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Effect of Shuanghuanglian Oral Solution on Liver Function in a Mouse Model of Non-alcoholic Steatohepatitis

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Medicinal Plant 2024年第4期15卷 99-100,106页

作者： Lihong GUO Lizhu LIU weiwei qin Yaxian CHENG Sleep Psychosomatic Medicine Center Taihe HospitalAffiliated Hospital of Hubei University of MedicineShiyan 442000China

[Objectives]To observe the effect of Shuanghuanglian oral solution on liver function in BABL/cJ mice in non-alcoholic steatohepatitis(NASH)model.[Methods]The BABL/cJ mice were randomly divided into three groups:a control group,a model group,and an experimental *** experimental group was administered with 10%Shuanghuanglian oral solution at a dose of 0.1 mL/(10 g·d),while the control group and experimental group received an equivalent dosage of normal *** three groups were treated for a period of 28 *** liver function of the mice in each group was examined after the treatment.[Results]The body mass,liver index,triacylglycerol(TG),total cholesterol(TC),aspartate aminotransferase(AST),and alanine aminotransferase(ALT)levels were all significantly reduced compared to the model group(P<0.05).[Conclusions]Shuanghuanglian oral solution has a beneficial effect on liver function in BABL/cJ mice.

关键词： BABL/cJ mice Shuanghuanglian oral solution Non-alcoholic steatohepatitis model Liver function

情志护理联合热敏灸对周围性面瘫患者的干预效果

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中外医疗 2024年第9期43卷 156-159页

作者：秦伟伟徐州市中医院神经内科江苏徐州221000

目的探讨周围性面瘫患者采用情志护理联合热敏灸的干预效果。方法方便选取徐州市中医院于2020年8月—2022年8月收治的78例周围性面瘫患者为研究对象,以随机数表法分为两组,对照组(n=39)采用常规护理联合热敏灸干预,观察组(n=39)采用情... 详细信息

目的探讨周围性面瘫患者采用情志护理联合热敏灸的干预效果。方法方便选取徐州市中医院于2020年8月—2022年8月收治的78例周围性面瘫患者为研究对象,以随机数表法分为两组,对照组(n=39)采用常规护理联合热敏灸干预,观察组(n=39)采用情志护理联合热敏灸干预,对比两组心理状态、睡眠质量、生活质量改善情况,以及治疗依从性和护理满意度评分。结果干预1个月后,观察组焦虑自评量表评分为(39.22±3.45)分、抑郁自评量表评分为(40.66±3.24)分,均低于对照组的(46.23±3.63)分、(47.47±3.78)分,差异有统计学意义(t=8.742、8.542,P均<0.05);干预1个月后,观察组睡眠质量和生活质量均优于对照组,差异有统计学意义(P均<0.05);观察组治疗依从性评分为(96.48±2.15)分、护理满意度评分为(97.61±1.57)分,均高于对照组,差异有统计学意义(P均<0.05)。结论情志护理干预联合热敏灸应用于周围性面瘫患者,效果较为理想,可改善其负面情绪,提高睡眠质量和生活质量,患者的治疗依从性评分和护理满意度评分较高。

关键词：周围性面瘫情志护理热敏灸睡眠质量生活质量治疗依从性

脓毒症小鼠急性肺损伤时ASAH1与细胞焦亡的关系

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中华麻醉学杂志 2024年第7期44卷 876-880页

作者：王蓓莹李大鹏张丹丹秦伟伟孙立新韩伟南京医科大学青岛临床医学院青岛266071 青岛市市立医院创伤外科青岛266071 青岛市市立医院麻醉科青岛266071 青岛市市立医院呼吸与危重症科青岛266071

目的评价脓毒症小鼠急性肺损伤时N-酰基鞘氨醇酰胺水解酶1(ASAH1)与细胞焦亡的关系。方法SPF级健康雄性C57BL/6小鼠40只,6~8周龄,体质量18~23 g,采用随机数字表法将小鼠分为4组(n=10):假手术组(Sham组)、急性肺损伤组(ALI组)、HCFU溶剂... 详细信息

