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Exploring the molecular mechanisms and potential therapeutic strategies of ferroptosis in ovarian cancer

BIOCELL 2024年第3期48卷 379-386页

作者： LISHA MA WANQI SHAO weili zhu Department of Gynecology Jiaxing University Master Degree Cultivation BaseZhejiang Chinese Medical UniversityJiaxingChina Department of Gynecology Jiaxing University Affiliated Women and Children’s HospitalJiaxingChina

The morbidity rate of ovarian cancer,a malignant tumour in gynaecological tumours,is rising,and it is considered to be the most lethal *** majority of patients are typically diagnosed during the advanced stages of the illness due to the elusive characteristics of ovarian cancer and an absence of highly sensitive and speciﬁc diagnostic *** excision of the lesions,along with chemotherapy,is the conventional treatment for ovarian cancer;however,resistance to platinum-based chemotherapeutic drugs and molecular targeted therapies frequently *** the survival rate and prognosis of patients with end-stage or recurring ovarian cancer requires the identiﬁcation of new therapeutic targets due to the absence of efﬁcient medications,and this has emerged as a highly demanding *** have demonstrated that ferroptosis effectively hinders the proliferation of ovarian cancer and induces the demise of malignant *** is composed of the cystine/glutamate antiporter system(the system Xc-)and glutathione peroxidase 4(GPX4).Solute carrier family 7 member 11(SLC7A11)and solute carrier family 3 member 2(SLC3A2)play crucial roles in the regulation of ferroptosis by facilitating the uptake of cystine into cells and the efﬂux of glutamate out of cells,*** cells,GPX4 is the exclusive enzyme employed for reducing liposomal peroxide through glutathione peroxidase *** occurrence of ferroptosis in ovarian cancer is strongly associated with three main pathways,namely,the GPX4-glutathione(GSH)protective pathway,the ferroptosis suppressor protein 1(FSP1)-coenzyme Q10(CoQ10)protective pathway,and the guanosine 5'-triphosphate cyclohydrolase I(GCH1)protective *** ovarian cancer cells,the postsynaptic density-95,discs-large,zona occludens 1(PDZ)-binding motif-angiopoietin-like 4-nicotinamide adenine dinucleotide phosphate oxidases 2(TAZ-ANGPTL4-NOX2)pathway can be regulated by Yes-associated protein(YAP)/TAZ,a downstream

关键词： Ovarian cancer Ferroptosis Therapy

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Effects of plant roots on soil preferential pathways and soil matrix in forest ecosystems

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Journal of Forestry Research 2015年第2期26卷 397-404页

作者： Yinghu Zhang Jianzhi Niu weili zhu Xiaoqing Du Jiao Li Key Laboratory Soil and Water Conservation and Desertification Combating Ministry of EducationCollege of Soil and Water ConservationBeijing Forestry University

To characterize effects of plant roots on preferential flow（PF）,we measured root length density（RLD）and root biomass（RB） in Jiufeng National Forest Park,Beijing,*** were made for RLD and RB between soil preferential pathways and soil *** and RB declined with the increasing soil depth（0–10,10–20,20–30,30–40,40–50,50–60 cm） in all experimental *** was greater in soil preferential pathways than in the surrounding soil matrix and was 69.5,75.0 and72.2 % for plant roots of diameter（d）／1,1 ／ d ／ 3 and3 ／ d ／ 5 mm,*** root systems had the most pivotal influence on soil preferential flow in this forest *** all experimental plots,RB content was the sum of RB from soil preferential pathways and the soil matrix in each soil *** respect to 6 soil depth gradient（0–10,10–20,20–30,30–40,40–50,50–60 cm） in each plot,the number of soil depth gradient that RB content was greater in soil preferential pathways than in the soil matrix was characterized,and the proportion was68.2 % in all plots.

关键词： Preferential flow Preferential pathways Soil matrix Root length density Root biomass

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Improving Tribological Performance of Gray Cast Iron by Laser Peening in Dynamic Strain Aging Temperature Regime

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Chinese Journal of Mechanical Engineering 2015年第5期28卷 904-910页

作者： FENG Xu ZHOU Jianzhong MEI Yufen HUANG Shu SHENG Jie zhu weili School of Mechanical Engineering Jiangsu University

