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Histological Features of Uterine Myometrial Dysfunction:Possible Involvement of Localized Inflammation

Current Medical Science 2024年第3期44卷 633-641页

作者： Sheng-lan ZHU Hui-ting ZHANG Yuan-yuan DU Yi JIANG Shao-shuai WANG wen-cheng ding Ling FENG National Clinical Research Center for Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective The latest perspective suggests that elevated levels of inflammation and cytokines are implicated in atonic postpartum hemorrhage.Lipopolysaccharide(LPS)has been widely used to induce inflammation in animal models.Therefore,this study aimed to induce uterine inflammation using LPS to investigate whether local inflammation triggers dysfunction and atrophy in the myometrium,as well as the potential underlying molecular mechanisms involved.Methods In vivo,an animal model was established by intraperitoneal injection of 300μg/kg LPS in rats on gestational day 21.Hematoxylin-eosin(H&E)staining and Masson staining were employed to determine morphological changes in the rat uterine smooth muscle.Enzyme-linked immunosorbent assay(ELISA)was used to detect inflammatory cytokines.Immunohistochemistry,tissue fluorescence,and Western blotting were conducted to assess the expression levels of the uterine contraction-related proteins Toll-like receptor 4(TLR4)and the nuclear factor kappa-B(NF-κB)signaling pathway.In vitro,human uterine smooth muscle cells(HUtSMCs)were exposed to 2μg/mL LPS to further elucidate the involvement of the TLR4/NF-κB signaling pathway in LPS-mediated inflammation.Results In this study,LPS induced uterine myometrial dysfunction in rats,leading to a disorganized arrangement,a significant increase in collagen fiber deposition,and widespread infiltration of inflammatory cells.In both in vivo animal models and in vitro HUtSMCs,LPS elevated IL-6,IL-1β,and TNF-αlevels while concurrently suppressing the expression of connexin 43(Cx43)and oxytocin receptor(OXTR).Mechanistically,the LPS-treated group exhibited TLR4 activation,and the phosphorylation levels of p65 and IκBαwere notably increased.Conclusion LPS triggered the TLR4/NF-κB signaling pathway,inducing an inflammatory response in the myometrium and leading to uterine myometrial dysfunction and uterine atony.

关键词： lipopolysaccharide inflammatory response TLR4 NF-κB myometrium

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Twin fetuses associated with double amniotic sacs diagnosed using transvaginal ultrasonography:A case report

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World Journal of Clinical Cases 2024年第18期12卷 3534-3538页

作者： Zheng-Qiao Liang wen-Qing ding Maternity and Child Longgang Maternity and Child Institute of Shantou University Medical CollegeShenzhen 518174Guangdong ProvinceChina

BACKGROUND Conjoined twins are a rare twin malformation commonly presenting as single amniotic sac twinning,with double amniotic sac twinning being extremely rare and poorly reported.Most conjoined twins are females.CASE SUMMARY A woman of childbearing age conceived naturally,and at 8 wk of gestation,transvaginal ultrasonography showed an embryo and cardiac tube pulsation in both amniotic sacs.On dynamic observation,the two embryos were connected in the lower abdomen,with restricted movement.A repeat transvaginal ultrasound at 11 wk showed that the intestinal tubes of both fetuses were connected in the lower abdomen.The pregnancy was terminated and labor was induced.CONCLUSION Transvaginal ultrasound may detect conjoined twin malformations in an early stage.Our case provides diagnostic insights for ultrasonographers and can help develop early therapeutic interventions.

关键词： Double amniotic sac Conjoined twins Yolk sac Transvaginal ultrasound Case report

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Electrical uniformity analyses on 12-inch Si-based Hf0.5Zr0.5O2 ferroelectric capacitor devices by atomic layer deposition

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Progress in Natural Science:Materials International 2024年第3期34卷 598-605页

作者： wen-Juan ding Yu Liu Zhi-Qiang Xiao Li Gao Yu-Chen Li Lin Zhu Xiang Li Wei-Min Li Shuang Chen Ai-Dong Li National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences and Collaborative Innovation Center of Advanced MicrostructuresNanjing University Jiangsu Leadmicro Nano-Technology Co. Ltd. Semiconductor Manufacturing North China Corp. Kuang Yaming Honors School Nanjing University

The study on the uniformity of electrical performance of large wafer-scale Hf0.5Zr0.5O2（HZO） ferroelectric capacitors is still lacking yet now. In this work, TiN/HZO/TiN metal-ferroelectric-metal（MFM） devices on 12-inch silicon wafers have been fabricated by thermal atomic layer deposition. The correlation of thickness uniformity with device-to-device variation of electrical properties and yield of the 12-inch MFM system was investigated. It was found that the uniformity of ferroelectric properties is closely related to the variation of HZO thickness of the MFM system, the concentration of oxygen vacancies in the micro-region of the HZO film, and the ferroelectric phase micro-distribution on 12-inch Si wafer. This work provides some important information for the performance optimization of HfO2-based ferroelectric random access memories.