目的评价脓毒症小鼠急性肺损伤时N-酰基鞘氨醇酰胺水解酶1(ASAH1)与细胞焦亡的关系。方法SPF级健康雄性C57BL/6小鼠40只,6~8周龄,体质量18~23 g,采用随机数字表法将小鼠分为4组(n=10):假手术组(Sham组)、急性肺损伤组(ALI组)、HCFU溶剂+急性肺损伤组(HA组)和ASAH1抑制剂HCFU+急性肺损伤组(AA组)。Sham组仅开腹腔,ALI组、HA组和AA组行盲肠结扎穿孔术,HA组小鼠术前2 h腹腔注射HCFU溶剂0.2 ml,AA组小鼠术前2 h腹腔注射HCFU 10 mg/kg。24 h时深麻醉下处死小鼠,摘除眼球取血,收集支气管肺泡灌洗液(BALF)、肺组织和血清标本。计算肺湿质量/干质量(W/D)比值,采用BCA法检测BALF蛋白浓度,HE染色观察肺组织病理学结果并行肺损伤评分;ELISA法测定BALF IL-1β、IL-6和TNF-α浓度;Western blot法检测肺组织NOD样受体热蛋白结构域相关蛋白3(NLRP3)、Gasdermin D蛋白(GSDMD)、ASAH1和半胱氨酸蛋白酶-1(caspase-1)的表达。结果与Sham组相比,ALI组、HA组和AA组肺损伤评分、W/D比值、BALF蛋白、血清IL-1β、IL-6和TNF-α浓度升高,肺组织NLRP3、GSDMD和caspase-1表达上调,ALI组和HA组ASAH1表达上调(P<0.05);与ALI组和HA组相比,AA组肺损伤评分、W/D比值、BALF蛋白、血清IL-1β、IL-6和TNF-α浓度升高,肺组织NLRP3、GSDMD及caspase-1表达上调,ASAH1表达下调(P<0.05或0.01)。结论ASAH1参与了脓毒症小鼠急性肺损伤的内源性保护机制,可能与其抑制细胞焦亡有关。

关键词：脓毒症急性肺损伤 N-酰基鞘氨醇酰胺水解酶1 细胞焦亡

水稻秸秆与园林基质混配用作无土草毯生产技术研究

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作物研究 2024年第2期38卷 117-124页

作者：黄思怡向佐湘覃韦玮陈桂华湖南农业大学农学院湖南长沙410128

为了筛选适宜的无土草毯基质配方,降低无土草毯生产成本,以水稻秸秆与园林基质为材料,将其按不同的比例混合,并添加2种不同来源的菌剂进行有氧发酵,配制成不同的基质处理,对不同混配基质的理化性状、植物毒性和种植草毯的坪用性状等指... 详细信息

为了筛选适宜的无土草毯基质配方,降低无土草毯生产成本,以水稻秸秆与园林基质为材料,将其按不同的比例混合,并添加2种不同来源的菌剂进行有氧发酵,配制成不同的基质处理,对不同混配基质的理化性状、植物毒性和种植草毯的坪用性状等指标进行比较分析。结果表明:添加北京金宝贝菌剂进行发酵且水稻秸秆与园林基质体积比为6∶4的处理基质物理性状较理想,有机质含量显著高于其他处理,且其养分含量较均衡,重金属含量符合NY/T 525-2021有机肥标准要求,其所建植的草毯坪用性状显著高于其他处理。在本试验条件下,该配方基质比较适合用于无土草毯栽培。

关键词：无土草毯水稻秸秆资源化利用栽培基质结缕草

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Semaphorin 7A promotes human vascular smooth muscle cell proliferation and migration through theβ-catenin signaling pathway

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BIOCELL 2023年第4期47卷 849-858页

