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Journal of Bionic Engineering 2024年第3期21卷 1360-1374页

作者： weilan liu Kunlong Li Yizhou Shen Huanyu Zhao Yaru Ni Zeyu Cai Lingfeng Zhao Zhen Wang Institute of Advanced Materials(IAM) School of Materials Science and EngineeringNanjing Tech UniversityNanjing211816China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing211100China Aviation Industry Aerodynamics Research Institute of China Shenyang110000China

Superhydrophobic coatings with high non-wetting properties are widely applied in anti-icing ***,the micro-nanostructures on the surfaces of superhydrophobic coatings are fragile under external forces,resulting in reduced ***,mechanical strength and durability play a crucial role in the utilization of superhydrophobic *** this study,we employed a two-step spraying method to fabricate superhydrophobic FEVE-based coatings with exceptional mechanical durability,utilizing fluorinated TiO_(2)nanoparticles and fluorinated Al_(2)O_(3)microwhiskers as the *** composite coating exhibited commendable non-wetting properties,displaying a contact angle of 164.84°and a sliding angle of 4.3°.On this basis,the stability of coatings was significantly improved due to the interlocking effect of Al_(2)O_(3)*** 500 tape peeling cycles,500 sandpaper abrasion tests,and 50 kg falling sand impact tests,the coatings retained superhydrophobicity,exhibiting excellent durability and application ***,the ice adhesion strength on the coatings was measured at only 65.4 kPa,while the icing delay time reached 271.8 s at-15℃.In addition,throughout 500 freezing/melting cycles,statistical analysis revealed that the superhydrophobic coatings exhibited a freezing initiation temperature as low as-17.25℃.

关键词： Superhydrophobic coatings Anti-icing Mechanical durability

Facilely Fabricating Superhydrophobic Resin-based Coatings with Lower Water Freezing Temperature and Ice Adhesion for Anti-icing Application

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Journal of Bionic Engineering 2019年第5期16卷 794-805页

作者： weilan liu Haifeng Chen Yizhou Shen Zhengwei Wu Institute of Advanced Materials(IAM)9 Jiangsu National Synergistic Innovation Center Jor Advanced Materials(SICAM) Nanjing Tech University(Nanjinglech)Nanjing 211816China Department of Materials Chemistry Qiuzhen SchoolHuzhou UniversityHuzhou 313000China College ofMaterials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 2W016China

This work is focused on the development of a facile strategy to fabricate superhydrophobic coatings,which are characterized with lower water freezing temperature and lower ice ***,a kind o f polyacrylic acid(PAA)based resin material is synthesized as the *** the functionally-modified S i02 nanoparticles are added to regulate the surface morphology for obtaining the ideal *** as-synthesized resin coatings possess strong bonding strength with metal substrate,and the surface hierarchical morphologies(10 wt% SiO2 nanoparticles)induce the robust superhydrophobicity with a high water contact angle of 152°.Also,the superhydrophobic coatings are endowed with high icephobicity,and the freezing temperature of reference water droplet is reduced to-20.33℃ comparing with that(-13.83℃)on the coatings without additive ***,the ice adhesion strength on the superhydrophobic coatings is only 250 kPa,exhibiting the great ability of ice repellence.

关键词： bioinspired surface coatings superhydrophobicity icing temperature ice adhesion

川赤芍总苷及其主成分芍药苷对痤疮相关炎症的抑制作用研究

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日用化学工业（中英文） 2024年第2期54卷 188-195页

作者：刘伟兰李丽何春年董银卯凌霄郭苗苗北京工商大学北京市植物资源开发重点实验室北京100048 中国医学科学院北京协和医学院药用植物研究所北京100193 北京尚捷优蓝科技有限公司北京100081

研究了川赤芍总苷及其主成分芍药苷对痤疮相关炎症的抑制作用。通过制备并基于高效液相色谱分析川赤芍总苷主活性成分含量;建立痤疮丙酸杆菌(Cropionibacterium acnes,***)诱导THP-1细胞炎症模型;采用CCK8法检测细胞相对活力,ELISA法快... 详细信息

