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Microstructure and Hydrogen Absorption/Desorption Behavior of Mg23-xLaxNi10 Alloy

Journal of Wuhan University of Technology(Materials Science) 2018年第2期33卷 476-484页

作者：董小平杨丽颖 PANG Yanrong WANG Tao wen lijuan College of Quality and Technical Supervision Hebei University Baoding 071002 China Research Center of New Energy Automobile Hebei University Baoding 071002 China

Induction melting was used as a routine method to synthesize Mg_（23）Ni_（10）, Mg_（22）LaNi_（10） and Mg_（21）La_2Ni_（10） alloys, and followed by a detailed microstructural characterization which included X-ray diffraction（XRD）, scanning electron microscopy（SEM） with energy dispersive spectrometer（EDS）, high resolution transmission electron microscope（HRTEM） and hydrogen absorption/desorption measurements. XRD analysis results showed that Mg_2Ni and Mg phases were detected in the XRD pattern of the Mg_（23）Ni_（10） alloy, however, the La addition results in conversion from Mg to LaMg_3 and La_2Mg_（17） phases and appearance of crystal defects included dislocations, twin grain boundary and vacancy in the Mg_（22）LaNi_（10） and Mg_（21）La_2Ni_（10） alloy textures. The total maximum hydrogen absorption capacity was 4.45 wt% for the Mg_（23）Ni_（10） alloy, however, the Mg_（22）LaNi_（10） and Mg_（21）La_2Ni_（10） alloys with vacancy, dislocations and twin grain boundary, absorbed 3.66 wt% and 3.60 wt%, respectively, indicating that the La addition led to decreasing of the maximum hydrogen absorption capacity. Besides, hydrogen absorption/desorption of 90% of saturated state expended for about 456 and 990 s for pristine Mg_（23）Ni_（10） alloy, by contrast, the time decreased owing to improvement of hydrogen absorption and desorption kinetics in the alloy with La element, with which the uptake time for hydrogen content to 90% of saturated state was 150 and 78 s, and 90% hydrogen can be released in 930 and 804 s for Mg_（22）LaNi_（10） and Mg_（21）La_2Ni_（10） alloys in the experimental condition.

关键词： Mg-based alloy microstructure hydrogen absorption/desorption behavior

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Regulation of pathological blood-brain barrier for intracranial enhanced drug delivery and anti-glioblastoma therapeutics

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Oncology Research 2021年第5期29卷 351-363页

作者： KAI WANG FENGTIAN ZHANG CHANGLONG wen ZHIHUA HUANG ZHIHAO HU YUwen ZHANG FUQIANG HU lijuan wen Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education Gannan Medical UniversityGanzhou341000China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou310058China Department of Orthopedics First Affiliated Hospital of Gannan Medical UniversityGanzhou341000China Medical College of Soochow University Suzhou215123China Department of Infectious Diseases Ganzhou People’s HospitalGanzhou341000China Ganzhou Key Laboratory of Neuroinflammation Research Gannan Medical UniversityGanzhou341000China

The blood-brain barrier(BBB)is an essential component in regulating and maintaining the homeostatic microenvironment of the central nervous system(CNS).During the occurrence and development of glioblastoma(GBM),BBB is pathologically destroyed with a marked increase in *** to the obstruction of the BBB,current strategies for GBM therapeutics still obtain a meager success rate and may lead to systemic ***,chemotherapy could promote pathological BBB functional restoration,which results in signiﬁcantly reduced intracerebral transport of therapeutic agents during multiple administrations of GBM and the eventual failure of GBM *** effective delivery of intracerebral drugs still faces severe ***,strategies that regulate the pathological BBB to enhance the transport of therapeutic agents across the barrier may provide new opportunities for the effective and safe treatment of *** article reviews the structure and function of BBB in physiological states,the mechanisms underlying BBB pathological fenestration during the development of GBM,and the therapeutic strategies of GBM based on BBB intervention and medicinal drugs transporting across the BBB.