作者： XIAOSU SONG FEN GAO HONG LI weiwei qin CHANJUAN CHAI GUOJUAN SHI HUIYU YANG Department of Cardiology The Second Hospital of Shanxi Medical UniversityTaiyuan030001China

Background:Vascular smooth muscle cells(VSMCs)undergo a conversion from a contractile phenotype to a proliferative synthetic phenotype,contributing to the pathogenesis of cardiovascular *** 7A(SEMA7A)is a glycosylphosphatidylinositol-anchored membrane protein that plays an important role in vascular homeostasis by regulating endothelial cell ***,the expression and role of SEMA7A in VSMCs remain ***:In this study,we screened for VSMC-regulating genes in publicly available datasets and analyzed the expression of SEMA7A in human coronary artery smooth muscle cells(hCASMCs)treated with platelet-derived growth factor-BB(PDGF-BB).The effects of SEMA7A overexpression and knockdown on hCASMC proliferation and migration were *** signaling pathways involved in the action of SEMA7A in hCASMCs were ***:Bioinformatic analysis showed that SEMA7A was significantly dysregulated in VSMCs treated with oxidized low-density lipoprotein or overexpressing progerin,a pro-atherogenic *** PDGF-BB stimulation led to a concentration-and time-dependent induction of *** of SEMA7A attenuated PDGF-BB-induced hCASMC proliferation and ***,overexpression of SEMA7A enhanced hCASMC proliferation and ***,SEMA7A stimulated the activation of theβ-catenin pathway and upregulated c-Myc,CCND1,and *** ofβ-catenin impaired SEMA7A-induced hCASMC proliferation and ***:SEMA7A triggers phenotype switching in VSMCs through theβ-catenin signaling pathway and may serve as a potential therapeutic target for cardiovascular diseases.

关键词： SEMA7A Vascular smooth muscle cell Phenotype switching Remodeling β-catenin

血清miR-155-5p和miR-146b-5p与继发性急性髓系白血病染色体畸变及预后的关系

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武警医学 2024年第1期35卷 14-20,24页

作者：严学倩刘利及月茹秦炜炜肖方陈怡空军军医大学第二附属医院血液内科西安710038

目的探究血清微小RNA(miR)-155-5p和miR-146b-5p与继发性急性髓系白血病(sAML)染色体畸变及预后的关系。方法选择2017-05至2020-04空军军医大学第二附属医院血液内科收治的sAML患者26例,另外纳入同期在医院进行体检的健康人25名作为健... 详细信息

目的探究血清微小RNA(miR)-155-5p和miR-146b-5p与继发性急性髓系白血病(sAML)染色体畸变及预后的关系。方法选择2017-05至2020-04空军军医大学第二附属医院血液内科收治的sAML患者26例,另外纳入同期在医院进行体检的健康人25名作为健康对照组。根据国际人类细胞遗传命名系统,将sAML患者分为染色体畸变组和染色体正常组。采用实时荧光定量PCR法检测血清miR-155-5p和miR-146b-5p水平,并记录患者随访期间的总生存期。结果与健康对照组相比,sAML组患者血清miR-155-5p显著升高[4.69(1.87,30.83)vs.1.13(0.79,1.78),Z=-4.070,P<0.001],而miR-146b-5p显著降低[1.79(1.55,2.44)vs.3.02(2.58,3.43),Z=-4.561,P<0.001]。二者联合诊断sAML的曲线下面积为0.922(95%CI:0.846~0.997)。与染色体正常组相比,染色体畸变组sAML患者血清miR-155-5p明显升高[19.26(4.45,46.65)vs.1.51(0.79,3.27),Z=-3.585,P<0.001],miR-146b-5p明显降低[1.55(1.50,1.97)vs.2.16(1.79,3.00),Z=-2.954,P=0.003]。血清miR-155-5p和miR-146b-5p水平识别染色体畸变的AUC分别为0.925(95%CI:0.826~1.000)、0.850(95%CI:0.703~0.997),联合AUC可提高至0.919(95%CI:0.812~1.000)。血清miR-155-5p和miR-146b-5p是染色体畸变的独立影响因素(P<0.05)。血清miR-155-5p高表达(≥4.27)和miR-146b-5p低表达(<1.62)患者的总生存率更低,中位生存时间更短(P<0.05)。Cox回归分析结果表明,血清miR-155-5p高表达和miR-146b-5p低表达是sAML患者死亡的独立危险因素(P<0.05)。结论血清miR-155-5p高表达和miR-146b-5p低表达与sAML患者染色体畸变和预后不良密切相关,二者有希望成为sAML染色体畸变和预后不良的风险预测指标。

