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Correlation between longitudinal crack occurrence and mold heat transfer in continuous casting based on process data mining

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Journal of Iron and Steel Research International 2024年第5期31卷 1139-1152页

作者： Zhi-qiang Peng Zi-bing Hou Kai Yi Kun-hui Guo Dong-wei Guo Guang-hua wen College of Materials Science and Engineering Chongqing UniversityChongqing400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing400044China

The correlation between the longitudinal crack occurrence and integrated heat transfer of the mold with data mining methods was ***,three kinds of support vector machine models based on principal component analysis with different input features were established to explore the effect of integrated heat transfer on the accuracy of the prediction model for the longitudinal *** results show that the accuracy was improved while features including mean and standard deviation of integrated heat transfer were ***,the difference in integrated heat transfer between defect and normal samples under the same process parameters was quantitatively *** with normal samples,the temperature difference of cooling water for defect samples decreased by 0.65%,and the temperature difference fluctuation increased by 31.1%.Finally,the literature data were used to provide support for the quantitative correlation according to defect formation mechanism.A new criterion for the prediction of longitudinal crack and a discovering method for correlation between product quality and process parameters in the manufacturing industry have been provided.

关键词： Continuous casting slab Longitudinal surface crack Heat transfer Data mining Quantitative correlation

Conquer coronary artery perforation with magic hands

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Journal of Geriatric Cardiology 2024年第4期21卷 379-386页

作者： Yi-Lun ZOU Jian-qiang LI Ding-Yu WANG Yong-Tai GONG Li SHENG yue LI Department of Cardiology the First Affiliated Hospital of Harbin Medical UniversityHarbinChina

Coronary artery perforation(CAP) poses a significant challenge for interventional cardiologists. Management of CAP depends on the location and severity of the perforation. The conventional method for addressing the perforation of large vessels involves the placement of a covered stent, while the perforation of distal and collateral vessels is typically managed using coils, autologous skin, subcutaneous fat, microspheres, gelatin sponge, thrombin or other substances. However, the above techniques have certain limitations and are not applicable in all scenarios. Our team has developed a range of innovative strategies for effectively managing CAP. This article provides an insightful review of the various tips and tricks for the treatment of CAP.

关键词： coronary sponge perforation

Bimetallic NiCoP catalysts anchored on phosphorus-doped lignin-based carbon for robust oxygen evolution performance

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Rare Metals 2024年第7期43卷 3084-3095页

作者： Ling-Ying-Zi Xiong Bo-wen Liu Lei Du yue-Kuan Zhou Xu-Liang Lin Huan Wang Guangdong Engineering Technology Research Center for Sensing Materials&Devices Guangzhou Key Laboratory of Sensing Materials&DevicesSchool of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou 510006China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Jieyang 515200China Sustainable Energy and Environment Thrust Function HubThe Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Division of Emerging Interdisciplinary Areas Department of Mechanical and Aerospace EngineeringThe Hong Kong University of Science and TechnologyHong Kong 999077China State Key Lab of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China

Oxygen evolution reaction(OER)catalysts are the key core materials that determine the performance of fuel cells,metal-air batteries,electrolytic water decomposition,and other *** this work,a green lignin-based non-precious metal OER catalyst was prepared by a simple ***,c arboxylated lignin was used to complex Ni and Co in situ,and then they were placed with sodium hypophosphite in the same tube furnace for upstream and downstream high-temperature calcination to construct a lignin carbon-based Ni-Co bimetallic OER catalyst(NiCoP@C).The synthesized catalyst is a porous bimetallic phosphide with a three-dimensional network structure and high-density electrochemical active ***@C exhibited favorable catalytic activity for the oxygen evolution reaction(OER)with overpotential of 280 mV at 10 mA·cm~(-2)and a Tafel slope of 77 mV·dec~(-1).Additionally,it exhibited remarkable durability during *** functional theory(DFT)calculations revealed that by leveraging the distinctive structure of transition metal phosphide nanoparticles incorporated into a reticulated substrate,the NiCoP@C catalyst offered an increased number of active sites for OER catalysis,significantly enhancing its stability during practical *** present study broadens the utilization pathways of biomass to"turn waste into treasure,"aligning the development concept of green sustainable development.

关键词： Oxygen evolution reaction Lignin Carbon-based catalyst Nickel-cobalt bimetal Metal phosphide

Solidification behaviour and hot cracking susceptibility of a novel Ni-based superalloy

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Journal of Iron and Steel Research International 2024年第4期31卷 956-966页

作者： yue Chen Shao-min Lv Xing-fei Xie Xiao-can wen Jng-long Qu Jin-hui Du High-Temperature Materials Institute China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China Beijing GAONA Materials and Technology Co. Ltd.Beijing 100081China Sichuan CISRI-GAONA Forging Co. Ltd.Deyang 610000SichuanChina

A novel Ni-based superalloy GH4151,with a γ′ volume fraction of about 55%and a service temperature capability up to 8oo oC,was *** to the different cooling conditions of various regions during the solidification of ingots,significant cooling rate variations may lead to the occurrence of hot *** scanning laser microscope was utilised to investigate the solidification process and phase precipitation behaviour of the GH4151 under wide range cooling *** characteristics of L→γ transformation were analysed,and the growth rates of at each stage were *** segregation behaviour was predicted using the Scheil equation,and the predicted results match well with the experimental *** sensitivity coefficient for hot cracking was modified,and cracking sensitivity coefficient values for the alloy under different cooling rates were computed,revealing that the alloy is most susceptible to hot cracking at 10℃/min cooling ***,controlling the cooling rate can reduce the possibility of hot cracking in ingot.

