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Impact factors of lymph node retrieval on survival in locally advanced rectal cancer with neoadjuvant therapy

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World Journal of Clinical Cases 2020年第24期8卷 6229-6242页

作者： Shi-wen Mei Zheng liu Zheng Wang Wei Pei Fang-Ze Wei Jia-Nan Chen Zhi-Jie Wang Hai-Yu Shen Juan Li fu-qiang Zhao Xi-Shan Wang Qian liu Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Conventional clinical guidelines recommend that at least 12 lymph nodes shouldbe removed during radical rectal cancer surgery to achieve accurate *** application of neoadjuvant therapy has changed the number of lymphnode *** To investigate factors affecting the number of lymph nodes dissected afterneoadjuvant chemoradiotherapy in locally advanced rectal cancer and to evaluatethe relationship of the total number of retrieved lymph nodes(TLN)with diseasefreesurvival(DFS)and overall survival(OS).METHODS A total of 231 patients with locally advanced rectal cancer from 2015 to 2017 wereincluded in this *** to the American Joint Committee on Cancer(AJCC)/Union for International Cancer Control(UICC)tumor-node-metastasis(TNM)classification system and the NCCN guidelines for rectal cancer,thepatients were divided into two groups:group A(TLN≥12,n=177)and group B(TLN<12,n=54).Factors influencing lymph node retrieval were analyzed byunivariate and binary logistic regression *** and OS were evaluated byKaplan-Meier curves and Cox regression *** The median number of lymph nodes dissected was 18(range,12-45)in group A and 8(range,2-11)in group *** lymph node ratio(number of positive lymphnodes/total number of lymph nodes)(P=0.039)and the interval betweenneoadjuvant therapy and radical surgery(P=0.002)were independent factors ofthe ***,TLN was not associated with sex,age,ASA score,clinical T orN stage,pathological T stage,tumor response grade(Dworak),downstaging,pathological complete response,radiotherapy dose,preoperative concurrentchemotherapy regimen,tumor distance from anal verge,multivisceral resection,preoperative carcinoembryonic antigen level,perineural invasion,intravasculartumor embolus or degree of *** pathological T stage(P<0.001)and TLN(P<0.001)were independent factors of DFS,and pathological T stage(P=0.011)and perineural invasion(P=0.002)were independent factors of ***

关键词： Lymph node retrieval Survival analysis Neoadjuvant therapy Rectal cancer Tumor-node-metastasis stage Prognosis

Low ligation has a lower anastomotic leakage rate after rectal cancer surgery

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World Journal of Gastrointestinal Oncology 2020年第6期12卷 632-641页

作者： Jia-Nan Chen Zheng liu Zhi-Jie Wang fu-qiang Zhao Fang-Ze Wei Shi-wen Mei Hai-Yu Shen Juan Li Wei Pei Zheng Wang Jun Yu Qian liu Department of Colorectal Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union CollegeBeijing 100021China Department of Surgery the Johns Hopkins University School of MedicineBaltimoreMD 21218United States

BACKGROUND For laparoscopic rectal cancer surgery,the inferior mesenteric artery(IMA)can be ligated at its origin from the aorta[high ligation(HL)]or distally to the origin of the left colic artery[low ligation(LL)].Whether different ligation levels are related to different postoperative complications,operation time,and lymph node yield remains ***,we designed this study to determine the effects of different ligation levels in rectal cancer *** To investigate the operative results following HL and LL of the IMA in rectal cancer *** From January 2017 to July 2019,this retrospective cohort study collected information from 462 consecutive rectal cancer *** to the ligation level,235 patients were assigned to the HL group while 227 patients were assigned to the LL *** regarding the clinical characteristics,surgical characteristics and complications,pathological outcomes and postoperative recovery were obtained and compared between the two groups.A multivariate logistic regression analysis was performed to evaluate the possible risk factors for anastomotic leakage(AL).RESULTS Compared to the HL group,the LL group had a significantly lower AL rate,with 6(2.8%)cases in the LL group and 24(11.0%)cases in the HL group(P=0.001).The HL group also had a higher diverting stoma rate(16.5%vs 7.5%,P=0.003).A multivariate logistic regression analysis was subsequently performed to adjust for the confounding factors and confirmed that HL(OR=3.599;95%CI:1.374-9.425;P=0.009),tumor located below the peritoneal reflection(OR=2.751;95%CI:0.772-3.985;P=0.031)and age(≥65 years)(OR=2.494;95%CI:1.080-5.760;P=0.032)were risk factors for *** were no differences in terms of patient demographics,pathological outcomes,lymph nodes harvested,blood loss,hospital stay and urinary function(P>0.05).CONCLUSION In rectal cancer surgery,LL should be the preferred method,as it has a lower AL and diverting stoma rate.

