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C-176 loaded Ce DNase nanoparticles synergistically inhibit the cGAS-STING pathway for ischemic stroke treatment

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Bioactive Materials 2023年第11期29卷 230-240页

作者： Zhixin Zhu Haipeng Lu Lulu Jin Yong Gao Zhefeng Qian Pan Lu weijun tong Pik Kwan Lo Zhengwei Mao Haifei Shi Department of Orthopedics 1st Affiliated Hospital of Zhejiang University School of MedicineQingchun Road 79Hangzhou31000China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Department of Chemistry and State Key Laboratory of Marine Pollution City University of Hong KongTat Chee AvenueKowloonHong Kong

The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell death.Cell free-double strand DNA(dsDNA)segments from ischemic tissue debris are engulfed by microglia and sensed by their cyclic GMP-AMP synthase(cGAS),which triggers robust activation of the innate immune stimulator of interferon genes(STING)pathway and initiate the chronic inflammatory cascade.The decomposition of immunogenic dsDNA and inhibition of the innate immune STING are synergistic immunologic targets for ameliorating neuroinflammation.To combine the anti-inflammatory strategies of STING inhibition and dsDNA elimination,we constructed a DNase-mimetic artificial enzyme loaded with C-176.Nanoparticles are self-assembled by amphiphilic copolymers(P[CL35-b-(OEGMA20.7-co-NTAMA14.3)]),C-176,and Ce^(4+)which is coordinated with nitrilotriacetic acid(NTA)group to form corresponding catalytic structures.Our work developed a new nano-drug that balances the cGAS-STING axis to enhance the therapeutic impact of stroke by combining the DNase-memetic Ce^(4+)enzyme and STING inhibitor synergistically.In conclusion,it is a novel approach to modulating central nervus system(CNS)inflammatory signaling pathways and improving stroke prognosis.

关键词： Ischemic stroke Ce-based nano-nuclease The cGAS-STING signaling pathway Anti-inflammation

二维MXenes材料在肿瘤诊疗中的最新进展及展望

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中国癌症杂志 2024年第6期34卷 598-606页

作者：胡飞翔(综述) 童彤彭卫军(审校) 复旦大学附属肿瘤医院放射诊断科复旦大学上海医学院肿瘤学系上海200032

二维MXenes材料是当前材料科学与生物医学领域的研究重点之一,其具有多种独特的材料特性:如出色的光学性能、高比表面积、优异的亲水性、易表面功能化修饰以及良好的电化学特性等。这些特性使得二维MXenes材料在诸多领域中具有广泛的应... 详细信息

二维MXenes材料是当前材料科学与生物医学领域的研究重点之一,其具有多种独特的材料特性:如出色的光学性能、高比表面积、优异的亲水性、易表面功能化修饰以及良好的电化学特性等。这些特性使得二维MXenes材料在诸多领域中具有广泛的应用潜力,尤其在生物医学领域中备受关注,其中在肿瘤的诊断与治疗领域中的新进展受到研究者的瞩目。近年来,MXenes研究的新进展主要集中在成像技术和治疗手段的更新,MXenes展现出一系列独特的物理化学性质,包括出色的荧光猝灭能力、卓越的X射线衰减性能以及优异的光热转换效率。这些特性使其在无创生物成像领域具有巨大的应用潜力。迄今为止,MXenes已在荧光成像、光声成像、计算机断层扫描以及磁共振成像(magnetic resonance imaging,MRI)等多个领域取得了显著的研究成果,通过设计复合型MXenes材料,亦可实现多模态成像,可拓宽单模态诊断技术的限制,为肿瘤成像提供新的思路。MXenes是理想的联合治疗材料,其在肿瘤治疗中主要体现在靶向载药和光学治疗特性,通过靶向载药精准化投递药物实现个体化治疗策略,从而避免全身化疗的不良反应。而如何通过合理的设计与修饰,制备出兼具诊断和治疗特性的MXenes探针是目前肿瘤研究领域中的热点与难点。本文旨在综述二维MXenes材料及其衍生物在肿瘤诊疗领域的最新发展、存在的机遇和挑战。同时,本综述还对材料的合成、表面修饰以及肿瘤成像等相关研究,以及当前环境下利用MXenes所面临的挑战和局限性进行探讨,对其性质、生物效应以及在肿瘤学领域的应用价值进行深入剖析,以期为肿瘤患者带来更加有效和安全的治疗方式。

关键词： MXenes材料光学治疗靶向载药肿瘤成像

Risk factors for intracerebral hemorrhage and coronary heart diseases over a 3-year period in patients admitted to some hospitals of tongliao city of Nei Monggol Autonomous Region Retrospective analysis on case data

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Neural Regeneration Research 2007年第9期2卷 569-573页

作者： Guohong Cui Yanfen Zhang weijun tong Department of Epidemiology and Health Statistics School of Radiation Medicine and Public Health Soochow University Suzhou 215123 Jiangsu Province China Department of Cardiology Tongliao Hospital Tongliao 028000 Nei Monggol Autonomous Region China