关键词： Blood-brain barrier Physiological Pathological Glioblastoma Intervention

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Regulation of pathological BBB restoration via nanostructured ROS-responsive glycolipid-like copolymer entrapping siVEGF for glioblastoma targeted therapeutics

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Nano Research 2022年第2期15卷 1455-1465页

作者： lijuan wen Yu Peng Kai Wang Zhihua Huang Shiying He Ruiwen Xiong Longping Wu Fengtian Zhang Fuqiang Hu National Engineering Research Center for Modernization of Tranditional Chinese Medicine-Hakka Medical Resources Branch College oj PharmacyGannan Medical UniversityGanzhou 341000China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Department of Orthopedics First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China Department of Orthopedics Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education Gannan Medical UniversityGanzhou 341000China

Glioblastoma(GBM)is one of the malignant brain tumors with high mortality and no curative *** elevated vascular endothelial growth factor(VEGF)in GBM seriously disrupts the blood brain barrier(BBB)with an increased permeability,resulting in poor outcome and *** interference has shown strong potential to inhibit VEGF expression,thus it is necessary to development an effective and safe gene delivery system possessing the ability to cross the BBB and target GBM *** study aims to explore the anti-GBM effect of angiopep-2(Ap)peptide modified reactive oxygen species(ROS)cleavable thioketal(TK)linked glycolipid-like nanocarrier(CSTKSA)delivering anti-VEGF siRNA(R),termed as Ap-CSTKSA/R *** functionalized modification produced an enhanced cellular uptake and a stronger bio-distribution of Ap-CSTKSA/R complexes in U87 MG cells and brain tumor tissues,***-CSTKSA/R complexes exhibited great superiority in GBM growth inhibition and finally translated into the longest survival period mainly via receptor-mediated targeting delivery,VEGF gene silencing accompanied with remarkable angiogenesis inhibition,and suppressed expression of caveolin-1 which is involved in BBB functional regulation in the occurrence and treatment of *** study indicated that Ap functionalization on ROS-responsive glycolipid-like copolymer exhibits a promising and effective gene delivery platform for GBM targeted treatment.

关键词： glioblastoma ROS-responsive siRNA blood brain barrier copolymer

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Numerical simulation of the climate effect of high-altitude lakes on the Tibetan Plateau

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Research in Cold and Arid Regions 2018年第5期10卷 379-391页

作者： YinHuan Ao ShiHua Lyu ZhaoGuo Li lijuan wen Lin Zhao Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Plateau Atmosphere and Environment Key Laboratory of Sichuan Province School of Atmospheric Sciences Chengdu University of Information Technology Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science & Technology

Lakes regulate the water and heat exchange between the ground and the atmosphere on different temporal and spatial scales. However, studies of the lake effect in the high-altitude Tibetan Plateau(TP) rarely have been performed until recently, and little attention has been paid to modelling of frozen lakes. In this study, the Weather Research and Forecasting Model(WRF v. 3.6.1) is employed to conduct three numerical experiments in the Ngoring Lake Basin(the original experiment, an experiment with a tuned model, and a no-lake experiment) to investigate the influences of parameter optimization on the lake simulation and of the high-altitude lake on the regional climate. After the lake depth, the roughness lengths, and initial surface temperature are corrected in the model, the simulation of the air temperature is distinctly improved. In the experiment using a tuned model, the simulated sensible-heat flux(H) is clearly improved, especially during periods of ice melting(from late spring to early summer) and freezing(late fall). The improvement of latent-heat flux(LE) is mainly manifested by the sharp increase in the correlation coefficient between simulation and observation, whereas the improvement in the average value is small. The optimization of initial surface temperature shows the most prominent effect in the first year and distinctly weakens after a freezing period. After the lakes become grassland in the model, the daytime temperature clearly increases during the freezing and melting periods; but the nocturnal cooling appears in other stages, especially from September to October. The annual mean H increases by 6.4 times in the regions of the Ngoring Lake and the Gyaring Lake, and the LE declines by 56.2%. The sum of H and LE increases from 71.2 W/m2(with lake) to 84.6 W/m2(no lake). For the entire simulation region, the sum of H and LE also increases slightly. After the lakes are removed, the air temperature increases significantly from June to September over the

关键词： Lake-surface temperature roughness length turbulent flux Ngoring Lake Tibetan Plateau

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A case of 46, XY/47, XYY mosaicism

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Discussion of Clinical Cases 2017年第2期4卷 27-28页

作者： Yanwei Guo lijuan wen Huimin Zhao Clinical Laboratory Baogang HospitalBaotouInner MongoliaChina

In some clinical features, the failure of the couple to reproduce may be related to the chromosome abnormality of the patient. This report was based on one example about the topic.

