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基于农村电商发展视角的农村剩余劳动力安置路径探析

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市场周刊 2024年第8期37卷 183-186页

作者：魏勇军湖南化工职业技术学院湖南株洲412000

随着我国城市化进程的加快,农村地区经济发展水平与城市间的差距逐渐加大,阻碍了我国社会经济的均衡发展,带来了一系列人力资源配给不均的问题。文章从农村电商发展的视角出发,探讨了农村剩余劳动力的安置路径,同时指出了政府在安置农... 详细信息

随着我国城市化进程的加快,农村地区经济发展水平与城市间的差距逐渐加大,阻碍了我国社会经济的均衡发展,带来了一系列人力资源配给不均的问题。文章从农村电商发展的视角出发,探讨了农村剩余劳动力的安置路径,同时指出了政府在安置农村剩余劳动力过程中的中介作用,需加强政府支持,构建完善的农村电商生态环境,促进农村剩余劳动力的有效安置。

关键词：农村电商剩余劳动力安置路径发展趋势

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农村电商对多维相对贫困减贫效应研究

智慧农业导刊 2024年第10期4卷 13-16页

作者：魏勇军湖南化工职业技术学院湖南株洲412000

该文用中介变量法探求发展农村电商对缓解农村多维相对贫困的作用机制。研究表明,农村电商对农村多为贫困人员的减贫效应,由我国东部地区向西部地区逐步增强,从事农业生产的效应强于非农业生产,受教育背景更高的多为贫困人口脱贫效应更... 详细信息

该文用中介变量法探求发展农村电商对缓解农村多维相对贫困的作用机制。研究表明,农村电商对农村多为贫困人员的减贫效应,由我国东部地区向西部地区逐步增强,从事农业生产的效应强于非农业生产,受教育背景更高的多为贫困人口脱贫效应更加明显。农村电商可以通过促进贫困人口进行创业,缓解贫困状况。

关键词：农村电商多维相对贫困中介效应家庭创业减贫效应

Physical and Numerical Simulation for Inner Crack Healing in Metals

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上海交通大学学报 2004年第Z2期38卷 130-135页

作者： Jingtao HAN Dongbin wei yongjun ZHANG School of Material Science and Engineering UST Beijing 100083 P.R.China University of Wollongong NSW 2522 Australia SHOUGANG Research Institute of Technology Beijing 100041 P.R.China

The research purpose on the healing of inner crack in metallic materials is to provide an effective approach for improving their properties and prolonging their lifetime. The crack healing process of 20MnMo steel with inner pre-crack was analyzed. It was found that all inner cracks could be healed in different degree. There were very fine ferrite grains in healing region. The micro-crack healing process in single crystal of BBC-Fe was simulated by the molecule dynamics method, which showed that the critical temperature of crack healing in BBC-Fe is 673K. There were micro-voids, dislocations and twins left after crack healing.

关键词： metal inner crack healing simulation

本科留学生“药学分子生物学”课程教学改革与实践

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生物加工过程 2024年第4期22卷 460-466页

作者：魏勇军张晓玲郑州大学药学院郑州大学合成生物学实验室河南郑州450001

随着我国经济的不断发展,教育实力不断提升,本科留学生数量稳步增加。近年来,多所高校纷纷招收药学或制药工程专业留学生。“药学分子生物学”是药学相关本科专业的必修课程。但是,药学本科留学生来自不同国家,文化背景和高中教学水平不... 详细信息

随着我国经济的不断发展,教育实力不断提升,本科留学生数量稳步增加。近年来,多所高校纷纷招收药学或制药工程专业留学生。“药学分子生物学”是药学相关本科专业的必修课程。但是,药学本科留学生来自不同国家,文化背景和高中教学水平不一,急需针对性地开展分子生物学课程教学工作。基于此,笔者及所在团队建立本科留学生“药学分子生物学”课程内容和教学模式,在跨学科融合、产学研用结合等方面提出了教学改革思路并加以实践,增加了相关课程思政的内容,旨在建立“药学分子生物学”教学体系,提高教师的“药学分子生物学”课程教学水平,锻炼留学生的科研思维,为培养高素质“知华”“友华”的药学专业人才奠定基础,也为国内本科生的药学分子生物学双语教学提供参考。

关键词：药学分子生物学本科留学生教学内容跨学科融合产学研用结合

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外部冲击对中国粮食安全的影响及对策

农业展望 2024年第3期20卷 10-15页

作者：魏勇军邓志英黄毅湖南化工职业技术学院湖南株洲412000 长沙民政职业技术学院商学院湖南长沙410004

保障粮食和农产品稳定安全供给是建设农业强国的头等大事。世界环境复杂多变,金融危机、中美贸易战以及全球新冠疫情等外部环境影响中国粮食安全。本研究将3次外部冲击分别定义为经济波动、对外关系与自然灾害,比较分析了3次外部冲击对... 详细信息

