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Localization and distribution of magnetic chemotherapeutic drugs with magnetic targeting in rat brain

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Chinese Medical Journal 2005年第10期118卷 824-827页

作者： LIAn-min ZHANGChuan-xiu FUXiang-ping ZHANGZhi-wen xueqing-hui YANRun-min YILin-hua CapitalTherapeuticCenterofBrainGliomas 304ClinicalCenterofPLAGeneralHospitalBeijing100037China

Background Magnetic targeting therapy may be a new method for the treatment of malignent tumors. The purpose of this study was to investigate the localization and distribution of ferrofluid microsphere of human serum albumin methotrexate (FM-HSA-MTX) carriers in the brain and to explore the magnetic targeting chemotherapy for malignant brain tumor. Methods Ninety SD rats were divided into three groups: targeting group, non-magnetic targeting group, and control group. Synthesized FM-HSA-MTX carriers (MTX 25 mg/kg) were injected into the systemic circulation via the caudal vein (magnetic targeting group, n=30). A 0.6 T magnetic field was placed around the right hemisphere. The non-magnetic targeting group (n=30) was administered with FM-HSA-MTX without external magnetic field, meanwhile the control group (n=30) was treated with MTX and a magnetic field. Random serial sacrifices (n=10) were conducted at 15, 30 and 45 minutes after drug administration. Bilateral hemispheres were collected respectively, and analyzed for total MTX content. Results MTX content in the right hemisphere of the magnetic targeting group was significantly higher than that in the other two groups at 15, 30 and 45 minutes after drug administration (P<0.05) No difference was seen between the non-targeting group and control group. In the magnetic targeting group, MTX returned to the peak level [(0.564±0.018) mg/g, q_(15-45)=32.252, P<0.05] 45 minutes after the injection but it deceased in the other two groups [non-magnetic targeting group: (0.060±0.015) mg/g, q_(15-45)=9.245, P<0.05, control group: (0.074±0.045) mg/g, q_(15-45)=6.299, P<0.05]. In the magnetic targeting group, the concentration of MTX in the right hemisphere was significantly higher than that in the left hemisphere (t_(45min)=21.135, P=0.000) but no difference was observed between bilateral hemispheres in the other two groups (non-magnetic targeting group: t_(45min)=0.434, P=0.670; control group: t_(45min)=0.533, P=0.600). Conclusion

关键词： ferrofluid microsphere human serum albumin methotrexate magnetic field

The Investigations of Nanosecond Pulse Argon Plasma Discharge of Low Pressure

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The Investigations of Nanosecond Pulse Argon Plasma Discharg...

第十五届全国等离子体科学技术会议

作者： xueqing wen,Cnunlei Feng,Yu Xin,Hongbin Ding~ School of Physics and Optical Electronic Technology,Dalian University of Technology,Dalian 116024,PR China

The behavior of argon plasma in a low pressure driven by nano-second pulsed plasma reactor is investigated using a global model and experimental *** time evolution of plasma density and the electron energy distribution function is calculated by solving energy balance equations and Boltzmann *** electron energy distribution function during and shortly after the pulse can be represented by a bi-temperature Maxwellian distribution indicating two energy groups of electrons. According to the calculation of effective electron temperature,we find that the high energy electrons which play an important role in excitation,ionization process in reactive plasma are much more dominant compared to low energy ***,the effective temperature is measured by use of optical emission spectroscopy with the same physical parameters as in our *** with the experimental studies, the simulation result agrees well with the experimental *** investigate the concentration variation verse time of the excited state 4p(1.5)2 of Argon atom. Excellent agreement is obtained between the simulation and ***, we report the variation of the effective electron temperature and concentration of the the excited state 4p(1.5)2 with gas pressure,pulse width and pulse rising edge.

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中途测井资料预测井底以下地层压力

天然气工业 2002年第4期22卷 23-26页

作者：肖慈珣张学庆文环明甄兆聪油气藏地质与开发工程国家重点实验室

在钻井过程中 ,准确求取或预测出井底以下尚未钻遇地层的压力 ,对实时指导钻井作业具有重要的意义。然而 ,由于能用于估算井底以下地层压力的可用资料太少 ,使这项研究具有较大的难度 ,目前还缺乏有效的方法。本文提出一种利用中途测井... 详细信息

在钻井过程中 ,准确求取或预测出井底以下尚未钻遇地层的压力 ,对实时指导钻井作业具有重要的意义。然而 ,由于能用于估算井底以下地层压力的可用资料太少 ,使这项研究具有较大的难度 ,目前还缺乏有效的方法。本文提出一种利用中途测井资料 ,结合过井地震数据 ,通过建立地震与测井信息之间的非线性映射关系 ,外推井底以下测井曲线 ,进而预测井底以下地层压力的新的研究思路和方法技术。通过在南海西部地区高温高压海洋钻井的实际应用 ,取得了良好的效果 ,外推的测井声波曲线与随后的实测曲线有很好的一致性 ,压力预测误差小于 10 %。