关键词： Chromosome Chimera Abnormal gene

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青藏铁路沿线湖泊及其与铁路最小距离演变研究

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高原气象 2025年第1期44卷 163-177页

作者：于涛张圣杰文莉娟王梦晓郑景元牛瑞佳兰州理工大学石油化工学院甘肃兰州730050 中国科学院西北生态环境资源研究院青海湖综合研究观测站甘肃兰州730000 中国科学院大学北京100049

受全球气候变化影响,青藏高原湖泊近年来变化剧烈,充分了解湖泊演变特征及其驱动因素对保护沿湖重大工程设施有重要意义。基于青海湖与错那湖的Landsat遥感影像、面积数据和水位观测数据,本文对两湖演变及其与青藏铁路最小距离变化进行... 详细信息

受全球气候变化影响,青藏高原湖泊近年来变化剧烈,充分了解湖泊演变特征及其驱动因素对保护沿湖重大工程设施有重要意义。基于青海湖与错那湖的Landsat遥感影像、面积数据和水位观测数据,本文对两湖演变及其与青藏铁路最小距离变化进行了细致研究,进一步结合中国区域高时空分辨率地面气象要素驱动数据集(CMFD)和气象站的气象数据,揭示了影响两湖水位变化的主要气象因子,结果表明:(1)1956-2004年青海湖呈退缩态势,2004年水位和面积达到最低值后转为逐渐增加,2004-2020年水位年均增长率为0.20 m·a^(-1),2004-2022年面积年均增长率为19.20 km^(2)·a^(-1)。2000-2018年的错那湖水位与从20世纪70年代至2022年的面积均呈轻微波动变化,水位和面积的年际最大变化值分别为0.60 m和9.98 km^(2)。(2)1990-2022年青海湖与青藏铁路最小距离先增加后减小,2004年后二者最小距离以19.6 m·a^(-1)的速率缩短,至2022年最小距离为74.3 m;2004-2022年错那湖与青藏铁路最小距离变化趋势不明显,至2022年二者最小距离为32.3 m。(3)青海湖的水位变化受风速、年降水量、向下短波辐射、向下长波辐射和比湿影响,贡献率分别为38%、24%、20%、14%和4%;错那湖水位变化主要受年降水量影响,其余气象因子与水位变化相关性不显著。

关键词：青海湖错那湖青藏铁路面积变化水位变化相关分析

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Analysis of SEIQ Immunization Model Strategy in Small-World

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Wuhan University Journal of Natural Sciences 2010年第2期15卷 109-112页

作者： CHEN Shengshuang, ZHOU Jiahua, wen lijuan, HUANG Zhangcan School of Science, Wuhan University of Technology, Wuhan430070, Hubei, China School of Science Wuhan University of Technology Wuhan China

In this paper, we analyze an immunization strategy in SEIQ （susceptible, eclipse, infected, quarantine） model in small- world networks by associating the immunization probability with the infection probability. First, based on the mean-field theory, we establish the transmission dynamics equation for SEIQ model and find the relevant critical threshold of immunization which is re- lated to the topology of the network, the infection rate of the eclipse and infection, the density of quarantine and so on. Then we explain the influence of the immunization probability to the transmission of infectious disease. Finally, by simulating the propagation of this model on disease and comparing the results with theory results, we find that this kind of immunization strategy is effective in SEIQ model in small-world complex networks.

关键词： SEIQ model immunization critical threshold simu-lation

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Dataset of Comparative Observations for Land Surface Processes over the Semi-Arid Alpine Grassland against Alpine Lakes in the Source Region of the Yellow River

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Advances in Atmospheric Sciences 2023年第6期40卷 1142-1157页

作者： Xianhong MENG Shihua LYU Zhaoguo LI Yinhuan AO lijuan wen Lunyu SHANG Shaoying WANG Mingshan DENG Shaobo ZHANG Lin ZHAO Hao CHEN Di MA Suosuo LI Lele SHU Yingying AN Hanlin NIU Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Zoige Plateau Wetland Ecosystem Research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Plateau Atmosphere and Environment Key Laboratory of Sichuan Province School of Atmospheric SciencesChengdu University of Information TechnologyChengdu 610225China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China University of Chinese Academy of Sciences Beijing 100049China

