检索结果-南通市图书馆

Chinese Journal of Electronics 2017年第5期26卷 1064-1072页

作者： JIA Zongpu wei xiaojuan GUO Hairu PENG weiping SONG Cheng College of Computer Science and Technology Henan Polytechnic University

We propose two novel methods to improve the source location privacy security protection and the node energy utilization in Wireless sensor networks(WSN).A privacy preservation protocol for source location in WSN based on angles(APS) and an Enhanced protocol for source location(EAPS),which dynamically adjusts emission radius during *** APS protocol produces geographically dispersed phantom source nodes and utilizes the energy from the energy-abundant regions to make the routing path versatile among the entire *** the EAPS protocol,according to the number of its own adjacent nodes,residual energy and the distance to the base station,a node adjusts its radius *** show that the two novel protocols can improve the security and take advantage of the residual energy in the network balance the network life and energy consumption in comparison with the existing routing protocols based on the phantom sources.

关键词： Wireless sensor networks(WSN) Source-location Privacy protection Phantom source nodes Security time

In Vitro Comparative Effect of Three Novel Borate Bioglasses on the Behaviors of Osteoblastic MC3T3-E1 Cells

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2014年第10期30卷 979-983页

作者： xiaojuan wei Tingfei Xi Yufeng Zheng Changqing Zhang Wenhai Huang Academy for Advanced Interdisplinary Studies Peking University College of Engineering Peking University Department of Orthopaedics Shanghai Sixth People's HospitalShanghai Jiaotong University Institute of Bio-engineering and Information Technology Materials School of Materials Science and EngineeringTongji University

Most related investigations focused on the effects of borate glass on cell proliferation/biocompatibility in vitro or bone repair in vivo; however, very few researches were carried out on other cell behaviors. Three novel borate bioglasses were designed as scaffolds for bone regeneration in this wok. Comparative effects of three bioglasses on the behaviors of osteoblastic MC3T3-E1 cells were evaluated. Excellent cytocompatibility of these novel borate bioglasses were approved in this work. Meanwhile, the promotion on cell proliferation, protein secretion and migration with minor cell apoptosis were also discussed in details, which contributed to the potential clinical application as a new biomaterial for orthopedics.

关键词： Comparative study Borate bioglass Osteoblastic cells Cell behavior In vitro

Research on the stability of virtual coupling train formation based on a PID controller under the influence of time delay

在线全文

学校读者我要写书评

暂无评论

Transportation Safety and Environment 2024年第3期6卷 133-139页

作者： Sixuan Qiu Ningzhou Li xiaojuan wei Gaosong Li School of Railway Transportation Shanghai Institute of TechnologyShanghai 201418China

As the latest research direction of train-to-train communication,virtual coupling train formation technology has attracted the attention of many *** paper studies the influence of time delay on the formation of virtual coupled *** proposed a distributed PID controller,which means that trains can still form a stable fleet operation under the influence of communication delay and control *** modelling and analysis,the research uses Matlab to conduct simulation,involving two sets of *** including speed,acceleration,position,position error,expected distance between adjacent trains and actual distance between adjacent trains are *** results demonstrate that the distributed PID controller can effectively control the impact of time delay on the virtual coupling fleet.

关键词： virtual coupling train-to-train communication time delay PID controller

Characterization of decellularized scaffold derived from porcine meniscus for tissue engineering applications

在线全文

学校读者我要写书评

暂无评论

Frontiers of Materials Science 2016年第2期10卷 101-112页

作者： Shuang GAO Zhiguo YUAN Tingfei XI xiaojuan wei Quanyi GUO Center for Biomaterial and Tissue Engineering Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China Key Laboratory of PLA Institute of Orthopaedics Chinese PLA General Hospital Beijing 100853 China Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 China

Menisci are fundamental fibrocartilaginous organs in knee joints. The injury in meniscus can impair normal knee function and predisposes patients to osteoarthritis. This study prepared decellularized meniscus scaffolds using a 1% （w/w） sodium dodecyl sulfate solution and sufficient rinsing steps. Complete cell removal was verified by hematoxylin and eosin staining and DNA content assay. Decellularized menisci had accordant tension properties to intact ones, but with declined compression properties. This occurred because the collagen fiber was not damaged but glycosami- noglycans was significantly lost during the decellularization process, which was confirmed by biochemical assay and histology staining. In vitro cytotoxicity assay demonstrated that decellularized meniscus scaffolds have no toxicity on L929 murine fibroblasts and porcine chondrocytes. Further experiment showed that porcine chondrocytes could adhere and proliferate on the scaffold surface, and some cells even could infiltrate into the scaffold. All results showed the potential of this decellularized meniscus to be the scaffolds in tissue engineering.