A high and stable brake disc friction coefficient is needed for automobile safety, while the coefficient degrades due to elevated temperature during the braking process. There is no better solution except changes in material composition and shape design optimization. In the dynamic strain aging（DSA） temperature regime of gray cast iron, micro-dimples with different dimple depth over diameter and surface area density are fabricated on the material surface by laser peening（LP） which is an LST method. Friction behavior and wear mechanism are investigated to evaluate the effects of surface texturing on the tribological performance of specimens under dry conditions. Through LP impacts assisted by DSA, the friction coefficients of the LPed specimens increase noticeably both at room temperature and elevated temperature in comparison to untreated specimens. Moreover, the coefficient of specimen with dimple depth over diameter of 0.03 and surface area density of 30% is up to 0.351 at room temperature, which dramatically rises up to 1.33 times that of untextured specimen and the value is still up to 0.3305 at 400℃ with an increasing ratio of 35% compared to that of untreated specimen. The surface of textured specimen shows better wear resistance compared to untreated specimen. Wear mechanism includes adhesive wear, abrasive wear and oxidation wear. It is demonstrated that LP assisted by DSA can substantially improve wear resistance, raise the friction coefficient as well as its stability of gray cast iron under elevated temperatures. Heat fade and premature wear can be effectively relieved by this surface modification method.

关键词： laser peening micro-dimples dynamic strain aging friction coefficient

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Quaternized polymer binder for lithium-sulfur batteries:The effect of cation structure on battery performance

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Journal of Energy Chemistry 2020年第4期29卷 165-172页

作者： Fang Wang Lv Li Da Lei Yongpeng Li He Yang weili zhu Fengxiang Zhang State Key Laboratory of Fine Chemicals School of Chemical and Petroleum EngineeringDalian University of Technology2 Dagong RoadLiaodongwan NewDistrictPanjin 124221LiaoningChina

Lithium–sulfur (Li–S) batteries are great candidates for energy storage systems, but need to overcome theissues of low sulfur utilization and polysulfide shuttling for use in large-scale commercial ***, quaternized polymers have received much attention for their polysulfide trapping propertiesdue to electrostatic interaction. In this work, we report a series of polyarylether sulfone (PSF) binderswith different cation structures including imidazolium (Im), triethylammonium (Tr), and morpholinium(Mo). The ability of the these quaternized binders and the conventional poly(vinylidene fluoride) or PVDFbinder to capture polysulfide increases in the order of PVDF << PSF-Mo < PSF-Tr< PSF-Im. The delocalizedcharge on the imidazolium cation may promote the interaction between PSF-Im and polysulfide asindicated by an X-ray photoelectron spectroscopic study. The PSF-Im based cathodes showed the highestcapacity retention (77% at 0.2 C after 100 cycles and 84% at 0.5 C after 120 cycles), and the bestrate capability. This work demonstrates the importance of the cation structure in the design of efficientquaternized binders for high performance Li–S batteries.

关键词： Quaternized binder Polysulfide Cycle stability Li-S battery

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Risks Associated with Misuse of Ketamine as a Rapid-Acting Antidepressant

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Neuroscience Bulletin 2016年第6期32卷 557-564页

作者： weili zhu Zengbo Ding Yinan Zhang Jie Shi Kenji Hashimoto Lin Lu National Institute on Drug Dependence Beijing Key Laboratory of Drug DependencePeking UniversityBeijing 100191，China Institute of Mental Health/Peking University Sixth Hospital Key Laboratory of Mental HealthBeijing 100191，China Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health，Chiba 260-8670，Japan

Abstract Major depression is a serious psychiatric disorder and remains a leading cause of disability worldwide. Con- ventional antidepressants take at least several weeks to achieve a therapeutic response and this lag period has hin- dered their ability to attain beneficial effects in depressed individuals at high risk of suicide. The non-competitive N- methyl-D-aspartate glutamate receptor antagonist ketamine has been shown to have rapid antidepressant effects in both rodents and humans. The emergence of ketamine as a fast- acting antidepressant provides promising new insights into the development of a rapid treatment response in patients with clinical depression. However, its safety and toxicity remain a concem. In this review, we focus on the limitations of ketamine, including neurotoicity, cognitive dysfunction, adverse events associated with mental status, psy- chotomimetic effects, cardiovascular events, and uropathic effects. Studies have shown that its safety and tolerability profiles are generally good at low doses and with short-term treatment in depressed patients. The adverse events associ- ated with ketamine usually occur with very high doses that are administered for prolonged periods of time and can be relieved by cessation. The antidepressant actions of its two enantiomers, S-ketamine （esketamine） and R-ketamine, are also discussed. R-ketamine has greater antidepressantactions than S-ketamine, without ketamine-related side- effects. Future treatment strategies should consider using R- ketamine for the treatment of depressed patients to decrease the risk of adverse events associated with long-term keta- mine use.

