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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li wei-Quan xu Jia-Bao Liao wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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How do moth and butterfly taste?——Molecular basis of gustatory receptors in Lepidoptera

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Insect Science 2020年第6期27卷 1148-1157页

作者： wei xu Agricultural Sciences College of ScienceHealthEngineering and EducationMurdoch UniversityWAAustralia

Insect gustatory system plays a central role in guiding insect feeding behaviors,insect-plant interactions and *** receptors(GRs)form the interface between the insect taste system and their ***,most studies on insect GRs are focused on Drosophila;much less attention has been paid to Lepidoptera species,which consist of a large number of serious agricultural crop *** the exceptional advances in the next generation sequencing(NGS),cellular biology,RNA interference(RNAi),and clustered regularly interspaced short palindromic repeats(CRISPR)technologies in recent years,extraordinary progresses have been achieved elucidating the molecular mechanisms of Lepidopteran *** this review,we highlighted these advances,discussed what these advances have revealed and provide our new insights into this field.

关键词： bitter receptor CO2 receptor GR43a sugar receptor taste receptor

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Syntheses of α-Hydroxyarylacetic Acids in the Presence of Different Phase Transfer Catalysts Under Sonication

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Chemical Research in Chinese Universities 2001年第2期17卷 175-177页

作者： xu wei-liang Zhejiang Univ Organ Chem Grp Huajiachi Sect Hangzhou 310029 Peoples R China

The syntheses of α-hydroxyarylacetic acids with a good yield in the presence of different phase transfer catalysts (PTC) under sonication were studied. The results obtained are superior to those by other similar methods. The data show that β-cyclodextrin (β-CD) is more efficient than other PTC. The preliminary reaction conditions are also discussed.

关键词： α-Hydroxyarylacetic acid Phase transfer catalyst Sonication

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Stochastic response of an axially moving viscoelastic beam with fractional order constitutive relation and random excitations

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Acta Mechanica Sinica 2013年第3期29卷 443-451页

作者： Di Liu wei xu Yong xu Department of Applied Mathematics Northwestern Polytechnical University

A convenient and universal residue calculus method is proposed to study the stochastic response behaviors of an axially moving viscoelastic beam with random noise excitations and fractional order constitutive relationship, where the random excitation can be decomposed as a nonstationary stochastic process, Mittag-Leffler internal noise, and external stationary noise excitation. Then, based on the Laplace transform approach, we derived the mean value function, variance function and covariance function through the Green＇s function technique and the residue calculus method, and obtained theoretical results. In some special case of fractional order derivative α , the Monte Carlo approach and error function results were applied to check the effectiveness of the analytical results, and good agreement was found. Finally in a general-purpose case, we also confirmed the analytical conclusion via the direct Monte Carlo simulation.

关键词： Axially moving beam Fractional derivatives Kelvin constitutive relationship Stationary nonstationary noise Residue calculus method Stochastic response

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Non-probabilistic Robust Optimal Design Method

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Chinese Journal of Mechanical Engineering 2009年第2期22卷 184-189页

作者： SUN wei xu Huanwei ZHANG xu School of Mechanical and Engineering Dalian University of Technology Dalian 116024 China

For the purpose of dealing with uncertainty factors in engineering optimization problems, this paper presents a new non-probabilistic robust optimal design method based on maximum variation estimation. The method analyzes the effect of uncertain factors to objective and constraints functions, and then the maximal variations to a solution are calculated. In order to guarantee robust feasibility the maximal variations of constraints are added to original constraints as penalty term; the maximal variation of objective function is taken as a robust index to a solution; linear physical programming is used to adjust the values of quality characteristic and quality variation, and then a bi-level mathematical robust optimal model is constructed. The method does not require presumed probability distribution of uncertain factors or continuous and differentiable of objective and constraints functions. To demonstrate the proposed method, the design of the two-bar structure acted by concentrated load is presented. In the example the robustness of the normal stress, feasibility of the total volume and the buckling stress are studied. The robust optimal design results show that in the condition of maintaining feasibility robustness, the proposed approach can obtain a robust solution which the designer is satisfied with the value of objective function and its variation.

关键词： variation analysis linear physical programming bi-level optimization robust design

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Expression analysis of GSK-3β in diapause pupal brains in the cotton bollworm, Helicoverpa armigera

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Insect Science 2015年第5期22卷 597-605页

作者： wei Chen wei-Hua xu Guangdong Province Key Laboratory for Biotechnology Drug Candidates School of Biosciences and Biopharmaceutics Guangdong Pharmaceutical University and State Key Laboratory of Biocontrol School of Life Sciences Sun Yat-sen University Guangzhou China

Diapause is an adaptive response to adverse environmental conditions, but the molecular mechanisms are unclear. Some signaling molecules have been identified in the regulation of diapause. GSK-3β is an important signaling protein involved in sev- eral signaling pathways. In this study, GSK-3β from the cotton bollworm, Helicoverpa armigera, was cloned using reverse transcription polymerase chain reaction and rapid am- plification of complementary DNA （cDNA） ends techniques. Sequence analysis showed that the full-length cDNA was 1447 bp containing a 292 bp 5＇-untranslated region （UTR）, a 162 bp 3＇-UTR and a 993 bp open reading frame （ORF）. The deduced Har-GSK-3β pro- tein has high identity to other known GSK-3β, as determined by Basic Local Alignment Search Tool analysis. Developmental expression of total GSK-3/3 and p-GSK-3β （Ser9） in diapause and non-diapanse pupal brains was investigated by Western blotting. Results indicated that the activity of GSK-3β is down-regulated in diapause pupal brains, which is further confirmed by Western blotting after diapause break. These finding suggest that the down-regulation of Har-GSK-3β activity may be important for pupal diapause.