关键词： meniscus scaffold decellularization biomechanical cytotoxicity tissueengineering

Dietary restriction to accompany the aging process in mice Can it be neuroprotective?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2010年第10期5卷 789-795页

作者： Shougang wei xiaojuan He Shaojun Yun Shuhua Zhang Zhongxin Xiao School of Public Health and Family Medicine Capital Medical University Beijing 100069 China

BACKGROUND： Prophylactic dietary restriction （DR）, whether lifelong or started in adulthood,retards the aging process and attenuates cognitive decline in rodents. However, whether the anti-aging and neuroprotective efficacy of DR initiate late in life or accompany the aging process remains ***： The present study sought to：（1） determine if DR could protect against behavioral decline in mice when implemented during the aging process induced by D-galactose and （2） examine neuronal apoptosis in these aged brains and whether DR could block ***, TIME AND SETTING： The randomized controlled animal study. The experiment was performed at the Experimental Animal Center of Capital Medical University and the Laboratory Center of School of Public Health of Captial Medical University of China from April 2006 to October ***： D-galactose （D-gal） was purchased from Beijing Chemical-Regent Company （Beijing, China）. Terminal transferase dUTP nick end labeling （TUNEL） detection kit was obtained from Roche, Germany. Assay kits for antioxidant enzyme activities and malondialdehyde contents were purchased from Jiancheng Institute of Biotechnology （Nanjing, China）. Morris water maze （Friends Honesty Life Sciences Co. Ltd., Hong Kong, China） and Flow Cytometry （Coulter, USA） were used in this ***： A total of 40 male Institute of Cancer Research （lCR） mice, 3 months old, were equally and randomly divided into D-gal treatment, DR treatment, D-gal ＋ DR treatment and normal control groups, and were then randomly assigned to one of two feeding regimens： ad libitum access to food or DR which received a 70% amount of daily food intake as that by ad libitum fed mice. There were two replicates per feeding regimen and mice were fed for 10 weeks,with or without a daily subcutaneous injection of D-gal at 100 mg/*** OUTCOME MEASURES： Animals＇ spatial learning and memory performance were tested in the Morris water maze. Neuronal apoptosis rates were eva

关键词： dietary restriction brain aging D-galactose behavioral performance neuronal apoptosis oxidative stress neural regeneration

Enhanced osteochondral regeneration with a 3D-Printed biomimetic scaffold featuring a calcified interfacial layer

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2024年第6期36卷 317-329页

作者： Di Wu Kaiwen Zheng Wenjing Yin Bin Hu Mingzhao Yu Qingxiao Yu xiaojuan wei Jue Deng Changqing Zhang Department of Orthopedic Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.600 Yishan RoadShanghai200233China Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.600 Yishan RoadShanghai200233China Shanghai Uniorlechnology Corporation No.258 Xinzhuan RoadShanghai201612China Academy for Engineering&Technology Fudan UniversityNo.220 Handan RoadShanghai200433China

The integrative regeneration of both articular cartilage and subchondral bone remains an unmet clinical need due to the difficulties of mimicking spatial complexity in native osteochondral tissues for artificial ***-by-layer fabrication strategies,such as 3D printing,have emerged as a promising technology replicating the stratified zonal architecture and varying microstructures and mechanical ***,the dynamic and circulating physiological environments,such as mass transportation or cell migration,usually distort the pre-confined biological properties in the layered implants,leading to undistinguished spatial variations and subsequently inefficient *** study introduced a biomimetic calcified interfacial layer into the scaffold as a compact barrier between a cartilage layer and a subchondral bone layer to facilitate osteogenic-chondrogenic *** calcified interfacial layer consisting of compact polycaprolactone(PCL),nano-hydroxyapatite,and tasquinimod(TA)can physically and biologically separate the cartilage layer(TA-mixed,chondrocytes-load gelatin methacrylate)from the subchondral bond layer(porous PCL).This introduction preserved the as-designed independent biological environment in each layer for both cartilage and bone regeneration,successfully inhibiting vascular invasion into the cartilage layer and preventing hyaluronic cartilage calcification owing to devascularization of *** improved integrative regeneration of cartilage and subchondral bone was validated through gross examination,micro-computed tomography(micro-CT),and histological and immunohistochemical analyses based on an in vivo rat ***,gene and protein expression studies identified a key role of Caveolin(CAV-1)in promoting angiogenesis through the Wnt/β-catenin pathway and indicated that TA in the calcified layer blocked angiogenesis by inhibiting CAV-1.

关键词： 3D-printed scaffold Calcified interfacial layer CAV-1 Osteochondral regeneration Tasquinimod

Research on control technology of elderly-assistant & walking-assistant robot based on tactile-slip sensation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering Sciences 2013年第1期11卷 89-96页

作者： Zhang Xiaodong Wang Yunxia wei xiaojuan School of Mechanical Engineering Xi'an Jiaotong University

In this paper,according to the old people's physical characteristics and their technical requirements for comfort and mastery when operating the robot,a control approach driven by tactile and slip senses is investigated to control the elderly-assistant & walking-assistant robot. First,on the basis of the proposed driving control system program of tactile and slip,a detection system of tactile and slip senses are designed. Based on the tactile and slip feature representation and extraction,an improved classification and recognition method is proposed which combines K-nearest neighbor (KNN) algorithm and K-means algorithm. And then,a robot control system based on TMS320F2812 is designed in this paper,including its hardware and software design. Then,a moving control method including the fuzzy adaptive control algorithm is presented for the walking-assistant robot to realize some different moving properties. At last,by the experimental verification in the walking-assistant robot,the research results show that the tactile and slip senses detection and recognition method is effective,and the whole control system has good feasibility and adaptability.