关键词： Rectal neoplasms Inferior mesenteric artery Anastomotic leakage Laparoscopy Ligation Postoperative complications

Impact of interval between neoadjuvant chemoradiotherapy and surgery in rectal cancer patients

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World Journal of Gastroenterology 2020年第31期26卷 4624-4638页

作者： Shi-wen Mei Zheng liu Fang-Ze Wei Jia-Nan Chen Zhi-Jie Wang Hai-Yu Shen Juan Li fu-qiang Zhao Wei Pei Zheng Wang Xi-Shan Wang Qian liu Department of Colorectal Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Epidemiologically,in China,locally advanced rectal cancer is a more common form of rectal *** neoadjuvant concurrent chemoradiotherapy can effectively reduce the size of locally invasive tumors and improve disease-free survival(DFS)and pathologic response after *** present,this modality has become the standard protocol for the treatment of locally advanced rectal cancer in many centers,but the optimal time for surgery after neoadjuvant therapy is still *** To investigate the impact of time interval between neoadjuvant therapy and surgery on DFS and pathologic response in patients with locally advanced rectal *** A total of 231 patients who were classified as having clinical stage II or III advanced rectal cancer and underwent neoadjuvant chemoradiation followed by surgery at the National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College from November 2014 to August 2017 were involved in this retrospective cohort *** patients were divided into two groups based on the different time intervals between neoadjuvant therapy and surgery:139(60.2%)patients were in group A(≤9 wk),and 92(39.2%)patients were in group B(>9 wk).DFS and pathologic response were analyzed as the primary *** secondary endpoints were postoperative complications and sphincter *** For the 231 patients included,surgery was performed at≤9 wk in 139(60.2%)patients and at>9 wk in 92(39.8%).The patients’clinical characteristics,surgical results,and tumor outcomes were analyzed through univariate analysis combined with multivariate regression *** overall pathologic complete response(pCR)rate was 27.2%(n=25)in the longer time interval group(>9 wk)and 10.8%(n=15)in the shorter time interval group(≤9 wk,P=0.001).The postoperative complications did not differ between the groups(group A,5%vs group B,5.4%;P=0.894).Surgical procedures for sphincter preservation were p

关键词： Interval time Advanced rectal cancer Disease-free survival Pathologic complete response Neoadjuvant therapy Surgery Complication Sphincter preservation

Fascia- vs vessel-oriented lateral lymph node dissection for rectal cancer: Short-term outcomes and prognosis in a single-center experience

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1080-1092页

作者： Wei Zhao Zhi-Jie Wang Shi-wen Mei Jia-Nan Chen Si-Cheng Zhou fu-qiang Zhao Ti-Xian Xiao FeiHuang Qian liu Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND For the management of lateral lymph node(LLN)metastasis in patients with rectal cancer,selective LLN dissection(LLND)is gradually being accepted by Chinese ***,fascia-oriented LLND allows radical tumor resection and protects of organ ***,there is a lack of studies comparing the efficacy of fascia-oriented and traditional vessel-oriented *** a preliminary study with a small sample size,we found that fasciaoriented LLND was associated with a lower incidence of postoperative urinary and male sexual dysfunction and a higher number of examined *** this study,we increased the sample size and refined the postoperative functional *** To compare the effects of fascia-and vessel-oriented LLND regarding short-term outcomes and *** We conducted a retrospective cohort study on data from 196 patients with rectal cancer who underwent total mesorectal excision and LLND from July 2014 to August *** short-term outcomes included perioperative outcomes and postoperative functional *** prognosis was measured based on overall survival(OS)and progression-free survival(PFS).RESULTS A total of 105 patients were included in the final analysis and were divided into fascia-and vesseloriented groups that included 41 and 64 patients,*** the short-term outcomes,the median number of examined LLNs was significantly higher in the fascia-oriented group than in the vessel-oriented *** were no significant differences in the other short-term *** incidence of postoperative urinary and male sexual dysfunction was significantly lower in the fascia-oriented group than in the vessel-oriented *** addition,there was no significant difference in the incidence of postoperative lower limb dysfunction between the two *** terms of prognosis,there was no significant difference in PFS or OS between the two *** It is safe and feasible to perform fascia-oriented LLND.