研究了川赤芍总苷及其主成分芍药苷对痤疮相关炎症的抑制作用。通过制备并基于高效液相色谱分析川赤芍总苷主活性成分含量;建立痤疮丙酸杆菌(Cropionibacterium acnes,***)诱导THP-1细胞炎症模型;采用CCK8法检测细胞相对活力,ELISA法快速检测细胞IL-1β、IL-8的分泌量,并用Western blot法验证。结果表明:在100μg/mL质量浓度下川赤芍根提取物能显著抑制***刺激引起的炎症因子IL-1β、IL-8(p<0.01)。从川赤芍根提取物中提取的川赤芍总苷,在相同浓度下对炎症因子IL-1β抑制率提高了20%。川赤芍总苷中芍药内酯苷、芍药苷、苯甲酰芍药苷含量分别为0.64%,26.3%,1.17%。其中芍药苷的含量最高,且对***刺激引起的炎症因子IL-1β抑制效果显著(p<0.01)。此外,芍药苷还能降低***刺激引起的活性氧和乳酸脱氢酶。综上所述,川赤芍总苷及其主成分芍药苷对改善***引起的皮肤炎症具有潜在的治疗价值。

关键词：痤疮川赤芍总苷芍药苷抗炎

SMC1A served as a potential therapeutic target to regulate malignant phenotypes of cervical cancer

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BIOCELL 2023年第11期47卷 2471-2484页

作者： weilan liu XIAOYAN DUAN KAIYUN QIN YAN JIANG CAIFU ZHAO CONGWEI DAI Department of Gynecology Hebei General HospitalShijiazhuang050051China

Introduction:Structural maintenance of chromosome 1A(SMC1A)is a crucial compound of the cohesin *** has been reported to regulate the epithelial-mesenchymal transition(EMT)process in multiple ***:The present study aims to further clarify the role of SMC1A in cervical ***:We analyzed data from four datasets and confirmed that SMC1A showed high expression in cervical cancer samples and was related to poor prognosis of patients with cervical *** proliferation of SiHa and C-33A with knockdown of SMC1A was assessed using CCK-8 and colony formation *** migration and invasion were estimated by wound healing assay and Transwell assay *** effect of SMC1A on the chemosensitivity of cisplatin and paclitaxel in cervical cancer cells was detected by flow cytometry ***:Results of the immunohistochemistry(IHC)assay confirmed that the expression of SMC1A was increased in tumor *** cell viability was remarkably suppressed in SiHa and C-33A by knocking down the expression of *** increase of E-cadherin expression and decrease of N-cadherin and Snail expression verified that inhibition of SMC1A suppressed the EMT process of cervical cancer ***,cell migration,and invasion were significantly repressed by the absence of *** and paclitaxel are effective chemotherapeutic agents used in the treatment of cervical *** of SMC1A remarkably promoted the apoptosis induced by cisplatin and paclitaxel,revealing that the chemotherapy resistance to cisplatin and paclitaxel in cervical cancer could reduce by knocking down ***,metastasis associated with colon cancer 1(MACC1)was identified as the downstream factor of *** upregulation reversed the proliferation and the EMT process induced by SMC1A ***:Therefore,our study concluded that SMC1A serves as a therapeutic molecular target to regulate the malignant phenotypes of cervical cancer.

关键词： SMC1A Cervical cancer MACC1 Proliferation Epithelial-mesenchymal transition(EMT)

Recent Progress in Optical Sensors Based on MXenes Quantum Dots and MXenes Nanosheets

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Journal of Analysis and Testing 2024年第1期8卷 95-113页

作者： Chunxiao Lin Xinhong Song weilan Ye Ting liu Mingcong Rong Li Niu Guangzhou Key Laboratory of Sensing Materials and Devices/Center for Advanced Analytical Science/School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China College of Ocean Science and Engineering Shanghai Maritime UniversityShanghai 201306China

In recent years,MXenes,as a new promising two-dimensional material,have received extensive attentions in the fields of environmental remediation,catalysts,sensors,and energy *** broaden the applications of MXenes in sensing,MXenes nanosheets(MNSs) and MXenes quantum dots(MQDs) are prepared by physical etching or chemical *** are monolayered or multilayered MXenes nanosheets within several nanometers in height,and can serve as the perfect reaction substrate and fluorescence *** are spherical,fluorescent MXenes QDs within several nanometers in size,which possess favorable stability and photo *** the distinct features such as high conductivity,favorable hydrophilicity,biocompatibility,abundant surface functional groups,and easy functionalization,MNSs and MQDs show potential applications in the fields of anti-counterfeiting,environmental monitoring,biosensing and *** review focuses on the research of MNS s/MQDs-based optical sensors,including colorimetric sensors,fluorescence sensors,electrochemiluminescence sensors,surface plasmon resonance sensors,and surface-enhanced Raman scattering ***,the current challenges and prospects concerning MNSs/MQDs-based optical sensing techniques are discussed.

