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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Data-Driven Fault-Tolerant Bipartite Consensus Tracking for Multi-Agent Systems With a Non-Autonomous Leader

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 279-281页

作者： Yan Zhou Guanghui wen Jialing Zhou Tao Yang the Department of Systems Science Southeast University the State Key Laboratory of CNS/ATM Beijing Institute of Technology the Beijing Institute of Technology (Zhuhai) the State Key Laboratory of Synthetical Automation for Process Industries Northeastern University

Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the continuous fault-tolerant control protocol via observer design is developed. In addition, it is strictly proved that the multi-agent system driven by the designed controllers can still achieve bipartite consensus tracking after faults occur.

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Is it possible to foot reflexology for infants with sensorineural hearing loss?

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World Journal of Clinical Cases 2025年第2期13卷 1-4页

作者： Min Ai Hang-Hang Zhang Jun-Bang Feng Chuan-Ming Li wen-Jing Wang Meng-Die Hu Department of Anesthesiology Nanan District People's Hospital of ChongqingChongqing 400060China Department of Breast and Thyroid Surgery Chongqing Bishan District Maternal and Child Health Care HospitalChongqing 402760China Department of Medical Imaging Chongqing University Central HospitalChongqing 400014China

Foot reflexology is a non-invasive and safe complementary therapy that works by massaging the reflex zones of the feet and exerts systemic or whole-body regulation through meridian nerve *** therapy is commonly used in the treatment of various conditions such as autism and Parkinson's ***,there is limited reporting on the use of foot reflexology therapy for infants with sensorineural hearing loss(SNHL).Currently,there is no definitive conclusion on how foot reflexology therapy can influence *** editorial holds some guiding significance regarding this clinical *** aim is to present physiological evidence of how foot reflexology therapy can impact infants with SNHL,thereby enhancing clinician’s awareness of foot reflexology in treating infants with SNHL.

关键词： Foot reflexology Sensorineural Hearing Loss Future perspectives Limitations Neural conduction

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缺陷对单层硅烯纳米梁振动频率的影响

原子与分子物理学报 2025年第6期42卷 76-82页

作者：张文博王静新疆大学物理科学与技术学院乌鲁木齐830017

由于硅纳米谐振器在量子计算、传感器、医学等方面存在广泛的应用,使其物理性质的研究具有重要意义.本文通过分子动力学模拟方法研究了掺杂元素、空位缺陷、掺杂浓度对单层硅烯纳米梁振动特性的影响.研究结果表明,单层硅烯纳米梁的振动... 详细信息

由于硅纳米谐振器在量子计算、传感器、医学等方面存在广泛的应用,使其物理性质的研究具有重要意义.本文通过分子动力学模拟方法研究了掺杂元素、空位缺陷、掺杂浓度对单层硅烯纳米梁振动特性的影响.研究结果表明,单层硅烯纳米梁的振动频率随着纳米梁长度的增加而减小.单元素、双元素掺杂均会导致单层硅烯纳米梁的振动频率的增加,且随着掺杂浓度的增加纳米梁的振动频率整体呈现增大的趋势.此外,单空位缺陷会导致单层硅烯纳米梁的振动频率随着缺陷浓度的增加而减小.掺杂-单空位缺陷的单层硅烯纳米梁的振动频率则呈现了随着掺杂浓度的增加先减小后增加的变化趋势.这些变化规律均是由掺杂元素、空位缺陷以及它们共同作用的结果.此研究结果对硅烯纳米谐振器,振荡器等纳米器件的设计具有一定的理论指导意义.

关键词：硅烯掺杂振动频率分子动力学

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-Min Xu Ke Wang Jia-Zhu wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia wenting Ye Yan Sun Jing Cai Fubing Yu Haiping wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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裸岩浅埋无封底PC组合围堰设计与施工关键技术

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国防交通工程与技术 2025年第1期23卷 65-69页

作者：卢文铁道战备舟桥处山东齐河251100

潍宿高铁墙夼水库特大桥53#~55#水中墩承台基础为挖井基础,墩位处最大水深为6.6 m,围堰内河床岩层为砂岩,基本无覆盖层。54#墩的承台施工采用钢管桩与钢板桩组合围堰,针对裸岩浅埋无封底围堰的施工特点,通过建模分析各个工况下围堰体系... 详细信息

潍宿高铁墙夼水库特大桥53#~55#水中墩承台基础为挖井基础,墩位处最大水深为6.6 m,围堰内河床岩层为砂岩,基本无覆盖层。54#墩的承台施工采用钢管桩与钢板桩组合围堰,针对裸岩浅埋无封底围堰的施工特点,通过建模分析各个工况下围堰体系的变形与受力情况,表明围堰结构及整体稳定性安全。无封底钢管桩与钢板桩组合围堰的综合性施工难度较大,介绍铣槽、沉桩、基槽内清淤、柱脚锚固浇筑等关键施工技术,现场实施效果良好。

关键词：裸岩浅埋无封底 PC组合围堰结构设计铣槽柱脚锚固混凝土浇筑

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锗锡浓度对硅锗锡合金性能影响的研究

原子与分子物理学报 2025年第5期42卷 163-174页

作者：顾永顺温淑敏内蒙古工业大学理学院呼和浩特010051

由于SiGeSn合金材料其具有高的载流子迁移率和较长的载流子寿命,并且其结构具有较高的热力学稳定性,所以在光电子领域中是一种具有非常大应用潜力的半导体材料.本文采用密度泛函理论中的广义梯度近似GGA+U的方法,构建并计算了本征半导体... 详细信息

