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The cessation and detoxification effect of tea filters on cigarette smoke

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Science china(Life sciences) 2010年第5期53卷 533-541页

作者： yan JingQi1,2,DI XiaoJing1,4,LIU CaiYi3,ZHANG HuiMin3,HUANG XiouQin3,ZHANG JunJing1,2,ZHAO yan5,ZHANG LongZe1,CHANG yanZhong4,LIANG YongLin2$,TAO Ran3 & ZHAO BaoLu1,21 state key laboratory of brain and cognitive Science,institute of biophysics,chinese academy of sciences,beijing 100101,china 2 key laboratory of Mental Health,institute of Psychology,chinese academy of sciences,beijing 100101,china 3 Addiction Branch,beijing Military Region General Hospital,beijing 100700,china 4 institute of Molecular Neurobiology,Hebei Normal University,Shijiazhuang 050016,china 5 Department of Food sciences and Technology,Harbin institute of Technology at weihai,weihai 264209,china state key laboratory of brain and cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing China key laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing China institute of Molecular Neurobiology Hebei Normal University Shijiazhuang China Addiction Branch Beijing Military Region General Hospital Beijing China Department of Food sciences and Technology Harbin Institute of Technology at Weihai Weihai China

To treat tobacco addiction,a tea filter was developed and studied for smoking *** work reports the smoking cessation effect of tea when it was used as a component of cigarette *** one trial it was found that after using the tea filters for 2 months,the volunteer smokers decreased their cigarette consumption by 56.5%,and 31.7% of them stopped *** work identified a new method and material,tea filter and theanine,which inhibit tobacco and nicotine addiction and provide an effective strategy for treating tobacco addiction.

关键词： cigarette smoking addiction cigarette cessation tea filter theanine nicotine dependence nicotine acetylcholine receptor(nAChR) dopamine public health free radical

Low threshold persistent spiking in a subpopulation of GABAergic interneurons

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Low threshold persistent spiking in a subpopulation of GABAe...

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： wei LU,Feng-Yu ZHANG,Bo WEN,Jin-Hui WANG~* state key laboratory of brain and cognitive sciences,institute of biophysics,chinese academy of sciences,beijing 100101,china

＜正＞Objective In rodents,the hippocampus has been studied extensively as a part of the brain system responsible for behavioral inhibition and attention,spatial memory,and *** studies suggested that interneurons play an important role in hippocampal *** intemeurons demonstrate persistent firing after repeated somatic current *** was known about electrophysiology and morphology properties of this kind of *** A transgenic mouse that expresses EGFP driven by the glutamic acid decarboxylase （GAD67） promoter was used to identify interneurons in brain *** performed whole cell recordings from intemeurons in the radiatum layer and lacunosum molecular layer of hippocampal CA1 area to detect their firing *** In about 20%of the EGFP-positive intemeurons,repeated somatic current injections eventually triggered persistent firing that outlasted the current injection by seconds or *** before the persistent spikes came up,the threshold potential decreased ***,the persistent spikes had a very low threshold potential. Voltage clamp recording showed higher probability of EPSCs in the persistent firing *** morphology of these intemeurons also indicated a great amount of connections with around *** This kind of intemeurons having persistent firing partem may play an important role in hippocampal network.

关键词： hippocampus intemeuron persistent spikes

Photoentrained activity in thalamic and hypothalamic neurons in birds

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Photoentrained activity in thalamic and hypothalamic neurons...

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： yan yanG,Qian XIAO,Qian WANG,Shu-Rong WANG~* state key laboratory of brain and cognitive Science,institute of biophysics,chinese academy of sciences,15 Datun Road,beijing 100101,china

＜正＞All animals are able to perceive space and *** behaviors in space and physiological processes fluctuate to adapt approximately to the 24-hour day/night cycle created by the self-rotation of our *** mammals including humans,this circadian biorhythm is entrained mainly by daily changes in ambient luminance detected by newly-found intrinsically photoreceptive retinal ganglion cells,which project to several brain regions including the hypothalamic suprachiasmatic nucleus and the thalamic lateral geniculate *** multiunit and brain slice recordings have revealed a circadian oscillation of suprachiasmatic activity,but our knowledge is completely lacking about whether and（if yes）how single thalamic cells would synchronize their firing rates to external light/dark cycles. Here we show by single-cell recording from the pigeon that there exist light-activated and light-inhibited neurons in the nucleus opticus principalis thalami,homologue of the lateral geniculate *** photosensitive thalamic neurons not only change firing rates in synchrony with the luminance level of light/dark cycles with various periods applied to the viewing eye but also memorize their own entrained firing pattern and replay spiking rhythmically for up to hours under constant photic *** light that maximally activates intrinsically photoreceptive retinal ganglion cells is much more potent than achromatic light for photoentrainment of thalamic *** cells as master clocks also possess such photoresponse *** results shed new light on the neural principle with which external light/dark cycles are translated into an internal rhythm in the organism and strongly support involvement of luminance encoding thalamic cells in biological rhythmicity.