关键词：微小RNA-155-5p 微小RNA-146b-5p 继发性急性髓系白血病染色体畸变预后

血清3-NT UCH-L1对帕金森病并发认知功能障碍的诊断效能分析

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中国实用神经疾病杂志 2024年第8期27卷 1028-1032页

作者：王倩刘丹秦伟伟张杰文袁艺铭驻马店市中心医院河南驻马店463000 河南省人民医院河南郑州450003 新乡医学院附属南阳市第二人民医院河南南阳473000

目的探讨血清3-硝基酪氨酸(3-NT)、泛素C末端水解酶L1(UCH-L1)水平与帕金森病患者并发认知功能障碍的关系及其诊断价值。方法纳入驻马店市中心医院2020-07—2023-07诊治的104例帕金森病患者作为研究对象,根据蒙特利尔认知功能评估量表(M... 详细信息

目的探讨血清3-硝基酪氨酸(3-NT)、泛素C末端水解酶L1(UCH-L1)水平与帕金森病患者并发认知功能障碍的关系及其诊断价值。方法纳入驻马店市中心医院2020-07—2023-07诊治的104例帕金森病患者作为研究对象,根据蒙特利尔认知功能评估量表(MoCA)评分将患者分为认知功能正常组48例和认知功能障碍组56例。采用酶联免疫吸附法检测血清3-NT、UCH-L1水平,采用Pearson法分析帕金森病认知功能障碍患者血清3-NT、UCH-L1水平与MoCA评分的相关性,采用受试者工作特征(ROC)曲线分析血清3-NT、UCH-L1水平对帕金森病患者认知功能障碍的诊断价值,采用Logistic多因素回归分析帕金森病患者认知功能障碍的影响因素。结果认知功能障碍组血清3-NT[(7.26±2.04)μg/L比(4.58±1.40)μg/L]、UCH-L1[(0.94±0.21)μg/L比(0.62±0.16)μg/L]水平及H-Y分期中/晚期患者比例(78.57%比16.67%)高于认知功能正常组(P<0.05)。认知功能障碍组语言[(4.93±0.52)分比(5.23±0.49)分]、命名[(2.11±0.35)分比(2.46±0.34)分]、注意力[(4.80±0.67)分比(5.31±0.45)分]、抽象思维[(1.21±0.26)分比(1.63±0.20)分]、视空间及执行能力[(2.89±0.39)分比(3.54±0.30)分]、定向力[(5.11±0.48)分比(5.50±0.31)分]、延迟记忆[(2.88±0.36)分比(4.02±0.41)分]、MoCA总分[(23.93±2.05)分比(27.69±1.08)分]低于认知功能正常组(P<0.05)。帕金森病认知功能障碍患者血清3-NT、UCH-L1水平与语言、命名、注意力、抽象思维、视空间及执行能力、定向力、延迟记忆、MoCA总分均呈负相关(P<0.05)。3-NT、UCH-L1单独及其联合诊断帕金森病患者认知功能障碍的AUC分别为0.869、0.852、0.951。3-NT、UCH-L1、H-Y分期均是帕金森病患者并发认知功能障碍的独立危险因素(P<0.05)。结论血清3-NT、UCH-L1水平可用于评估帕金森病患者认知功能障碍的发生。

关键词：帕金森病认知功能障碍 3-硝基酪氨酸泛素C末端水解酶L1 血清危险因素

Dynamic Coupling Analysis of Semisubmersible Platform Float-over Method for Docking Case