关键词： Rectal cancer Lateral lymph nodes Lymph node excision Fascia anatomy Treatment outcome Prognosis

Association of sexually transmitted infection with semen quality in men from couples with primary and secondary infertility

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Asian Journal of Andrology 2022年第3期24卷 317-322页

作者： shun Bai Yuan Li Mei-Hong Hu Li Wu Li-Jun Shui Xiao-Han Wang Yi-Xun liu Qiu-Ling Yue Li-Na Yu Kai-qiang fu Xian-Hong Tong Xue-Chun Hu Bo Xu Reproductive and Genetic Hospital The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Dermatology Department The Fifth People’s Hospital of Hainan ProvinceHaikou 570100China Provincial Hospital Affiliated to Anhui Medical University Hefei 230001China Department of Urology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Reproductive Medicine Center The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China College of Veterinary Medicine Qingdao Agricultural UniversityQingdao 266109China

This study aims to compare the prevalence of sexually transmitted infections(STIs)with semen quality in men from couples with primary and secondary *** samples were collected from 133 men who requested fertility *** tract infection with Ureaplasma spp.(UU),Mycoplasma hominis(MH),Mycoplasma genitalium(MG),Chlamydia trachomatis(CT),Neisseria gonorrhoeae(NG),and herpes simplex virus-2(HSV-2)was assessed by PCR-based diagnostic *** all patients,the prevalence of STIs was higher in men from couples with primary infertility than that in men from couples with secondary infertility(39.7%vs 21.7%,P=0.03).The prevalence of UU was 28.8%and 13.3%in men from couples with primary and secondary infertility,*** from couples with primary infertility were more likely to be positive for UU than men from couples with secondary infertility(P=0.04).Regarding the UU subtype,the prevalence of Ureaplasma urealyticum(Uuu)and Ureaplasma parvum(Uup;including Uup1,Uup3,Uup6,and Uup14)did not differ between the two *** associations between the prevalence rates of MH,MG,and CT were found in men from either infertility group.A lower sperm concentration was associated with STI pathogen positivity in men with primary infertility according to the crude model(P=0.04).The crude and adjusted models showed that semen volume(both P=0.03)and semen leukocyte count(both P=0.02)were independently associated with secondary *** findings suggest the importance of classifying the type of infertility during routine diagnosis of seminal tract infections.

关键词： primary infertility secondary infertility semen parameters sexually transmitted infections

Transition edge sensor-based detector:from X-ray to γ-ray

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Nuclear Science and Techniques 2022年第7期33卷 61-72页

作者： Shuo Zhang Jing-Kai Xia Tao Sun wen-Tao Wu Bing-Jun Wu Yong-Liang Wang Robin Cantor Ke Han Xiao-Peng Zhou Hao-Ran liu fu-You Fan Si-Ming Guo Jun-Cheng Liang De-Hong Li Yan-Ru Song Xu-Dong Ju qiang fu Zhi liu Center for Transformative Science ShanghaiTech UniversityShanghai201210China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai200050China STAR Cryoelectronics 25-A Bisbee CourtSanta FeNM87508-1338USA Shanghai Laboratory for Particle Physics and Cosmology INPAC and Department of Physics and AstronomyShanghai Jiao Tong UniversityShanghai200240China School of Physics Beihang UniversityBeijing100191China Division of Ionizing Radiation National Institute of MetrologyNIMNo.18 Bei San Huan Dong LuChaoyang DistBeijing100029China

A transition edge sensor(TES)is extremely sensitive to changes in temperature,and combined with a high-Z metal of a certain thickness,it can realize high-energy resolution measurements of particles such as X-rays.X-rays with energies below 10 keV have a weak penetrating ability,hence,only gold or bismuth of a few micrometers in thickness can guarantee a quantum efficiency higher than 70%.Therefore,the entire structure of the TES X-ray detector in this energy range can be realized using a microfabrication ***,for X-rays or γ-rays from 10 keV to 200 keV,submillimeter absorber layers are required,which cannot be realized using the microfabrication *** paper first briefly introduces a set of TES X-ray detectors and their auxiliary systems,and then focuses on the introduction of the TES γ-ray detector with an absorber based on a submillimeter lead-tin alloy *** detector achieved a quantum efficiency above 70% near 100 keV and an energy resolution of approximately 161.5 eV at 59.5 keV.