关键词：中途测井资料预测井底以下地层压力石油钻井地震数据

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中日巨额外汇储备的成因及运作比较

新金融 2006年第9期 33-35页

作者：翁雪琴苏州职业大学管理系金融教研室

文章对中国和日本巨额外汇储备的成因和运作进行了对比分析,指出日本是在资本过剩情况下,大量增加外汇储备的,是在大量资本输出情况下购买美国国债的,日本巨额外汇储备不仅没有给日本经济造成负面影响,反而带来较好的投资回报。而中国... 详细信息

文章对中国和日本巨额外汇储备的成因和运作进行了对比分析,指出日本是在资本过剩情况下,大量增加外汇储备的,是在大量资本输出情况下购买美国国债的,日本巨额外汇储备不仅没有给日本经济造成负面影响,反而带来较好的投资回报。而中国是在资本不足、大量资本输入的情况下用大量储备外汇来对外间接投资的,对国家的整体福利是一个巨大的损失,并承担了对外资产价格和汇率变动的风险。

关键词：外汇储备中日比较

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做好电视剧编排稳步提升收视率

数字传媒研究 2018年第11期35卷 34-35页

作者：韩钿畅温雪青内蒙古广播电视台

对于电视传播而言,节目编排是其中十分重要的环节,与电视的传播效果有密不可分的关系。尤其是电视剧的编排,直接影响收视率的提升。随着电视节目的日益丰富,电视剧的传播也面临着越来越大的挑战。因此,对电视剧进行合理的编排越来越重要。

关键词：电视剧节目编排收视率

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology Research 2025年第1期33卷 199-212页

作者： wen YANG BIN TANG DAN XU wenXIU YANG Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported ***,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(p<0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCR7 CCL21 ERK1/2 Lenalidomide Diffuse large B-cell lymphoma(DLBCL)

Experimental Study on Geometry Characteristics of Turbulent Premixed Flames for Natural Gas/Air Mixtures

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Journal of Thermal Science 2025年第1期34卷 268-282页

作者： ZHENG Weilin WANG Qijiao XIAO Huahua CHEN Xiaoxiao XIE Fan ZENG wen Liaoning Key Lab of Advanced Test Technology for Aerospace Propulsion System Shenyang Aerospace University State Key Laboratory of Fire Science University of science and Technology of China AVIC Shenyang Aircraft Design and Research Institute

In this study,focusing on the geometry characteristics of spherical expanding flame,the turbulent premixed flames of natural gas/air mixtures were investigated in a fan-stirred turbulent *** effects of initial temperature（T=300-400 K）,initial pressure（P=0.1-0.3 MPa）,turbulence intensity（u'=1.0-2.7 m/s）,oxygen volumetric percentage(φ（O2）=15%-21%) and carbon dioxide volumetric percentage(φ（CO2）=0-20%)were delved *** flame profile under the Cartesian coordinate system was derived from the schlieren images taken by the high-speed ***,from both macroscopic and microscopic perspectives,the influence of experimental conditions on the flame geometry characteristics was explored through flame front extraction,wavelet decomposition and network *** results demonstrate that for significant flame wrinkling,changes in species concentrations and turbulence intensity have more pronounced effects on the flame wrinkling *** wrinkling of the flame front maintains a certain degree of similarity,as evidenced by the locally concentrated distribution of the angles of the maximum fluctuation *** disturbance energy under large-scale（D6-D8） disturbances exhibits relatively high values with a similar trend,exerting a significant impact on the geometry characteristics of the flame *** peaks of correlation degree are scattered either with the decomposition scale or the development of flame radius,indicating no linear correlation between different detail ***,the probability distribution of node degrees in key wrinkled regions exhibits different trends with that of large-scale wrinkling and disturbance energy,especially with changes in initial *** occurs because the number of key wrinkles varies based on the perturbation's strength or the region's ***,an increase in the fluctuation frequency of the flame's local radius may not necessarily lead to an increase in the number of key folded regions.

关键词： fan-stirred turbulent combustor geometry characteristics large-scale wrinkling network topology wavelet decomposition

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高速插齿时切削液的试验研究

湖南大学学报 1982年第2期 57-63页

作者：温松明洪学勤黄省长

本文介绍并分析了20号机械油和GQY-2水基切削液在高速插齿中的试验结果。

关键词：切削液润滑性能机械油试验结果润滑冷却液插齿刀齿轮刀具圆周进给量刀具磨损机床调整参数试验研究