检索结果-南通市图书馆

Palmitic acid reduces the methylation of the FOXO1 promoter to suppress the development of diffuse large B-cell lymphoma via modulating the miR-429/DNMT3A axis

引用

Chinese Journal of Natural Medicines 2024年第6期22卷 554-567页

作者： LI Weiming GAO Ming XUE Weili LI Xiaoli CHANG Yu ZHANG Kaixin wen chenyu ZHANG Mingzhi Department of Oncology Henan University of Traditional Chinese MedicineZhengzhou 450000China Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China

Diffuse large B-cell lymphoma(DLBCL)is characterized by significant treatment *** acid(PA)has shown promising antitumor *** study aims to elucidate the molecular mechanisms by which PA influences DLBCL *** quantified the expression levels of microRNAs(miRNAs),Forkhead box protein O1(FOXO1),and DNA methyltransferase 3A(DNMT3A)in both untreated and PA-treated DLBCL tumors and cell *** were made of cell viability,apoptosis,and autophagy-related protein expression following PA *** analyses among miR-429,DNMT3A,and FOXO1 were conducted using luciferase reporter assays and methylation-specific(MSP)Polymerase chain reaction(PCR).After transfecting the miR-429 inhibitor,negative control(NC)inhibitor,shRNA against DNMT3A(sh-DNMT3A),shRNA negative control(sh-NC),over-expression vector for DNMT3A(oe-DNMT3A),or overexpression negative control(oe-NC),we evaluated the effects of miR-429 and DNMT3A on cell viability,mortality,and autophagy-related protein expression in PA-treated DLBCL cell *** efficacy of PA was also tested in vivo using DLBCL tumor-bearing mouse ***-429 and FOXO1 expression levels were downregulated,whereas DNMT3A was upregulated in DLBCL compared to the control *** treatment was associated with enhanced autophagy,mediated by the upregulation of miR-429 and downregulation of *** luciferase reporter assay and MSP confirmed that miR-429 directly inhibits DNMT3A,thereby reducing FOXO1 *** experiments demonstrated that PA promotes autophagy and inhibits DLBCL progression by upregulating miR-429 and modulating the DNMT3A/FOXO1 *** vivo PA signific-antly reduced the growth of xenografted tumors through its regulatory impact on the miR-429/DNMT3A/FOXO1 *** acid may modulate autophagy and inhibit DLBCL progression by targeting the miR-429/DNMT3A/FOXO1 signaling pathway,suggesting a novel therapeutic target for DLBCL management.

关键词： Palmitic acid Diffuse large B-cell lymphoma MiR-429 DNMT3A FOXO1 Autophagy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sulfonate-functionalization in Zn-iodine batteries as one stone kills two birds:iodine limiter and uniform Zn plating guidance layer

引用

Science China Materials 2024年第9期67卷 2889-2897页

作者： wentao Qu chenyu wen Baohui Chen Yong Cai Ming Zhang Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics&Devices School of Physics and ElectronicsHunan UniversityChangsha410082China Engineering Research Center of Advanced Semiconductor Technology and Application of Ministry of Education&Key Laboratory for Micro-/Nano-Optoelectronic Devices of Ministry of Education College of Semiconductors(College of Integrated Circuits)Hunan UniversityChangsha410082China College of Materials Science and Engineering Hunan UniversityChangsha410082China Changsha Semiconductor Technology and Application Innovation Research Institute College of Semiconductors(College of Integrated Circuits)Hunan UniversityChangsha410082China State Key Laboratory of Disaster Prevention&Reduction for Power Grid(Hunan Electric Power Corporation Disaster Prevention and Reduction Center) Changsha410007China

Aqueous Zn-iodine(Zn-I_(2))batteries have attracted extensive research interest as an emerging redox conversion energy storage system due to the low cost and high ***,the shuttling effects of polyiodides arising from incomplete redox conversion and inhomogeneous Zn plating on the Zn anode surface always hinder the commercial application of Zn-I_(2)*** this work,a two-birds-with-one-stone strategy is reported for long-life Zn-I_(2)*** on the strategy,the sulfonate-functionalized carbon fiber not only acts as the excellent iodine limiter to inhibit iodine species shuttling,but also as the uniform Zn plating guidance layer on the Zn anode surface to prevent the inhomogeneous deposition of Zn^(2+).Consequently,a superior cycling stability(a capacity of 124 mAh g^(-1)after 10,000 cycles at 5 A g^(-1))is *** calculations illustrate that sulfonate groups successfully induce charge redistribution on the carbon substrate,thereby strengthening the electronic interactions of the iodine species with the carbon *** charge-enriched sulfonate groups can guide the uniform deposition of Zn^(2+)through a strong Coulombic effect with Zn^(2+).This work gives a new perspective on the integrated design of cathodes and anodes for rechargeable batteries.