关键词： tactile and slip senses control system elderly-assistant & walking-assistant robot fuzzy adaptive control

Fluffy hybrid nanoadjuvants for reversing the imbalance of osteoclastic andosteogenic niches in osteoporosis

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2024年第9期39卷 354-374页

作者： Guoyang Zhang Yuhao Kang Jizhao Dong c Dingyi Shi Yu Xiang Haihan Gao Zhiqi Lin xiaojuan wei Ren Ding Beibei Fan Hongmei Zhang Tonghe Zhu Liren Wang Xiaoyu Yan Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine No.600 Yishan RoadShanghai200233China Shanghai Jiao Tong University School of Medicine No.227 South Chongqing RoadShanghai200025China Multidisciplinary Centre for Advanced Materials Institute for Frontier Medical TechnologySchool of Chemistry and Chemical EngineeringShanghai University of Engineering ScienceNo.333 Longteng RoadShanghai201620China Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine Department of OrthopedicsNo.181 Youyi RoadShanghai201900China Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine Department of PharmacyNo.181 Youyi RoadShanghai201900China Regenerative Sports Medicine and Translational Youth Science and Technology Innovation Workroom Shanghai Jiao Tong University School of MedicineNo.227 South Chongqing RoadShanghai200025China Regenerative Sports Medicine Lab of the Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.600 Yishan RoadShanghai200233China

Osteoporosis is majorly caused by an imbalance between osteoclastic and osteogenic niches. Despite thedevelopment of nationally recognized first-line anti-osteoporosis drugs, including alendronate (AL), their lowbioavailability, poor uptake rate, and dose-related side effects present significant challenges in treatment. Thiscalls for an urgent need for more effective bone-affinity drug delivery systems. In this study, we produced hybridstructures with bioactive components and stable fluffy topological morphology by cross-linking calcium andphosphorus precursors based on mesoporous silica to fabricate nanoadjuvants for AL delivery. The subsequentgrafting of -PEG-DAsp8 ensured superior biocompatibility and bone targeting capacity. RNA sequencing revealedthat these fluffy nanoadjuvants effectively activated adhesion pathways through CARD11 and CD34 molecularmechanisms, hence promoting cellular uptake and intracellular delivery of AL. Experiments showed that smalldoseAL nanoadjuvants effectively suppress osteoclast formation and potentially promote osteogenesis. In vivoresults restored the balance between osteogenic and osteoclastic niches against osteoporosis as well as theconsequent significant recovery of bone mass. Therefore, this study constructed a drug nanoadjuvant withpeculiar topological structures and high bone targeting capacities, efficient intracellular drug delivery as well asbone bioactivity. This provides a novel perspective on drug delivery for osteoporosis and treatment strategies forother bone diseases.

关键词： Osteoporosis nanoadjuvants topological morphology bone niches Adhesion

Progress of Beam Position Monitor for HIAF in 2019

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IMP & HIRFL Annual Report 2019年第1期 319-320页

作者： Li Min Mao Ruishi Zhao Tiecheng wei xiaojuan 不详

BPMs deliver the center-of-mass information of the beam and act as a monitor for the longitudinal bunch shape[1].39 BPMs will be installed in the BRing of High Intensity heavy-ion Accelerator Facility(HIAF).

关键词： bunch beam BPM

Research Progress on Analysis and Detection Techniques of Veterinary Drug Residues in Animal Foods

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Agricultural Biotechnology 2019年第5期8卷 60-64,69页

作者： Bing LI Xuzheng ZHOU Fusheng CHENG xiaojuan wei weiwei Wang Jiyu ZHANG Lanzhou Institute of Husbandry and Pharmaceutical Sciences Chinese Academy of Agricultural Sciences/Key Laboratory of Veterinary Pharmaceutics Discovery Ministry of Agriculture/Key Laboratory of New Animal Drug Project of Gansu Province

As an important guarantee for the prevention and control of animal diseases,veterinary drugs have important functions in improving animal production performance and product quality and maintaining ecological *** are an important guarantee for the healthy development of animal husbandry,food safety and public ***,the irrational use and abuse of veterinary drugs and feed pharmaceutical additives are widespread,causing harmful substances in animal foods and damage to human health,and threatening the sustainable development of the environment and animal husbandry as *** order to ensure human health,it is urgent to develop a simple,rapid,high-sensitivity,high-throughput and low-cost veterinary drug residue detection *** this paper,the sample pretreatment methods and detection techniques for the analysis of veterinary drug residues in animal foods were reviewed.

关键词： Animal food Veterinary drug residue Sample preparation Detection techniques