关键词： MXenes quantum dots Fluorescence Colorimetry Electrochemiluminescence Surface plasmon resonance

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马克思主义大众化之“生活化”问题思考

甘肃社会科学 2011年第3期 198-201页

作者：刘维兰吴远河海大学公共管理学院南京210098 淮南师范学院经济管理系安徽淮南232038

马克思主义生活化是马克思主义内在本质体现,同时也是当下现实的社会、文化生活急剧变化的趋势使然及新的历史条件下巩固马克思主义在意识形态领域的指导地位,实现马克思主义大众化的必然要求。在当前形势下,实现马克思主义生活化要通... 详细信息

马克思主义生活化是马克思主义内在本质体现,同时也是当下现实的社会、文化生活急剧变化的趋势使然及新的历史条件下巩固马克思主义在意识形态领域的指导地位,实现马克思主义大众化的必然要求。在当前形势下,实现马克思主义生活化要通过强化问题意识、实现话语转换并在此基础上转变大众认知模式,才能使马克思主义真正进入大众的头脑,指导大众的日常生活实践,实现真正意义上的大众化。

关键词：马克思主义大众化生活化

Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2024年

作者： Shiwen liu Xuerui Wan Meng Zhao Jiaqi Wang weilan Wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

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发展与创新:澳大利亚新艺术教育国家课程大纲述评

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外国中小学教育 2016年第1期 52-56页

作者：刘维兰袁丽中央音乐学院管弦系北京师范大学教育学部

澳大利亚《艺术教育国家课程大纲》的出台是正在进行的澳大利亚国家课程改革第二阶段的一个重要部分,大纲对艺术教育的意义、形式和定义进行了基本规定,提出了艺术教育国家课程设置的原则,划分了全学段的基本内容,体现出其关注国家发展... 详细信息

澳大利亚《艺术教育国家课程大纲》的出台是正在进行的澳大利亚国家课程改革第二阶段的一个重要部分,大纲对艺术教育的意义、形式和定义进行了基本规定,提出了艺术教育国家课程设置的原则,划分了全学段的基本内容,体现出其关注国家发展、具有创新性和时代意义的特点,从而对我国完善艺术教育国家课程带来各艺术形式学科综合性发展、反映时代发展需要、厘清学校艺术教育和艺术产业之间的关系以及实施的综合策略等启示。

关键词：澳大利亚艺术教育国家课程

北京市中考英语口语考试对教学的反拨作用探究

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英语教师 2019年第4期19卷 36-41,49页

作者：刘蔚岚北京师范大学附属中学北京100000

选择北京市东城区、西城区、海淀区、昌平区、通州区部分九年级师生进行问卷调查及访谈,了解现阶段北京市九年级英语口语教与学的现状,探究北京市2018年开始实施的中考英语口语考试对初中英语教与学的反拨作用。研究表明,口语考试这种... 详细信息

选择北京市东城区、西城区、海淀区、昌平区、通州区部分九年级师生进行问卷调查及访谈,了解现阶段北京市九年级英语口语教与学的现状,探究北京市2018年开始实施的中考英语口语考试对初中英语教与学的反拨作用。研究表明,口语考试这种新型的测试方式对九年级英语口语教与学产生了积极的反拨作用,提高了教师对英语口语教学的重视程度,加强了学生口语学习的动力。

关键词：英语中考口语考试评分标准口语活动

qGW11a/OsCAT8,encoding an amino acid permease,negatively regulates grain size and weight in rice

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The Crop Journal 2024年第4期12卷 1150-1158页

作者： Peng Gao Feifan Chen Haitang liu Shijun Fan Jierui Zeng Xue Diao Yang liu Wencheng Song Shifu Wang Jing Li Xiaobo Zhu Bin Tu weilan Chen Ting Li Yuping Wang Bingtian Ma Shigui Li Hua Yuan Peng Qin State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Rice Research InstituteSichuan Agricultural UniversityChengdu 611130SichuanChina

Grain size is a key factor influencing grain weight in *** this study,a chromosome segment substitution line(CSSL9-17)was identified,that exhibits a significant reduction in both grain size and weight compared to its donor parent *** investigation identified two quantitative trait loci(QTL)on chromosome 11,designated qGW11a and qGW11b,which contribute to 1000-grain weight with an additive ***_Os11g05690,encoding the amino acid permease OsCAT8,is the target gene of *** of OsCAT8 resulted in decreased grain weight,while OsCAT8 knockout mutants exhibited increased grain *** 287-bp located within the OsCAT8 promoter region of 93-11 negatively regulates its activity,which is subsequently correlated with an increase in grain size and *** results suggest that OsCAT8 functions as a negative regulator of grain size and grain weight in rice.

关键词： Rice Grain size Grain weight QTL OsCAT8