关键词： 12-Inch Si wafer Atomic layer deposition Electrical uniformity Ferroelectric random access memory Hf0.5Zr0.5O2 ferroelectric thin film

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High-throughput screening of novel TFEB agonists in protecting against acetaminopheninduced liver injury in mice

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Acta Pharmaceutica Sinica B 2024年第1期14卷 190-206页

作者： Xiaojuan Chao Mengwei Niu Shaogui Wang Xiaowen Ma Xiao Yang Hua Sun Xujia Hu Hua Wang Li Zhang Ruili Huang Menghang Xia Andrea Ballabio Hartmut Jaeschke Hong-Min Ni wen-Xing ding Department of Pharmacology Toxicology and TherapeuticsUniversity of Kansas Medical CenterKansas CityKS 66160USA NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Oncology the First Affiliated Hospital of Anhui Medical UniversityAnhui Medical UniversityHefei 230032China National Center for Advancing Translational Sciences National Institutes of HealthBethesdaMD 20892USA Telethon Institute of Genetics and Medicine TIGEMPozzuoliNaples 80131Italy Medical Genetics Department of Translational MedicineFederico II UniversityNaples 80131Italy Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Department of Internal Medicine Division of GastroenterologyHepatology&MotilityUniversity of Kansas Medical CenterKansas CityKS 66160USA

Macroautophagy(referred to as autophagy hereafter)is a major intracellular lysosomal degradation pathway that is responsible for the degradation of misfolded/damaged proteins and organelles.Previous studies showed that autophagy protects against acetaminophen(APAP)-induced injury(AILI)via selective removal of damaged mitochondria and APAP protein adducts.The lysosome is a critical organelle sitting at the end stage of autophagy for autophagic degradation via fusion with autophagosomes.In the present study,we showed that transcription factor EB(TFEB),a master transcription factor for lysosomal biogenesis,was impaired by APAP resulting in decreased lysosomal biogenesis in mouse livers.Genetic loss-of and gain-of function of hepatic TFEB exacerbated or protected against AILI,respectively.Mechanistically,overexpression of TFEB increased clearance of APAP protein adducts and mitochondria biogenesis as well as SQSTM1/p62-dependent non-canonical nuclear factor erythroid 2-related factor 2(NRF2)activation to protect against AILI.We also performed an unbiased cell-based imaging high-throughput chemical screening on TFEB and identified a group of TFEB agonists.Among these agonists,salinomycin,an anticoccidial and antibacterial agent,activated TFEB and protected against AILI in mice.In conclusion,genetic and pharmacological activating TFEB may be a promising approach for protecting against AILI.

关键词： Autophagy DILI Drug screening Hepatotoxicity Lysosome Mitochondria Mitophagy NRF2

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Financing the price-setting newsvendor with sales effort

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Journal of Management Analytics 2020年第4期7卷 564-590页

作者： wen ding Huihui Song Antai College of Economics&Management Shanghai Jiao Tong UniversityShanghaiPeople’s Republic of China

In this paper,we consider the financing issues in a supply chain where the capitalconstrained retailer should use limited funds to pay for both order and sales.The retailer decides the retail price,order quantity exante and sales effort expost,and he supports these operational activities by two financing sources:bank loan and trade credit.We illustrate that in this two-stage problem,the price-setting retailer’s equilibrium sales effort and retail price are both related to the market realization value and the retailer’s cash level.These two financing sources are both able to stimulate the retailer to promote sales.If the retailer’s cash level is reasonably high,both parties(supplier and retailer)benefit from trade credit.By contrast,if the retailer’s cash level is low,trade credit may discourage the retailer from sales promotion.Counterintuitively,our study shows that the retailer spends more on sales when the market is good than when it is bad.

