle and interaction between the filler and the wall, the forward extrusion of Al 6061 tubes filled with various particles was studied. The analysis regarding internal volume variation of round tubes during forward extrusion indicates that with the diameter reduction the volume of tubes decreases commonly. The cavity shrinkage brings about triaxial pressure on the filler, resulted in compaction and densification of it. Loose powders filling leads to higher extrusion load. Due to dissimilar migration behaviors of the particles, the load?stroke curves of the tubes filled with fine powders and coarse balls are quite different. Small Lankford value of the tube wall material leads to higher hydrostatic pressure of the filler and then more powders are compacted.

关键词： tube forward extrusion powder deformation behavior densification

Therapeutic targets in gastrointestinal stromal tumors

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World Journal of Translational Medicine 2015年第1期4卷 25-37页

作者： Jia-Qing Zhu wen-Bin ou College of Life Sciences Zhejiang Sci-Tech University Zhejiang Provincial Key Laboratory of Applied Enzymology Yangtze Delta Region Institute of Tsinghua University

Gastrointestinal stromal tumors(GISTs) are the most common type of mesenchymal tumor of the gastrointestinal tract. The tumorigenesis of GISTs is driven by gain-of-function mutations in KIT or plateletderived growth factor receptor α(PDGFRA),resultingin constitutive activation of the tyrosine kinase and its downstream signaling pathways. Oncogenic KIT or PDGFRA mutations are compelling therapeutic targets for the treatment of GISTs,and the KIT/PDGFRA inhibitor imatinib is the standard of care for patients with metastatic GISTs. However,most GIST patients develop clinical resistance to imatinib and other tyrosine kinase inhibitors. Five mechanisms of resistance have been characterized:(1) acquisition of a secondary point mutation in KIT or PDGFRA;(2) genomic amplification of KIT;(3) activation of an alternative receptor tyrosine kinase;(4) loss of KIT oncoprotein expression; and(5) wild-type GIST. Currently,sunitinib is used as a secondline treatment for patients after imatinib failure,and regorafenib has been approved for patients whose disease is progressing on both imatinib and sunitinib. Phase Ⅱ/Ⅲ trials are currently in progress to evaluate novel inhibitors and immunotherapies targeting KIT,its downstream effectors such as phosphatidylinositol 3-kinase,protein kinase B and mammalian target of rapamycin,heat shock protein 90,and histone deacetylase inhibitor. Other candidate targets have been identified,including ETV1,AXL,insulin-like growth factor 1 receptor,KRAS,FAS receptor,protein kinase c theta,ANO1(DOG1),CDC37,and aurora kinase A. These candidates warrant clinical evaluation as novel therapeutic targets in GIST.

关键词： Gastrointestinal stromal tumors Tyrosine kinase inhibitors KIT Platelet-derived growth factor receptorα Targets

Gut microbiota induced abnormal amino acids and their correlation with diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 883-895页

作者： Sheng-Qun Jiang Su-Na Ye Yin-Hua Huang Yi-wen ou Ke-Yang Chen Jian-Su Chen Shi-Bo Tang Aier Eye Hospital Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Aier Eye Institute and Changsha Aier Hospital Changsha 410000Hunan ProvinceChina The First Affiliated Hospital of Bengbu Medical University Bengbu 233000Anhui ProvinceChina School of Public Health Anhui Medical UniversityHefei 230000Anhui ProvinceChina

AIM:To explore the correlation of gut microbiota and the metabolites with the progression of diabetic retinopathy(DR)and provide a novel strategy to elucidate the pathological mechanism of ***:The fecal samples from 32 type 2 diabetes patients with proliferative retinopathy(PDR),23 with nonproliferative retinopathy(NPDR),27 without retinopathy(DM),and 29 from the sex-,age-and BMI-matched healthy controls(29 HC)were analyzed by 16S rDNA gene *** fecal samples from PDR,DM,and HC groups were assayed by untargeted *** metabolites were measured using liquid chromatographymass spectrometry(LC-MS)*** between gut microbiota and fecal metabolites were ***:A cluster of 2 microbiome and 12 metabolites accompanied with the severity of DR,and the close correlation of the disease progression with PDR-related microbiome and metabolites were *** be specific,the structure of gut microbiota differed in four *** and richness of gut microbiota were significantly lower in PDR and NPDR groups,than those in DM and HC groups.A cluster of microbiome enriched in PDR group,including Pseudomonas,Ruminococcaceae-UCG-002,Ruminococcaceae-UCG-005,Christensenellaceae-R-7,was *** analysis showed that the glucose and nicotinate degradations were significantly higher in PDR group than those in HC ***,serine,ornithine,and arachidonic acid were significantly enriched in PDR group,while proline was enriched in HC *** analysis illustrated that arginine biosynthesis,lysine degradation,histidine catabolism,central carbon catabolism in cancer,D-arginine and D-ornithine catabolism were elevated in PDR *** analysis revealed that Ruminococcaceae-UCG-002 and Christensenellaceae-R-7 were positively associated with L-arginine,ornithine levels in fecal ***:This study elaborates the different microbiota structure in the gut from four *** relative abundance of