BACKGROUND： Intracerebral hemorrhage（ICH） and coronary heart disease （CHD） have the same pathological base, atherosclerosis, and the similar risk factors,such as smoking ,drinking, hypertension, hyperlipemia, diabetes mellitus, etc; but the distributions of two diseases are very different in the populations. This may be related to the exposure of risk factors and different effects of risk factors on two diseases. OBJECTIVE： To analyze the distribution difference of risk factors for ICH and CHD in the populations of tongliao city of Nei Monggol Autonomous Region. DESIGN： Retrospective analysis. SETTING： School of Radiation Medicine and Public Health, Soochow University; tongliao Hospital, Nei Monggol Autonomous Region. PARTICIPANTS： Random sampling was used to select 6 hospitals from 10 hospitals affiliated to tongliao City of Nei Monggol Autonomous Region. Totally 1 672 medical records of patients with ICH and 2 195 medical records of patients with CHD admitted to Department of Neurology and Department of Cardiovascular Internal Medicine of above-mentioned 6 hospitals between January 2003 and December 2005 were collected according to the investigation need. METHODS： The subjects, whose medical records were involved, were performed retrospective analysis with pre-prepared questionnaire ＂Stroke and Coronary Heart Disease Epidemiologic Questionnaire＂. The main contents included： ①Social demography condition： The distributions of gender, age, nationality, etc. ②Previous history of disease： hypertension, diabetes mellitus, etc. ③Related risk factors： systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, smoking, drinking and glucose （GLU）. The database of Epidata was transformed to SPSS database. Single-and multiple-factor non-conditional Logistic regression analysis were performed on the data, and OR value and 95% CI were calculated. The distribution differences of risk factors for two diseases were compar

关键词： cerebral hemorrhage coronary heart disease risk factor

All-fiber generation of arbitrary cylindrical vector beams on the first-order Poincare sphere

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Photonics Research 2020年第8期8卷 1268-1277页

作者： LIPENG FENG YAN LI SIHAN WU XUN GUAN CHEN YANG weijun tong WEI LI JIFANG QIU XIAOBIN HONG YONG ZUO HONGXIANG GUO ERHU CHEN JIAN WU State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China Center for Optics Photonicsand LasersUniversite LavalQuebecQC G1V 0A6Canada State Key Laboratory of Optical Fibre and Cable Manufacture Technology Yangtze Optical Fibre and Cable Joint Stock Limited CompanyWuhan 430074China Beijing Institute of Tracking and Telecommunications Technology Beijing 100094China

We propose a linear mapping relationship between the polarization of the fundamental mode and the cylindrical vector(CV)modes on the first-order Poincaresphere(FOPS)in fiber.The new method is based on the fourdimensional complex Jones matrices in terms of the linearly polarized mode bases.With our theoretical model,an all-fiber approach to generate arbitrary CV beams on the FOPS is proposed theoretically and verified experimentally.In the experiment,through the combination of a mode converter and a two-segment cascaded few-mode fiber with fixed stresses,it is possible to generate all CV modes on the FOPS by only adjusting the polarization of the fundamental mode.The Stokes parameters of the output light are measured to verify our scheme,which shows good agreement with the theoretical prediction.The method may provide a convenient way to generate CV beams and evolve the polarization states in any path on the FOPS,which is expected to have potential applications in encoding information and quantum computation.

关键词： fiber polarization cylindrical

Mathematical representation of 2D image boundary contour using fractional implicit polynomial

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Optoelectronics Letters 2023年第4期19卷 252-256页

作者： tong Yuerong YU Lina LI weijun LIU Jingyi WU Min YANG Yafei Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China School of Materials Science and Optoelectronic Technology&School of Integrated Circuits University of Chinese Academy of SciencesBeijing 100049China Beijing Key Laboratory of Semiconductor Neural Network Intelligent Sensing and Computing Technology Beijing 100083China DapuStor Corporation Shenzhen 518100China

Implicit polynomial(IP)fitting is an effective method to quickly represent two-dimensional(2D)image boundary contour in the form of mathematical function.Under the same maximum degree,the fractional implicit polynomial(FIP)can express more curve details than IP and has obvious advantages for the representation of complex boundary contours.In existing studies,algebraic distance is mainly used as the fitting objective of the polynomial.Although the time cost is reduced,there are problems of low fitting accuracy and spurious zero set.In this paper,we propose a two-stage neural network with differentiable geometric distance,which uses FIP to achieve mathematical representation,called TSEncoder.In the first stage,the continuity constraint is used to obtain a rough outline of the fitting target.In the second stage,differentiable geometric distance is gradually added to fine-tune the polynomial coefficients to obtain a contour representation with higher accuracy.Experimental results show that TSEncoder can achieve mathematical representation of 2D image boundary contour with high accuracy.