关键词： Ni-based superalloy Solidification behaviour In-situ observation Clyne and Davies's criterion:Hot cracking susceptibility

Establishment and evaluation of a prognostic model for patients with unresectable gastric cancer liver metastases

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World Journal of Clinical Cases 2024年第13期12卷 2182-2193页

作者： Zheng-Yao Chang wen-Xing Gao yue Zhang wen Zhao Di Wu Lin Chen Department of General Surgery The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Endocrinology The First Medical Center of Chinese PLA General HospitalBeijing 100853China School of Medicine Nankai UniversityTianjin 300071China

BACKGROUND Liver metastases(LM)is the primary factor contributing to unfavorable outcomes in patients diagnosed with gastric cancer(GC).The objective of this study is to analyze significant prognostic risk factors for patients with GCLM and develop a reliable nomogram model that can accurately predict individualized prognosis,thereby enhancing the ability to evaluate patient *** To analyze prognostic risk factors for GCLM and develop a reliable nomogram model to accurately predict individualized prognosis,thereby enhancing patient outcome *** Retrospective analysis was conducted on clinical data pertaining to GCLM(type III),admitted to the Department of General Surgery across multiple centers of the Chinese PLA General Hospital from January 2010 to January *** dataset was divided into a development cohort and validation cohort in a ratio of 2:*** the development cohort,we utilized univariate and multivariate Cox regression analyses to identify independent risk factors associated with overall survival in GCLM ***,we established a prediction model based on these findings and evaluated its performance using receiver operator characteristic curve analysis,calibration curves,and clinical decision curves.A nomogram was created to visually represent the prediction model,which was then externally validated using the validation *** A total of 372 patients were included in this study,comprising 248 individuals in the development cohort and 124 individuals in the validation *** on Cox analysis results,our final prediction model incorporated five independent risk factors including albumin levels,primary tumor size,presence of extrahepatic metastases,surgical treatment status,and chemotherapy *** 1-,3-,and 5-years Area Under the Curve values in the development cohort are 0.753,0.859,and 0.909,respectively;whereas in the validation cohort,they are observed to be 0.772,0.848,and ***,th

关键词： Gastric cancer Liver metastases Nomogram Prognostic model Survival analysis

Identification and immune analysis of antimicrobial peptides from the cigarette beetle(Lasioderma serricorne)

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Insect Science 2024年第4期31卷 1121-1134页

作者： yue Zhang Yi Yan Guy Smagghe Hong Yang Ren-huai Dai wen-jia Yang Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangChina Guizhou Provincial Key Laboratory for Rare Animal and Economic Insect of the Mountainous Region College of Biology and Environmental EngineeringGuiyang UniversityGuiyangChina

Antimicrobial peptides(AMPs)in insects are endogenous peptides that are effector components of the innate defense system of the *** may serve as antimicrobial agents because of their small molecular weight and broad-spectrum antimicrobial *** this study,we performed transcriptome analysis of cigarette beetle(Lasioderma serricorne)larvae,parasitized by the ectoparasitic wasp,Anisopteromalus *** AMP genes were significantly upregulated following *** parasitism,postulating the hypothesis that the parasitization enhanced the host's resistance against pathogenic microorganisms through the regulation of host AMP ***,3 AMP genes(LsDef1,LsDef2,and LsCole)were significantly upregulated and we studied their immune function in *** challenge and functional analysis showed that LsCole was responsible for the immune response against Gram-negative and Gram-positive bacteria,while LsDef1 and LsDef2 were involved in insect defense against Gram-positive *** recombinant LsCole exhibited antimicrobial activities against the Gram-negative bacterium Escherichia coli and the Gram-positive bacterium Staphylococcus ***2 showed an antibacterial effect against *** and LsDef2 exhibited antibiofilm activity against *** 2 AMPs disrupted cell membranes and caused leakage of *** cell *** results indicated that the 3 AMPs in *** are involved in the innate immunity of this pest *** AMPs may have potential as antimicrobial agents for bacterial infection ***,data are discussed in relation to new control strategies with greater biosafety against pest insects with use of microbial biocontrol agents in combination with RNA interference against the insect's defensive AMP genes.

