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Long-term exposure to aryl hydrocarbon receptor agonist neburon induces reproductive toxicity in male zebrafish(Danio rerio)

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Journal of Environmental Sciences 2024年第8期142卷 193-203页

作者： Fucong Zhang Chen Tang yue Zhu Qian Wang xin Huang Chunyan Yang Chengyong He Zhenghong Zuo Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems School of Life SciencesXiamen UniversityXiamen 361102China

Neburon is a phenylurea herbicide that is widely used worldwide,but its toxicity is poorly *** our previous study,we found that neburon has strong aryl hydrocarbon receptor(AhR)agonist activity,but whether it causes reproductive toxicity is not *** the present study,zebrafish were conducted as a model organism to evaluate whether environmental concentrations of neburon(0.1,1 and 10μg/L)induce reproductive disorder in *** exposure to neburon for 150 days from embryo to adult,that the average spawning egg number in high concentration group was 106.40,which was significantly lower than 193.00in control *** result was mainly due to the abnormal male reproductive behavior caused by abnormal transcription of genes associated with reproductive behavior in the brain,such as *** proportions of spermatozoa in the medium and high concentration groups were 82.40%and 83.84%,respectively,which were significantly lower than 89.45%in control *** result was mainly caused by hormonal disturbances and an increased proportion of apoptotic *** hormonal disruption was due to the significant changes in the transcription levels of key genes in the hypothalamus-pituitary-gonadal axis following neburon *** treatment also significantly activated the AhR signaling pathway,causing oxidative stress damage and eventually leading to a significant increase in apoptosis in the exposed ***,these data filled the currently more vacant profile of neburon toxicity and might provide information to assess the ecotoxicity of neburon on male reproduction at environmentally relevant concentrations.

关键词： Zebrafish Neburon Male reproductive toxicity HPG axis AhR agonist

Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors

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Nano Research 2024年第2期17卷 836-847页

作者： Shuping Li xin Li Jiaqi Meng weier Bao Shuang Wang Peng Ye Xiao-Dong Gao wei wei Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education School of BiotechnologyJiangnan UniversityWuxi 214122China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Bacterial outer membrane vesicles(OMVs)are potent immunostimulants of regulating the tumor microenvironment(TME)for immunotherapy,and can be used to deliver ***,the severe systemic inflammatory response triggered by OMVs upon intravenous(i.v.)injection has limited their ***,we developed a safe and effective strategy by conjugating doxorubicin-loaded serum albumin(SA-DOX,AD)onto the surface of OMVs using a matrix metalloproteinase(MMP)-cleavable peptide linker(cL).This approach enabled the dynamic shielding of OMVs to reduce the systemic side effects while simultaneously enhancing the anti-tumor effects through ***,the resulting OMV-cL-AD formulation exhibited significantly enhanced accumulation at the tumor site after ***,facilitated by the SA decoration on the OMVs ***,the shield on the OMV-cL-AD was cleaved by the over-expressed MMP in the TME,leading to the release of both OMVs and *** process provided OMV-induced immunotherapy and DOX-induced chemotherapy,resulting in synergistic tumor *** conclusion,our work demonstrated the potential of OMV-cL-AD as an effective immunochemotherapy strategy that can prolong the survival time of mice without inducing side effects.

关键词： outer membrane vesicles doxorubicin tumor microenvironment immunotherapy chemotherapy

Total Factor Productivity with Chinese Characteristics

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Social Sciences in China 2024年第1期45卷 54-70页

作者： Fan xin Liu wei School of Economics Renmin University of China

Although total factor productivity(TFP)is a common concept in mainstream Western economics,its origins are actually embedded in Marx's understanding of improving labor *** an important element of labor productivity under socialized production conditions,TFP is further reflected in the category of"socially necessary labor time"in two distinct ***-examining TFP from the perspective of Marxist political economy and incorporating it into the theoretical system of political economy of socialism with Chinese characteristics vividly illustrates the essence of"adhering to original principles,assimilating foreign concepts,and embracing a forward-looking vision"within political economy of socialism with Chinese *** practice,it is necessary to start with Marx's theory of productive labor and delineate the sectors involved in productive labor so that TFP and its fluctuations can be measured in a more relevant *** the context of the new era and the new journey,as the key to achieving high-quality economic development in China,efforts are needed to increase *** requires balancing economic factors such as the long term and short term,supply and demand,and gross quantity and structure,and promoting transformative changes in the quality,efficiency,and dynamism of economic development.