Thousands of lakes on the Tibetan Plateau(TP) play a critical role in the regional water cycle, weather, and climate. In recent years, the areas of TP lakes underwent drastic changes and have become a research hotspot. However, the characteristics of the lake-atmosphere interaction over the high-altitude lakes are still unclear, which inhibits model development and the accurate simulation of lake climate effects. The source region of the Yellow River(SRYR) has the largest outflow lake and freshwater lake on the TP and is one of the most densely distributed lakes on the TP. Since 2011,three observation sites have been set up in the Ngoring Lake basin in the SRYR to monitor the lake-atmosphere interaction and the differences among water-heat exchanges over the land and lake surfaces. This study presents an eight-year(2012–19), half-hourly, observation-based dataset related to lake–atmosphere interactions composed of three sites. The three sites represent the lake surface, the lakeside, and the land. The observations contain the basic meteorological elements,surface radiation, eddy covariance system, soil temperature, and moisture(for land). Information related to the sites and instruments, the continuity and completeness of data, and the differences among the observational results at different sites are described in this study. These data have been used in the previous study to reveal a few energy and water exchange characteristics of TP lakes and to validate and improve the lake and land surface model. The dataset is available at National Cryosphere Desert Data Center and Science Data Bank.

关键词： field observation dataset lake-atmosphere interaction energy and water exchanges the source region of the Yellow River Tibetan Plateau

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陆面数据同化方法在绿洲农田土壤温湿度模拟中的应用

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农业工程学报 2010年第7期26卷 60-65页

作者：文莉娟吕世华中国科学院寒区旱区环境与工程研究所兰州730000

为准确预测绿洲农田土壤水分的变化以利于合理分配有限的水资源,该文利用耦合于中尺度大气数值模式MM5和WRF中的NoahLsm与集合卡尔曼滤波方法建立了一维的陆面数据同化系统,将其应用到绿洲农田土壤的水热模拟研究。模拟结果表明:在陆面... 详细信息

为准确预测绿洲农田土壤水分的变化以利于合理分配有限的水资源,该文利用耦合于中尺度大气数值模式MM5和WRF中的NoahLsm与集合卡尔曼滤波方法建立了一维的陆面数据同化系统,将其应用到绿洲农田土壤的水热模拟研究。模拟结果表明:在陆面数据同化系统中同化土壤湿度后,不仅提高了绿洲农田土壤湿度的模拟精度,还可在一定程度上提高土壤温度和潜热的模拟性能;在同化土壤湿度的基础上进一步同化土壤温度,可显著提高绿洲农田土壤温度的模拟精度。若将研究结果进一步应用到中尺度大气数值模式MM5和WRF,可以较好地监测大面积的土壤温湿度变化以便做出合理的水资源调配。

关键词：水资源土壤湿度温度绿洲农田陆面同化

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城市下垫面辐射热作用过程差异分析

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太阳能学报 2024年第3期45卷 446-452页

作者：文莉娟刘大龙西安建筑科技大学建筑学院西安710055

为了研究城市不同下垫面辐射热作用过程的差异,选取4种下垫面(草地、混凝土、铺面砖、沥青)为研究对象,测量不同下垫面反射的短波辐照度、向上的长波辐照度、地表热流强度以及空气温度、风速等环境参量。分析对比不同下垫面辐射热传递... 详细信息

为了研究城市不同下垫面辐射热作用过程的差异,选取4种下垫面(草地、混凝土、铺面砖、沥青)为研究对象,测量不同下垫面反射的短波辐照度、向上的长波辐照度、地表热流强度以及空气温度、风速等环境参量。分析对比不同下垫面辐射热传递过程中的差异。结果表明:大气逆辐照度占下垫面吸收辐射热的65%以上,4种下垫面以长波辐射的形式释放热量均在75%以上;下垫面与空气间的换热主要以辐射换热的方式进行;夏季草地热稳定性最好,混凝土下垫面的热稳定性最差;冬季混凝土的热稳定性最好,铺面砖的热稳定性最差。

关键词：太阳能建筑下垫面辐射热过程热传导辐射换热

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