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Journal of Ocean University of China 2024年第2期23卷 345-357页

作者： DING Hongyan qin Licheng ZHANG Puyang SONG Zhengrong XIE weiwei State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China Offshore Oil Engineering Co. Ltd.Tianjin 300461China

In this paper,the multi-body coupled dynamic characteristics of a semisubmersible platform and an HYSY 229 barge were ***,coupled hydrodynamic analysis of the HYSY 229 barge and the semisubmersible platform was *** hydrodynamic parameters were obtained using the retardation function method of three-dimensional frequency-domain potential flow *** results of the hydrodynamic analysis were highly consistent with the test findings,verifying the accuracy of the multifloating hydrodynamic coupling analysis,and key hydrodynamic parameters were solved for different water depths and the coupling *** to the obtained results,the hydrodynamic influence was the largest in shallow waters when the coupling effect was ***,the coupled motion equation combined with viscous damping,fender system,and mooring system was established,and the hydrodynamics,floating body motion,and dynamic response of the fender system were *** analysis revealed good agreement among the surge,sway,and yaw motions of the two floating ***,when the wave period reached 10 s,the motion of the two floating bodies showed severe shock,and a relative motion was also ***,excessive constraints should be added between the two floating bodies during construction to ensure construction *** numerical analysis and model test results of the semisubmersible platform and HYSY 229 barge at a water depth of 42 m and sea conditions of 0°,45°,and 90° were in good agreement,and the error was less than 5%.The maximum movement of the HYSY 229 barge reached 2.61 m in the sway direction,whereas that of the semisubmersible platform was 2.11 *** construction,excessive constraints should be added between the two floating bodies to limit their relative movement and ensure construction safety.

关键词： float-over method semisubmersible platform coupling hydrodynamic fender system time-domain analysis

Estimation of free core nutation parameters and availability of computing options

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Geodesy and Geodynamics 2024年第1期15卷 61-74页

作者： weiwei Yang Xiaoming Cui Jianqiao Xu qingchao Liu Ming qin State Key Laboratory of Geodesy and Earth's Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China University of Chinese Academy of Sciences Beijing 100049China Hubei Luojia Laboratory Wuhan 430079China

The Earth’s Free Core Nutation(FCN) causes Earth tides and forced nutation with frequencies close to the FCN that exhibit resonance ***-precision superconducting gravimeter(SG) and very long baseline interferometry(VLBI) provide good observation techniques for detecting the FCN ***,some choices in data processing and solution procedures increase the uncertainty of the FCN *** this study,we analyzed the differences and the effectiveness of weight function and ocean tide corrections in the FCN parameter detection using synthetic data,SG data from thirty-one stations,and the 10 celestial pole offset(CPO) *** results show that significant discrepancies are caused by different computing options for a single SG *** stacking method,which results in a variation of0.24-5 sidereal days(SDs) in the FCN period(T) and 10^(3)-10^(4) in the quality factor(Q) due to the selection of the weighting function and the ocean tide model(OTM),can effectively suppress this *** statistical analysis results of synthetic data shows that although different weight choices,while adjusting the proportion of diurnal tidal waves involved,do not significantly improve the accuracy of fitted FCN parameters from gravity *** study evaluated a series of OTMs using the loading correction *** fitting of FCN parameters can be improved by selecting the mean of appropriate OTMs based on the evaluation *** the estimation of the FCN parameters based on the forced nutation,it was found that the weight function P_(1) is more suitable than others,and different CPO series(after 2009) resulted in a difference of 0.4 SDs in the T and of 103 in the *** estimated the FCN parameters for SG(T=430.4±1.5 SDs and Q=1.52×10^(4)±2.5×10^(3)) and for VLBI(T=429.8±0.7 SDs,Q=1.88×10^(4)±2.1×10^(3)).

关键词： Free core nutation Superconducting gravimeter Very long baseline interferometry Weight function Ocean tide model