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The Effect of Glycation on the Structure and Function of Bovine Serum Albumin by Serials of Reducing Sugars

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The Effect of Glycation on the Structure and Function of Bov...

2008年全国生物化学与分子生物学学术大会

作者： yan wei Lan Chen Ji Chen Lin Ge Rong-qiao He (state key Lab of brain and cognitive Science,institute of biophysics,chinese academy of sciences,beijing,100101,china.)

Glycation,non-enzymatic glycation(NEG)is a spontaneous condensation reaction between a reducing carbohydrate and a free amine group such as the α-/ε-amino groups of a *** levels of glycated protein may lead to long-term tissue damage associated with the pathogenic effects observed in diabetics, including poor circulation to extremities,retinopathy,nephropathy,neuropathy,and coronary artery disease.

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人神经tau蛋白与DNA相互作用

生物化学与生物物理进展 2004年第10期31卷 918-923页

作者：曲梅花李辉徐艳娟赫荣乔中国科学院生物物理研究所中国科学院物理研究所

通过凝胶阻滞实验表明 ,人类神经tau能够与不同来源的DNA (λDNA ,质粒DNA以及PCR产物 )相结合 ,形成tau DNA复合物 .每分子神经tau大约与长度为 6～ 10bp的核苷酸片段结合 .原子力显微镜直接证实了tau与线性质粒DNA相结合形成串珠样的... 详细信息

通过凝胶阻滞实验表明 ,人类神经tau能够与不同来源的DNA (λDNA ,质粒DNA以及PCR产物 )相结合 ,形成tau DNA复合物 .每分子神经tau大约与长度为 6～ 10bp的核苷酸片段结合 .原子力显微镜直接证实了tau与线性质粒DNA相结合形成串珠样的结构 .采用单克隆抗体Tau 1,进行免疫组织化学的实验显示 ,神经tau不但弥散地分布在SY5Y细胞系的细胞质内 ,同时也存在于细胞核中 ,并形成染色致密的斑点 .以上结果提示 :神经tau在细胞核中可能参与了某种重要的生物学功能 .

关键词：人神经tau DNA 相互作用原子力显微镜(AFM)

Two Pairs of Neurons Control Drosophila Larval Light Preference

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Two Pairs of Neurons Control Drosophila Larval Light Prefere...

The 1st International Symposium on brain Function and Disorders（SBFD）

作者： GONG Zhe-Feng LIU Jiang-Qu GUO Chao ZHOU yan-Qiong LIU Li state key laboratory of brain and cognitive Science institute of biophysics chinese academy of sciences beijing 100101 P.R.china

＜正＞Phototaxis is a basic response to environmental stimuli in the fruit fly Drosophila *** larvae,which prefer darkness to light,receive visual input from two bilateral groups of 12 photoreceptor neurons,known as t...

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MiR-124 is required for proper cell proliferation in early development of Xenopus eye and brain

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MiR-124 is required for proper cell proliferation in early d...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Kai-Li LIU,wei-Chuan MO,Ying LIU,Xiu-Mei WANG,Rong QIU,Rong-Qiao HE 1 The state key laboratory of brain and cognitive Science,institute of biophysics,chinese academy of sciences, beijing 100101,china 2 Graduate School of the chinese academy of sciences,beijing 100039,china