关键词： Synchrotron radiation instrumentation X-ray spectrometers Cryogenic detectors Transition edge sensor

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氧化修饰高密度脂蛋白的研究进展

生物化学与生物物理进展 2000年第3期27卷 261-265页

作者：傅强刘秉文 *** 华西医科大学生物化学与分子生物学研究所成都610041

血浆高密度脂蛋白 (HDL)与低密度脂蛋白 (LDL)一样可以在体内外发生氧化修饰 ,引起其理化性质发生一系列的改变 ,如多不饱和脂肪酸过氧化 ,卵磷脂水解 ,蛋白质发生聚合或分解等 .活体内HDL可能在动脉壁巨噬细胞、内皮细胞及中性粒细胞... 详细信息

血浆高密度脂蛋白 (HDL)与低密度脂蛋白 (LDL)一样可以在体内外发生氧化修饰 ,引起其理化性质发生一系列的改变 ,如多不饱和脂肪酸过氧化 ,卵磷脂水解 ,蛋白质发生聚合或分解等 .活体内HDL可能在动脉壁巨噬细胞、内皮细胞及中性粒细胞、单核细胞的作用下发生氧化修饰 .氧化修饰HDL可能通过清道夫受体途径代谢 .氧化修饰HDL产生多种致动脉粥样硬化作用 .维生素E。

关键词：动脉粥样硬化 OX-HDL 氧化修饰清道夫受体途径

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陶瓷行业在“碳达峰碳中和”背景下节能审查路径探讨

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佛山陶瓷 2024年第4期34卷 60-63页

作者：高富强陈凯刘艺罗翠珊游文慧唐寰宇黄泽铭曾令可广东能效科技有限公司广州511447 广东省技术经济研究发展中心广州510715 华南理工大学材料学院广州510640

随着“碳达峰碳中和”时代的到来,各个行业在固定资产投资项目的节能审查的重视程度均提高到一定的高度,本文以陶瓷行业为例,结合国家最新节能审查要求,初步探讨分析陶瓷行业中节能审查的路径。

关键词：节能审查碳达峰碳中和固定资产投资

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江苏省里下河地区富硒土壤元素地球化学特征及其成因机制

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物探与化探 2024年第4期48卷 1114-1124页

作者：廖启林黄顺生许伟伟崔晓丹金洋刘玲汪媛媛李文博周强自然资源部国土(耕地)生态监测与修复工程技术创新中心江苏南京210018 江苏省地质调查研究院江苏南京210018

基于江苏省里下河平原区所积累的有关生态地球化学调查数据,通过元素分布对比、相关分析、R型聚类分析、主成分分析等,系统探讨了该区富硒土壤的元素地球化学特征和成因机制,为合理开发利用第四纪沉积类型的富硒土地资源等提供了依据或... 详细信息

基于江苏省里下河平原区所积累的有关生态地球化学调查数据,通过元素分布对比、相关分析、R型聚类分析、主成分分析等,系统探讨了该区富硒土壤的元素地球化学特征和成因机制,为合理开发利用第四纪沉积类型的富硒土地资源等提供了依据或线索。研究结果显示:里下河富硒土壤为典型的第四纪沉积成因,富有机质、偏还原的封闭的潟湖相沉积环境是形成局地富硒土壤的基础;富硒土壤特征元素组合为Se-OM-N-K-Fe-Co,主要位于地表30 cm以上深度,Se含量多为(0.3~0.4)×10^(-6),分布均匀;土壤中大多数元素之间有显著正相关性,Se-OM、Se-CEC的相关系数r分别为0.74、0.66,Se和pH之间有较显著负相关性,相关系数为-0.35;富硒土壤形成要经历成土母质初始富集、成土期间再富集和成土后表生富集3个富Se阶段,以及非潟湖相沉积物(如海相沉积等)的干扰,有机质吸附、胶体吸附和生物地球化学作用是导致土壤Se富集的主要原因;富硒土壤中还伴有Cu、Pb、Zn、Ni、Co、V等相对富集,但相关重金属未超标。

关键词：富硒土壤元素地球化学特征成因机制里下河地区江苏

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