关键词： total factor productivity(TFP) technological progress technological effciency high-quality development

Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine

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Chinese Journal of Integrative Medicine 2024年第5期30卷 468-479页

作者： ZHONG Yi LI xin-yue LIANG Tian-jun DING Bao-zhu MA Ke-xin REN Wen-xuan LIANG Wen-jie College of Integrated Traditional Chinese and Western Medicine Hebei University of Chinese MedicineHebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney DiseasesInstitute of Integrated Traditional Chinese and Western MedicineShijiazhuang 050200China Department of Cardiovascular Internal Medicine the Second Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi Province 332000China Graduate School Hebei Medical UniversityShijiazhuang 050017China Rural Physician College Hebei Medical UniversityShijazhuang 050017China Medical Department the First Hospital of Hebei Medical UniversityShijiazhuang 050030China

Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases(CVDs),such as diabetic cardiomyopathy,ischemia/reperfusion injury,myocardial infarction,heart failure and *** RNAs(nc RNAs)are important regulatory *** Chinese medicine(CM)compounds,including their effective components,can regulate pyroptosis and exert myocardium-protecting *** mechanisms underlying this protection include inhibition of inflammasome protein expression,Toll-like receptor 4–NF-κB signal pathway activation,oxidative stress,endoplasmic reticulum stress(ERS),and mixed lineage kinase 3 expression and the regulation of silent information regulator *** NLRP3 protein is an important regulatory target for CVD prevention and treatment with *** the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.

关键词： pyroptosis cardiovascular diseases Chinese medicine NOD-like receptor protein 3 mechanisms

Global patterns of soil phosphatase responses to nitrogen and phosphorus fertilization

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Pedosphere 2024年第1期34卷 200-210页

作者： Xiaomei GOU Yongqing REN xin QIN Xiaorong wei Jingjing WANG State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau the Research Center of Soil and Water Conservation and Ecological EnvironmentChinese Academy of Sciences and Ministry of EducationYangling 712100China Institute of Soil and Water Conservation Chinese Academy of Sciences and Ministry of Water ResourcesYangling 712100China River and Lake Management Office Shaanxi Provincial Department of Water ResourcesXi'an 710004China College of Natural Resources and Environment Northwest A&F UniversityYangling 712100China University of Chinese Academy of Sciences Beijing 100049China CAS Center for Excellence in Quaternary Science and Global Change Xi'an 710061China

Hydrolysis of organic phosphorus(P) by soil phosphatases is an important process of P cycling in terrestrial ecosystems, significantly affected by nitrogen(N) and/or P fertilization. However, how soil acid phosphatase(ACP) and alkaline phosphatase(ALP) activities respond to N and/or P fertilization and how these responses vary with climatic regions, ecosystem types, and fertilization management remain unclear. This knowledge gap hinders our ability to assess P cycling and availability from a global perspective. We performed a meta-analysis to evaluate the global patterns of soil ACP and ALP activities in response to N and/or P addition. We also examined how climatic regions(arctic to tropical), ecosystem types(cropland, grassland, and forest), and fertilization management(experiment duration and fertilizer type and application rate) affected changes in soil phosphatases after fertilization. It was shown that N fertilizer resulted in 10.1% ± 2.9% increase in soil ACP activity but a minimal effect on soil ALP activity. In contrast, P fertilizer resulted in 7.7% ± 2.6% decrease in soil ACP activity but a small increase in soil ALP activity. The responses of soil ACP and ALP activities to N and/or P fertilization were largely consistent across climatic regions but varied with ecosystem types and fertilization management, and the effects of ecosystem types and fertilization management were enzyme-dependent. Random forest analysis identified climate(mean annual precipitation and temperature) and change in soil pH as the key factors explaining variations in soil ACP and ALP activities. Therefore, N input and ecosystem types should be explicitly disentangled when assessing terrestrial P cycling.

关键词： acid phosphatase alkaline phosphatase ecosystem type fertilization management meta-analysis phosphorus cycling phosphorus limitation

Drinking water quality & health risk assessment of secondary water supply systems in residential neighborhoods

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 47-62页

作者： Yating wei Dong Hu Chengsong Ye Heng Zhang Haoran Li xin Yu College of the Environment&Ecology Xiamen UniversityXiamen 361102China School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China

Secondary water supply systems(SWSSs)are important components of the water supply infrastructure that ensure residents’drinking water *** are characterized by long detention time,warm temperature,and unreasonable management,which may trigger the deterioration of water quality and increase *** this study,drinking water quality index(DWQI)and health risk assessment(HRA)were selected and modified to quantitatively assess the water quality and health risks of SWSSs in residential *** total,121 seasonal water samples were *** was observed that the water quality was excellent with the DWQI of 0.14±0.04,excluding one sample,which was extremely poor owing to its excessive total bacterial *** HRA results revealed that the health risks were low:negligible non-carcinogenic risk for any population;negligible and acceptable carcinogenic risk for children aged 6–17 and ***,samples revealed higher carcinogenic risk(7.63×10−5±3.29×10−6)for children aged 0–5,and arsenic was the major *** samples had poor water quality and higher health risks,which called for *** further investigate the water quality and health risks of SWSSs,monthly sampling was conducted during *** 24 water samples were qualified in Chinese standard(GB 5749-2022)and characterized as excellent *** HRA results were consistent with the seasonal samples’and the health risks were mainly concentrated in ***,our study provides a suitable framework for water quality security,advice for managers,and references for administrators in other cities.