关键词： Capital-constrained retailer sales effort trade credit bank loan pricesetting

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基于干细胞与生物3D打印技术的皮肤组织工程研究与应用进展

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中国生物化学与分子生物学报 2024年第2期40卷 198-207页

作者：李玲丁文刘明黑龙江省黑河市疾病预防控制中心检验科黑龙江黑河164300 浙江工业大学材料科学与工程学院材料成形与控制工程研究所杭州310014 浙江省肿瘤医院中国科学院杭州医学研究所细胞治疗技术研究与工程实验室杭州310022

皮肤是人体内非常复杂的器官,构建仿生的皮肤模型一直是是临床和研究中的热点与难点。3D生物打印技术的出现解决了皮肤构建物的问题,它可以通过定制皮肤形状,精确分配细胞和其他材料,实现快速可靠的仿生皮肤替代品生产,满足临床和工业... 详细信息

皮肤是人体内非常复杂的器官,构建仿生的皮肤模型一直是是临床和研究中的热点与难点。3D生物打印技术的出现解决了皮肤构建物的问题,它可以通过定制皮肤形状,精确分配细胞和其他材料,实现快速可靠的仿生皮肤替代品生产,满足临床和工业要求。此外,它具有优异的性能、灵活性、高分辨率、重现性和高通量,可以用于药物筛选、化妆品测试以及皮肤移植等,并且可以为更多烧伤或糖尿病患者提供有效的皮肤替代物。结合干细胞的3D生物打印技术给研究和医疗专业人员带来更多解决皮肤疾病的方案。多能干细胞是有吸引力的候选细胞,因为,它们除了在伦理上被接受外,还可以根据患者的情况进行基因定制,实现具有预定结构的细胞载体,可以纳入血管网络、毛囊和汗腺等仿生层次的结构,以提高组织功能和美学植入。该文主要综述3D生物打印技术进行皮肤构建的研究现状,重点讨论了不同3D生物打印工艺构建皮肤的特点,并剖析了含有附属器的皮肤构建物下游应用需求,为本领域在体外生理或病理模型构建、再生医学和临床等研究提供参考。

关键词：干细胞 3D生物打印皮肤

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Comparative investigations of ternary thermite Al/Fe_(2)O_(3)/CuO and Al/Fe_(2)O_(3)/Bi_(2)O_(3) from pyrolytic,kinetics and combustion behaviors

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Defence Technology（防务技术） 2023年第8期26卷 180-190页

作者： Shi Li Jia-lin Chen Tao Guo wen ding Lin Jiang Miao Yao Jia-xing Song Li-feng Xie Yi-ming Mao College of Field Engineering Army Engineering University of PLANanjing210007China School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094China Xi'an Rare Metal Materials Research Institute Co. Ltd.Xi'an710016China

To develop new energy enhancement energetic materials with great combustion performance and thermal stability,two kinds of ternary thermite,Al/Fe_(2)O_(3)/CuO and Al/Fe_(2)O_(3)/Bi_(2)O_(3),were prepared and analyzed via mechanical ball milling.The samples were characterized by SEM,XRD,TG-DSC,constant volume and constant pressure combustion experiments.The first exothermic peaks of Al/Fe_(2)O_(3)/CuO and Al/Fe_(2)O_(3)/Bi_(2)O_(3) appear at 579°C and 564.5°C,respectively.The corresponding activation energies are similar.The corresponding mechanism functions are set as G(a) = [-ln(1-a)]^(3/4) and G(a) =[-ln(1-a)]2/3,respectively,which belong to the Avrami-Erofeev equation.Al/Fe_(2)O_(3)/CuO has better thermal safety.For small dose samples,its critical temperature of thermal explosion is 121.05°C higher than that of Al/Fe_(2)O_(3)/Bi_(2)O_(3).During combustion,the flame of Al/Fe_(2)O_(3)/CuO is spherical,and the main products are FeAl_(2)O_(4) and Cu.The flame of Al/Fe_(2)O_(3)/Bi_(2)O_(3)is jet-like,and the main products are Al_(2)O_(3),Bi and Fe.Al/Fe_(2)O_(3)/Bi_(2)O_(3)has better ignition and gas production performance.Its average ignition energy is 4.2 J lower than that of Al/Fe_(2)O_(3)/CuO.Its average step-up rate is 28.29 MPa/s,which is much higher than 6.84 MPa/s of Al/Fe_(2)O_(3)/CuO.This paper provides a reference for studying the thermal safety and combustion performance of ternary thermite.