＜正＞Objective MiR-124 is one of the most abundant miRNAs enriched in developing and adult brain and eye.A recent report showed that miR-124 regulated adult neurogenesis in mammalian brain;however,its function in neural development remains *** have found that miR-124 starts to be expressed in Xenopus eye and brain from early neural development,and its overexpression leads to malformation of eye and *** present study is to reveal the cellular and molecular mechanisms of its role in early development of Xenopus eye and *** Effects of downregulation and overexpression of miR-124 on neurogenesis and expression of its target candidates in eye and brain were ***-124 precursor molecules or antisense inhibitor and/or mRNAs of miR-124 target candidates was microinjected into one dorsal-animal blastomere at 8-cell stage of Xenopus emebyos for gain-/loss-of functional and rescue *** proliferation in eye and brain was detected by BrdU incorporation and phosphorylated histone-H3 immunohistochemistry *** cells were identified by expression of NCAM and *** expression of neural markers and miR-124 target candidates was checked by RT-PCR,whole-mount in situ hybridization and ***（1） Downregulation of miR-124 decreases cell proliferation and upregulates expression of NCAM and N-tubulin during early neural development;while overexpression of miR-124 gives reverse effects.（2） MiR- 124 negatively regulates expression of candidate target neuroD1,which is expressed complementarily to miR-124 in eye and brain.（3） NeuroD1 overexpression effects in eye mimic that of miR-124 downregulation;and coinjection of neuroD1 with miR-124 can rescue the eye defects caused by overexpression of *** MiR-124 is required for the proper cell proliferation and targets neuroD1 in eye and brain during the early neural development.

关键词： miR-124 cell proliferation neural development neuroDl

Experience improves feature extraction in Drosophila

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Experience improves feature extraction in Drosophila

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Yue-Qing PENG~1,Wang XI~1,wei ZHANG~1,Ke ZHANG~1,Aike GUO~(1,2) 1 institute of Neuroscience,key laboratory for Neurobiology,Shanghai institutes for Biological sciences,chinese academy of sciences,Shanghai 200031,china 2 state key laboratory of brain and cognitive Science,institute of biophysics,chinese academy of sciences,beijing 100101,china

＜正＞Prior exposure to a pattern in the visual scene can enhance subsequent recognition of that pattern in many species from honeybees to ***,whether prior experience with a visual feature of an object,such as color or shape,can also facilitate later recognition of that particular feature from multiple visual features is largely *** feature extraction is the ability to select the key component from multiple visual *** a visual flight simulator,we designed a novel protocol for visual feature extraction to investigate the effects of prior experience on visual reinforcement learning in *** found that,following conditioning with a visual feature of objects among combinatorial shapecolor features,wild type flies exhibited poor ability to extract the correct visual ***,the ability for visual feature extraction was greatly enhanced in the flies previously trained with that visual feature ***,we demonstrated that flies might possess the ability to extract the abstract category of "shape",but not a particular shape. Finally,this experience-dependent feature extraction is absent in flies with defective mushroom bodies,one of the central brain structures in *** results indicate that prior experience can enhance visual feature extraction in Drosophila, and that mushroom bodies are required for this experience-dependent visual cognition.

关键词： learning and memory Drosophila mushroom body visual feature experience-dependent behavior flight simulator

The Changes of Histone Methylation Induced by Adolescent Social Stress Regulate the Resting-state Activity in mPFC

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Research 2024年第3期2023卷 273-283页

作者： Jiesi Wang wei Zhang Hang Xu Bart Ellenbroek Jiajie Dai Li Wang Chaogan yan weiwen Wang CAS key laboratory of Mental Health Institute of PsychologyChinese Academy of SciencesBeijing.China Department of Psychology University of Chinese Academy of SciencesBeijingChina School of Psychology Victoria University of WellingtonKelburnWellington 6012New Zealand CAS key laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijingChina.

Early-life stress can lead to sustained alterations in regional resting-state brain functions, but the underlying molecular mechanism remains unclear. Stress can also induce sustained changes in epigenetic modifications across brain regions, which are not limited to a few genes;rather, they often tend to produce global levels of change. The functional implication of these changes also remains to be elucidated. We hypothesize that global epigenetic changes may partly modulate the resting-state functions of brain regions to influence behavior. To test this hypothesis, we used an adolescent social stress (ASS) model in mice and examined the relationship between epigenetic modifications and regional resting-state brain activity using resting-state functional magnetic resonance imaging (rs-fMRI). The results showed that, compared to the control mice, the stressed mice showed increased anxiety and social avoidance behaviors and greater levels of dimethylation of histone H3 at lysine 9 (H3K9me2) in the medial prefrontal cortex (mPFC). In addition, the resting-state activity represented by the amplitude of low-frequency fluctuation (ALFF) was significantly lower in the mPFC of stressed mice. To verify the relationship of H3K9me2 and ALFF, the specific inhibition of H3Kme2 was performed by using the drug UNC0642, which reversed the anxiety behavior induced by ASS and significantly increase the ALFF value of mPFC in both normal and ASS animals. Our study is the first to report an association between histone modifications and rs-fMRI findings, providing a new perspective for understanding of the significance of regional brain epigenetic changes and a possible molecular explanation for rs-fMRI findings.

关键词： sustained mPFC alterations