关键词： Antidepressant Ketamine Fast-acting Depression Safety

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The abuse of anesthetic propofol: associated with cognitive impairment

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Science China(Life Sciences) 2018年第11期61卷 1428-1431页

作者： weili zhu Wen Zhang Jiali Li Zengbo Ding Yingjie Huang Lin Lu National Institute on Drug Dependence Peking University Institute of Mental Health/Peking University Sixth Hospital and Key Laboratory of Mental Health Peking University

Propofol (2,6-diisopropylphenol)is a widely used intravenous anesthetic for the fast induction of anesthesia and rapid recovery from general *** a γ-aminobu-tyric acid(GABA)receptor agonist,propofol exerts the anesth... 详细信息

关键词： recovery effects fast GABA

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九又四分之三站台通往其它世界的出口

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北京电影学院学报 2007年第1期 96-98页

作者：朱维莉中国人民公安大学公安情报分析系

在《哈里波特》中有一个奇特的站台，普通人对它视而不见。只有前往魔法世界的人才可以看见这个站台，并且顺利通过。这就是著名的九又四分之三站台，它在暗示我们，在我们熟悉的世界之外，还有许许多多的世界不为常人所知，而它们确实... 详细信息

在《哈里波特》中有一个奇特的站台，普通人对它视而不见。只有前往魔法世界的人才可以看见这个站台，并且顺利通过。这就是著名的九又四分之三站台，它在暗示我们，在我们熟悉的世界之外，还有许许多多的世界不为常人所知，而它们确实在那里，时而与我们的世界平行，时而与我们的世界交错，时而离我们远去。

关键词：世界出口普通人波特

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新世纪以来图书馆社会教育职能研究述评

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图书馆 2016年第1期 98-103页

作者：韩宇朱伟丽中山大学图书馆广州510275

文章利用中国知网数据库获取新世纪以来我国学者在CSSCI期刊上发表的关于图书馆社会教育职能相关文献200余篇,通过文献阅读总结出五大研究主题,并提出了目前图书馆社会教育职能的定位,最后,对图书馆教育职能的未来做出设想。

关键词：社会教育图书馆职能图书馆学基础理论

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农户绿色生产驱动机制构建研究——基于TAM-SLA理论框架

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中国特色社会主义研究 2023年第3期 71-79页

作者：陈凯朱伟丽北京林业大学经济管理学院

在资源约束趋紧、环境问题突出、碳减排压力明显、粮食安全遭受威胁等背景下,促进农户绿色生产是推动农业生产绿色转型和高质量发展的重要途径。对河南省产粮大县农户的调研发现,由于绿色生产生计资本匮乏、规制政策不完善导致农户绿色... 详细信息

在资源约束趋紧、环境问题突出、碳减排压力明显、粮食安全遭受威胁等背景下,促进农户绿色生产是推动农业生产绿色转型和高质量发展的重要途径。对河南省产粮大县农户的调研发现,由于绿色生产生计资本匮乏、规制政策不完善导致农户绿色生产意愿与行为出现背离现象,绿色生产的稳定性和持续性不高。结合技术接受模型(TAM)和可持续生计理论框架(SLA),剖析了生计资本、政府规制、感知有用性和感知易用性、农户绿色生产生计策略转型和生计结果之间的互动关系,构建了农户绿色生产长效驱动机制,并结合国际经验提出促进农户绿色生产的本土化规制政策。

关键词：绿色生产驱动机制规制政策技术接受模型可持续生计理论

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美国大学图书馆游戏服务的调查与思考

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图书情报工作 2009年第23期53卷 99-102页

作者：韩宇朱伟丽中山大学图书馆广州510275

通过网络调查,总结出美国大学图书馆提供游戏服务的几种方式,如游戏资源借用、举办游戏主题活动、开发信息素养游戏、将游戏应用于信息素养教学。分析游戏对于大学图书馆读者服务具有的几点价值,如形成特色馆藏、创新服务内容、宣传图... 详细信息

通过网络调查,总结出美国大学图书馆提供游戏服务的几种方式,如游戏资源借用、举办游戏主题活动、开发信息素养游戏、将游戏应用于信息素养教学。分析游戏对于大学图书馆读者服务具有的几点价值,如形成特色馆藏、创新服务内容、宣传图书馆服务、开展信息素养教育。在此基础上对我国大学图书馆开展游戏服务提出建立游戏馆藏、开辟游戏空间、开展游戏活动、在图书馆服务工具设计中融入游戏理念、将游戏与信息素养教育相结合的5点建议,供国内大学图书馆开展相关服务参考。

关键词：读者服务游戏服务信息素养美国大学图书馆

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