关键词： sulfonate-functionalization iodine limiter uniform deposition Zn plating guidance layer Zn-iodine batteries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于Arduino的公共场地智能导盲犬应用

引用

集成电路应用 2024年第5期41卷 320-321页

作者：温辰宇于慧洋太原学院山西030012

阐述基于Arduino的公共场所智能导盲犬的特点,分析现有导盲技术和Arduino技术的融合,展望未来智能导盲犬在公共场所的应用前景。

关键词： Arduino平台智能导盲犬智能导航传感技术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于Arduino的智能导盲犬在公共环境中的可行性分析

引用

电子技术（上海） 2024年第5期53卷 302-303页

作者：温辰宇于慧洋太原学院山西030032

阐述Arduino为导盲犬提供的增强功能,包括环境感知和数据分析、智能反馈系统、导航和定位增强、环境互动和通信、遥控和紧急响应、机器学习和行为预测、能源管理。分析技术难题与解决方案。

关键词：传感器技术 Arduino 智能导盲犬

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于PVDF-TrFE薄膜的柔性压电纳米发电机

引用

半导体技术 2014年第12期39卷 930-935页

作者：皮朝阳张敬维文宸宇吴东平复旦大学专用集成电路与系统国家重点实验室上海200433

实验制备的柔性压电纳米发电机用旋涂得到的PVDF-Tr FE薄膜作为有源层来实现机电转换。纳米发电机的有源层PVDF-Tr FE薄膜在外加电场和温度场下被极化。在极化过程中,PVDF-Tr FE薄膜的部分顺电相(α相)转变成铁电相或压电相(β相)。纳... 详细信息

实验制备的柔性压电纳米发电机用旋涂得到的PVDF-Tr FE薄膜作为有源层来实现机电转换。纳米发电机的有源层PVDF-Tr FE薄膜在外加电场和温度场下被极化。在极化过程中,PVDF-Tr FE薄膜的部分顺电相(α相)转变成铁电相或压电相(β相)。纳米发电机上下电极间的电压分布经过Comsol Multiphysics的数值分析,发现其垂直于PVDF-Tr FE薄膜方向。纳米发电机产生的峰值开路输出电压值VOC为7 V,短路输出电流密度ISC/AE为0.53μA/cm2。实验发现纳米发电机的短路输出电流ISC与有效工作面积间AE近似有线性关系,而物理模型计算得到的ISC也揭示了ISC和AE两者间的线性关系,实验结果验证了物理模型计算结果的准确性。因此,增加纳米发电机的有效工作面积AE可以增强其短路输出电流和输出功率。

关键词：自供能 PVDF—TrFE 纳米发电机柔性压电

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

双层外立面对竖直向下火蔓延影响的实验研究

引用

山东理工大学学报（自然科学版） 2024年第5期38卷 25-32页

作者：闫维纲温晨煜俞潇远吴习上海理工大学能源与动力工程学院上海200093

通过实验研究了层间效应对聚甲基丙烯酸甲酯向下火蔓延特性的影响。在6组不同立面间距的条件下,对火焰高度、温度、质量损失速率和火蔓延速率等参数进行研究,建立了传热物理模型并进行理论分析,得到了聚甲基丙烯酸甲酯在预热区和热解区... 详细信息

通过实验研究了层间效应对聚甲基丙烯酸甲酯向下火蔓延特性的影响。在6组不同立面间距的条件下,对火焰高度、温度、质量损失速率和火蔓延速率等参数进行研究,建立了传热物理模型并进行理论分析,得到了聚甲基丙烯酸甲酯在预热区和热解区的辐射、对流热反馈的函数表达式。实验结果表明:随着外立面之间间距的增大,火焰厚度减小,火焰形状发生不规则变化;质量损失速率的对数与火焰高度的对数呈线性关系;在间距不同的情况下,火焰的最高温度保持不变;随着间距的增加,火蔓延速率分3个阶段逐渐下降。理论分析表明:间距变化时,对流和辐射热反馈所占主导地位不同,当间距大于6 cm时,辐射热反馈几乎可以忽略不计,且理论分析与实验结果一致。

关键词：双层外立面层间效应质量损失速率火蔓延速率火蔓延模型

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

网络工程教学改革研究

引用

无线互联科技 2017年第7期14卷 27-28页

作者：任德昊李文藻文成玉成都信息工程大学通信工程学院计算机通信教研室四川成都610225

文章介绍了"网络工程"课程性质、课程特点,提出了一种在理论教学的同时加强学生的动手能力,自主创新思维的改革理论。其将实验教学与工程实施相结合,形成一套高效的工程类理论课程的教学模式。

关键词：网络工程自主创新教学改革

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Malvaceae-specific miRNA targeting the newly duplicated GaZIP1L to regulate Zn^(2+)ion transporter capacity in cotton ovules

引用

Science China(Life Sciences) 2021年第3期64卷 339-351页

作者： Xingpeng wen Gai Huang chenyu Li Yuxian Zhu Institute for Advanced Studies Wuhan UniversityWuhan 430072China State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China