保障粮食和农产品稳定安全供给是建设农业强国的头等大事。世界环境复杂多变,金融危机、中美贸易战以及全球新冠疫情等外部环境影响中国粮食安全。本研究将3次外部冲击分别定义为经济波动、对外关系与自然灾害,比较分析了3次外部冲击对中国粮食安全的影响,短期来看,外部冲击一定程度上对中国粮价和粮食贸易造成波动,但长期来看影响有限。在应对措施方面,通过国内宏观经济的调控、支农补贴政策、多边谈判、关税政策、全国范围内的统筹协调、粮食结构调整、逐步完善的预警机制以及不断提高的农业配送条件,保障了中国粮食市场的均衡。为应对外部环境变化确保中国粮食长久安全,应优化粮食供给结构,提高应对外部突发事件的能力,维护稳定经贸关系,逐步开拓新兴市场。

关键词：农业经济外部冲击金融危机中美贸易战新冠疫情粮食安全

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青春期肠道微生态研究进展

儿科药学杂志 2024年第9期30卷 41-45页

作者：林一凡卫海燕魏勇军郑州大学附属儿童医院郑州450018 郑州大学药学院郑州450001

肠道微生物群(gut microbiota,GM)具有参与营养吸收代谢、阻止病原入侵、保护肠道屏障和参与神经内分泌调节等作用[1]。研究证实肠道微生态失调影响人体的健康,甚至引发疾病[2],例如肥胖[3]、炎症性肠病[4]、癌症[5-6]等。肠道菌群通过... 详细信息

肠道微生物群(gut microbiota,GM)具有参与营养吸收代谢、阻止病原入侵、保护肠道屏障和参与神经内分泌调节等作用[1]。研究证实肠道微生态失调影响人体的健康,甚至引发疾病[2],例如肥胖[3]、炎症性肠病[4]、癌症[5-6]等。肠道菌群通过反馈等机制维持自身的稳定与平衡[7]。饮食、环境、压力、生活方式、益生菌和抗生素等因素均可以改变肠道菌群的多样性和构成,进而影响肠道菌群的稳态,引发肠道微生态失调。16S rDNA基因扩增子测序和宏基因组测序等多组学技术为肠道微生物与环境和宿主的关系研究提供了可靠的工具。采用粪便标本来检测宿主肠道菌群的种类及多样性,其中硬壁菌门(Firmicutes)/拟杆菌门(Bacteroidetes)(F/B)值被认为是健康和疾病的重要预测指标[8]。

关键词：粪便标本肠道微生态失调组学技术神经内分泌调节炎症性肠病肠道菌群肠道微生物吸收代谢

Heterologous biosynthesis of medicarpin using engineered Saccharomyces cerevisiae

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Synthetic and Systems Biotechnology 2023年第4期8卷 749-756页

作者： Chujie Lu Rui Du Hao Fu Jizhao Zhang Ming Zhao yongjun wei wei Lin Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization NanjingChina School of Pharmacy Nanjing University of Chinese MedicineNanjingChina Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationSchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhouChina Department of Pathogen Biology School of Medicine&Holistic Integrative MedicineNanjing University of Chinese MedicineNanjingChina Xinjiang Institute of Traditional Chinese Medicine and Ethnic Medicine UrumqiChina

Medicarpin is an important bioactive compound with multiple medicinal activities,including anti-tumor,anti-osteoporosis,and anti-bacterial *** is associated with pterocarpans derived from medicinal plants,such as Sophora japonica,Glycyrrhiza uralensis Fisch.,and Glycyrrhiza glabra ***,these medicinal plants contain only low amounts of ***,the planting area for medicarpin-producing plants is limited;consequently,the current medicarpin supply cannot meet the high demands of medicinal *** this study,eight key genes involved in medicarpin biosynthesis were identified using comparative transcriptome and bioinformatic *** vitro and in vivo enzymatic reaction confirmed the catalytic functions of candidate enzymes responsible for the biosynthesis of medicarpin and medicarpin *** engineering of these genes in Saccharomyces cerevisiae achieved the heterologous biosynthesis of medicarpin using liquiritigenin as a substrate,with a final medicarpin yield of 0.82±0.18 mg/*** increasing the gene copy numbers of vestitone reductase(VR)and pterocarpan synthase(PTS),the final medicarpin yield was increased to 2.05±0.72 mg/*** study provides a solid foundation for the economic and sustainable production of medicarpin through a synthetic biology strategy.

