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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis bodrov Anton bogomyagkov Serge bondarenko Stewart boogert Maarten boonekamp Marcello borri Angelo bosotti Vincent boudry Mohammed boukidi Igor boyko Ivanka bozovic Giuseppe bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin chen Danping chen Fuqing chen Fusan chen Gang chen Guoming chen Hua-Xing chen Huirun chen Jinhui chen Ji-Yuan chen Kai chen Mali chen Mingjun chen Mingshui chen Ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen wei chen Xiang chen Xiaoyu chen Xin chen Xun chen Xurong chen Ye chen Ying chen Yukai chen Zelin chen Zilin chen Gang chen boping chen Chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

过渡金属体系非线性光学性质计算的ECP基组研究

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化学学报 2005年第6期63卷 465-472,F006页

作者：刘彩萍吴克琛洪涛莽朝永张明昕韦永勤周张锋庄伯涛中国科学院福建物质结构研究所结构化学国家重点实验室福州350002

有效核势(ECP)方法是计算含有过渡金属体系的电子结构及物理性质的有效方法.本文比较了一系列典型的ECP基组对计算含过渡金属体系非线性光学性质精度的影响.分别在HF,MP2和DFT理论水平上对过渡金属元素使用不同的ECP基组,计算了几个过... 详细信息

有效核势(ECP)方法是计算含有过渡金属体系的电子结构及物理性质的有效方法.本文比较了一系列典型的ECP基组对计算含过渡金属体系非线性光学性质精度的影响.分别在HF,MP2和DFT理论水平上对过渡金属元素使用不同的ECP基组,计算了几个过渡金属有机化合物的静态一阶超极化率β0.研究结果表明使用有效核势计算含过渡金属体系时,核电子的选取是提高计算精度的前提,ns和np电子应该和nd电子一同作为价电子处理;对于重原子,必须考虑自旋-轨道耦合相对论效应.经过综合评估,认为使用Stuttgart/Dresden赝势的ECP基组,MHF,在计算含有过渡金属体系非线性光学性质方面是比较好的基组;StuttgartRSC1997和SBKJCVDZ相对而言是较好的基组;基组Lanl2dz,Hay-WadtMB(n+1)和Hay-WadtVDZ(n+1)由于没有考虑自旋-轨道耦合,计算精确度次之;而基组CRENBL和CRENBS计算的偏差要大一些,尤其是CRENBS基组由于价电子选择得太少而导致与实验值的偏差最大.

关键词：基组非线性光学性质过渡金属自旋价电子相对论效应赝势 ECP 研究结果 MB

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin Liu Yue Huang Guang-cheng Xiao qing-Cui Bu Jin-Lu Qu Shu zhang Shuang-Nan zhang Shu-Mei Jia Fang-Jun Lu Xiang Ma Lian tao wei zhang Li chen Li-Ming Song Ti-Pei Li Yu-Peng Xu Xue-Lei Cao yong chen Cong-Zhan Liu Ce Cai Zhi Chang Gang chen Tian-Xiang chen Yi-Bao chen Yu-Peng chen wei Cui wei-wei Cui Jing-Kang Deng yong-wei Dong Yuan-Yuan Du Min-Xue Fu Guan-Hua Gao He Gao Min Gao Ming-Yu Ge Yu-Dong Gu Ju Guan cheng-cheng Guo Da-wei Han Jia Huo Lu-Hua Jiang wei-Chun Jiang Jing Jin yong-Jie Jin Ling-Da Kong Bing Li cheng-Kui Li Gang Li Mao-Shun Li wei Li Xian Li Xiao-bo Li Xu-Fang Li Yang-Guo Li Zheng-wei Li Xiao-Hua Liang Jing-Yuan Liao Bai-Sheng Liu Guo-qing Liu Hong-wei Liu Xiao-Jing Liu Yi-Nong Liu bo Lu Xue-feng Lu Qi Luo tao Luo Bin Meng Yi Nang Jian-Yin Nie Ge Ou Na Sai Ren-cheng Shang Xin-Ying Song Liang Sun Ying Tan You-Li Tuo chen Wang Guo-feng Wang Juan Wang Ling-Jun Wang Weng-Shuai Wang Yu-Sa Wang Xiang-Yang Wen Bai-Yang wu bo-Bing wu Mei wu Shuo Xiao Shao-Lin Xiong He Xu Jia-wei Yang Sheng Yang Yan-Ji Yang Yi-Jung Yang Qi-Bin Yi Qian-qing Yin Yuan You Ai-Mei zhang cheng-Mo zhang Fan zhang Hong-Mei zhang Juan zhang Tong zhang Wan-Chang zhang Wen-Zhao zhang Yi zhang Yi-Fei zhang yong-Jie zhang Yuan-Hang zhang Yue zhang Zhao zhang Zhi zhang Zi-Liang zhang Hai-Sheng Zhao Xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-ke zhou Jian-feng zhou Yu-Xuan Zhu Ren-Lin zhuang Yue Zhu key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite

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Science China(Physics,Mechanics & Astronomy) 2020年第4期63卷 2-19页

作者： Shuang-Nan zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu yong chen XueLei Cao qingCui Bu Zhi Chang Gang chen Li chen TianXiang chen YiBao chen YuPeng chen wei Cui weiwei Cui JingKang Deng yongwei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor chengcheng Guo Dawei Han wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang weiChun Jiang Jing Jin yongJie Jin Bing Li chengKui Li Gang Li MaoShun Li wei Li Xian Li Xiaobo Li XuFang Li YanGuo Li ZiJian Li Zhengwei Li XiaoHua Liang JinYuan Liao Guoqing Liu Hongwei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu bo Lu Xuefeng Lu tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai Rencheng Shang GuoHong Shen Liang Sun Ying Tan Lian tao YouLi Tuo chen Wang Chunqin Wang Guofeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang wu boBing wu Mei wu Guangcheng Xiao ShaoLin Xiong LinLi Yan Jiawei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei zhang ChunLei zhang chengMo zhang Fan zhang HongMei zhang Juan zhang Qiang zhang ShenYi zhangs Shu zhang Tong zhang WanChang zhang wei zhang WenZhao zhang Yi zhang YiFei zhang yongJie zhang Yue zhang Zhao zhang Zhi zhang ZiLiang zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng Jianfeng zhou YuXuan Zhu Yue Zhu RenLin zhuang key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China

As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be *** we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results.

关键词： X-and γ-ray telescopes and instrumentation neutron stars black holes X-ray binaries γ-ray bursts

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-wei Liu Yi-Peng Jing Gang Wang Hao-Tong zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan chen Jian-Jun chen Kun-Xin chen Li chen Xue-Lei chen Xiao-Yan chen Ying chen Norbert Christlieb Jia-Ru Chu chen-zhou Cui Yi-Qiao Dong Bing Du Dong-wei Fan Lei feng Jian-Ning Fu Peng Gao Xue-Fei Gong bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han bo-Liang He Jin-Liang Hou yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang qing-Sheng tao Yuan Tian Dan Wang Da-Qi Wang feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng wei Ming-Zhi wei Hong wu ke-Fei wu Xue-Bing wu Yu-Zhong wu Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-feng Yang Hui-qin Yang Ming Yang Zheng-Qiu Yao yong Yu Hui Yuan Hai-bo Yuan Hai-Long Yuan wei-Min Yuan Chao Zhai En-Peng zhang Hua-wei zhang Jian-Nan zhang Li-Pin zhang wei zhang yong zhang Yan-Xia zhang Zheng-Chao zhang Ming Zhao Fang zhou Xu zhou Jie Zhu yong-Tian Zhu Si-cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)

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Military Medical Research 2022年第4期9卷 389-403页