MicroRNAs(miRNAs)play critical roles in regulating gene expression in plants,yet their functions underlying cultivated diploid Gossypium arboreum cotton ovule development are largely ***,we acquired small RNA profiles from *** ovules and fibers collected at different growth stages,and identified 46 novel miRNAs that accounted for 23.7%of all miRNAs in *** reported in the latest plant sRNA *** analysis of 84(including 38 conserved)differentially expressed *** miRNAs,we detected 215 putative protein-coding genes in 26 biological processes as their potential targets.A Malvaceae-specific novel miRNA named gar-miRN44 was found to likely regulate cotton ovule growth by targeting to a newly duplicated Zn^(2+)ion transporter gene *** cotton ovule development,gar-miRN44 transcript level decreased sharply after 10 to 15 days post-anthesis(DPA),while that of the GaZIP1L increased significantly,with a concomitant increase of Zn^(2+)ion concentration in late ovule developmental *** dynamics simulation and ion absorption analysis showed that GaZIP1L has stronger Zn2+ion binding ability than the original GaZIP1,indicating that the newly evolved GaZIP1L may be more suitable for maintaining high Zn2+ion transport capacity that is likely required for cotton ovule growth via enhanced cellulose synthase *** systematic miRNA profiling in *** and characterization of gar-miRN44 not only contribute to the understanding of miRNA function in cotton,but also provide potential targets for plant breeding.

关键词： gar-miRN44 Malvaceae GaZIP1L Zn^(2+)ion transport cotton ovule development

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deformation mechanism and hydrocarbon significance of Eocene organic-rich fine-grained soft sediments in the Leijia Region,Liaohe Depression

引用

Frontiers of Earth Science 2024年第1期18卷 83-97页

作者： Yijie wen Jianguo ZHANG Shu TAO chenyu CAI School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China Key Laboratory of Strategy Evaluation for Shale Gas(Ministry of Land Resources) China University of Geosciences(Beijing)Beijing 100083China School of Foreign Languages China University of Geosciences(Beijing)Beijing 100083China

The deformation structure of soft sediments has always been a research hotspot,which is of great significance for analyzing the tectonic and sedimentary evolution background of a basin,as well as the physical properties of *** studies have reported that a large number of soft sediment deformation structures are developed in the western part of Liaohe *** this study,through core observation and thin section identification,various types of deformation structures are identified in the core samples which are collected from the upper Es4 in the Leijia region,western sag of Liaohe depression,such as liquefied dikes,liquefied breccia,convoluted laminae,annular bedding,synsedimentary faults,vein structures,*** on the characteristics of core structure,single well profile and continuous well profile,combined with the regional background,this study clarifies that the deformation structure of soft sediments in the study area is mainly caused by seismic *** is found that the permeability and porosity of deformation layers in the study area are higher than those of the undeformation layers,which proves that the deformation structure of soft sediments has a good effect on improving the physical properties of reservoirs.

关键词： soft sediment deformation structure Liaohe depression organic-rich fine-grained soft sediments hydrocarbon significance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gregariousness in lepidopteran larvae

引用

Insect Science 2024年第5期31卷 1353-1364页

作者： chenyu Qian Chao wen Xiaoli Guo Xinya Yang Xiujun wen Tao Ma Cai Wang College of Forestry and Landscape Architecture South China Agricultural UniversityGuangzhouChina School of Grassland Science Bejing Forestry UniversityBeijingChina Bejing Key Laboratory for Forest Pest Control Beijing Forestry UniversityBejingChina

The gregarious lifestyle of lepidopteran larvae is diverse and shaped by a com-plex interplay of ecological and evolutionary *** review showed that the larval-aggregation behavior has been reported in 23 lepidopteran families,indicating multiple evolution of this *** larvae live in sibling groups throughout all larval in-stars and even pupation stages,which may result from the *** contrast,group fusion may occur among different sibling or foraging groups of larvae and form larger ag-gregates,and the gregariousness of these species might be driven by the *** group size and foraging patterns vary greatly across species,it is generally associ-ated with improved larval survivorship and accelerated ***,the advan-tages of group living,such as facilitating feeding activities,adjusting the temperature,and defending natural enemies,may diminish along with development,with strong intraspe-cific competition occurring at later instars,even when food is ***,the group sizes and fission-fusion dynamics of certain gregarious lepidopteran larvae may be a consequence of their cost-benefit balance depending on various biotic and abiotic *** and aggregation pheromones,silk trails,or body contact contribute to collective movement and group cohesion of gregarious lepidopteran ***,frequent con-tact among group members may cause the horizontal transmission of pathogens and pes-ticides,which may bring an integrated pest management strategy controlling gregarious lepidopteran pests.

关键词： aggregation chemical communication cost-benefit balance group living Lepidoptera presocial insect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：