关键词： Medicarpin Glycyrrhiza glabra L. Saccharomyces cerevisiae Medicarpin biosynthesis pathway Transcriptome sequencing Pterocarpan

Characterization of Panax ginseng UDP- Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rhl in Metabolically Engineered Yeasts

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Molecular Plant 2015年第9期8卷 1412-1424页

作者： wei wei Pingping Wang yongjun wei Qunfang Liu Chengshuai Yang Guoping Zhao Jianmin Yue Xing Yan Zhihua Zhou CAS-Key Laboratory of Synthetic Biology institute of Plant Physiology and Ecology Shanghai institutes for Biological Sciences Chfnese Academy of SciencesShanghai 200032 China State Key Laboratory of Drug Research Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203China These authors contributed equally to this article.

Ginsenosides, the main pharmacologically active natural compounds in ginseng （Panax ginseng）, are mostly the glycosylated products of protopanaxadiol （PPD） and protopanaxatriol （PPT）. No uridine diphosphate glycosyltransferase （UGT）, which catalyzes PPT to produce PPT-type ginsenosides, has yet been reported. Here, we show that UGTPgl, which has been demonstrated to regio-specifically glycosylate the C20-OH of PPD, also specifically glycosylates the C20-OH of PPT to produce bioactive ginsenoside FI. We report the characterization of four novel UGT genes isolated from P. ginseng, sharing high deduced amino acid identity （〉84%） with UGTPgl. We demonstrate that UGTPgl00 specifically glycosylates the C6-OH of PPT to produce bioactive ginsenoside Rhl, and UGTPgl01 catalyzes PPT to produce F1, followed by the generation of ginsenoside Rgl from FI. However, UGTPgl02 and UGTPgl03 were found to have no detectable activity on PPT. Through structural modeling and site-directed mutagenesis, we identified several key amino acids of these UGTs that may play important roles in determining their activities and substrate regio-specificities. Moreover, we constructed yeast recombinants to biosynthesize F1 and Rhl by introducing the genetically engineered PPT-producing pathway and UGTPgl or UGTPgl00. Our study reveals the possible biosynthetic pathways of PPT-type ginsenosides in Panax plants, and provides a sound manufacturing approach for bioactive PPT-type ginsenosides in yeast via synthetic biology strategies.

关键词： UDP-glycosyltransferase triterpenoids protopanaxatriol ginsenoside F1 ginsenoside Rhl,Panax ginseng

Benthic microbial biogeography along the continental shelf shaped by substrates from the Changjiang River plume

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Acta Oceanologica Sinica 2022年第1期41卷 118-131页

作者： yongjun wei Shan Jiang Lingmin Tian Liping wei Jie Jin Juan Severino Pino Ibanhez Yan Chang Xiaodao wei Ying Wu Key Laboratory of Advanced Drug Preparation Technologies of Ministry of Education School of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China Department of Food Science and Engineering Jinan UniversityGuangzhou 510632China Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China School of Natural Sciences Trinity College DublinDublin 2Ireland Instituto de Investigacions Marinas Consejo Superior de Investigaciones CientificasVigo 36208Spain Institute of Eco-Chongming East China Normal UniversityShanghai 202162China

Coastal zones are active reactors of continental material including that transported by rivers via a series of microbiota-mediated reactions. Nevertheless, current knowledge of the ecology and functioning of the microbiota in coastal areas affected by large riverine inputs remains insufficient on a global scale. Here, an investigation on sediment microbial composition, including taxonomy and metabolic network, as well as their relationship with major benthic reaction substrates, namely carbon, nitrogen, sulphur and phosphorus, was conducted in the continental shelf affected by the spread of the Changjiang River plume. Surface sediment samples(48 samples)were collected during March 2018, obtaining a mean Operational Taxonomic Units(OTUs) number of 3 ***, Acidobacteria and Actinobacteria were abundant phyla in the studied sediments. Bray-Curtis distance analysis classified the 48 samples into 4 clusters(MG1 to MG4) at the phylum-level. MG1 and MG2 are found near the river mouth, receiving substantial land-derived particles from the Changjiang River ***-attached microbes may be settled in these regions and influenced the observed sediment microbial diversity and biomass, e.g., increased Crenarchaeota relative abundance. The relative enrichment of these two groups in heterotrophic microbes further suggests a reliance of benthic microbiota on substrates with terrestrial origin, particularly specialized on processing sulphur-rich substrates. Regions MG3 and MG4 are located in the outer margin of the area affected by the Changjiang River plume, mainly fed by settling pelagic particles from phytoplankton. Compared to MG1 and MG2, a significant increase in the abundance of Thaumarcheota(phylumlevel) and Nitrosopumilus(genus-level) was found in MG3, suggesting nitrogen-related transformations as the key reactions to sustain microbial metabolism in this region. Coupled with the identified variations in the taxonomic composition, significant differenc

关键词： benthic microbiota biogeography benthic substrate Changjiang River plume East China Sea Yellow Sea