关键词： proliferative retinopathy gut microbiota Ruminococcaceae amino acid metabolism arginine

Is traumatic meniscal lesion associated with acute fracture morphology changes of tibia plateau? A series of arthroscopic analysis of 67 patients

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World Journal of Clinical Cases 2021年第1期9卷 81-90页

作者： Yan-Dong Chen Shu-Xiang Chen Hong-Guang Liu Xiang-Sheng Zhao wen-Huan ou Huan-Xi Li Hong-Xing Huang 3^rd Institute of Clinical Medicine Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Department of Joint Trauma Jiangmen Wuyi Hospital of Traditional Chinese MedicineAffiliated Jiangmen Traditional Chinese Medicine Hospital of Jinan UniversityJiangmen 529031Guangdong ProvinceChina Department of Radiology Jiangmen Wuyi Hospital of Traditional Chinese MedicineJiangmen 529031Guangdong ProvinceChina Science and Education Section The Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510378Guangdong ProvinceChina

BACKGRouND Computed tomography(CT)has become a routine preoperative examination for tibial plateau fractures(TPFs).Assessing the location of the fragment and intercondylar eminence fracture can provide clinicians with valuable information;however,the evaluation of traumatic meniscal lesion(TML)and arthroscopic management are *** To predict TML by three-dimensional skeletal anatomy changes in unilateral TPF and bilateral TPF on preoperative thin layer *** Acute fracture of tibial plateau patients undergoing arthroscopic surgery between December 2017 and December 2019 were included in this retrospective *** type,zone,and location of TMLs were diagnosed based on the operation records and/or arthroscopic *** of three-dimensional fracture morphology included the following:Frontal fragment width of plateau,sagittal fragment subsiding distance(FSD),sagittal fracture line distance,sagittal posterior tibial slope,and transversal area ratio of fragment area)on preoperative CT three-dimensional *** correlation of TML with skeletal values was calculated according to unicondylar TPFs and bicondylar *** A total of 67 patients were enrolled in this study,among which 30 patients had TMLs,lateral/medial(23/7).FSD was a particularly positive factor to predict TML,with odds ratio of 2.31(1.26-5.63).On sagittal view of CT,FSD degree of 8 mm and posterior tibial slope exceeding 11.74°implied enhanced risk of TML in bicondylar *** coronal view,once fragment width of plateau surpassed 3 cm,incidence of TML reached 100%.On transverse view,area ratio of fragment as enhanced risk of 5.5%and FSD>4.3 mm for predicting TML were observed in unicondylar *** TML can be predicted by different parameters on preoperative CT views according to unicondylar fractures and bicondylar TPFs.

关键词： Traumatic meniscal lesion Knee Three-dimensional computerized tomography Posterior tibial slope Unicondylar fracture Bicondylar fracture

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一种薄膜体声波谐振器的设计与验证

西安电子科技大学学报 2019年第4期46卷 144-149页

作者：申洪霞欧文中国科学院大学微电子学院北京101400 中国科学院微电子研究所北京100020 华进半导体封装先导技术研发中心有限公司江苏无锡214000

为简化薄膜体声波谐振器薄膜厚度的设计,提出一种薄膜体声波谐振器薄膜厚度的设计方法。仿真结构由诱导层和其上层的电极层-压电层-电极层的三明治结构组成。在最优有效机电耦合系数下确定初始薄膜体声波谐振器的薄膜厚度;然后确定诱导... 详细信息

为简化薄膜体声波谐振器薄膜厚度的设计,提出一种薄膜体声波谐振器薄膜厚度的设计方法。仿真结构由诱导层和其上层的电极层-压电层-电极层的三明治结构组成。在最优有效机电耦合系数下确定初始薄膜体声波谐振器的薄膜厚度;然后确定诱导层厚度及其相应的频偏值;使用频偏值补偿并联谐振频率,重新计算补偿后的薄膜体声波谐振器中电极层与压电层的最优厚度比值,并使用COMSOL Multiphysics进行仿真验证。当并联谐振频率为3.60 GHz时,100 nm的氮化铝的频偏值为0.20 GHz。氮化铝的有效机电耦合系数最优为5.907%,进行频率补偿后,氮化铝的串联谐振频率和并联谐振频率分别为3.48 GHz和3.60 GHz,设计方法得到了验证。诱导层有效地优化了压电层C轴特性,减少了能量损耗。

关键词：薄膜体声波谐振器氮化铝诱导层

Updating of PI3K/Akt/m TOR Signaling Pathway Inhibition in Breast Cancers

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Updating of PI3K/Akt/m TOR Signaling Pathway Inhibition in B...