关键词： Ternary thermite Thermal kinetics Reaction mechanism Combustion

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乡村治理共同体视角下农民集体决议法治化的双重样态与实现路径

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武汉大学学报（哲学社会科学版） 2024年第4期77卷 141-152页

作者：丁文陈源媛华中师范大学法学院湖北武汉430079

基层政府、人民法院、乡村自治主体形塑了乡村治理共同体。乡村治理共同体内部理应呈现出的行政行为介入规范自治、司法权力嵌入保障私权、自治主体纠偏回归法治等预设样态,是农民集体决议法治化的应然图景。然而,行政行为偏差、司法裁... 详细信息

基层政府、人民法院、乡村自治主体形塑了乡村治理共同体。乡村治理共同体内部理应呈现出的行政行为介入规范自治、司法权力嵌入保障私权、自治主体纠偏回归法治等预设样态,是农民集体决议法治化的应然图景。然而,行政行为偏差、司法裁判冲突、自治秩序混乱等治理乱象表明,治理共同体内部存在的行政机关权责失衡、司法机关审理规则不明、自治主体落实约束制度缺位,已然成为农民集体决议法治化面临的现实困境。立足于村民自治与国家法治的融合发展,以细化权责清单、统一司法规则、完善制度保障为依托,厘清行政机关介入农民集体决议事项的权力限度与责任范围、明确司法机关处理农民集体决议纠纷的案由类型与撤销权客体、强化自治主体重作农民集体决议的内部约束与司法约束,是农民集体决议法治化的重要路径。

关键词：乡村治理治理共同体农民集体决议乡村矛盾纠纷法治乡村村民自治治理规则

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土地经营权入股公司:股东出资、保本投资与配套制度

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河南社会科学 2024年第2期32卷 68-78页

作者：丁文陈林基华中师范大学法学院湖北武汉430079

土地经营权入股发展农业产业化经营是深化农村土地制度改革的重要举措,也是促进农业适度规模经营、实现小农户和现代农业发展有机衔接的重要途径。土地经营权入股公司应定性为股东出资行为,以公司法为基础,完善股东出资、法人运行与配... 详细信息

土地经营权入股发展农业产业化经营是深化农村土地制度改革的重要举措,也是促进农业适度规模经营、实现小农户和现代农业发展有机衔接的重要途径。土地经营权入股公司应定性为股东出资行为,以公司法为基础,完善股东出资、法人运行与配套措施等方面的法律法规。在股东出资方面,应限定出资标的物范围,完善农村土地价值评估机制。在法人运行方面,为农民股东优先配置可转换的、可累积的及可参与嗣后分配的优先股以基本实现其“保底收益+按股分红”目的;为农民股东配置优先股赎回权、清算优先权与股份回购保险以基本实现“保本退出”目的。在配套措施方面,国家应灵活运用宏观调控措施以改善农业弱质性问题,完善农村社会保障制度以破除农民失地失业困境。

关键词：土地经营权入股股东出资优先股国家调节

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数字经济提升了产业链关键环节的控制能力吗?——基于数字产业化和产业数字化的对比研究

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科学学研究 2024年第3期42卷 541-553页

作者：庞磊丁文丽云南师范大学经济与管理学院云南昆明650500 昆明学院云南昆明650500

数字经济依托数字技术载体,将大数据作为关键生产要素,改变了传统产业链模式。文章结合投入产出表以及国泰安数据库,统计测算2016-2022年数字经济、产业链中心度与中介度数据,对比研究数字产业化与产业数字化提升产业链关键环节控制能... 详细信息

数字经济依托数字技术载体,将大数据作为关键生产要素,改变了传统产业链模式。文章结合投入产出表以及国泰安数据库,统计测算2016-2022年数字经济、产业链中心度与中介度数据,对比研究数字产业化与产业数字化提升产业链关键环节控制能力问题,得出结论:一是数字经济、数字产业化与产业数字化显著地提升了产业链关键环节控制能力,作用强度依次减弱;二是数字经济提升产业链关键环节控制能力存在区域异质性,东部沿海至大西北综合经济区依次减弱;三是数字经济提升产业链关键环节控制能力存在行业异质性,专用设备至交通运输设备、仓储和邮政行业依次减弱;四是数字技术创新承担数字经济、数字产业化、产业数字化与产业链关键环节控制能力的部分中介效应,数字经济与产业链中心度、中介度的中介效应强度分别为0.4452和0.3635,占总效应比例分别为76.36%和64.45%。据此,提出了具有针对性的对策建议。

关键词：数字经济数字技术关键环节中心度中介度

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