作者： Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani qing Ting Tan Sami Akbulut kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui zhou Xian-tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong chen Xing chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai qin-Yu feng qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-yong qin wei wei Gang wei Li-Ying Xu Hui-Chao Xue Hua-wei Yang wei-Ge Yang Chao-Jie zhang Fan zhang Guan-Xin zhang Shao-Kun zhang Shu-Qun zhang Ye-Qiang zhang Yue-Peng zhang Sheng-Chu zhang Dai-wei Zhao Xiang-Min Zheng Le-wei Zheng Gao-Ran Xu Wen-bo zhou Gao-Song wu Department of Thyroid and Breast Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Department of Pathology University of Chicago Pritzker School of MedicineChicagoIL60637USA Department of Surgical Oncology and Breast Surgery Oncology CenterFaculty of MedicineMansoura UniversityMansoura35516Egypt Department of Breast Surgery Beijing University of Chinese MedicineBeijing100700China Department of Infectious Diseases and Tropical Medicine Faculty of MedicineMashhad University of Medical SciencesMashhad***Iran Breast Department KK Women’s and Children’s Hospital100 Bukit Timah RoadSingapore229899Singapore Department of Surgery Department of Public HealthDepartment of BiostatisticsBioinformatics and Medical InformaticsInonu University Faculty of Medicine44280MalatyaTurkey Department of General Surgery Faculty of MedicineÇanakkale Onsekiz Mart University17020ÇanakkaleTurkey Department of Radiology Cancer InstituteImam Khomeini HospitalTehran University of Medical SciencesTehran***Iran Department of Surgery College of Medicine and Medical SciencesArabian Gulf University-BahrainManama26671Bahrain Department of Radiology International Faculty of MedicineIstanbul Medipol University34810IstanbulTurkey Department of General Surgery Faculty of MedicineSakarya University54050SakaryaTurkey Department of Surgery HiU Clinic170Gwongwang-roPaldal-guSuwon16488Korea Department of Radiology Faculty of MedicineAtaturk University25240ErzurumTurkey Academic Support and Education Center Hırkai Serif DistrictKececi Cesmesi StrDoktorlar BuildingB/734091IstanbulTurkey Department of General and Digestive Surgery Hospital General CastellonAvda Benicassim S/N12812004CastellónSpain Radiology Department Ankara Training and Research Hospital305018AnkaraTurkey Department of Surgery The University of Hong KongChina The University of Hong Kong-Shenzhen Hospital Shenzhen518053China University of Miami Health System and Miller School of Medicine 1475 NW 12th AvenueM

Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the *** of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and *** approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM.

关键词： Granulomatous mastitis Granulomatous lobular mastitis Idiopathic granulomatous mastitis Diagnosis Treatment

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin Ling Qiao-Nan Shan Xu-yong wei Rui Wang Chang-Ku Jia Li zhuang Tian Shen Li-Min Ding Zhi-Dan Xu Lai-Bang Luo Li-bo Sun Guang-Ming Li Tai-Shi Fang Nan Jiang Kun zhang Zhao-Jie Su Zhi-Hai Peng Ren Lang tao Jiang Qiang He Lin-Sen Ye Yang Yang Yu-Ting He Wen-Zhi Guo Liu-Gen Lan Xu-yong Sun Dong chen Zhi-Shui chen Da-wei zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi bo Wang Jiang Liu Qian Lu wei Rao Jin-Zhen Cai tao Lv Jia-Yin Yang Pu-Sen Wang Lin Zhong Jing-Sheng Ma Qi-Gen Li Sheng-Dong wu Chang-Jiang Lu Cai-De Lu Dong-Hua zhang Xuan Wang Zi-Qiang Li Mu-Jian Teng Jun-Jie Li Wen-tao Jiang Jian-Hua Li Quan-Bao zhang Ning-Qi Zhu Zheng-Xin Wang Kang He Qiang Xia Shao-Hua Song Zhi-Ren Fu wei Qiu Guo-Yue Lv Rui-Peng Song Ji-zhou Wang Zheng Wang Jian zhou Gang chen Ying-Peng Zhao Li Li Ze-Min Hu Qi-Jie Luo Zhong-zhou Si Bin Xie Xiao-Shun He Zhi-yong Guo Shu-Sen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China Liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma Liver transplantation Conversion