关键词： Helicoverpa armigera GSK-3β pupal diapauses RACE

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Multistate circularly polarized luminescence switches based on dual stimuli-responsive chiral[2]rotaxanes

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Science China Chemistry 2024年第12期67卷 4202-4211页

作者： wei-Tao xu xue Li Xiao-Qin xu xu-Qing Wang Hai-Bo Yang wei Wang Wuhu Hospital East China Normal University(The Second People’s HospitalWuhu)Wuhu 241001China Shanghai Key Laboratory of Green Chemistry and Chemical Processes State Key Laboratory of Petroleum Molecular and Process EngineeringSchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Shanghai Center of Brain-inspired Intelligent Materials and Devices East China Normal UniversityShanghai 200241China

Aiming at the construction of novel multistate circularly polarized luminescence(CPL)switches,dual stimuli-responsive chiral[2]rotaxanes towards anions and light have been designed and *** the light-controlled on/off F?rster resonance energy transfer(FRET)switching between the emissive stoppers and anion-induced controllable motions of the chiral wheel for the precise regulations of chirality information transfer from the chiral wheel to the emissive stoppers,precisely switching between four CPL emission states with varied emission wavelengths and dissymmetry factors has been successfully realized,making them a promising platform for practical uses such as information storage and *** proof-of-concept study not only provides a novel design strategy for multistate CPL switching but also contributes excellent candidates for the construction of novel smart chiral luminescent materials.

关键词： mechanically interlocked molecules Förster resonance energy transfer aggregation-induced emission pillararene spiropyran

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Heteroclinic cycles in a new class of four-dimensional discontinuous piecewise affine systems

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Chinese Physics B 2018年第11期27卷 250-256页

作者： Wenjing xu wei xu Li Cai School of Science Northwestern Polytechnical University Xi＇ an 710129 China

It is a huge challenge to give an existence theorem for heteroclinic cycles in the high-dimensional discontinuous piecewise systems（DPSs）. This paper first provides a new class of four-dimensional（4 D） two-zone discontinuous piecewise affine systems（DPASs）, and then gives a useful criterion to ensure the existence of heteroclinic cycles in the systems by rigorous mathematical analysis. To illustrate the feasibility and efficiency of the theory, two numerical examples, exhibiting chaotic behaviors in a small neighborhood of heteroclinic cycles, are discussed.

关键词： heteroclinic cycle chaos discontinuous piecewise affine system

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Hawking-Page transition and the dual relations of anti-de Sitter black holes surrounded by dark energy in general dimensions

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Communications in Theoretical Physics 2024年第7期76卷 94-104页

作者： Zhang Xin xu wei School of Mathematics and Physics China University of GeosciencesWuhan 430074China

Recently,a dual relation T_(0)(n+1)=T_(HP)(n)between the minimum temperature(T_(0)(n+1))black hole phase and the Hawking-Page transition(T_(HP)(n))black hole phase in two successive dimensions was introduced by wei et al(2020 ***.D10210411);this was reminiscent of the anti-de Sitter/conformal field theory(AdS/CFT)correspondence,as the Hawking-Page transition temperature could be treated as the temperature of the dual physical quantity on the boundary and the latter corresponds to that in the *** this paper,we discuss the Hawking-Page transition and the dual relations in Ads black holes surrounded by dark energy in general *** findings reveal the occurrence of the Hawking-Page transition between the thermal AdS radiation and thermodynamically stable large AdS black holes,in both the spacetime surrounded by phantom dark energy and the spacetime surrounded by quintessence dark *** discuss the effects of the phantom dark energy and quintessence dark energy on the Hawking-Page transition *** the dual relation in particular,it works well for the case of an AdS black holes surrounded by phantom dark *** the case of an Ads black hole surrounded by quintessence dark energy,the dual relation should be modified under an open assumption that the state parameter and the density parameter of the quintessence dark energy depend on the dimensions of the spacetime.

关键词： Hawking-Page transition dark energy black hole thermodynamics

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Super solutions of the model RB

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Frontiers of Computer Science 2022年第6期16卷 191-193页

作者： Guangyan ZHOU wei xu Department of Mathematics Beijing Technology and Business UniversityBeijing 100048China School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China

1 Introduction Constraint satisfaction problems(CSPs)have come to play a prominent role in the area of computer science,statistical physics and information theory.A CSP instance involves a set of variables and a set of constraints,and the task is to find a solution(an assignment of variables that satisfies all the constraints)or to prove the *** RB[1]is a CSP model proposed to overcome the trivial unsatisfiability of standard Model B[2].

关键词： theory. constraints trivial

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