由于SiGeSn合金材料其具有高的载流子迁移率和较长的载流子寿命,并且其结构具有较高的热力学稳定性,所以在光电子领域中是一种具有非常大应用潜力的半导体材料.本文采用密度泛函理论中的广义梯度近似GGA+U的方法,构建并计算了本征半导体Si_(96)与五组掺杂模型Si_(92)Ge_(2)Sn_(2)、Si_(88)Ge_(4)Sn_(4)、Si_(84)Ge_(6)Sn_(6)、Si_(80)Ge_(8)Sn_(8)、Si_(76)Ge_(10)Sn_(10)的电子结构及光学性质.通过对计算结果的分析可知,Ge,Sn的加入使得Si材料的带隙宽度减小,并且发生了由间接带隙向直接带隙的转变;Ge,Sn浓度最高的SiGeSn合金的形成能相对较高,稳定性相较于Ge,Sn含量低的材料较差;随着Ge,Sn掺杂浓度的提高,电子态密度图显示出越来越明显的杂化现象,并且态密度的峰值主要有Si原子的s轨道提供;Ge,Sn浓度的提高还使得SiGeSn合金的吸收系数在可见光及近红外区域内增加、反射率在可见光及以上波段范围内提高、折射率变低、消光系数曲线向红外区域移动等光学性质变化,表明可以通过调节Ge,Sn浓度来获得合适的光学特性,这为SiGeSn半导体在红外区域光电材料和器件的应用上提供了研究方向.

关键词： SiGeSn 电子特性光学性质

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五味子甲素改善氧化应激引起的内皮功能障碍

中国药理学通报 2025年第1期41卷 122-130页

作者：侯惠民张文文赵卫萍赵鑫朴贤美寒地心血管疾病国家重点实验室哈尔滨医科大学药学院药理学教研室黑龙江省生物医药工程重点实验室—省部共建国家重点实验室培育基地心血管药物研究教育部重点实验室黑龙江哈尔滨150086

目的探究五味子甲素(schizandrin A,SchA)对氧化应激引起内皮功能障碍的拮抗作用及其作用机制。方法选用人脐静脉内皮细胞(human umbilical vein endothelial cells,HUVECs)作为研究对象,采用MTT实验检测SchA对HUVECs活力的影响;通过流... 详细信息

目的探究五味子甲素(schizandrin A,SchA)对氧化应激引起内皮功能障碍的拮抗作用及其作用机制。方法选用人脐静脉内皮细胞(human umbilical vein endothelial cells,HUVECs)作为研究对象,采用MTT实验检测SchA对HUVECs活力的影响;通过流式细胞技术检测细胞中ROS的含量;试剂盒检测HUVECs中MDA、CAT的含量以及细胞上清液中NO、ET-1的含量;Western blot实验检测细胞中SOD1、p-eNOS/eNOS蛋白以及Nrf2/Keap1/HO-1通路蛋白的表达情况;免疫荧光实验检测细胞Nrf2的入核情况。结果SchA通过激活Nrf2/Keap1/HO-1信号通路逆转LPS或缺氧诱导的HUVECs内ROS和MDA含量的升高及SOD1和CAT含量的下降;SchA逆转LPS诱导的HUVECs中p-eNOS和eNOS蛋白表达的降低及逆转细胞培养液中NO含量的下降和ET-1含量的升高;Nrf2抑制剂ML385逆转SchA对氧化应激及内皮功能障碍的拮抗作用。结论SchA拮抗LPS及缺氧诱导的氧化应激,SchA通过上调Nrf2/Keap1/HO-1信号通路改善氧化应激引起的内皮功能障碍。

关键词： SchA 氧化应激内皮功能障碍 Nrf2/Keap1/HO-1信号通路 HUVECs LPS

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初中生认知控制对替代性攻击行为的影响:激惹和触发的情境边界条件

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心理学报 2025年第1期57卷 36-57页

作者：林爽程塨渌刘文白学军天津师范大学心理学部天津300387 辽宁师范大学心理学院大连116029 广西师范大学教育学部桂林541004

本研究通过3个实验探索了初中生认知控制对替代性攻击行为的影响以及认知控制影响替代性攻击行为的激惹和触发情境边界条件。实验1考察了一般性认知控制对替代性攻击行为的影响,结果发现一般性认知控制不能有效降低替代性攻击行为的攻... 详细信息

本研究通过3个实验探索了初中生认知控制对替代性攻击行为的影响以及认知控制影响替代性攻击行为的激惹和触发情境边界条件。实验1考察了一般性认知控制对替代性攻击行为的影响,结果发现一般性认知控制不能有效降低替代性攻击行为的攻击比例。实验2探讨了特异性认知控制对替代性攻击行为的有效抑制作用,结果发现无论在高激惹情境还是低激惹情境,主动控制和反应性控制启动条件下的替代性攻击行为均显著低于基线水平。实验3则探究了特异性认知控制抑制替代性攻击行为的激惹和触发情境边界条件,结果发现特异性认知控制、激惹情境、触发情境三者的交互作用显著,激惹和触发情境能够有效调节特异性认知控制对替代性攻击行为的影响。而且,在高激惹高触发和高激惹低触发情境下,主动性控制减基线的攻击比例显著高于反应性控制减基线,但在低激惹高触发和低激惹低触发情境下主动性控制减基线的攻击比例与反应性控制减基线不存在显著差异。此外,高激惹高触发情境下主动性控制减基线的攻击比例是所有条件下最高的。以上结果说明,特异性认知控制能够有效抑制初中生的替代性攻击行为,其中主动性控制的情境边界出现在高激惹高触发情境。

关键词：认知控制替代性攻击行为激惹情境触发情境情境边界条件