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun Liu Dan-Dan Li wei Dong Yu-Qi Liu Yang wu Da-Xuan Tang Fu-Chun zhang Meng Qiu Qi Hua Jing-Yu He Jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-Jun Jiang bo Cui Jiang-Bin chen Yang-Gan Wang Hai-Rong Wang qin Yu Jing He Yi-Lin Mao Xiao-Fang Bin Yue Deng Yu-Dan Tian qing-Hua Han Da-Jin Liu Li-qin Duan Ming-Jun Zhao Cui-Ying zhang Hai-Ying Dai Ze-Hua Li Ying Xiao You-Zhi Hu Xiao-Yu Huang Kun Xing Xin Jiang Chao-feng Liu Jing An feng-Chun Li tao tao Jin-Fa Jiang Ying Yang Yao-Rong Dong Lei zhang Guang Fu Ying Li Shu-wei Huang Li-Ping Dou Lan-Jun Sun Ying-Qiang Zhao Jie Li Yun Xia Jun Liu Fan Liu Wen-Jin He Ying Li Jian-Cong Tan Yang Lin Ya-Bin zhou Jian-Fei Yang Guo-qing Ma Hui-Jun chen He-Ping Liu Zong-wu Liu Jian-Xiong Liu Xiao-Jia Luo Xiao-Hong Bin Ya-Nan Yu Hai-Xia Dang Bing Li Fei Teng Wang-Min Qiao Xiao-Long Zhu Bing-wei chen Qi-Guang chen Chun-Ti Shen yong-Yan Wang Yun-Dai chen Zhong Wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

Measurement of the neutron total cross section of carbon at the Back-n white neutron beam of CSNS

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Nuclear Science and Techniques 2019年第9期30卷 73-82页

作者： Xing-Yan Liu Yi-wei Yang Rong Liu Jie Wen Zhong-wei Wen Zi-Jie Han Zhi-zhou Ren Qi An Huai-yong Bai Jie Bao Ping Cao Qi-Ping chen yong-Hao chen Pin-Jing cheng Zeng-Qi Cui Rui-Rui Fan Chang-qing feng Min-Hao Gu feng-qin Guo Chang-Cai Han Guo-Zhu He yong-cheng He Yue-feng He Han-Xiong Huang wei-Ling Huang Xi-Ru Huang Xiao-Lu Ji Xu-Yang Ji Hao-Yu Jiang wei Jiang Han-tao Jing Ling Kang Ming-tao Kang bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Shu-Bin Liu Guang-Yuan Luan Ying-Lin Ma Chang-Jun Ning Bin-Bin Qi Jie Ren Xi-Chao Ruan Zhao-Hui Song Hong Sun Xiao-Yang Sun Zhi-Jia Sun Zhi-Xin Tan Hong-qing Tang Jing-Yu Tang Peng-cheng Wang Qi Wang tao-feng Wang Yan-feng Wang Zhao-Hui Wang Zheng Wang qing-Biao wu Xiao-Guang wu Xuan wu Li-Kun Xie Han Yi Li Yu tao Yu yong-Ji Yu Guo-Hui zhang Jing zhang Lin-Hao zhang Li-Ying zhang qing-Min zhang Qi-wei zhang Xian-Peng zhang Yu-Liang zhang Zhi-yong zhang Ying-Tan Zhao Liang zhou Zu-Ying zhou Dan-Yang Zhu ke-Jun Zhu Peng Zhu Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics State key Laboratory of Particle Detection and Electronics Chinese Academy of Sciences(CAS) Department of Modern Physics University of Science and Technology of China State key Laboratory of Nuclear Physics and Technology School of PhysicsPeking University key Laboratory of Nuclear Data China Institute of Atomic Energy Institute of High Energy Physics Chinese Academy of Sciences(CAS) Spallation Neutron Source Science Center University of South China Northwest Institute of Nuclear Technology Department of Engineering and Applied Physics University of Science and Technology of China Beihang University Xi’an Jiaotong University

To verify the performance of the neutron total cross-sectional spectrometer, the neutron total cross section of carbon is initially measured in the energy range of 1 eV to 20 MeV using the time-of-flight method. The measurement is performed at the Back-n white neutron source with a 76-m time-of-flight path using the China Spallation Neutron Source. A multilayer fast fission chamber with 235U and 238U is employed as the neutron detector. The diameter and thickness of the natural graphite sample are 70 mm and 40 mm, respectively. Signal waveforms are collected using a data acquisition system. Off-line data processing was used to obtain the neutron time-of-flight spectra and transmissions. The uncertainty of the counting statistics is generally approximately 3% for each bin in the energy range of 1–20 MeV. It is determined that the results for the neutron total cross section of carbon obtained using ^235U cells are in good agreement with the results obtained using 238U cells within limits of statistical uncertainty. Moreover, the measured total cross sections show good agreement with the broadening evaluated data.

关键词： CSNS Back-n white neutron source NTOX Neutron total cross section Carbon Multilayer fast fission chamber