关键词： Drinking water quality Water quality index Health risk assessment Secondary water supply systems Heavy metals

Vibration Suppression for Active Magnetic Bearings Using Adaptive Filter with Iterative Search Algorithm

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CES Transactions on Electrical Machines and Systems 2024年第1期8卷 61-71页

作者： Jin-Hui Ye Dan Shi yue-Sheng Qi Jin-Hui Gao Jian-xin Shen IEEE Department of Electrical Engineering Zhejiang UniversityHangzhou 310027China CES and IEEE

Active Magnetic Bearing(AMB) is a kind of electromagnetic support that makes the rotor movement frictionless and can suppress rotor vibration by controlling the magnetic force. The most common approach to restrain the rotor vibration in AMBs is to adopt a notch filter or adaptive filter in the AMB controller. However, these methods cannot obtain the precise amplitude and phase of the compensation current. Thus, they are not so effective in terms of suppressing the vibrations of the fundamental and other harmonic orders over the whole speed range. To improve the vibration suppression performance of AMBs,an adaptive filter based on Least Mean Square(LMS) is applied to extract the vibration signals from the rotor displacement signal. An Iterative Search Algorithm(ISA) is proposed in this paper to obtain the corresponding relationship between the compensation current and vibration signals. The ISA is responsible for searching the compensating amplitude and shifting phase online for the LMS filter, enabling the AMB controller to generate the corresponding compensation force for vibration suppression. The results of ISA are recorded to suppress vibration using the Look-Up Table(LUT) in variable speed range. Comprehensive simulations and experimental validations are carried out in fixed and variable speed range, and the results demonstrate that by employing the ISA, vibrations of the fundamental and other harmonic orders are suppressed effectively.

关键词： Active Magnetic Bearing(AMB) Adaptive filter Iterative search algorithm Least mean square(LMS) Vibration suppression

The Role of Renewable Protocatechol Acid in Epoxy Coating Modification: Significantly Improved Antibacterial and Adhesive Properties

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Chinese Journal of Polymer Science 2024年第1期42卷 63-72,I0008页

作者： Ming-Xuan Chen Jin-yue Dai Li-yue Zhang Shuai-Peng Wang Jing-Kai Liu Yong-Gang Wu xin-Wu Ba Xiao-Qing Liu School of Chemistry and Materials Science Hebei UniversityBaoding 071000China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of Marine Materials and Related Technologies Chinese Academy of SciencesNingbo 315201China

It is of great significance to design epoxy coatings with superior antibacterial properties and high adhesive properties, as well as excellent processing, superior durability, and high transparency. However, it is still a challenge because of the common complex design and synthesis. Herein, the bio-based monomer protocatechuic acid(PCA) was used as raw material, the catechol structure with high bonding and antibacterial properties was introduced into the flexible alkane segment of ethylene glycol diglycidyl ether(EGDE) through an efficient, and green method, and it was cured with isophorone diamine(IPDA) to prepare corresponding thermosets. The cured resins exhibited excellent allaround qualities, particularly in bonding and antibacterial. When 30% PCA was added to pure epoxy resin, the adhesion between substrate and coating increased from 4.40 MPa to 13.60 MPa and the antibacterial rate of coating against E. coli and S. aureus could approach 100%. All of this is due to the fact that the catechol structure present in PCA has the ability to interact with various substrates and alter the permeability of bacterial cell membranes. The architecture of this method offers a fresh approach to dealing with the issues of challenging raw material selection and complex synthesis techniques.

关键词： Epoxy coatings Thermosets Catechol structure Antibacterial High adhesion

Integrated Frequency-constrained Scheduling Considering Coordination of Frequency Regulation Capabilities from Multi-source Converters

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 261-274页

作者： Jiaming Li Ying Qiao Zongxiang Lu wei Ma xin Cao Rongfu Sun the Department of Electrical Engineering Tsinghua UniversityBeijing 100084China the China Suntien Green Energy Limited Company Shijiazhuang 050011China the State Grid Jibei Electric Power Company Beijing 100054China

As the proportion of renewable energy(RE)increases,the inertia and the primary frequency regulation(FR)capability of the power system ***,ensuring frequency security in the scheduling model has become a new technical requirement in power systems with a high share of *** to a shortage of conventional synchronous generators,the frequency support of multi-source converters has become an indispensable part of the system frequency resources,especially variable-speed wind turbine generation(WTG)and battery energy storage(BES).Quantitative expression of the FR capability of multi-source converters is necessary to construct frequency-constrained scheduling ***,the frequency support performance of these converter-interfaced devices is related to their working states,operation modes,and parameters,and the complex coupling of these factors has not been fully exploited in existing *** this study,we propose an integrated frequency-constrained scheduling model considering the coordination of FR capabilities from multi-source *** FR control strategies and variable FR parameters for WTG with or without reserved power are modeled,and multi-target allocation of BES capacity between tracking dispatch instruction and emergency FR is ***,the variable FR capabilities of WTG and BES are embedded into the integrated frequency-constrained scheduling *** nonlinear constraints for frequency security are precisely linearized through an improved iteration-based *** effectiveness of the proposed model is verified in a modified IEEE 24-bus standard *** results suggest that the coordinated participation of BES and WTG in FR can effectively reduce the cost of the scheduling model while meeting frequency security constraints.

关键词： Battery energy storage(BES) wind turbine generation(WTG) frequency regulation(FR) frequency security power system scheduling