关键词： antimicrobial activity antimicrobial peptides innate immune response Lasioderma serricorne RNA interference

Autophagy and its role in gastrointestinal diseases

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World Journal of Gastroenterology 2024年第36期30卷 4014-4020页

作者： Bo-Zong Shao wen-Gang Zhang Zhen-Yu Liu En-qiang Linghu Department of Gastroenterology First Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100853China

Gastrointestinal disorders encompass a spectrum of conditions affecting various organs within the digestive system,such as the esophagus,stomach,colon,rectum,pancreas,liver,small intestine,and bile *** role of autophagy in the etiology and progression of gastrointestinal diseases has garnered significant *** paper seeks to evaluate the impact and mechanisms of autophagy in gastrointestinal disorders by synthesizing recent research ***,we delve into inflammation-related gastrointestinal conditions,including ulcerative colitis,Crohn’s disease,and pancreatitis,as well as gastrointestinal cancers such as esophageal,gastric,and colorectal ***,we provide commentary on a recent publication by Chang et al in the World Journal of *** objective is to offer fresh perspectives on the mechanisms and therapeutic approaches for these gastrointestinal *** review aims to offer new perspectives on the mechanisms and therapeutic strategies for gastrointestinal disorders by critically analyzing relevant *** discussed,the role of autophagy in gastrointestinal diseases is complex and,at times,*** harness the full therapeutic potential of autophagy in treating these conditions,more in-depth research is imperative.

关键词： Autophagy Inflammation Cancer Inflammatory bowel disease Pancreatitis

Long noncoding RNAs HAND2-AS1 ultrasound microbubbles suppress hepatocellular carcinoma progression by regulating the miR-873-5p/tissue inhibitor of matrix metalloproteinase-2 axis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1547-1563页

作者： qiang Zou Hao-wen Wang Xi-Liang Di Yuan Li Hui Gao Department of Interventional Therapy Tianjin Medical University Cancer Institute and HospitalTianjin 300060China National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China College of Animal Science and Technology Northeast Agricultural UniversityHarbin 150030Heilongjiang ProvinceChina Department of Hematology and Oncology Linyi People’s HospitalLinyi 251500Shandong ProvinceChina Department of Comprehensive Oncology Baotou Cancer HospitalBaotou 014030Inner Mongolia Autonomous RegionChina

BACKGROUND Increasing data indicated that long noncoding RNAs(lncRNAs)were directly or indirectly involved in the occurrence and development of tumors,including hepatocellular carcinoma(HCC).Recent studies had found that the expression of lncRNA HAND2-AS1 was downregulated in HCC tissues,but its role in HCC progression is *** targeted microbubble destruction mediated gene transfection is a new method to overexpress *** To study the role of ultrasound microbubbles(UTMBs)mediated HAND2-AS1 in the progression of HCC,in order to provide a new reference for the treatment of *** In vitro,we transfected HAND2-AS1 siRNA into HepG2 cells by UTMBs,and detected cell proliferation,apoptosis,invasion and epithelial-mesenchymal transition(EMT)by cell counting kit-8 assay,flow cytometry,Transwell invasion assay and Western blotting,*** addition,we transfected miR-837-5p mimic into UTMBs treated cells and observed the changes of cell ***,the UTMBs treated HepG2 cells were transfected together with miR-837-5p mimic and tissue inhibitor of matrix metalloproteinase-2(TIMP2)overexpression vector,and we detected cell proliferation,apoptosis,invasion and *** vivo,we established a mouse model of subcutaneous transplantation of HepG2 cells and observed the effect of HAND2-AS1 silencing on tumor formation *** We found that UTMBs carrying HAND2-AS1 restricted cell proliferation,invasion,and EMT,encouraged apoptosis,and HAND2-AS1 silencing eliminated the effect of ***,miR-873-5p targets the gene HAND2-AS1,which also targets the 3’UTR of *** miR-873-5p mimic counteracted the impact of ***,miR-873-5p mimic solely or in combination with pcDNA-TIMP2 had been transformed into HepG2 cells exposed to *** discovered that TIMP2 reversed the effect of miR-873-5p mimic caused by the blocked signalling cascade for matrix metalloproteinase(MMP)2/*** vivo results showed that HAND2-AS1 silencing sig

关键词： Hepatocellular carcinoma Ultrasound microbubbles Long noncoding RNA HAND2-AS1 miR-873-5p Tissue inhibitor of matrix metalloproteinase-2

Resection of polyps involving the appendiceal orifice by combined endo-laparoscopic surgery: Two case reports

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1948-1952页

作者： yue-Yi Zhang Jun-Yang Lu qiang Wang Ai-Ming Yang Department of Gastroenterology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of General Surgery State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUND The management of polyps involving the appendiceal orifice(AO)presents notable *** resection is frequently hindered by operational complexities,a heightened risk of incomplete removal,and an elevated risk of procedural complications,including ***,surgical resection may entail unnecessary excision of intestinal segments,leading to potential *** SUMMARY Here,we reported two patients who presented with polyps deeply situated within the AO,with indistinct boundaries making it challenging to ensure completeness using traditional endoscopic *** overcome these challenges,we em-ployed combined endo-laparoscopic surgery(CELS),achieving curative resection without postoperative *** The application of CELS in managing polyps involving the AO is emerging as a safe and effective treatment modality.

关键词： Polyps Laterally spreading tumor Appendiceal orifice Endoscopic resection Combined endo-laparoscopic surgery Case report