关键词： polynomial contour representation

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基础研究在高端润滑材料发展中的重要性

炼油与化工 2024年第2期35卷 1-5页

作者：乔韦军王波周磊郝敏彤刘通中国石油石油化工研究院大庆化工研究中心黑龙江大庆163714 兰州中石油润滑油添加剂有限公司甘肃兰州730000

基础研究在高端润滑材料发展中起着至关重要的作用。润滑材料在现代工业中影响着机械设备的性能和寿命。高端润滑材料的研发需要深入的基础研究支持,以解决润滑材料在极端条件下的性能挑战。基础研究可以揭示材料的微观结构和性质,为新... 详细信息

基础研究在高端润滑材料发展中起着至关重要的作用。润滑材料在现代工业中影响着机械设备的性能和寿命。高端润滑材料的研发需要深入的基础研究支持,以解决润滑材料在极端条件下的性能挑战。基础研究可以揭示材料的微观结构和性质,为新材料的设计和合成提供指导。此外,基础研究还可以探索新的润滑机制和技术,从而提高润滑材料的性能和稳定性。文中以Ⅳ类基础油聚α-烯烃(PAO)和Ⅴ类基础油(烷基萘)为例,分析了基础研究对于高端润滑材料的重要性,最后对中国高端润滑行业未来进行了展望。

关键词：基础研究高端润滑材料机制与技术

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激光点云技术在河塘清淤工程量测量中的应用

城市道桥与防洪 2024年第2期 250-252,265,I0022页

作者：同伟军盛雅楠陈楚楚中交路桥华东工程有限公司上海市201203 中交路桥建设有限公司北京市100027

河塘清淤回填工程量测量,是工程管理的重点。传统河塘清淤回填测量,需要人员在河塘附近甚至塘底进行测量,存在安全性低、测量效率低下、数据不准确等问题。通过对激光点云技术在河塘清淤工程量测量中的应用进行分析,探讨了清淤工程量的... 详细信息

河塘清淤回填工程量测量,是工程管理的重点。传统河塘清淤回填测量,需要人员在河塘附近甚至塘底进行测量,存在安全性低、测量效率低下、数据不准确等问题。通过对激光点云技术在河塘清淤工程量测量中的应用进行分析,探讨了清淤工程量的测量和计算方法,为清淤工程量的顺利统计提供了技术保证,也为类似的工程提供有益参考。

关键词：河塘清淤激光点云断面法 DTM法

Distributed curvature sensing based on a bending loss-resistant ring-core fiber

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Photonics Research 2020年第2期8卷 165-174页

作者： LI SHEN HAO WU CAN ZHAO LEI SHEN RUI ZHANG weijun tong SONGNIAN FU MING TANG Wuhan National Laboratory for Optoelectronics(WNLO)&National Engineering Laboratory for Next Generation Internet Access System School of Optical and Electronic InformationHuazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Optical Fiber and Cable Manufacture Technology Yangtze Optical Fiber and Cable Joint Stock Limited Company(YOFC)R&D CenterWuhan 430073China

A theoretical and experimental study on curvature sensing using a Brillouin optical time-domain analyzer based on the ring-core fiber(RCF)is reported.The Brillouin gain spectrum of the RCF is investigated,and the Brillouin frequency shift(BFS)dependence on temperature and strain is calibrated.We theoretically analyze the fiber bending-induced BFS and peak Brillouin gain variation for the RCF through a numerical simulation method,and the RCF is revealed to have a high curvature sensitivity.Distributed curvature sensing is successfully demonstrated,with the bending radius ranging from 0.5 to 1.5 cm,corresponding to a BFS variation from 32.90 to7.81 MHz.The RCF takes advantage of great bending loss resistance,and the maximum macrobending loss at the extreme bending radius of 0.5 cm is less than 0.01 d B/turn.Besides,the peak Brillouin gain of the RCF is discovered to vary significantly in response to fiber bending,which is expected to be another parameter for distributed curvature determination.The results imply that the RCF is a promising candidate for highly sensitive distributed curvature measurement,especially in sharp bending circumstances.

关键词： fiber bending curvature

口腔肿瘤术后患者口腔健康现状及其影响因素分析

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军事护理 2024年第4期41卷 29-32页

作者：俞瑾娴刘婷袁卫军顾芬上海交通大学医学院附属第九人民医院护理部上海200023

目的调查口腔肿瘤术后患者的口腔健康现状及其影响因素,为提高患者口腔健康生活质量提供参考依据。方法2023年1-7月,便利抽样法选取某三级甲等医院接受手术治疗的147例口腔肿瘤患者为研究对象,采用口腔健康影响程度量表(oral health imp... 详细信息

目的调查口腔肿瘤术后患者的口腔健康现状及其影响因素,为提高患者口腔健康生活质量提供参考依据。方法2023年1-7月,便利抽样法选取某三级甲等医院接受手术治疗的147例口腔肿瘤患者为研究对象,采用口腔健康影响程度量表(oral health impact profile-14,OHIP-14)对其进行调查。结果口腔肿瘤术后患者的口腔健康得分(22.0±13.52)分,多元逐步回归分析显示,手术次数、疾病诊断、气管切开、体质指数对口腔肿瘤术后患者口腔健康程度有影响(均P<0.05)。结论口腔肿瘤患者的口腔健康状况一般,护理人员对于多次手术、口腔恶性肿瘤、气管切开及体质量指数<18.5 kg/m^(2)患者的口腔健康状况应予以关注,及时进行评估及干预,从而提高患者术后口腔健康状况。

关键词：口腔肿瘤口腔健康影响因素